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Jian-Zhi Wang

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Guang Yu; Yiyuan Xia; Tonghai Yan; Ye Feng; Xinghua Liu; Hongbin Luo; Jian-Zhi Wang; Xiaochuan Wang
Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.
Cai-Xia Peng; Xiao-Ping Hong; Juan Hu; Dan Liu; Yuan-Yuan Wu; Ling-Qiang Zhu; Jian-Zhi Wang
Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model.
Yu Luo; Zhong-Fei Ni; Yun-Juan Nie; Hai-Rong Shi; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.

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2013: Guang Yu; Yiyuan Xia; Tonghai Yan; Ye Feng; Xinghua Liu; Hongbin Luo; Jian-Zhi Wang; Xiaochuan Wang
Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.
Neurobiology of aging 2013;34(7):1748-58.
2013: Cai-Xia Peng; Xiao-Ping Hong; Juan Hu; Dan Liu; Yuan-Yuan Wu; Ling-Qiang Zhu; Jian-Zhi Wang
Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model.
Neurobiology of aging 2013;34(6):1555-63.
2013: Yu Luo; Zhong-Fei Ni; Yun-Juan Nie; Hai-Rong Shi; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.
Biochimica et biophysica acta 2013;1833(5):1235-43.
2013: Yan Xiong; Yang Yang; Xin-Wen Zhou; Xiu-Lian Wang; Fu-Yuan Cao; Xiao-Peng Jing; Rong Liu; You-Ming Lu; Mei Qiu; Xu-Ying Sun; Jian-Zhi Wang
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.
Neurobiology of aging 2013;34(3):745-56.
2013: Gao-Shang Chai; Xiang-Shu Cheng; Xia Jiang; Zhi-Wei Ma; Zhong-Fei Ni; Jian-Zhi Wang; Qun Wang; Ao-Ji Xie; Gong-Ping Liu
Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine.
Journal of neurochemistry 2013;124(3):388-96.
2013: Xiong Wang; Zhi-Hao Wang; Yuan-Yuan Wu; Yan-Si Xiong; Xin-Ya Gao; Dan Liu; Lu Tan; Hui Tang; Jian-Zhi Wang; Xiang Wang; Ling-Qiang Zhu
Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway.
Molecular neurobiology 2013;47(1):373-81.
2013: Yang Yang; Shou-Peng Zhang; Run-Xia Gu; Xiao-Peng Jing; Dan Ke; Mei Qiu; Xu-Ying Sun; Fangxu Tang; Jian-Zhi Wang; Xiu-Lian Wang; Yan Xiong; Rong Liu
High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling.
PloS one 2013;8(1):e55384.
2013: Jian-Zhi Wang; Yi-Yuan Xia; Inge Grundke-Iqbal; Khalid Iqbal
Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration.
Journal of Alzheimer's disease : JAD 2013;33 Suppl 1():S123-39.
2012: Xiao-Hong Li; Bing-Ling Lv; Jian-Zhi Wang; Jia-Zhao Xie; Jia-Yu Zhang; Xiang-Shu Cheng; Lai-Ling Du; Xia Jiang; Xin-Wen Zhou
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.
Neuromolecular medicine 2012;14(4):338-48.
2012: Shao-Hui Wang; Yang-Yang Yin; Juan Hu; Xiao-Mei Liao; Dan Liu; Jian-Zhi Wang; Ling-Qiang Zhu
NGF promotes long-term memory formation by activating poly(ADP-ribose)polymerase-1.
Neuropharmacology 2012;63(6):1085-92.
2012: Xin-An Liu; Jie Song; Qing Tian; Qian Jiang; Qun Wang; Jian-Zhi Wang
Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response.
Apoptosis : an international journal on programmed cell death 2012;17(10):1039-49.
2012: Xiu-Ping Liu; Min Qu; Fu-Yuan Cao; Dan Ke; Gong-Ping Liu; Qun Wang; Yao Zhang; Hong-Yun Zheng; Jian-Zhi Wang
Upregulation of astrocytes protein phosphatase-2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice.
Glia 2012;60(9):1279-88.
2012: Xiu-Qing Yao; Yang-Yang Yin; Xiao-Xue Zhang; Xia-Chun Li; Bin Liu; Dan-Ju Luo; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
FEBS letters 2012;586(16):2522-8.
2012: Xiao-Hong Li; Jing Liu; Bing-Ling Lv; Jia-Zhao Xie; Xin-Wen Zhou; Jian-Zhi Wang
AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation.
Neurobiology of aging 2012;33(7):1400-10.
2012: Xu-Ying Sun; Rong Liu; You-Ming Lu; Qun Wang; Xiao-Chuan Wang; Xiu-Lian Wang; Yu-Ping Wei; Ao-Ji Xie; Yan Xiong; Yang Yang; Jian-Zhi Wang
Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A).
The Journal of biological chemistry 2012;287(14):11174-82.
2012: Ying Yang; Jian Zhang; Ling-Qiang Zhu; Dan Liu; Lei Pei; Ronald S Petralia; Kun Qian; You Shang; Xiaogang Shu; Qing Tian; Weihong Tu; Jian-Zhi Wang; Ya-Xian Wang; Yan Wu; Xin Xu; Youming Lu
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.
Neuron 2012;73(4):774-88.
2012: Gong-Ping Liu; Cai-Xia Peng; Hai-Hong Shi; Qun Wang; Wei Wei; Xiu-Qing Yao; Jun Yin; Yao Zhang; Xin Zhou; Juan Hu; Hong-Lian Li; Jian-Zhi Wang
I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis.
Neurobiology of aging 2012;33(2):254-64.
2012: Zan-Chao Liu; Na Qu; Jie Song; Jiang Chu; Zheng-Qi Fu; Li Han; Jian-Zhi Wang; Yu-Ping Wei; Jia-Yu Zhang; Qing Tian
Bip enhanced the association of GSK-3β with tau during ER stress both in vivo and in vitro.
Journal of Alzheimer's disease : JAD 2012;29(4):727-40.
2012: Ning-Ning Chen; Dan-Ju Luo; Jian-Zhi Wang; Qun Wang; Yi Wang; Xiu-Qing Yao; Cong Yu; Gong-Ping Liu
Pesticides induce spatial memory deficits with synaptic impairments and an imbalanced tau phosphorylation in rats.
Journal of Alzheimer's disease : JAD 2012;30(3):585-94.
2011: Xia Jiang; Qing Tian; Jian-Zhi Wang; Yue Wang; Jia-Zhao Xie; Xin-Wen Zhou; Ling-Qiang Zhu
Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C.
Journal of neurochemistry 2011;118(5):864-78.
2011: Xiu-Qing Yao; Yang-Yang Yin; Xiao-Xue Zhang; Ning-Ning Chen; Bin Liu; Dan Liu; Dan-Ju Luo; Zhong-Fei Ni; Jian-Zhi Wang; Qun Wang; Xiong Wang; Gong-Ping Liu
Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.
The Biochemical journal 2011;437(2):335-44.
2011: Xiao-Ping Hong; Cai-Xia Peng; Wei Wei; Qing Tian; Ying-Hua Liu; Fu-Yuan Cao; Qun Wang; Jian-Zhi Wang
Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone.
Neurochemical research 2011;36(2):288-96.
2011: Wei Wei; Zelan Wei; Chang-E Zhang; Ying-Hua Liu; Darrell D Mousseau; Qing Tian; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats.
Journal of Alzheimer's disease : JAD 2011;27(3):639-50.
2011: Gang Yin; Ling-Yun Li; Hong-Bin Luo; Min Qu; Jian-Zhi Wang; Xin-Wen Zhou
Upregulation of AKT attenuates amyloid-β-induced cell apoptosis.
Journal of Alzheimer's disease : JAD 2011;25(2):337-45.
2011: Guang Yu; Yi Li; Qing Tian; Rong Liu; Qun Wang; Jian-Zhi Wang; Xiaochuan Wang
Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.
Journal of Alzheimer's disease : JAD 2011;24(3):525-35.
2010: Xiao-Ping Hong; Cai-Xia Peng; Wei Wei; Qing Tian; Ying-Hua Liu; Xiu-Qing Yao; Yao Zhang; Fu-Yuan Cao; Qun Wang; Jian-Zhi Wang
Essential role of tau phosphorylation in adult hippocampal neurogenesis.
Hippocampus 2010;20(12):1339-49.
2010: Xu Chen; Jun Wu; Dong Hua; Kai Shu; Jian-Zhi Wang; Ling Li; Ting Lei
The c-Jun N-terminal kinase inhibitor SP600125 is neuroprotective in amygdala kindled rats.
Brain research 2010;1357():104-14.
2010: Yuan-Jian Yang; Peng-Fei Wu; Li-Hong Long; Dan-Fang Yu; Wen-Ning Wu; Zhuang-Li Hu; Hui Fu; Na Xie; You Jin; Lan Ni; Jian-Zhi Wang; Fang Wang; Jian-Guo Chen
Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function.
Aging cell 2010;9(5):709-21.
2010: Z Yao; Z Guo; C Yang; Qing Tian; Cheng-Xin Gong; G Liu; Jian-Zhi Wang
Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation.
Neuroscience 2010;168(2):405-15.
2010: Ling-Qiang Zhu; Hong-Yun Zheng; Cai-Xia Peng; Dan Liu; Hong-Lian Li; Qun Wang; Jian-Zhi Wang
Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(10):3839-48.
2010: Ling-Qiang Zhu; Dan Liu; Juan Hu; Jin Cheng; Shao-Hui Wang; Qun Wang; Fang Wang; Jian-Guo Chen; Jian-Zhi Wang
GSK-3 beta inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(10):3624-33.
2010: Zheng-Qi Fu; Ying Yang; Jie Song; Qian Jiang; Zan-Chao Lin; Qun Wang; Ling-Qiang Zhu; Jian-Zhi Wang; Qing Tian
LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro.
Journal of Alzheimer's disease : JAD 2010;21(4):1107-17.
2010: Hai-Hong Wang; Hong-Lian Li; Rong Liu; Yao Zhang; Kai Liao; Qun Wang; Jian-Zhi Wang; Shi-Jie Liu
Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors.
Journal of Alzheimer's disease : JAD 2010;21(1):167-79.
2010: Ze-Fen Wang; Jun Yin; Yao Zhang; Ling-Qiang Zhu; Qing Tian; Xiao-Chuan Wang; Hong-Lian Li; Jian-Zhi Wang
Overexpression of tau proteins antagonizes amyloid-beta-potentiated apoptosis through mitochondria-caspase-3 pathway in N2a cells.
Journal of Alzheimer's disease : JAD 2010;20(1):145-57.
2010: Xin-An Liu; Kai Liao; Rong Liu; Hai-Hong Wang; Yao Zhang; Qi Zhang; Qun Wang; Hong-Lian Li; Qing Tian; Jian-Zhi Wang
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Journal of Alzheimer's disease : JAD 2010;19(3):953-62.
2010: Yang-Yang Yin; Hao Liu; Xiao-Bin Cong; Zhao Liu; Qun Wang; Jian-Zhi Wang; Ling-Qiang Zhu
Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats.
Journal of Alzheimer's disease : JAD 2010;19(2):735-46.
2009: Ying-Hua Liu; Wei Wei; Jun Yin; Gong-Ping Liu; Qun Wang; Fu-Yuan Cao; Jian-Zhi Wang
Proteasome inhibition increases tau accumulation independent of phosphorylation.
Neurobiology of aging 2009;30(12):1949-61.
2009: Wen-Zhen Zhu; Wei-de Zhong; Wei Wang; Chuan-Jia Zhan; Cheng-Yuan Wang; Jian-Pin Qi; Jian-Zhi Wang; Ting Lei
Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease.
Radiology 2009;253(2):497-504.
2009: Yao Zhang; Qing Tian; Qi Zhang; Xinwen Zhou; Shijie Liu; Jian-Zhi Wang
Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection.
Pathophysiology : the official journal of the International Society for Pathophysiology / ISP 2009;16(4):311-6.
2009: Jian-Zhi Wang
The advances of Pathophysiology in China-Welcoming Global Collaboration.
Pathophysiology : the official journal of the International Society for Pathophysiology / ISP 2009;16(4):251-2.
2009: Rong Liu; Jian-Zhi Wang
Protein phosphatase 2A in Alzheimer's disease.
Pathophysiology : the official journal of the International Society for Pathophysiology / ISP 2009;16(4):273-7.
2009: Chang-E Zhang; Wei Wei; Ying-Hua Liu; Jun-Hua Peng; Qing Tian; Gong-Ping Liu; Yao Zhang; Jian-Zhi Wang
Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain.
The American journal of pathology 2009;174(4):1481-91.
2009: Qing Tian; Jun-Xia Zhang; Yao Zhang; Feng Wu; Qian Tang; Cheng Wang; Zhi-Yong Shi; Jing-Hui Zhang; Sang Liu; Yue Wang; Qi Zhang; Jian-Zhi Wang
Biphasic effects of forskolin on tau phosphorylation and spatial memory in rats.
Journal of Alzheimer's disease : JAD 2009;17(3):631-42.
2009: Zhi-qun Ling; Qing Tian; Li Wang; Zheng-Qi Fu; Xiao-Chuan Wang; Qun Wang; Jian-Zhi Wang
Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin.
Journal of Alzheimer's disease : JAD 2009;16(2):287-300.
2009: Jia-Yu Zhang; Caixia Peng; Hairong Shi; Shaohui Wang; Qun Wang; Jian-Zhi Wang
Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
Journal of Alzheimer's disease : JAD 2009;16(1):39-47.
2008: Chang-E Zhang; Qing Tian; Wei Wei; Jun-Hua Peng; Gong-Ping Liu; Xin-Wen Zhou; Qun Wang; Dao Wen Wang; Jian-Zhi Wang
Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus.
Neurobiology of aging 2008;29(11):1654-65.
2008: Yue Wang; Jun-Xia Zhang; Xiao-Xia Du; Li Zhao; Qing Tian; Ling-Qiang Zhu; Shao-Hui Wang; Jian-Zhi Wang
Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3.
Journal of neurochemistry 2008;106(6):2364-74.
2008: Xin-An Liu; Ling-Qiang Zhu; Qi Zhang; Hai-Rong Shi; Shao-Hui Wang; Qun Wang; Jian-Zhi Wang
Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A.
Neurochemical research 2008;33(9):1811-20.
2008: Gong-Ping Liu; Yao Zhang; Xiu-Qing Yao; Chang-E Zhang; Jiang Fang; Qun Wang; Jian-Zhi Wang
Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
Neurobiology of aging 2008;29(9):1348-58.
2008: Jian-Zhi Wang; Fei Liu
Microtubule-associated protein tau in development, degeneration and protection of neurons.
Progress in neurobiology 2008;85(2):148-75.
2008: Xiao-Chuan Wang; Yin-Chun Zhang; Nithiananda Chatterjie; Inge Grundke-Iqbal; Khalid Iqbal; Jian-Zhi Wang
Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.
Neurochemical research 2008;33(6):1138-44.
2008: Hai-Rong Shi; Ling-Qiang Zhu; Shao-Hui Wang; Xin-An Liu; Qing Tian; Qi Zhang; Qun Wang; Jian-Zhi Wang
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(6):879-88.
2008: Xiao-Chuan Wang; Xiao-Xia Du; Qing Tian; Jian-Zhi Wang
Correlation between choline signal intensity and acetylcholine level in different brain regions of rat.
Neurochemical research 2008;33(5):814-9.
2008: Yong-Jie Zhang; Ya-Fei Xu; X-H Liu; Dong Li; Jun Yin; Y-H Liu; X-Q Chen; Jian-Zhi Wang
Carboxyl terminus of heat-shock cognate 70-interacting protein degrades tau regardless its phosphorylation status without affecting the spatial memory of the rats.
Journal of neural transmission (Vienna, Austria : 1996) 2008;115(3):483-91.
2008: R Liu; Xin-Wen Zhou; Heikki Tanila; C Bjorkdahl; Jian-Zhi Wang; Zhi-Zhong Guan; Yihai Cao; Jan-�ke GUSTAFSSON; Bengt Winblad; Jin-Jing Pei
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.
Journal of cellular and molecular medicine 2008;12(1):241-57.
2007: Ling-Qiang Zhu; Shao-Hui Wang; Dan Liu; Yang-Yang Yin; Qing Tian; Xiao-Chuan Wang; Qun Wang; Jian-Guo Chen; Jian-Zhi Wang
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(45):12211-20.
2007: Jiang Fang; Rong Liu; Qing Tian; Xiao-ping Hong; Shao-hui Wang; Fu-Yuan Cao; Xi-ping Pan; Jian-Zhi Wang
Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices.
Acta pharmacologica Sinica 2007;28(11):1717-23.
2007: Dan Li; Xiao Qian Chen; Wu-Jian Li; Yu-Hui Yang; Jian-Zhi Wang; Albert Cheung Hoi Yu
Cytoglobin up-regulated by hydrogen peroxide plays a protective role in oxidative stress.
Neurochemical research 2007;32(8):1375-80.
2007: Ying Yang; Xi-Fei Yang; Yi-Peng Wang; Qing Tian; Xiao-Chuan Wang; Hong-Lian Li; Qun Wang; Jian-Zhi Wang
Inhibition of protein phosphatases induces transport deficits and axonopathy.
Journal of neurochemistry 2007;102(3):878-86.
2007: Shaohui Wang; Lingqiang Zhu; Hairong Shi; Hongyun Zheng; Qing Tian; Qun Wang; Rong Liu; Jian-Zhi Wang
Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5.
Neurochemical research 2007;32(8):1329-35.
2007: Jun-Hua Peng; Chang-E Zhang; Wei Wei; Xiao-Ping Hong; Xi-Ping Pan; Jian-Zhi Wang
Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats.
Neuropharmacology 2007;52(7):1521-7.
2007: Qing-Guo Ren; Xiao-Mei Liao; Xiao-Qian Chen; Gong-Ping Liu; Jian-Zhi Wang
Effects of tau phosphorylation on proteasome activity.
FEBS letters 2007;581(7):1521-8.
2007: Hong-Lian Li; Hai-Hong Wang; Shi-Jie Liu; Yan-Qiu Deng; Yong-Jie Zhang; Qing Tian; Xiao-Chuan Wang; Xiao-Qian Chen; Ying Yang; Jia-Yu Zhang; Qun Wang; Huaxi Xu; Francesca-Fang Liao; Jian-Zhi Wang
Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3591-6.
2006: Y Zhang; Hong Lian Li; D-L Wang; Shi-Jie Liu; Jian-Zhi Wang
A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology.
Journal of neural transmission (Vienna, Austria : 1996) 2006;113(10):1487-97.
2006: Ze-Fen Wang; Hong-Lian Li; Xia-Chun Li; Qi Zhang; Qing Tian; Qun Wang; Huaxi Xu; Jian-Zhi Wang
Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture.
Journal of neurochemistry 2006;98(4):1167-75.
2006: Yong-Jie Zhang; Ya-Fei Xu; Ying-Hua Liu; Jun Yin; Hong-Lian Li; Qun Wang; Jian-Zhi Wang
Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1431-42.
2006: Jun-Xia Zhang; Yue Wang; Qing Tian; Ling-Qiang Zhu; Jian-Zhi Wang
[Duration of tau hyperphosphorylation and spatial memory deficit induced by single injection of Forskolin into lateral ventricle of rat].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2006;28(3):355-9.
2006: Qing-Guo Ren; Xiao-Mei Liao; Ze-Fen Wang; Zhong-sen Qu; Jian-Zhi Wang
The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation.
FEBS letters 2006;580(10):2503-11.
2006: Zhong-sen Qu; Qing Tian; Xin-Wen Zhou; Qun Wang; Qi Zhang; Jian-Zhi Wang
[Mechanism of tau hyperphosphorylation in brain cortex of diabetic rats and effect of LiCl].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2006;28(2):244-8.
2006: Xu Li; Fen Lu; Jian-Zhi Wang; Cheng-Xin Gong
Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.
The European journal of neuroscience 2006;23(8):2078-86.
2006: Jian-Zhi Wang; Ze-fen Wang
Role of melatonin in Alzheimer-like neurodegeneration.
Acta pharmacologica Sinica 2006;27(1):41-9.
2005: Zhong-sen Qu; Qing Tian; Xin-Wen Zhou; Xiao-Chuan Wang; Qun Wang; Qi Zhang; Jian-Zhi Wang
[Alteration of beta-amyloid and glutamate transporter in the brain of diabetes rats and the underlying mechanism].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2005;27(6):708-11.
2005: Yong-Jie Zhang; Ya-Fei Xu; Ying-Hua Liu; Jun Yin; Jian-Zhi Wang
Nitric oxide induces tau hyperphosphorylation via glycogen synthase kinase-3beta activation.
FEBS letters 2005;579(27):6230-6.
2005: Rong Liu; Jin-Jing Pei; Xiao-Chuan Wang; Xin-Wen Zhou; Qing Tian; Bengt Winblad; Jian-Zhi Wang
Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms.
Journal of neurochemistry 2005;94(5):1225-34.
2005: Ying-Chun Zhang; Xiao-Mei Liao; Jian-Zhi Wang
[Effect of different culture media on viability and tau protein expression in rat hippocampal slices].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2005;27(4):513-7.
2005: Ling-Qiang Zhu; Shao-hui Wang; Zhi-qun Ling; Qun Wang; Mao-qiong Hu; Jian-Zhi Wang
Inhibition of melatonin biosynthesis activates protein kinase a and induces Alzheimer-like tau hyperphosphorylation in rats.
Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences 2005;20(2):83-7.
2005: Hai-hong Wang; Ai Hong Zhang; Ling-Qiang Zhu; Qun Wang; Jian-Zhi Wang
Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell.
Acta pharmacologica Sinica 2005;26(6):679-84.
2005: Guo-Gang Xu; Yan-Qiu Deng; Shi-Jie Liu; Hong-Lian Li; Jian-Zhi Wang
Prolonged Alzheimer-like tau hyperphosphorylation induced by simultaneous inhibition of phosphoinositol-3 kinase and protein kinase C in N2a cells.
Acta biochimica et biophysica Sinica 2005;37(5):349-54.
2005: Yan-Qiu Deng; Guo-gang Xu; Ping Duan; Qi Zhang; Jian-Zhi Wang
Effects of melatonin on wortmannin-induced tau hyperphosphorylation.
Acta pharmacologica Sinica 2005;26(5):519-26.
2005: Yong Jie Zhang; Ya-Fei Xu; Xiao Qian Chen; Xiao Chuan Wang; Jian-Zhi Wang
Nitration and oligomerization of tau induced by peroxynitrite inhibit its microtubule-binding activity.
FEBS letters 2005;579(11):2421-7.
2005: J Y Zhang; Shi-Jie Liu; Hong Lian Li; Jian-Zhi Wang
Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(4):547-55.
2005: Xia-Chun Li; Ze-Fen Wang; Jun-Xia Zhang; Qun Wang; Jian-Zhi Wang
Effect of melatonin on calyculin A-induced tau hyperphosphorylation.
European journal of pharmacology 2005;510(1-2):25-30.
2005: Xiao-Chuan Wang; Jing Zhang; Xian Yu; Liu Han; Zhen-Tao Zhou; Yao Zhang; Jian-Zhi Wang
Prevention of isoproterenol-induced tau hyperphosphorylation by melatonin in the rat.
Sheng li xue bao : [Acta physiologica Sinica] 2005;57(1):7-12.
2004: Yi Peng Wang; Ze Fen Wang; Ying Chun Zhang; Qing Tian; Jian-Zhi Wang
Effect of amyloid peptides on serum withdrawal-induced cell differentiation and cell viability.
Cell research 2004;14(6):467-72.
2004: Shi Jie Liu; Jia Yu Zhang; Hong Lian Li; Zheng-Yu Fang; Qun Wang; Heng Mei Deng; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Jian-Zhi Wang
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain.
The Journal of biological chemistry 2004;279(48):50078-88.
2004: Ling-Qiang Zhu; Shao Hui Wang; Zhi-qun Ling; Dan Ling Wang; Jian-Zhi Wang
Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat.
Journal of pineal research 2004;37(2):71-7.
2004: Dan-Ling Wang; Zhi-qun Ling; Fu-Yuan Cao; Ling-Qiang Zhu; Jian-Zhi Wang
Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.
Journal of pineal research 2004;37(1):11-6.
2004: Ze-fen Wang; Jian-Zhi Wang
Overexpression of amyloid precursor protein inhibits neurite outgrowth and disrupts cytoskeleton in N2a cells.
Chinese medical journal 2004;117(5):775-8.
2004: Ying-chun Zhang; Ze-fen Wang; Qun Wang; Yi-peng Wang; Jian-Zhi Wang
Melatonin attenuates beta-amyloid-induced inhibition of neurofilament expression.
Acta pharmacologica Sinica 2004;25(4):447-51.
2004: Shu Peng Li; Yan Qiu Deng; Xiao Chuan Wang; Yi Peng Wang; Jian-Zhi Wang
Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity.
Journal of pineal research 2004;36(3):186-91.
2004: Yi-peng Wang; Xian-tao Li; Shi-jie Liu; Xin-Wen Zhou; Xiao-Chuan Wang; Jian-Zhi Wang
Melatonin ameliorated okadaic-acid induced Alzheimer-like lesions.
Acta pharmacologica Sinica 2004;25(3):276-80.
2004: Ya-Fei Xu; Yong Jie Zhang; Ai Hong Zhang; Qi Zhang; Tangchun Wu; Jian-Zhi Wang
Attenuation of okadaic acid-induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms.
Cell stress & chaperones 2004;9(3):304-12.
2003: Shi Jie Liu; Ai Hong Zhang; Hong Lian Li; Qun Wang; Heng Mei Deng; William Netzer; Huaxi Xu; Jian-Zhi Wang
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.
Journal of neurochemistry 2003;87(6):1333-44.
2003: Zheng-Yu Fang; Shi-Jie Liu; Xiao-Chuan Wang; Rong Liu; Qun Wang; Zheng-Yue Chen; Jian-Zhi Wang
[Effect of calpain on the degradation of tau protein in rat brain cortex extracts].
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003;35(7):629-34.
2003: Shi-Jie Liu; Zheng-Yu Fang; Ying Yang; Heng Mei Deng; Jian-Zhi Wang
Alzheimer-like phosphorylation of tau and neurofilament induced by cocaine in vivo.
Acta pharmacologica Sinica 2003;24(6):512-8.
2003: Li Sun; S Y Liu; Xin-Wen Zhou; Xiao-Chuan Wang; Rong Liu; Qun Wang; Jian-Zhi Wang
Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats.
Neuroscience 2003;118(4):1175-82.
2002: Shi-Jie Liu; Jian-Zhi Wang
Alzheimer-like tau phosphorylation induced by wortmannin in vivo and its attenuation by melatonin.
Acta pharmacologica Sinica 2002;23(2):183-7.
2001: Yi-peng Wang; Z L Wei; Xiao-Chuan Wang; Qun Wang; Jian-Zhi Wang
[Comparative study of the expression and phosphorylation of neurofilament proteins of brain gray matter in Alzheimer's disease].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2001;23(5):445-9.
2001: X T Li; Qun Wang; Z L Wei; Y H Yuan; Jian-Zhi Wang
[Alzheimer-like protein phosphatase deficiency leads to abnormal phosphorylation and accumulation of neurofilaments].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2001;23(5):439-44.
1999: Y P Du; Q H Hu; Jian-Zhi Wang; Di-xun Wang
[Effect of ET-1 antisense oligodeoxynucleotide on the hemodynamics of normal and experimental hypertensive rats].
Sheng li xue bao : [Acta physiologica Sinica] 1999;51(4):413-8.