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Junying Wang

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Christina B Madsen-Duggan; John S Debenham; Thomas F Walsh; Lin Yan; Pei Huo; Junying Wang; Xinchun Tong; Julie Lao; Tung M Fong; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Mark T Goulet; Jeffrey J Hale
Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.
Fa-Xiang Ding; Hong Shen; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ning Ren; Tian-Quan Cai; Junying Wang; Xinchun Tong; Tom Holt; Qing Chen; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.
Lin Yan; Pei Huo; John S Debenham; Christina B Madsen-Duggan; Julie Lao; Richard Z Chen; Jing Chen Xiao; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Nancy N Tsou; Richard G Ball; Junying Wang; Xinchun Tong; Thomas J Bateman; Vijay B G Reddy; Tung M Fong; Jeffrey J Hale
Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.

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All Publications

2010: Christina B Madsen-Duggan; John S Debenham; Thomas F Walsh; Lin Yan; Pei Huo; Junying Wang; Xinchun Tong; Julie Lao; Tung M Fong; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Mark T Goulet; Jeffrey J Hale
Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.
Bioorganic & medicinal chemistry letters 2010;20(12):3750-4.
2010: Fa-Xiang Ding; Hong Shen; Larissa C Wilsie; Mihajlo L Krsmanovic; Andrew K P Taggart; Ning Ren; Tian-Quan Cai; Junying Wang; Xinchun Tong; Tom Holt; Qing Chen; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.
Bioorganic & medicinal chemistry letters 2010;20(11):3372-5.
2010: Lin Yan; Pei Huo; John S Debenham; Christina B Madsen-Duggan; Julie Lao; Richard Z Chen; Jing Chen Xiao; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Nancy N Tsou; Richard G Ball; Junying Wang; Xinchun Tong; Thomas J Bateman; Vijay B G Reddy; Tung M Fong; Jeffrey J Hale
Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.
Journal of medicinal chemistry 2010;53(10):4028-37.
2010: John S Debenham; Christina B Madsen-Duggan; Richard B Toupence; Thomas F Walsh; Junying Wang; Xinchun Tong; Sanjeev Kumar; Julie Lao; Tung M Fong; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; Yue Feng; Donald J Marsh; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Mark T Goulet
Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.
Bioorganic & medicinal chemistry letters 2010;20(4):1448-52.
2009: Linus S Lin; Thomas J Lanza; James P Jewell; Ping Liu; Carrie Jones; Gerard R Kieczykowski; Kelly Treonze; Qian Si; Salony Manior; Gloria C Koo; Xinchun Tong; Junying Wang; Anne Schuelke; James V Pivnichny; Regina Wang; Conrad E Raab; Stella Vincent; Philip Davies; Malcolm MacCoss; Richard A Mumford; William K Hagmann
Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.
Journal of medicinal chemistry 2009;52(11):3449-52.
2009: John S Debenham; Christina B Madsen-Duggan; Junying Wang; Xinchun Tong; Julie Lao; Tung M Fong; Marie-Therese Schaeffer; Jing Chen Xiao; Cathy C R-R Huang; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; D Euan Macintyre; Jeffrey J Hale; Thomas F Walsh
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.
Bioorganic & medicinal chemistry letters 2009;19(9):2591-4.
2009: Petr Vachal; Joan M Fletcher; Tung M Fong; Cathy C R-R Huang; Julie Lao; Jing Chen Xiao; Chun-Pyn Shen; Alison M Strack; Lauren P Shearman; Sloan Stribling; Richard Z Chen; Andrea Frassetto; Xinchun Tong; Junying Wang; Richard G Ball; Nancy N Tsou; Gerard J Hickey; Donald Thompson; TD Faidley; Susan Nicolich; Joana Achanfuo-Yeboah; Donald F Hora; Jeffrey J Hale; William K Hagmann
1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.
Journal of medicinal chemistry 2009;52(8):2550-8.
2008: Qiaolin Deng; Jessica L Frie; Daria M Marley; Richard T Beresis; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Kang Cheng; Ester Carballo-Jane; Junying Wang; Xinchun Tong; M Gerard Waters; James R Tata; Steven L Colletti
Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.
Bioorganic & medicinal chemistry letters 2008;18(18):4963-7.
2008: Richard Z Chen; Andrea Frassetto; Julie Lao; Ruey-Ruey C Huang; Jing Chen Xiao; Matthew J Clements; Thomas F Walsh; Jeffrey J Hale; Junying Wang; Xinchun Tong; Tung M Fong
Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor.
European journal of pharmacology 2008;584(2-3):338-42.
2008: Lauren P Shearman; D Sloan Stribling; Ramon E Camacho; Kimberly Rosko; Junying Wang; Sharon Tong; Yue Feng; Donald J Marsh; Hong Yu; Xiaoming Guan; Stephanie K Spann; Douglas J MacNeil; Tung M Fong; Joseph M Metzger; Mark T Goulet; William K Hagmann; Christopher W Plummer; Paul E Finke; Sander G Mills; Shrenik K Shah; Quang Truong; Lex H T Van Der Ploeg; D Euan MacIntyre; Alison M Strack
Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.
European journal of pharmacology 2008;579(1-3):215-24.
2007: Hong Shen; Michael J Szymonifka; Divya Kharbanda; Qiaolin Deng; Ester Carballo-Jane; Kenneth K Wu; Tsuei-Ju Wu; Kang Cheng; Ning Ren; Tian-Quan Cai; Andrew K P Taggart; Junying Wang; Xinchun Tong; M Gerard Waters; Milton L Hammond; James R Tata; Steven L Colletti
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A.
Bioorganic & medicinal chemistry letters 2007;17(24):6723-8.
2007: Ping Liu; Linus S Lin; Terence G Hamill; James P Jewell; Thomas J Lanza; Raymond E Gibson; Stephen M Krause; Christine Ryan; Waisi Eng; Sandra Sanabria; Xinchun Tong; Junying Wang; Dorothy A Levorse; Karen Owens; Tung M Fong; Chun-Pyn Shen; Julie Lao; Sanjeev Kumar; Wenji Yin; Joseph F Payack; Shawn A Springfield; Richard Hargreaves; H Donald Burns; Mark T Goulet; William K Hagmann
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.
Journal of medicinal chemistry 2007;50(15):3427-30.
2007: Tung M Fong; Xiao-Ming Guan; Donald J Marsh; Chun-Pyn Shen; D Sloan Stribling; Kimberly Rosko; Julie Lao; Hong Yu; Yue Feng; Jing Chen Xiao; Lex H T Van Der Ploeg; Mark T Goulet; William K Hagmann; Linus S Lin; Thomas J Lanza; James P Jewell; Ping Liu; Shrenik K Shah; Hongbo Qi; Xinchun Tong; Junying Wang; Suoyu S Xu; Barbara Francis; Alison M Strack; D Euan MacIntyre; Lauren P Shearman
Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1013-22.
2007: Helen E Armstrong; Amy Galka; Linus S Lin; Thomas J Lanza; James P Jewell; Shrenik K Shah; Ravindra N Guthikonda; Quang Truong; Linda L Chang; Grace Quaker; Vincent J Colandrea; Xinchun Tong; Junying Wang; Sherry Xu; Tung M Fong; Chun-Pyn Shen; Julie Lao; Jing Chen; Lauren P Shearman; D Sloan Stribling; Kimberly Rosko; Alison M Strack; Sookhee Ha; Lex H T Van Der Ploeg; Mark T Goulet; William K Hagmann
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2007;17(8):2184-7.
2007: Christina B Madsen-Duggan; John S Debenham; Thomas F Walsh; Richard B Toupence; Song X Huang; Junying Wang; Xinchun Tong; Julie Lao; Tung M Fong; Marie-Therese Schaeffer; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; D Euan MacIntyre; Lex H T Van Der Ploeg; Mark T Goulet
Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2007;17(7):2031-5.
2006: Linus S Lin; Thomas J Lanza; James P Jewell; Ping Liu; Shrenik K Shah; Hongbo Qi; Xinchun Tong; Junying Wang; Suoyu S Xu; Tung M Fong; Chun-Pyn Shen; Julie Lao; Jing Chen Xiao; Lauren P Shearman; D Sloan Stribling; Kimberly Rosko; Alison M Strack; Donald J Marsh; Yue Feng; Sanjeev Kumar; Koppara Samuel; Wenji Yin; Lex H T Van Der Ploeg; Mark T Goulet; William K Hagmann
Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
Journal of medicinal chemistry 2006;49(26):7584-7.
2006: John S Debenham; Christina B Madsen-Duggan; Thomas F Walsh; Junying Wang; Xinchun Tong; George A Doss; Julie Lao; Tung M Fong; Marie-Therese Schaeffer; Jing Chen Xiao; Cathy R-R C Huang; Chun-Pyn Shen; Yue Feng; Donald J Marsh; D Sloan Stribling; Lauren P Shearman; Alison M Strack; D Euan MacIntyre; Lex H T Van Der Ploeg; Mark T Goulet
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2006;16(3):681-5.
2005: Christopher W Plummer; Paul E Finke; Sander G Mills; Junying Wang; Xinchun Tong; George A Doss; Tung M Fong; Julie Lao; Marie-Therese Schaeffer; Jing Chen; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Lex H T Van Der Ploeg
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.
Bioorganic & medicinal chemistry letters 2005;15(5):1441-6.
2005: Laura C Meurer; Paul E Finke; Sander G Mills; Thomas F Walsh; Richard B Toupence; John S Debenham; Mark T Goulet; Junying Wang; Xinchun Tong; Tung M Fong; Julie Lao; Marie-Therese Schaeffer; Jing Chen; Chun-Pyn Shen; D Sloan Stribling; Lauren P Shearman; Alison M Strack; Lex H T Van Der Ploeg
Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists.
Bioorganic & medicinal chemistry letters 2005;15(3):645-51.
2003: Lauren P Shearman; Kimberly Rosko; R Fleischer; Junying Wang; S Xu; X S Tong; B A Rocha
Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice.
Behavioural pharmacology 2003;14(8):573-82.
2002: Ihor E Kopka; David N Young; Linus S Lin; Richard A Mumford; Plato A Magriotis; Malcolm MacCoss; Sander G Mills; Gail Van Riper; Ermengilda McCauley; Linda E Egger; Usha Kidambi; John A Schmidt; Kathryn Lyons; Ralph A Stearns; Stella Vincent; Adria Colletti; Zhen Wang; Sharon Tong; Junying Wang; Song Zheng; Karen Owens; Dorothy A Levorse; William K Hagmann
Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2002;12(4):637-40.