FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

James Wang

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Genes & Molecular Sequences

Procedures

Cloning, Molecular

Co-author Network

Publications

TOP 3
James C Wang
A journey in the world of DNA rings and beyond.
Anna M Azarova; Yi Lisa Lyu; Chao-Po Lin; Yuan-Chin Tsai; Johnson Yiu-Nam Lau; James C Wang; Leroy F Liu
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.
Kelvin Y Kwan; Rebecca J Greenwald; Subhasis Mohanty; Arlene H Sharpe; Albert C Shaw; James C Wang
Development of autoimmunity in mice lacking DNA topoisomerase 3beta.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of James Wang (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2009: James C Wang
A journey in the world of DNA rings and beyond.
Annual review of biochemistry 2009;78():31-54.
2007: Anna M Azarova; Yi Lisa Lyu; Chao-Po Lin; Yuan-Chin Tsai; Johnson Yiu-Nam Lau; James C Wang; Leroy F Liu
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):11014-9.
2007: Kelvin Y Kwan; Rebecca J Greenwald; Subhasis Mohanty; Arlene H Sharpe; Albert C Shaw; James C Wang
Development of autoimmunity in mice lacking DNA topoisomerase 3beta.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(22):9242-7.
2007: James C Wang
Unlocking and opening a DNA gate.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):4773-4.
2006: Yi Lisa Lyu; Chao-Po Lin; Anna M Azarova; li cai; James C Wang; Leroy F Liu
Role of topoisomerase IIbeta in the expression of developmentally regulated genes.
Molecular and cellular biology 2006;26(21):7929-41.
2005: Vera A Stupina; James C Wang
Viability of Escherichia coli topA mutants lacking DNA topoisomerase I.
The Journal of biological chemistry 2005;280(1):355-60.
2004: Vera A Stupina; James C Wang
DNA axial rotation and the merge of oppositely supercoiled DNA domains in Escherichia coli: effects of DNA bends.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8608-13.
2003: Yi Lisa Lyu; James C Wang
Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7123-8.
2003: Kelvin Y Kwan; Peter B Moens; James C Wang
Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2526-31.
2002: Yong Wang; Yi Lisa Lyu; James C Wang
Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(19):12114-9.
2002: James C Wang
Cellular roles of DNA topoisomerases: a molecular perspective.
Nature reviews. Molecular cell biology 2002;3(6):430-40.
2002: Yong Wang; A Simon Lynch; Sue-Jane Chen; James C Wang
On the molecular basis of the thermal sensitivity of an Escherichia coli topA mutant.
The Journal of biological chemistry 2002;277(2):1203-9.
2001: Richard J Bennett; James C Wang
Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: studies of fusion proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11108-13.
2001: Kelvin Y Kwan; James C Wang
Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5717-21.
2000: Jonathan Bath; Ling Juan Wu; Jeff Errington; James C Wang
Role of Bacillus subtilis SpoIIIE in DNA transport across the mother cell-prespore division septum.
Science (New York, N.Y.) 2000;290(5493):995-7.
2000: Richard J Bennett; M F Noirot-Gros; James C Wang
Interaction between yeast sgs1 helicase and DNA topoisomerase III.
The Journal of biological chemistry 2000;275(35):26898-905.
1999: S Olland; James C Wang
Catalysis of ATP hydrolysis by two NH(2)-terminal fragments of yeast DNA topoisomerase II.
The Journal of biological chemistry 1999;274(31):21688-94.
1999: S K Kim; James C Wang
Gene silencing via protein-mediated subcellular localization of DNA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8557-61.
1999: Richard J Bennett; James L Keck; James C Wang
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.
Journal of molecular biology 1999;289(2):235-48.
1999: B P Tu; James C Wang
Protein footprinting at cysteines: probing ATP-modulated contacts in cysteine-substitution mutants of yeast DNA topoisomerase II.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):4862-7.
1999: Q Liu; James C Wang
Similarity in the catalysis of DNA breakage and rejoining by type IA and IIA DNA topoisomerases.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(3):881-6.
1998: Q Liu; James C Wang
Identification of active site residues in the "GyrA" half of yeast DNA topoisomerase II.
The Journal of biological chemistry 1998;273(32):20252-60.
1998: James C Wang
Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine.
Quarterly reviews of biophysics 1998;31(2):107-44.
1998: Richard J Bennett; J A Sharp; James C Wang
Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae.
The Journal of biological chemistry 1998;273(16):9644-50.
1998: S J Chen; James C Wang
Identification of active site residues in Escherichia coli DNA topoisomerase I.
The Journal of biological chemistry 1998;273(11):6050-6.
1998: S K Kim; James C Wang
Localization of F plasmid SopB protein to positions near the poles of Escherichia coli cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1523-7.
1998: Wei Li; James C Wang
Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1010-3.
1997: Wei Li; James C Wang
Footprinting of yeast DNA topoisomerase II lysyl side chains involved in substrate binding and interdomainal interactions.
The Journal of biological chemistry 1997;272(49):31190-5.
1997: S Y Shaw; James C Wang
Chirality of DNA trefoils: implications in intramolecular synapsis of distant DNA segments.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1692-7.
1996: R Hanai; R Liu; P Benedetti; Paul Caron; A S Lynch; James C Wang
Molecular dissection of a protein SopB essential for Escherichia coli F plasmid partition.
The Journal of biological chemistry 1996;271(29):17469-75.
1996: K Schnetz; James C Wang
Silencing of the Escherichia coli bgl promoter: effects of template supercoiling and cell extracts on promoter activity in vitro.
Nucleic acids research 1996;24(12):2422-8.
1996: JOAQUIM ROCA; J M Berger; S C Harrison; James C Wang
DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4057-62.
1996: R Hanai; Paul Caron; James C Wang
Human TOP3: a single-copy gene encoding DNA topoisomerase III.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3653-7.
1996: J M Berger; S J Gamblin; S C Harrison; James C Wang
Structure and mechanism of DNA topoisomerase II.
Nature 1996;379(6562):225-32.
1996: JOAQUIM ROCA; James C Wang
The probabilities of supercoil removal and decatenation by yeast DNA topoisomerase II.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(1):17-27.
1996: James C Wang
DNA topoisomerases.
Annual review of biochemistry 1996;65():635-92.
1995: N Lue; A Sharma; A Mondragón; James C Wang
A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications.
Structure (London, England : 1993) 1995;3(12):1315-22.
1995: N F Lue; James C Wang
ATP-dependent processivity of a telomerase activity from Saccharomyces cerevisiae.
The Journal of biological chemistry 1995;270(37):21453-6.
1995: Caroline A Austin; KL Marsh; R A Wasserman; Elaine Willmore; P J Sayer; James C Wang; L Mark Fisher
Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta.
The Journal of biological chemistry 1995;270(26):15739-46.
1995: R A Kim; Paul Caron; James C Wang
Effects of yeast DNA topoisomerase III on telomere structure.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2667-71.
1995: A S Lynch; James C Wang
SopB protein-mediated silencing of genes linked to the sopC locus of Escherichia coli F plasmid.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(6):1896-900.
1994: R Hanai; James C Wang
Protein footprinting by the combined use of reversible and irreversible lysine modifications.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11904-8.
1994: R A Wasserman; James C Wang
Mechanistic studies of amsacrine-resistant derivatives of DNA topoisomerase II. Implications in resistance to multiple antitumor drugs targeting the enzyme.
The Journal of biological chemistry 1994;269(33):20943-51.
1994: JOAQUIM ROCA; James C Wang
DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism.
Cell 1994;77(4):609-16.
1994: Paul Caron; P Watt; James C Wang
The C-terminal domain of Saccharomyces cerevisiae DNA topoisomerase II.
Molecular and cellular biology 1994;14(5):3197-207.
1994: R A Wasserman; James C Wang
Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine.
Cancer research 1994;54(7):1795-800.
1994: JOAQUIM ROCA; R Ishida; J M Berger; T Andoh; James C Wang
Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1781-5.
1994: A S Lynch; James C Wang
Use of an inducible site-specific recombinase to probe the structure of protein-DNA complexes involved in F plasmid partition in Escherichia coli.
Journal of molecular biology 1994;236(3):679-84.
1994: Paul Caron; James C Wang
Appendix. II: Alignment of primary sequences of DNA topoisomerases.
Advances in pharmacology (San Diego, Calif.) 1994;29B():271-97.
1994: James C Wang
Appendix. I: An introduction to DNA supercoiling and DNA topoisomerase-catalyzed linking number changes of supercoiled DNA.
Advances in pharmacology (San Diego, Calif.) 1994;29B():257-70.
1993: M R Gartenberg; James C Wang
Identification of barriers to rotation of DNA segments in yeast from the topology of DNA rings excised by an inducible site-specific recombinase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10514-8.
1993: R Hanai; James C Wang
The mechanism of sequence-specific DNA cleavage and strand transfer by phi X174 gene A* protein.
The Journal of biological chemistry 1993;268(32):23830-6.
1993: James C Wang; A S Lynch
Transcription and DNA supercoiling.
Current opinion in genetics & development 1993;3(5):764-8.
1993: Piero Benedetti; P Fiorani; L Capuani; James C Wang
Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine.
Cancer research 1993;53(18):4343-8.
1993: R A Wasserman; Caroline A Austin; L Mark Fisher; James C Wang
Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase II alpha in yeast.
Cancer research 1993;53(15):3591-6.
1993: JOAQUIM ROCA; J M Berger; James C Wang
On the simultaneous binding of eukaryotic DNA topoisomerase II to a pair of double-stranded DNA helices.
The Journal of biological chemistry 1993;268(19):14250-5.
1993: J E Lindsley; James C Wang
On the coupling between ATP usage and DNA transport by yeast DNA topoisomerase II.
The Journal of biological chemistry 1993;268(11):8096-104.
1993: A S Lynch; James C Wang
Anchoring of DNA to the bacterial cytoplasmic membrane through cotranscriptional synthesis of polypeptides encoding membrane proteins or proteins for export: a mechanism of plasmid hypernegative supercoiling in mutants deficient in DNA topoisomerase I.
Journal of bacteriology 1993;175(6):1645-55.
1993: J E Lindsley; James C Wang
Study of allosteric communication between protomers by immunotagging.
Nature 1993;361(6414):749-50.
1992: M R Gartenberg; James C Wang
Positive supercoiling of DNA greatly diminishes mRNA synthesis in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11461-5.
1992: JOAQUIM ROCA; James C Wang
The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases.
Cell 1992;71(5):833-40.
1992: R A Kim; James C Wang
Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase.
The Journal of biological chemistry 1992;267(24):17178-85.
1991: J E Lindsley; James C Wang
Proteolysis patterns of epitopically labeled yeast DNA topoisomerase II suggest an allosteric transition in the enzyme induced by ATP binding.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10485-9.
1991: James C Wang
DNA topoisomerases: why so many?
The Journal of biological chemistry 1991;266(11):6659-62.
1990: Elaine A Ostrander; P Benedetti; James C Wang
Template supercoiling by a chimera of yeast GAL4 protein and phage T7 RNA polymerase.
Science (New York, N.Y.) 1990;249(4974):1261-5.
1990: James C Wang; Paul Caron; R A Kim
The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?
Cell 1990;62(3):403-6.
1990: P R Strauss; James C Wang
The TOP2 gene of Trypanosoma brucei: a single-copy gene that shares extensive homology with other TOP2 genes encoding eukaryotic DNA topoisomerase II.
Molecular and biochemical parasitology 1990;38(1):141-50.
1989: Mary-Ann Bjornsti; Piero Benedetti; G A Viglianti; James C Wang
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.
Cancer research 1989;49(22):6318-23.
1989: R A Kim; James C Wang
Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae.
Journal of molecular biology 1989;208(2):257-67.
1989: R A Kim; James C Wang
A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings.
Cell 1989;57(6):975-85.
1989: R M Lynn; Mary-Ann Bjornsti; Paul Caron; James C Wang
Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3559-63.
1989: S T Worland; James C Wang
Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae.
The Journal of biological chemistry 1989;264(8):4412-6.
1989: R M Lynn; James C Wang
Peptide sequencing and site-directed mutagenesis identify tyrosine-319 as the active site tyrosine of Escherichia coli DNA topoisomerase I.
Proteins 1989;6(3):231-9.
1988: G N Giaever; James C Wang
Supercoiling of intracellular DNA can occur in eukaryotic cells.
Cell 1988;55(5):849-56.
1988: John L. Nitiss; James C Wang
DNA topoisomerase-targeting antitumor drugs can be studied in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(20):7501-5.
1988: M Tsai-Pflugfelder; L F Liu; A A Liu; K M Tewey; J Whang-Peng; T Knutsen; K Huebner; C M Croce; James C Wang
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7177-81.
1988: A J Courey; James C Wang
Influence of DNA sequence and supercoiling on the process of cruciform formation.
Journal of molecular biology 1988;202(1):35-43.
1988: James C Wang; G N Giaever
Action at a distance along a DNA.
Science (New York, N.Y.) 1988;240(4850):300-4.
1988: G N Giaever; L Snyder; James C Wang
DNA supercoiling in vivo.
Biophysical chemistry 1988;29(1-2):7-15.
1987: Mary-Ann Bjornsti; James C Wang
Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):8971-5.
1987: S L Swanberg; James C Wang
Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase.
Journal of molecular biology 1987;197(4):729-36.
1981: James C Wang; K Kirkegaard
DNA topoisomerases.
Gene amplification and analysis 1981;2():455-73.