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Gary Wang

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Gary T Wang; Robert A Mantei; Robert D Hubbard; Julie L Wilsbacher; Qian Zhang; Lora Tucker; Xiaoming Hu; Peter Kovar; Eric F Johnson; Donald J Osterling; Jennifer J Bouska; Jieyi Wang; Steven K Davidsen; Randy L Bell; George S Sheppard
Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.
Steve D Fidanze; Scott A Erickson; Gary T Wang; Robert A Mantei; Richard F Clark; Bryan K Sorensen; Nwe Y BaMaung; Peter Kovar; Eric F Johnson; Kerren K Swinger; Kent D Stewart; Qian Zhang; Lora A Tucker; William N Pappano; Julie L Wilsbacher; Jieyi Wang; George S Sheppard; Randy L Bell; Steven K Davidsen; Robert D Hubbard
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Julie L Wilsbacher; Qian Zhang; Lora A Tucker; Robert D Hubbard; George S Sheppard; Nwe Y BaMaung; Steve D Fidanze; Gary T Wang; Xiaoming Hu; Steven K Davidsen; Randy L Bell; Jieyi Wang
Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.

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All Publications

2010: Gary T Wang; Robert A Mantei; Robert D Hubbard; Julie L Wilsbacher; Qian Zhang; Lora Tucker; Xiaoming Hu; Peter Kovar; Eric F Johnson; Donald J Osterling; Jennifer J Bouska; Jieyi Wang; Steven K Davidsen; Randy L Bell; George S Sheppard
Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.
Bioorganic & medicinal chemistry letters 2010;20(20):6067-71.
2010: Steve D Fidanze; Scott A Erickson; Gary T Wang; Robert A Mantei; Richard F Clark; Bryan K Sorensen; Nwe Y BaMaung; Peter Kovar; Eric F Johnson; Kerren K Swinger; Kent D Stewart; Qian Zhang; Lora A Tucker; William N Pappano; Julie L Wilsbacher; Jieyi Wang; George S Sheppard; Randy L Bell; Steven K Davidsen; Robert D Hubbard
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorganic & medicinal chemistry letters 2010;20(8):2452-5.
2008: Julie L Wilsbacher; Qian Zhang; Lora A Tucker; Robert D Hubbard; George S Sheppard; Nwe Y BaMaung; Steve D Fidanze; Gary T Wang; Xiaoming Hu; Steven K Davidsen; Randy L Bell; Jieyi Wang
Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation.
The Journal of biological chemistry 2008;283(35):23721-30.
2007: Gary T Wang; Robert A Mantei; Megumi Kawai; Jason S Tedrow; David M Barnes; Jieyi Wang; Qian Zhang; Pingping Lou; Lora A Garcia; Jennifer J Bouska; Melinda Yates; Chang Park; Russell A Judge; Rick Lesniewski; George S Sheppard; Randy L Bell
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids.
Bioorganic & medicinal chemistry letters 2007;17(10):2817-22.
2006: George S Sheppard; Jieyi Wang; Megumi Kawai; Steve D Fidanze; Nwe Y BaMaung; Scott A Erickson; David M Barnes; Jason S Tedrow; Lawrence Kolaczkowski; Anil Vasudevan; David C Park; Gary T Wang; William J Sanders; Robert A Mantei; Fabio Palazzo; Lora Tucker-Garcia; Pingping Lou; Qian Zhang; Chang H Park; Ki H Kim; Andrew M Petros; Edward T Olejniczak; David G Nettesheim; Philip J Hajduk; Jack Henkin; Rick Lesniewski; Steven K Davidsen; Randy L Bell
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
Journal of medicinal chemistry 2006;49(13):3832-49.
2006: Gaoquan Li; Lisa Hasvold; Zhi-Fu Tao; Gary T Wang; Stephen L Gwaltney; Jyoti Patel; Peter Kovar; Robert B Credo; Zehan Chen; Haiying Zhang; Chang Park; Hing L Sham; Thomas J Sowin; Saul H Rosenberg; Nan-Horng Lin
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(8):2293-8.
2005: Gary T Wang; Gaoquan Li; Robert A Mantei; Zehan Chen; Peter Kovar; Wendy Gu; Zhan Xiao; Haiying Zhang; Hing L Sham; Thomas J Sowin; Saul H Rosenberg; Nan-Horng Lin
1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
Journal of medicinal chemistry 2005;48(9):3118-21.
2005: Gary T Wang; Sheldon Wang; Robert Gentles; Thomas J Sowin; Sandra T Leitza; Edward B Reilly; Thomas W von Geldern
Amino-substituted heterocycles as isosteres of trans-cinnamides: design and synthesis of heterocyclic biaryl sulfides as potent antagonists of LFA-1/ICAM-1 binding.
Bioorganic & medicinal chemistry letters 2005;15(1):195-201.
2005: Gary T Wang; Xilu Wang; Weibo Wang; Lisa Hasvold; Gerry Sullivan; Charles W Hutchins; Steve O'Conner; Robert Gentiles; Thomas J Sowin; Jerry Cohen; Wen-Zhen Gu; Haiying Zhang; Saul H Rosenberg; Hing L Sham
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Bioorganic & medicinal chemistry letters 2005;15(1):153-8.
2005: Gary T Wang; Sheldon Wang; Robert Gentles; Thomas J Sowin; Clarence J Maring; Dale J Kempf; Warren M Kati; Vincent S Stoll; Kent D Stewart; Graeme Laver
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.
Bioorganic & medicinal chemistry letters 2005;15(1):125-8.
2004: Qun Li; Gary T Wang; Tongmei Li; Stephen L Gwaltney; Keith W Woods; Akiyo Claiborne; Xilu Wang; Wendy Gu; Jerry Cohen; Vincent S Stoll; Charles W Hutchins; David Frost; Saul H Rosenberg; Hing L Sham
Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(21):5371-6.
2004: Nan-Horng Lin; Le Wang; Xilu Wang; Gary T Wang; Jerry Cohen; Wen-Zhen Gu; Haiying Zhang; Saul H Rosenberg; Hing L Sham
Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.
Bioorganic & medicinal chemistry letters 2004;14(20):5057-62.
2004: Le Wang; Gary T Wang; Xilu Wang; Yunsong Tong; Gerry Sullivan; David Park; Nicholas M Leonard; Qun Li; Jerry Cohen; Wen-Zhen Gu; Haiying Zhang; Joy Bauch; Clarissa Jakob; Charles W Hutchins; Vincent S Stoll; Kennan Marsh; Saul H Rosenberg; Hing L Sham; Nan-Horng Lin
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
Journal of medicinal chemistry 2004;47(3):612-26.
2001: Gary T Wang; Yuanwei Chen; Sanyi Wang; Robert Gentles; Thomas J Sowin; Warren M Kati; Steven W Muchmore; Vincent L Giranda; Kent Stewart; Hing L Sham; Dale J Kempf; W Graeme Laver
Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.
Journal of medicinal chemistry 2001;44(8):1192-201.
2001: Gary T Wang; Sanyi Wang; Yuanwei Chen; Robert Gentles; Thomas J Sowin
Synthesis of 2-substituted (+/-)-(2r,3r,5r)-tetrahydrofuran-3,5-dicarboxylic acid derivatives.
The Journal of organic chemistry 2001;66(6):2052-6.
1999: Warren M Kati; Hing L Sham; J Owen McCall; Debra A Montgomery; Gary T Wang; W Rosenbrook; L Miesbauer; Alex M Buko; Daniel W Norbeck
Inhibition of 3C protease from human rhinovirus strain 1B by peptidyl bromomethylketonehydrazides.
Archives of biochemistry and biophysics 1999;362(2):363-75.