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Tracey Bradshaw

Research Profile

Chemicals & Drugs

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Drug Screening Assays, Antitumor

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Drug Resistance, Neoplasm

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Publications

TOP 3
Wardah M Din; Jeff R Fry; Khoo T Jin; Tracey D Bradshaw; Jessica Chu; Garry Clarke; Christophe Wiart
Antioxidant and cytoprotective effects of an ethanol extract of Acalypha wilkesiana var. macafeana from Malaysia.
Frankie Lam; Hui Mao; Yuanjiang Pan; Scott Roberts; Tracey D Bradshaw; Shudong Wang
ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities.
Jihong Zhang; Malcolm F G Stevens; Tracey D Bradshaw
Temozolomide: mechanisms of action, repair and resistance.

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All Publications

2013: Wardah M Din; Jeff R Fry; Khoo T Jin; Tracey D Bradshaw; Jessica Chu; Garry Clarke; Christophe Wiart
Antioxidant and cytoprotective effects of an ethanol extract of Acalypha wilkesiana var. macafeana from Malaysia.
Natural product communications 2013;8(3):375-80.
2012: Frankie Lam; Hui Mao; Yuanjiang Pan; Scott Roberts; Tracey D Bradshaw; Shudong Wang
ZJU-6, a novel derivative of Erianin, shows potent anti-tubulin polymerisation and anti-angiogenic activities.
Investigational new drugs 2012;30(5):1899-907.
2012: Jihong Zhang; Malcolm F G Stevens; Tracey D Bradshaw
Temozolomide: mechanisms of action, repair and resistance.
Current molecular pharmacology 2012;5(1):102-14.
2011: Boon Shing Tan; Kai Hung Tiong; Tracey D Bradshaw; Heng Lungh Choo; Ashwin Muruhadas; Nirmal Randhawa; Malcolm F G Stevens; Chee-Onn Leong
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells.
Molecular cancer therapeutics 2011;10(10):1982-92.
2011: Jihong Zhang; Marc Geoffery Hummersone; Charles A Laughton; Srinivasan Madhusudan; Malcolm F G Stevens; Tracey D Bradshaw
Certain imidazotetrazines escape O6-methylguanine-DNA methyltransferase and mismatch repair.
Oncology 2011;80(3-4):195-207.
2011: Gareth Hall; Tracey D Bradshaw; Charles A Laughton; Malcolm F Stevens; Jonas Emsley
Structure of Mycobacterium tuberculosis thioredoxin in complex with quinol inhibitor PMX464.
Protein science : a publication of the Protein Society 2011;20(1):210-5.
2010: Jihong Zhang; Malcolm F G Stevens; Charles A Laughton; Srinivasan Madhusudan; Tracey D Bradshaw
Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications.
Oncology 2010;78(2):103-14.
2010: Eng-Hui Chew; Amrita A Nagle; Yaochun Zhang; Silvia Scarmagnani; Puvithira Palaniappan; Tracey D Bradshaw; Arne Holmgren; Andrew D Westwell
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention.
Free radical biology & medicine 2010;48(1):98-111.
2009: Lyudmila Turyanska; Tracey D Bradshaw; Jason Sharpe; Mei Li; Stephen Mann; Neil R Thomas; Amalia Patanè
The biocompatibility of apoferritin-encapsulated PbS quantum dots.
Small (Weinheim an der Bergstrasse, Germany) 2009;5(15):1738-41.
2009: Tracey D Bradshaw; David R Bell
Relevance of the aryl hydrocarbon receptor (AhR) for clinical toxicology.
Clinical toxicology (Philadelphia, Pa.) 2009;47(7):632-42.
2009: Rana Bazzi; Tracey D Bradshaw; Craig Rowlands; Malcolm F G Stevens; David R Bell
2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the aryl hydrocarbon receptor.
Toxicology and applied pharmacology 2009;237(1):102-10.
2009: Tracey D Bradshaw; J E Wren; M Bruce; David A Barrett; Chee-Onn Leong; Margaret Gaskell; E K Wright; Peter B Farmer; Colin Henderson; R Wolf; Malcolm F G Stevens
Preclinical toxicokinetic evaluation of phortress [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species.
Pharmacology 2009;83(2):99-109.
2008: Tracey D Bradshaw; Erica Stone; Valentina Trapani; Chee-Onn Leong; Charles S Matthews; Robert te Poele; Malcolm F G Stevens
Mechanisms of acquired resistance to 2-(4-Amino-3-methylphenyl)benzothiazole in breast cancer cell lines.
Breast cancer research and treatment 2008;110(1):57-68.
2007: Andriani Athanasiou; Anna B Clarke; Amy E Turner; Nethia M Kumaran; Sara Vakilpour; Paul A Smith; Dimitra Bagiokou; Tracey D Bradshaw; Andrew D Westwell; Lin Fang; Dileep N Lobo; Cris S Constantinescu; Vittorio Calabrese; Andrzej Loesch; S P H Alexander; Richard H Clothier; David A Kendall; Timothy E Bates
Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.
Biochemical and biophysical research communications 2007;364(1):131-7.
2007: Andrew J McCarroll; Tracey D Bradshaw; Andrew D Westwell; Charles S Matthews; Malcolm F G Stevens
Quinols as novel therapeutic agents. 7.1 Synthesis of antitumor 4-[1-(arylsulfonyl-1H-indol-2-yl)]-4-hydroxycyclohexa-2,5-dien-1-ones by Sonogashira reactions.
Journal of medicinal chemistry 2007;50(7):1707-10.
2006: Cedric J Lion; Charles S Matthews; Geoffrey Wells; Tracey D Bradshaw; Malcolm F G Stevens; Andrew D Westwell
Antitumour properties of fluorinated benzothiazole-substituted hydroxycyclohexa-2,5-dienones ('quinols').
Bioorganic & medicinal chemistry letters 2006;16(19):5005-8.
2006: Eng-Hui Chew; Charles S Matthews; Jihong Zhang; Andrew J McCarroll; Thilo Hagen; Malcolm F G Stevens; Andrew D Westwell; Tracey D Bradshaw
Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets.
Biochemical and biophysical research communications 2006;346(1):242-51.
2006: David A Vasselin; Andrew D Westwell; Charles S Matthews; Tracey D Bradshaw; Malcolm F G Stevens
Structural studies on bioactive compounds. 40.(1) Synthesis and biological properties of fluoro-, methoxyl-, and amino-substituted 3-phenyl-4H-1-benzopyran-4-ones and a comparison of their antitumor activities with the activities of related 2-phenylbenzothiazoles.
Journal of medicinal chemistry 2006;49(13):3973-81.
2006: Catriona G Mortimer; Geoffrey Wells; Jean-Philippe Crochard; Erica Stone; Tracey D Bradshaw; Malcolm F G Stevens; Andrew D Westwell
Antitumor benzothiazoles. 26.(1) 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines.
Journal of medicinal chemistry 2006;49(1):179-85.
2005: Tracey D Bradshaw; Charles S Matthews; Jennifer C Cookson; Eng-Hui Chew; Manish Shah; Kevin Bailey; Anne Monks; Erik Harris; Andrew D Westwell; Geoffrey Wells; Charles A Laughton; Malcolm F G Stevens
Elucidation of thioredoxin as a molecular target for antitumor quinols.
Cancer research 2005;65(9):3911-9.
2005: A Mukherjee; Andrew D Westwell; Tracey D Bradshaw; Malcolm F G Stevens; James Carmichael; Stewart Graham Martin
Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study.
British journal of cancer 2005;92(2):350-8.
2005: Jane M Berry; Tracey D Bradshaw; Iduna Fichtner; Ruobo Ren; Carl H Schwalbe; Geoffrey Wells; Eng-Hui Chew; Malcolm F G Stevens; Andrew D Westwell
Quinols as novel therapeutic agents. 2.(1) 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents.
Journal of medicinal chemistry 2005;48(2):639-44.
2004: Chee-Onn Leong; Marie Suggitt; David J Swaine; Michael C Bibby; Malcolm F G Stevens; Tracey D Bradshaw
In vitro, in vivo, and in silico analyses of the antitumor activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazoles.
Molecular cancer therapeutics 2004;3(12):1565-75.
2004: Eileen Brantley; Valentina Trapani; Michael C Alley; Curtis Hose; Tracey D Bradshaw; Malcolm F G Stevens; Edward A Sausville; Sherman F Stinson
Fluorinated 2-(4-amino-3-methylphenyl)benzothiazoles induce CYP1A1 expression, become metabolized, and bind to macromolecules in sensitive human cancer cells.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(12):1392-401.
2004: Iduna Fichtner; Anne Monks; Curtis Hose; Malcolm F G Stevens; Tracey D Bradshaw
The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models.
Breast cancer research and treatment 2004;87(1):97-107.
2004: Tracey D Bradshaw; Andrew D Westwell
The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate.
Current medicinal chemistry 2004;11(8):1009-21.
2003: Monica Pallis; Tracey D Bradshaw; Andrew D Westwell; Martin Grundy; Malcolm F G Stevens; Nigel Russell
Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds.
Biochemical pharmacology 2003;66(9):1695-705.
2003: Geoffrey Wells; Jane M Berry; Tracey D Bradshaw; Angelika Burger; Angela Seaton; Bo Wang; Andrew D Westwell; Malcolm F G Stevens
4-Substituted 4-hydroxycyclohexa-2,5-dien-1-ones with selective activities against colon and renal cancer cell lines.
Journal of medicinal chemistry 2003;46(4):532-41.
2003: Chee-Onn Leong; Margaret Gaskell; E A Martin; RT Heydon; Peter B Farmer; Michael C Bibby; Patricia A Cooper; John A Double; Tracey D Bradshaw; Malcolm F G Stevens
Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
British journal of cancer 2003;88(3):470-7.
2003: Ian Hutchinson; Tracey D Bradshaw; Charles S Matthews; Malcolm F G Stevens; Andrew D Westwell
Antitumour benzothiazoles. Part 20: 3'-cyano and 3'-alkynyl-substituted 2-(4'-aminophenyl)benzothiazoles as new potent and selective analogues.
Bioorganic & medicinal chemistry letters 2003;13(3):471-4.
2003: Sean E O'Brien; Helen L Browne; Tracey D Bradshaw; Andrew D Westwell; Malcolm F G Stevens; Charles A Laughton
Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1.
Organic & biomolecular chemistry 2003;1(3):493-7.
2002: Tracey D Bradshaw; MS Chua; Helen L Browne; Valentina Trapani; Edward A Sausville; Malcolm F G Stevens
In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles.
British journal of cancer 2002;86(8):1348-54.
2002: Tracey D Bradshaw; Michael C Bibby; John A Double; Iduna Fichtner; Patricia A Cooper; Michael C Alley; Susan Donohue; Sherman F Stinson; Joseph E Tomaszewjski; Edward A Sausville; Malcolm F G Stevens
Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.
Molecular cancer therapeutics 2002;1(4):239-46.
2002: Tracey D Bradshaw; Valentina Trapani; David A Vasselin; Andrew D Westwell
The aryl hydrocarbon receptor in anticancer drug discovery: friend or foe?
Current pharmaceutical design 2002;8(27):2475-90.
2002: Andrea I Loaiza-Pérez; Valentina Trapani; Curtis Hose; Sheo S Singh; Jane Trepel; Malcolm F G Stevens; Tracey D Bradshaw; Edward A Sausville
Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.
Molecular pharmacology 2002;61(1):13-9.
2001: Ian Hutchinson; MS Chua; Helen L Browne; Valentina Trapani; Tracey D Bradshaw; Andrew D Westwell; Malcolm F G Stevens
Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles.
Journal of medicinal chemistry 2001;44(9):1446-55.
2001: DF Shi; Tracey D Bradshaw; MS Chua; Andrew D Westwell; Malcolm F G Stevens
Antitumour benzothiazoles. Part 15: The synthesis and physico-chemical properties of 2-(4-aminophenyl)benzothiazole sulfamate salt derivatives.
Bioorganic & medicinal chemistry letters 2001;11(8):1093-5.
2001: Tracey D Bradshaw; Malcolm F G Stevens; Andrew D Westwell
The discovery of the potent and selective antitumour agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203) and related compounds.
Current medicinal chemistry 2001;8(2):203-10.
2000: MS Chua; E Kashiyama; Tracey D Bradshaw; Sherman F Stinson; Eileen Brantley; Edward A Sausville; Malcolm F G Stevens
Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
Cancer research 2000;60(18):5196-203.
2000: Tracey D Bradshaw; MS Chua; S Orr; Charles S Matthews; Malcolm F G Stevens
Mechanisms of acquired resistance to 2-(4-aminophenyl)benzothiazole (CJM 126, NSC 34445).
British journal of cancer 2000;83(2):270-7.
2000: Geoffrey Wells; Tracey D Bradshaw; P Diana; Angela Seaton; DF Shi; Andrew D Westwell; Malcolm F G Stevens
Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives.
Bioorganic & medicinal chemistry letters 2000;10(5):513-5.
1999: E Kashiyama; Ian Hutchinson; MS Chua; Sherman F Stinson; LR Phillips; G Kaur; Edward A Sausville; Tracey D Bradshaw; Andrew D Westwell; Malcolm F G Stevens
Antitumor benzothiazoles. 8. Synthesis, metabolic formation, and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles.
Journal of medicinal chemistry 1999;42(20):4172-84.
1999: MS Chua; DF Shi; S Wrigley; Tracey D Bradshaw; Ian Hutchinson; P Nicholas Shaw; David A Barrett; L A Stanley; Malcolm F G Stevens
Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines.
Journal of medicinal chemistry 1999;42(3):381-92.
1998: Tracey D Bradshaw; DF Shi; R J Schultz; K D Paull; Lloyd R Kelland; A Wilson; C Garner; H H Fiebig; S Wrigley; Malcolm F G Stevens
Influence of 2-(4-aminophenyl)benzothiazoles on growth of human ovarian carcinoma cells in vitro and in vivo.
British journal of cancer 1998;78(4):421-9.
1998: Tracey D Bradshaw; S Wrigley; DF Shi; R J Schultz; K D Paull; Malcolm F G Stevens
2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
British journal of cancer 1998;77(5):745-52.
1996: DF Shi; Tracey D Bradshaw; S Wrigley; C J McCall; P Lelieveld; I Fichtner; Malcolm F G Stevens
Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo.
Journal of medicinal chemistry 1996;39(17):3375-84.