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Liya Wang

Research Profile

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

Mitochondrion

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Phosphorylation

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Cloning, Molecular

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Publications

TOP 3
Ren Sun; Staffan Eriksson; Liya Wang
Oxidative stress induced S-glutathionylation and proteolytic degradation of mitochondrial thymidine kinase 2.
Louise Egeblad; Staffan Eriksson; Susanne Flodin; Susanne Gräslund; Liya Wang; Martin Welin; Jan Balzarini; Pär Nordlund
Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.
Liya Wang; Ren Sun; Staffan Eriksson
The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.

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All Publications

2012: Ren Sun; Staffan Eriksson; Liya Wang
Oxidative stress induced S-glutathionylation and proteolytic degradation of mitochondrial thymidine kinase 2.
The Journal of biological chemistry 2012;287(29):24304-12.
2012: Louise Egeblad; Staffan Eriksson; Susanne Flodin; Susanne Gräslund; Liya Wang; Martin Welin; Jan Balzarini; Pär Nordlund
Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.
PloS one 2012;7(5):e37724.
2011: Liya Wang; Ren Sun; Staffan Eriksson
The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs.
Antimicrobial agents and chemotherapy 2011;55(6):2552-8.
2010: Martin Welin; Louise Egeblad; Andreas Johansson; Pål Stenmark; Liya Wang; Susanne Flodin; Tomas Nyman; Lionel Trésaugues; Tetyana Kotenyova; Ida Johansson; Staffan Eriksson; Hans Eklund; Pär Nordlund
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.
The FEBS journal 2010;277(23):4920-30.
2010: Rahma Wehelie; Staffan Eriksson; Göran Bölske; Liya Wang
Thymidylate synthases of Mycoplasma mycoides subsp. mycoides SC and Ureaplasma parvum are flavin-dependent.
Veterinary microbiology 2010;145(3-4):265-72.
2010: Liya Wang; Claudine Hames; Sebastian R Schmidl; Jörg Stülke
Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae.
Molecular microbiology 2010;77(6):1502-11.
2010: Liya Wang; Staffan Eriksson
Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):400-3.
2010: R Sun; Staffan Eriksson; Liya Wang
Identification and characterization of mitochondrial factors modulating thymidine kinase 2 activity.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):382-5.
2010: Liya Wang
Deoxynucleoside salvage enzymes and tissue specific mitochondrial DNA depletion.
Nucleosides, nucleotides & nucleic acids 2010;29(4-6):370-81.
2010: Jay Lin; Vincent Roy; Liya Wang; Li You; Luigi A Agrofoglio; Dominique Deville-Bonne; Tamara R McBrayer; Steven J Coats; Ray F Schinazi; Staffan Eriksson
3'-(1,2,3-Triazol-1-yl)-3'-deoxythymidine analogs as substrates for human and Ureaplasma parvum thymidine kinase for structure-activity investigations.
Bioorganic & medicinal chemistry 2010;18(9):3261-9.
2008: Cecilia Carnrot; Liya Wang; Dimitri Topalis; Staffan Eriksson
Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.
Protein science : a publication of the Protein Society 2008;17(9):1486-93.
2008: Liya Wang; Staffan Eriksson
5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.
Nucleosides, nucleotides & nucleic acids 2008;27(6):858-62.
2008: Staffan Eriksson; Liya Wang
Molecular mechanisms of mitochondrial DNA depletion diseases caused by deficiencies in enzymes in purine and pyrimidine metabolism.
Nucleosides, nucleotides & nucleic acids 2008;27(6):800-8.
2007: Louise Egeblad-Welin; Martin Welin; Liya Wang; Staffan Eriksson
Structural and functional investigations of Ureaplasma parvum UMP kinase--a potential antibacterial drug target.
The FEBS journal 2007;274(24):6403-14.
2007: Liya Wang
The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates.
The FEBS journal 2007;274(8):1983-90.
2007: Martin Welin; Liya Wang; Staffan Eriksson; Hans Eklund
Structure-function analysis of a bacterial deoxyadenosine kinase reveals the basis for substrate specificity.
Journal of molecular biology 2007;366(5):1615-23.
2007: Urszula Kosinska; Cecilia Carnrot; Michael P B Sandrini; Anders R Clausen; Liya Wang; Jure Piskur; Staffan Eriksson; Hans Eklund
Structural studies of thymidine kinases from Bacillus anthracis and Bacillus cereus provide insights into quaternary structure and conformational changes upon substrate binding.
The FEBS journal 2007;274(3):727-37.
2006: Cecilia Carnrot; Susan R Vogel; Youngjoo Byun; Liya Wang; Werner Tjarks; Staffan Eriksson; Andrew J Phipps
Evaluation of Bacillus anthracis thymidine kinase as a potential target for the development of antibacterial nucleoside analogs.
Biological chemistry 2006;387(12):1575-81.
2005: Urszula Kosinska; Cecilia Carnrot; Staffan Eriksson; Liya Wang; Hans Eklund
Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme.
The FEBS journal 2005;272(24):6365-72.
2004: Martin Welin; Urszula Kosinska; Nils-Egil Mikkelsen; Cecilia Carnrot; Chunying Zhu; Liya Wang; Staffan Eriksson; Birgitte Munch-Petersen; Hans Eklund
Structures of thymidine kinase 1 of human and mycoplasmic origin.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):17970-5.
2004: Rahma Wehelie; Staffan Eriksson; Liya Wang
Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1499-502.
2003: Liya Wang; Staffan Eriksson
Mitochondrial deoxyguanosine kinase mutations and mitochondrial DNA depletion syndrome.
FEBS letters 2003;554(3):319-22.
2003: Cecilia Carnrot; Rahma Wehelie; Staffan Eriksson; Göran Bölske; Liya Wang
Molecular characterization of thymidine kinase from Ureaplasma urealyticum: nucleoside analogues as potent inhibitors of mycoplasma growth.
Molecular microbiology 2003;50(3):771-80.
2003: Liya Wang; Ann Saada (Reisch); Staffan Eriksson
Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy.
The Journal of biological chemistry 2003;278(9):6963-8.
2001: Liya Wang; J Westberg; Göran Bölske; Staffan Eriksson
Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: evidence for efficient utilization of deoxynucleosides.
Molecular microbiology 2001;42(4):1065-73.
2001: A Herrström Sjöberg; Liya Wang; Staffan Eriksson
Antiviral guanosine analogs as substrates for deoxyguanosine kinase: implications for chemotherapy.
Antimicrobial agents and chemotherapy 2001;45(3):739-42.
2000: Liya Wang; Staffan Eriksson
Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria.
The Biochemical journal 2000;351 Pt 2():469-76.
1999: Liya Wang; Birgitte Munch-Petersen; A Herrström Sjöberg; U Hellman; T Bergman; Hans Jörnvall; Staffan Eriksson
Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates.
FEBS letters 1999;443(2):170-4.
1998: A H Sjöberg; Liya Wang; Staffan Eriksson
Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs.
Molecular pharmacology 1998;53(2):270-3.
1996: Liya Wang; U Hellman; Staffan Eriksson
Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA.
FEBS letters 1996;390(1):39-43.