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Chikara Aizawa

Research Profile

Chemicals & Drugs

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Nasal Mucosa

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Publications

TOP 3
Izumi Watanabe; Yukari Hagiwara; Shin-etsu Kadowaki; Tomoki Yoshikawa; Katsuhiro Komase; Chikara Aizawa; Hiroshi Kiyono; Yoshifumi Takeda; Jerry R McGhee; Joe Chiba; Tetsutaro Sata; Takeshi Kurata; Shin-ichi Tamura
Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K).
Yasuko Asahi; Tomoki Yoshikawa; Izumi Watanabe; Takuya Iwasaki; Hideki Hasegawa; Yuko Sato; Shin-ichiro Shimada; Masanobu Nanno; Yoshiaki Matsuoka; Makoto Ohwaki; Yoichiro Iwakura; Yujiro Suzuki; Chikara Aizawa; Tetsutaro Sata; Takeshi Kurata; Shin-ichi Tamura
Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines.
H Asanuma; K Hirokawa; M Uchiyama; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata; Tetsutaro Sata; Shin ichi Tamura
Immune responses and protection in different strains of aged mice immunized intranasally with an adjuvant-combined influenza vaccine.

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All Publications

2002: Izumi Watanabe; Yukari Hagiwara; Shin-etsu Kadowaki; Tomoki Yoshikawa; Katsuhiro Komase; Chikara Aizawa; Hiroshi Kiyono; Yoshifumi Takeda; Jerry R McGhee; Joe Chiba; Tetsutaro Sata; Takeshi Kurata; Shin-ichi Tamura
Characterization of protective immune responses induced by nasal influenza vaccine containing mutant cholera toxin as a safe adjuvant (CT112K).
Vaccine 2002;20(29-30):3443-55.
2002: Yasuko Asahi; Tomoki Yoshikawa; Izumi Watanabe; Takuya Iwasaki; Hideki Hasegawa; Yuko Sato; Shin-ichiro Shimada; Masanobu Nanno; Yoshiaki Matsuoka; Makoto Ohwaki; Yoichiro Iwakura; Yujiro Suzuki; Chikara Aizawa; Tetsutaro Sata; Takeshi Kurata; Shin-ichi Tamura
Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2930-8.
2001: H Asanuma; K Hirokawa; M Uchiyama; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata; Tetsutaro Sata; Shin ichi Tamura
Immune responses and protection in different strains of aged mice immunized intranasally with an adjuvant-combined influenza vaccine.
Vaccine 2001;19(28-29):3981-9.
2001: Y Hagiwar; T Tsuji; Takuya Iwasaki; Shin-etsu Kadowaki; H Asanuma; Z Chen; Katsuhiro Komase; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Effectiveness and safety of mutant Escherichia coli heat-labile enterotoxin (LT H44A) as an adjuvant for nasal influenza vaccine.
Vaccine 2001;19(15-16):2071-9.
2001: Yukari Hagiwara; Takuya Iwasaki; H Asanuma; Yuko Sato; Tetsutaro Sata; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Effects of intranasal administration of cholera toxin (or Escherichia coli heat-labile enterotoxin) B subunits supplemented with a trace amount of the holotoxin on the brain.
Vaccine 2001;19(13-14):1652-60.
2000: Shin-etsu Kadowaki; Z Chen; H Asanuma; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Protection against influenza virus infection in mice immunized by administration of hemagglutinin-expressing DNAs with electroporation.
Vaccine 2000;18(25):2779-88.
1999: Z Chen; Tomoki Yoshikawa; Shin-etsu Kadowaki; Yukari Hagiwara; Keiko Matsuo; H Asanuma; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Protection and antibody responses in different strains of mouse immunized with plasmid DNAs encoding influenza virus haemagglutinin, neuraminidase and nucleoprotein.
The Journal of general virology 1999;80 ( Pt 10)():2559-64.
1999: Yukari Hagiwara; Katsuhiro Komase; Z Chen; Keiko Matsuo; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Mutants of cholera toxin as an effective and safe adjuvant for nasal influenza vaccine.
Vaccine 1999;17(22):2918-26.
1999: Z Chen; Keiko Matsuo; H Asanuma; Hidehiro Takahashi; Takuya Iwasaki; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Enhanced protection against a lethal influenza virus challenge by immunization with both hemagglutinin- and neuraminidase-expressing DNAs.
Vaccine 1999;17(7-8):653-9.
1998: Z Chen; Y Sahashi; Keiko Matsuo; H Asanuma; Hidehiro Takahashi; Takuya Iwasaki; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Comparison of the ability of viral protein-expressing plasmid DNAs to protect against influenza.
Vaccine 1998;16(16):1544-9.
1998: H Asanuma; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
IgA antibody-forming cell responses in the nasal-associated lymphoid tissue of mice vaccinated by intranasal, intravenous and/or subcutaneous administration.
Vaccine 1998;16(13):1257-62.
1998: Shin ichi Tamura; Takuya Iwasaki; Amy Thompson; H Asanuma; Z Chen; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata
Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection.
The Journal of general virology 1998;79 ( Pt 2)():291-9.
1998: Katsuhiro Komase; S Tamura; K Matsuo; K Watanabe; N Hattori; A Odaka; Y Suzuki; Takeshi Kurata; Chikara Aizawa
Mutants of Escherichia coli heat-labile enterotoxin as an adjuvant for nasal influenza vaccine.
Vaccine 1998;16(2-3):248-54.
1997: Shin ichi Tamura; A Yajima; E Hatori; S Tamura; H Asanuma; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata
Effects of frequent intranasal administration of adjuvant-combined influenza vaccine on the protection against virus infection.
Vaccine 1997;15(16):1784-90.
1997: H Asanuma; Amy Thompson; Takuya Iwasaki; Yuko Sato; Y Inaba; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Isolation and characterization of mouse nasal-associated lymphoid tissue.
Journal of immunological methods 1997;202(2):123-31.
1997: Shin ichi Tamura; E Hatori; T Tsuruhara; Chikara Aizawa; Takeshi Kurata
Suppression of delayed-type hypersensitivity and IgE antibody responses to ovalbumin by intranasal administration of Escherichia coli heat-labile enterotoxin B subunit-conjugated ovalbumin.
Vaccine 1997;15(2):225-9.
1996: Shin ichi Tamura; K Miyata; Keiko Matsuo; H Asanuma; Hidehiro Takahashi; K Nakajima; Yujiro Suzuki; Chikara Aizawa; Takeshi Kurata
Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(10):3892-900.
1995: H Asanuma; Y Inaba; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Characterization of mouse nasal lymphocytes isolated by enzymatic extraction with collagenase.
Journal of immunological methods 1995;187(1):41-51.
1995: Shin ichi Tamura; K Ishihara; K Miyata; Chikara Aizawa; Takeshi Kurata
Mechanism of enhancement of the immune responses to influenza vaccine with cholera toxin B subunit and a trace amount of holotoxin.
Vaccine 1995;13(4):339-41.
1995: H Asanuma; F Koide; Yujiro Suzuki; T Nagamine; Chikara Aizawa; Takeshi Kurata; Shin ichi Tamura
Cross-protection against influenza virus infection in mice vaccinated by combined nasal/subcutaneous administration.
Vaccine 1995;13(1):3-5.
1994: Shin ichi Tamura; Y Shoji; K Hasiguchi; Chikara Aizawa; Takeshi Kurata
Effects of cholera toxin adjuvant on IgE antibody response to orally or nasally administered ovalbumin.
Vaccine 1994;12(13):1238-40.
1994: Shin ichi Tamura; H Asanuma; Y Ito; K Yoshizawa; T Nagamine; Chikara Aizawa; Takeshi Kurata
Formulation of inactivated influenza vaccines for providing effective cross-protection by intranasal vaccination in mice.
Vaccine 1994;12(4):310-6.
1992: Shin ichi Tamura; Y Ito; H Asanuma; Y Hirabayashi; Yujiro Suzuki; T Nagamine; Chikara Aizawa; Takeshi Kurata
Cross-protection against influenza virus infection afforded by trivalent inactivated vaccines inoculated intranasally with cholera toxin B subunit.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(3):981-8.
1992: Shin ichi Tamura; H Asanuma; Y Ito; Y Hirabayashi; Yujiro Suzuki; T Nagamine; Chikara Aizawa; Takeshi Kurata; A Oya
Superior cross-protective effect of nasal vaccination to subcutaneous inoculation with influenza hemagglutinin vaccine.
European journal of immunology 1992;22(2):477-81.
1992: S Gizurarson; Shin ichi Tamura; Chikara Aizawa; Takeshi Kurata
Stimulation of the transepithelial flux of influenza HA vaccine by cholera toxin B subunit.
Vaccine 1992;10(2):101-6.
1991: Shin ichi Tamura; H Funato; Y Hirabayashi; Yujiro Suzuki; T Nagamine; Chikara Aizawa; Takeshi Kurata
Cross-protection against influenza A virus infection by passively transferred respiratory tract IgA antibodies to different hemagglutinin molecules.
European journal of immunology 1991;21(6):1337-44.
1991: Y Hirabayashi; Shin ichi Tamura; Yujiro Suzuki; T Nagamine; Chikara Aizawa; K Shimada; Takeshi Kurata
H-2-unrestricted adjuvant effect of cholera toxin B subunit on murine antibody responses to influenza virus haemagglutinin.
Immunology 1991;72(3):329-35.
1990: K Kikuta; Y Hirabayashi; T Nagamine; Chikara Aizawa; Y Ueno; A Oya; Takeshi Kurata; Shin ichi Tamura
Cross-protection against influenza B type virus infection by intranasal inoculation of the HA vaccines combined with cholera toxin B subunit.
Vaccine 1990;8(6):595-9.
1990: Shin ichi Tamura; H Funato; Y Hirabayashi; K Kikuta; Yujiro Suzuki; T Nagamine; Chikara Aizawa; M Nakagawa; Takeshi Kurata
Functional role of respiratory tract haemagglutinin-specific IgA antibodies in protection against influenza.
Vaccine 1990;8(5):479-85.
1990: Y Hirabayashi; H Kurata; H Funato; T Nagamine; Chikara Aizawa; Shin ichi Tamura; K Shimada; Takeshi Kurata
Comparison of intranasal inoculation of influenza HA vaccine combined with cholera toxin B subunit with oral or parenteral vaccination.
Vaccine 1990;8(3):243-8.
1990: K Kikuta; H Kurata; T Nagamine; Chikara Aizawa; Y Ueno; Takeshi Kurata; Shin ichi Tamura
Enhancement of DTH response by cholera toxin B subunit inoculated intranasally together with influenza HA vaccine.
Microbiology and immunology 1990;34(3):337-46.
1989: Shin ichi Tamura; H Funato; T Nagamine; Chikara Aizawa; Takeshi Kurata
Effectiveness of cholera toxin B subunit as an adjuvant for nasal influenza vaccination despite pre-existing immunity to CTB.
Vaccine 1989;7(6):503-5.
1989: Shin ichi Tamura; H Kurata; H Funato; T Nagamine; Chikara Aizawa; Takeshi Kurata
Protection against influenza virus infection by a two-dose regimen of nasal vaccination using vaccines combined with cholera toxin B subunit.
Vaccine 1989;7(4):314-20.
1989: Shin ichi Tamura; Y Samegai; H Kurata; K Kikuta; T Nagamine; Chikara Aizawa; Takeshi Kurata
Enhancement of protective antibody responses by cholera toxin B subunit inoculated intranasally with influenza vaccine.
Vaccine 1989;7(3):257-62.
1988: Shin ichi Tamura; Y Samegai; H Kurata; T Nagamine; Chikara Aizawa; Takeshi Kurata
Protection against influenza virus infection by vaccine inoculated intranasally with cholera toxin B subunit.
Vaccine 1988;6(5):409-13.