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Michael Walter

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Moulinath Acharya; Chanchal Birdi; Tim Footz; Lijia Huang; Farideh Mirzayans; Michael W Sharp; Michael A Walter
Yeast two-hybrid analysis of a human trabecular meshwork cDNA library identified EFEMP2 as a novel PITX2 interacting protein.
M Hermina Strungaru; Pascal Belleau; Fred B Berry; Tim Footz; Yi Liu; Vincent Raymond; Elena V Semina; Michael A Walter
PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.
Moulinath Acharya; Lijia Huang; Valerie C Fleisch; W Ted Allison; Michael A Walter
A complex regulatory network of transcription factors critical for ocular development and disease.

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2012: Moulinath Acharya; Chanchal Birdi; Tim Footz; Lijia Huang; Farideh Mirzayans; Michael W Sharp; Michael A Walter
Yeast two-hybrid analysis of a human trabecular meshwork cDNA library identified EFEMP2 as a novel PITX2 interacting protein.
Molecular vision 2012;18():2182-9.
2011: M Hermina Strungaru; Pascal Belleau; Fred B Berry; Tim Footz; Yi Liu; Vincent Raymond; Elena V Semina; Michael A Walter
PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3.
Investigative ophthalmology & visual science 2011;52(10):7625-33.
2011: Moulinath Acharya; Lijia Huang; Valerie C Fleisch; W Ted Allison; Michael A Walter
A complex regulatory network of transcription factors critical for ocular development and disease.
Human molecular genetics 2011;20(8):1610-24.
2011: Tim Footz; Vincent Raymond; Mansoor Sarfarazi; Stéphane Dubois; Michael A Walter
Co-variation of STI1 and WDR36/UTP21 alters cell proliferation in a glaucoma model.
Molecular vision 2011;17():1957-69.
2010: Ming Ye; Karyn M Berry-Wynne; Mika Asai-Coakwell; Periasamy Sundaresan; Tim Footz; Curtis R French; Marc Abitbol; Valerie C Fleisch; Nathan Corbett; W Ted Allison; Garry Drummond; Michael A Walter; Tully Underhill; Andrew J Waskiewicz; Ordan J Lehmann
Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.
Human molecular genetics 2010;19(2):287-98.
2009: Moulinath Acharya; David J Lingenfelter; Lijia Huang; Philip J Gage; Michael A Walter
Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells.
The Journal of biological chemistry 2009;284(50):34829-38.
2009: Yoko A Ito; Tim Footz; Fred B Berry; Farideh Mirzayans; May Yu; Arif O Khan; Michael A Walter
Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia.
Investigative ophthalmology & visual science 2009;50(8):3573-9.
2009: Tim Footz; Faisal Idrees; Moulinath Acharya; Kathy Kozlowski; Michael A Walter
Analysis of mutations of the PITX2 transcription factor found in patients with Axenfeld-Rieger syndrome.
Investigative ophthalmology & visual science 2009;50(6):2599-606.
2009: Tim Footz; Jill L Johnson; Stéphane Dubois; Nicolas Boivin; Vincent Raymond; Michael A Walter
Glaucoma-associated WDR36 variants encode functional defects in a yeast model system.
Human molecular genetics 2009;18(7):1276-87.
2008: Bhaskar Chanda; Mika Asai-Coakwell; Ming Ye; Andrew J Mungall; Margaret Barrow; William B Dobyns; Hourinaz Behesti; Jane C Sowden; Nigel P Carter; Michael A Walter; Ordan J Lehmann
A novel mechanistic spectrum underlies glaucoma-associated chromosome 6p25 copy number variation.
Human molecular genetics 2008;17(22):3446-58.
2008: Fred B Berry; Jonathan M Skarie; Farideh Mirzayans; Yannick Fortin; Thomas J Hudson; Vincent Raymond; Brian A Link; Michael A Walter
FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.
Human molecular genetics 2008;17(4):490-505.
2008: Christina D Fetterman; Bruce Rannala; Michael A Walter
Identification and analysis of evolutionary selection pressures acting at the molecular level in five forkhead subfamilies.
BMC evolutionary biology 2008;8():261.
2007: R Brian Lowry; Douglas B Gould; Michael A Walter; Paul R Savage
Absence of PITX2, BARX1, and FOXC1 mutations in De Hauwere syndrome (Axenfeld-Rieger anomaly, hydrocephaly, hearing loss): a 25-year follow up.
American journal of medical genetics. Part A 2007;143A(11):1227-30.
2007: Yoko A Ito; Tim Footz; Tara C Murphy; Winnie Courtens; Michael A Walter
Analyses of a novel L130F missense mutation in FOXC1.
Archives of ophthalmology 2007;125(1):128-35.
2007: M Hermina Strungaru; Irina Dinu; Michael A Walter
Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations.
Investigative ophthalmology & visual science 2007;48(1):228-37.
2006: Yahya Tamimi; Jonathan M Skarie; Tim Footz; Fred B Berry; Brian A Link; Michael A Walter
FGF19 is a target for FOXC1 regulation in ciliary body-derived cells.
Human molecular genetics 2006;15(21):3229-40.
2006: Fred B Berry; Farideh Mirzayans; Michael A Walter
Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade.
The Journal of biological chemistry 2006;281(15):10098-104.
2006: Fred B Berry; Matthew A Lines; J Martin Oas; Tim Footz; D Alan Underhill; Philip J Gage; Michael A Walter
Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis.
Human molecular genetics 2006;15(6):905-19.
2005: Fred B Berry; Yahya Tamimi; Michelle V Carle; Ordan J Lehmann; Michael A Walter
The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis.
Human molecular genetics 2005;14(18):2619-27.
2005: Fred B Berry; Megan A O'Neill; Miguel Coca-Prados; Michael A Walter
FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner.
Molecular and cellular biology 2005;25(4):1415-24.
2004: Douglas B Gould; Michael A Walter
Mutational analysis of BARHL1 and BARX1 in three new patients with Joubert syndrome.
American journal of medical genetics. Part A 2004;131(2):205-8.
2004: Yahya Tamimi; Matthew A Lines; Miguel Coca-Prados; Michael A Walter
Identification of target genes regulated by FOXC1 using nickel agarose-based chromatin enrichment.
Investigative ophthalmology & visual science 2004;45(11):3904-13.
2004: Tara C Murphy; Ramsey A Saleem; Tim Footz; Robert Ritch; Barbara McGillivray; Michael A Walter
The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions.
Investigative ophthalmology & visual science 2004;45(8):2531-8.
2004: Rosemary Ekong; Steve Jeremiah; David J Judah; Ordan J Lehmann; Farideh Mirzayans; Ying-Chun Hung; Michael A Walter; Shomi Bhattacharya; Timothy W Gant; Sue Povey; Jonathan Wolfe
Chromosomal anomalies on 6p25 in iris hypoplasia and Axenfeld-Rieger syndrome patients defined on a purpose-built genomic microarray.
Human mutation 2004;24(1):76-85.
2004: Douglas B Gould; Mohamad S Jaafar; Mark K Addison; Francis Munier; Robert Ritch; Ian M MacDonald; Michael A Walter
Phenotypic and molecular assessment of seven patients with 6p25 deletion syndrome: relevance to ocular dysgenesis and hearing impairment.
BMC medical genetics 2004;5():17.
2004: Matthew A Lines; Kathy Kozlowski; Stephen C Kulak; R Rand Allingham; Elise Héon; Robert Ritch; Alex V Levin; M Bruce Shields; Karim F Damji; Anna Newlin; Michael A Walter
Characterization and prevalence of PITX2 microdeletions and mutations in Axenfeld-Rieger malformations.
Investigative ophthalmology & visual science 2004;45(3):828-33.
2004: Ramsey A Saleem; Sharmila Banerjee-Basu; Tara C Murphy; Andreas D Baxevanis; Michael A Walter
Essential structural and functional determinants within the forkhead domain of FOXC1.
Nucleic acids research 2004;32(14):4182-93.
2003: Esmond J Sanders; Michael A Walter; Eve Parker; Carlos Arámburo; Steve Harvey
Opticin binds retinal growth hormone in the embryonic vitreous.
Investigative ophthalmology & visual science 2003;44(12):5404-9.
2003: Ramsey A Saleem; Sharmila Banerjee-Basu; Fred B Berry; Andreas D Baxevanis; Michael A Walter
Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1.
Human molecular genetics 2003;12(22):2993-3005.
2003: Ramsey A Saleem; Tara C Murphy; Jeffery M Liebmann; Michael A Walter
Identification and analysis of a novel mutation in the FOXC1 forkhead domain.
Investigative ophthalmology & visual science 2003;44(11):4608-12.
2003: Michael A Walter
PITs and FOXes in ocular genetics: the Cogan lecture.
Investigative ophthalmology & visual science 2003;44(4):1402-5.
2002: Ordan J Lehmann; Neil D Ebenezer; Rosemary Ekong; Louise Ocaka; Andrew Mungall; Scott Fraser; James I McGill; Roger A Hitchings; Peng Khaw; Jane C Sowden; Sue Povey; Michael A Walter; Shomi S Bhattacharya; Tim Jordan
Ocular developmental abnormalities and glaucoma associated with interstitial 6p25 duplications and deletions.
Investigative ophthalmology & visual science 2002;43(6):1843-9.
2002: James S Friedman; Mathieu Faucher; Paul Hiscott; Vincent L Biron; Mario Malenfant; Pierre Turcotte; Vincent Raymond; Michael A Walter
Protein localization in the human eye and genetic screen of opticin.
Human molecular genetics 2002;11(11):1333-42.
2002: Matthew A Lines; Kathy Kozlowski; Michael A Walter
Molecular genetics of Axenfeld-Rieger malformations.
Human molecular genetics 2002;11(10):1177-84.
2002: Fred B Berry; Ramsey A Saleem; Michael A Walter
FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain.
The Journal of biological chemistry 2002;277(12):10292-7.
2002: James S Friedman; Michael A Walter
Biomedicine. Under pressure.
Science (New York, N.Y.) 2002;295(5557):983-4.
2002: Ramsey A Saleem; Michael A Walter
The complexities of ocular genetics.
Clinical genetics 2002;61(2):79-88.
2001: James S Friedman; Michael A Walter
Use of radiation hybrid panels to map genetic loci.
Molecular biotechnology 2001;19(2):205-10.
2001: Ramsey A Saleem; Sharmila Banerjee-Basu; Fred B Berry; Andreas D Baxevanis; Michael A Walter
Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1.
American journal of human genetics 2001;68(3):627-41.
2001: James S Friedman; B F Koop; Vincent Raymond; Michael A Walter
Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes.
Genomics 2001;71(2):252-5.
2001: Farideh Mirzayans; Michael A Walter
Genomic mismatch scanning for the mapping of genetic traits.
Methods in molecular biology (Clifton, N.J.) 2001;175():37-46.
2000: Douglas B Gould; Michael A Walter
Cloning, characterization, localization, and mutational screening of the human BARX1 gene.
Genomics 2000;68(3):336-42.
2000: Kathy Kozlowski; Michael A Walter
Variation in residual PITX2 activity underlies the phenotypic spectrum of anterior segment developmental disorders.
Human molecular genetics 2000;9(14):2131-9.
2000: James S Friedman; R Ducharme; Vincent Raymond; Michael A Walter
Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection.
Investigative ophthalmology & visual science 2000;41(8):2059-66.
2000: Farideh Mirzayans; Douglas B Gould; Elise Héon; Gail Billingsley; Joanne C Cheung; AJ Mears; Michael A Walter
Axenfeld-Rieger syndrome resulting from mutation of the FKHL7 gene on chromosome 6p25.
European journal of human genetics : EJHG 2000;8(1):71-4.
1999: GE Winnier; Tsutomu Kume; KY Deng; R Rogers; J Bundy; C Raines; Michael A Walter; Brigid L M Hogan; Simon J Conway
Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles.
Developmental biology 1999;213(2):418-31.
1999: WG Pearce; B C Mielke; Stephen C Kulak; Michael A Walter
Histopathology and molecular basis of iridogoniodysgenesis syndrome.
Ophthalmic genetics 1999;20(2):83-8.
1999: James S Friedman; Michael A Walter
Glaucoma genetics, present and future.
Clinical genetics 1999;55(2):71-9.
1998: AJ Mears; Tim Jordan; Farideh Mirzayans; Stéphane Dubois; Tsutomu Kume; M Parlee; Robert Ritch; B Koop; W L Kuo; C Collins; J Marshall; Douglas B Gould; W Pearce; Peter Carlsson; S Enerbäck; Jean Morissette; Shomi Bhattacharya; B Hogan; Vincent Raymond; Michael A Walter
Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly.
American journal of human genetics 1998;63(5):1316-28.
1998: JE Tucker; Robert J Winkfein; Sabita K Murthy; James S Friedman; Michael A Walter; Douglas J Demetrick; Paul P M Schnetkamp
Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger.
Human genetics 1998;103(4):411-4.
1998: Stephen C Kulak; Kathy Kozlowski; E V Semina; WG Pearce; Michael A Walter
Mutation in the RIEG1 gene in patients with iridogoniodysgenesis syndrome.
Human molecular genetics 1998;7(7):1113-7.
1998: Tsutomu Kume; KY Deng; Virginia P Winfrey; Douglas B Gould; Michael A Walter; Brigid L M Hogan
The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.
Cell 1998;93(6):985-96.
1997: Douglas B Gould; AJ Mears; WG Pearce; Michael A Walter
Autosomal dominant Axenfeld-Rieger anomaly maps to 6p25.
American journal of human genetics 1997;61(3):765-8.
1997: Farideh Mirzayans; AJ Mears; S W Guo; WG Pearce; Michael A Walter
Identification of the human chromosomal region containing the iridogoniodysgenesis anomaly locus by genomic-mismatch scanning.
American journal of human genetics 1997;61(1):111-9.
1996: AJ Mears; Farideh Mirzayans; Douglas B Gould; WG Pearce; Michael A Walter
Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25.
American journal of human genetics 1996;59(6):1321-7.
1996: Michael A Walter; Farideh Mirzayans; AJ Mears; K Hickey; WG Pearce
Autosomal-dominant iridogoniodysgenesis and Axenfeld-Rieger syndrome are genetically distinct.
Ophthalmology 1996;103(11):1907-15.
1995: Farideh Mirzayans; WG Pearce; Ian M MacDonald; Michael A Walter
Mutation of the PAX6 gene in patients with autosomal dominant keratitis.
American journal of human genetics 1995;57(3):539-48.