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Hao Wang

Research Profile

Chemicals & Drugs

Procedures

Nuclear Magnetic Resonance, Biomolecular

Phenomena

Genes & Molecular Sequences

Molecular Structure

Concepts & Ideas

Physiology

Lipid Peroxidation

Co-author Network

Publications

TOP 3
Hai Huang; Albena Kozekova; Carmelo J Rizzo; Hao Wang; Michael P Stone
Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct.
Hai Huang; Albena Kozekova; R Stephen Lloyd; Amanda K McCullough; Carmelo J Rizzo; Markus Voehler; Hao Wang; Michael P Stone
γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.
Hai Huang; Ivan D Kozekov; Albena Kozekova; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
DNA cross-link induced by trans-4-hydroxynonenal.

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All Publications

2011: Hai Huang; Albena Kozekova; Carmelo J Rizzo; Hao Wang; Michael P Stone
Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct.
Journal of the American Chemical Society 2011;133(40):16101-10.
2011: Hai Huang; Albena Kozekova; R Stephen Lloyd; Amanda K McCullough; Carmelo J Rizzo; Markus Voehler; Hao Wang; Michael P Stone
γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.
Chemical research in toxicology 2011;24(7):1123-33.
2010: Hai Huang; Ivan D Kozekov; Albena Kozekova; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
DNA cross-link induced by trans-4-hydroxynonenal.
Environmental and molecular mutagenesis 2010;51(6):625-34.
2009: Hai Huang; Hye-Young Kim; Ivan D Kozekov; Young-Jin Cho; Hao Wang; Albena Kozekova; Thomas Harris; Carmelo J Rizzo; Michael P Stone
Stereospecific formation of the (R)-gamma-hydroxytrimethylene interstrand N2-dG:N2-dG cross-link arising from the gamma-OH-1,N2-propano-2'-deoxyguanosine adduct in the 5'-CpG-3' DNA sequence.
Journal of the American Chemical Society 2009;131(24):8416-24.
2009: Hai Huang; Hao Wang; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Conformational interconversion of the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N(2)-deoxyguanosine adduct when mismatched with deoxyadenosine in DNA.
Chemical research in toxicology 2009;22(1):187-200.
2008: Hai Huang; Hao Wang; Nan Qi; Albena Kozekova; Carmelo J Rizzo; Michael P Stone
Rearrangement of the (6S,8R,11S) and (6R,8S,11R) exocyclic 1,N2-deoxyguanosine adducts of trans-4-hydroxynonenal to N2-deoxyguanosine cyclic hemiacetal adducts when placed complementary to cytosine in duplex DNA.
Journal of the American Chemical Society 2008;130(33):10898-906.
2008: Michael P Stone; Young-Jin Cho; Hai Huang; Hye-Young Kim; Ivan D Kozekov; Albena Kozekova; Hao Wang; Irina G Minko; R Stephen Lloyd; Thomas Harris; Carmelo J Rizzo
Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources.
Accounts of chemical research 2008;41(7):793-804.
2008: Jozsef Szekely; Hao Wang; Katherine M Peplowski; Charles G Knutson; Lawrence J Marnett; Carmelo J Rizzo
"One-pot" syntheses of malondialdehyde adducts of nucleosides.
Nucleosides, nucleotides & nucleic acids 2008;27(2):103-9.
2007: Charles G Knutson; Hao Wang; Carmelo J Rizzo; Lawrence J Marnett
Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the rat.
The Journal of biological chemistry 2007;282(50):36257-64.
2006: Hao Wang; Ivan D Kozekov; Albena Kozekova; Pamela J Tamura; Lawrence J Marnett; Thomas Harris; Carmelo J Rizzo
Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy.
Chemical research in toxicology 2006;19(11):1467-74.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Albena Kozekova; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; Carmelo J Rizzo; R Stephen Lloyd; Michael P Stone
Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(8):1019-29.
2006: Michael B Otteneder; Charles G Knutson; J Scott Daniels; Muhammed F Hashim; Brenda C Crews; Rory P Remmel; Hao Wang; Carmelo J Rizzo; Lawrence J Marnett
In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(17):6665-9.
2006: Young-Jin Cho; Hao Wang; Ivan D Kozekov; Andrew J Kurtz; Jaison Jacob; Markus Voehler; Jarrod Smith; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence.
Chemical research in toxicology 2006;19(2):195-208.
2005: Young-Jin Cho; Hye-Young Kim; Hai Huang; Alvira Slutsky; Irina G Minko; Hao Wang; Lubomir V Nechev; Ivan D Kozekov; Albena Kozekova; Pamela J Tamura; Jaison Jacob; Markus Voehler; Thomas Harris; R Stephen Lloyd; Carmelo J Rizzo; Michael P Stone
Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct.
Journal of the American Chemical Society 2005;127(50):17686-96.
2004: Hao Wang; Lawrence J Marnett; Thomas Harris; Carmelo J Rizzo
A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine.
Chemical research in toxicology 2004;17(2):144-9.
2003: Hao Wang; Ivan D Kozekov; Thomas Harris; Carmelo J Rizzo
Site-specific synthesis and reactivity of oligonucleotides containing stereochemically defined 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.
Journal of the American Chemical Society 2003;125(19):5687-700.
2001: Hao Wang; Carmelo J Rizzo
Stereocontrolled syntheses of all four stereoisomeric 1,N2-deoxyguanosine adducts of the lipid peroxidation product trans-4-hydroxynonenal.
Organic letters 2001;3(22):3603-5.