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Lu-Hai Wang

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Physiology

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Cell Transformation, Neoplastic

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Publications

TOP 3
Hung-Ju Shih; Lu-Hai Wang; Meng-Hsun Wu; Gan-Guang Liou; Wei-Wen Chang; Hsiao-Huei Chen; Linyi Chen; Yen-An Chen; Hsin-Ling Hsu
Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity.
Kai-Ti Lin; Huei-Jane Chen; Wen-Ling Chen; Jianli Gong; Te-Hsuan Jang; Chien-Feng Li; Lu-Hai Wang
Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.
Kai-Yuan Lin; Chein Tai; Chia-Lang Fang; You-Cheng Hseu; K J Senthil Kumar; Lu-Hai Wang; Hsin-Ling Yang; Yih-Huei Uen
Clinical significance of increased guanine nucleotide exchange factor Vav3 expression in human gastric cancer.

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All Publications

2012: Hung-Ju Shih; Lu-Hai Wang; Meng-Hsun Wu; Gan-Guang Liou; Wei-Wen Chang; Hsiao-Huei Chen; Linyi Chen; Yen-An Chen; Hsin-Ling Hsu
Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity.
Oncotarget 2012;3(11):1401-15.
2012: Kai-Ti Lin; Huei-Jane Chen; Wen-Ling Chen; Jianli Gong; Te-Hsuan Jang; Chien-Feng Li; Lu-Hai Wang
Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.
Cancer research 2012;72(12):3000-9.
2012: Kai-Yuan Lin; Chein Tai; Chia-Lang Fang; You-Cheng Hseu; K J Senthil Kumar; Lu-Hai Wang; Hsin-Ling Yang; Yih-Huei Uen
Clinical significance of increased guanine nucleotide exchange factor Vav3 expression in human gastric cancer.
Molecular cancer research : MCR 2012;10(6):750-9.
2011: Yu-Chen Tsai; Shan Wan; Lu-Hai Wang; Yi Lisa Lyu; Sidney Pestka; Loren W Runnels; Leroy F Liu
Interferon-β signaling contributes to Ras transformation.
PloS one 2011;6(8):e24291.
2010: Shih Sheng Jiang; Wen-Tsen Fang; Ya-Hsiue Hou; Shiu-Feng Huang; B Linju Yen; Junn-Liang Chang; Shih-Miao Li; Hui-Ping Liu; Ying-Lan Liu; Chih-Ting Huang; Yu-Wei Li; Te-Hsuan Jang; Shih-Hsuan Chan; Su Jing Yang; Chao A Hsiung; Cheng-Wen Wu; Lu-Hai Wang; I-Shou Chang
Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(17):4363-73.
2010: Min Yang; Lu-Hai Wang; Pan-Ge Liu; He-Gang Ren; Bin-Yuan Liu; Wei-Dong Yan
[UV/Visible spectroscopic study of the beta-diketonate zirconium active species for olefin polymerization].
Guang pu xue yu guang pu fen xi = Guang pu 2010;30(6):1566-9.
2009: Peter W Schlosshauer; Wei Li; Kai-Ti Lin; Joseph L-K Chan; Lu-Hai Wang
Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells.
Gynecologic oncology 2009;114(3):516-22.
2008: Weizhou Zhang; George Z Cheng; Jianli Gong; Ulrich Hermanto; Cong S Zong; Joseph Chan; Jin Q Cheng; Lu-Hai Wang
RACK1 and CIS mediate the degradation of BimEL in cancer cells.
The Journal of biological chemistry 2008;283(24):16416-26.
2008: George Z Cheng; Wei Zhou Zhang; Mei Sun; Qi Wang; Domenico Coppola; Mena Mansour; Li Mei Xu; Carliann Costanzo; Jin Q Cheng; Lu-Hai Wang
Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function.
The Journal of biological chemistry 2008;283(21):14665-73.
2008: S Uttamsingh; X Bao; K T Nguyen; M Bhanot; J Gong; Joseph L-K Chan; F Liu; T T Chu; Lu-Hai Wang
Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells.
Oncogene 2008;27(18):2626-34.
2008: George Z Cheng; Weizhou Zhang; Lu-Hai Wang
Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay.
Cancer research 2008;68(4):957-60.
2008: George Z Cheng; Sungman Park; Shaokun Shu; Lili He; William Kong; Weizhou Zhang; Zengqiang Yuan; Lu-Hai Wang; Jin Q Cheng
Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery.
Current cancer drug targets 2008;8(1):2-6.
2007: Kathryn Masker; Alicia Golden; Christian J Gaffney; Virginia Mazack; William Schwindinger; Weizhou Zhang; Lu-Hai Wang; David J Carey; Marius Sudol
Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src.
Virology 2007;364(1):10-20.
2007: Lu-Hai Wang; Joseph L-K Chan; Wei Li
Rapamycin together with herceptin significantly increased anti-tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells.
International journal of cancer. Journal international du cancer 2007;121(1):157-64.
2007: George Z Cheng; Joseph Chan; Qi Wang; Weizhou Zhang; Calvin D Sun; Lu-Hai Wang
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel.
Cancer research 2007;67(5):1979-87.
2006: Zhongyun Dong; Yin Liu; Shan Lu; Amy Wang; Kiwon Lee; Lu-Hai Wang; Monica Revelo; Shan Lu
Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2315-25.
2006: Xianyang Yio; Matthew Diamond; Jie-Yu Zhang; HAREL WEINSTEIN; Lu-Hai Wang; Lawrence Werther; Steven Itzkowitz
Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways.
Gastroenterology 2006;130(6):1696-706.
2006: Weizhou Zhang; Cong S Zong; Ulrich Hermanto; Pablo Lopez Bergami; Ze'ev Ronai; Lu-Hai Wang
RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.
Molecular and cellular biology 2006;26(2):413-24.
2005: Pablo López Bergami; Hasem Habelhah; Anindita Bhoumik; Weizhou Zhang; Lu-Hai Wang; Ze'ev Ronai
RACK1 mediates activation of JNK by protein kinase C [corrected].
Molecular cell 2005;19(3):309-20.
2004: Lu-Hai Wang
Molecular signaling regulating anchorage-independent growth of cancer cells.
The Mount Sinai journal of medicine, New York 2004;71(6):361-7.
2003: Shailaja Uttamsingh; Cong S Zong; Lu-Hai Wang
Matrix-independent activation of phosphatidylinositol 3-kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros-transformed chicken embryo fibroblasts.
The Journal of biological chemistry 2003;278(21):18798-810.
2002: Maithao N Le; Ronald A Kohanski; Lu-Hai Wang; Henry B Sadowski
Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.
Molecular endocrinology (Baltimore, Md.) 2002;16(12):2764-79.
2002: Pallavi Sachdev; Liyu Zeng; Lu-Hai Wang
Distinct role of phosphatidylinositol 3-kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes.
The Journal of biological chemistry 2002;277(20):17638-48.
2002: Ulrich Hermanto; Cong S Zong; Weiqun Li; Lu-Hai Wang
RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.
Molecular and cellular biology 2002;22(7):2345-65.
2002: Kevin T Nguyen; Cong S Zong; Shailaja Uttamsingh; Pallavi Sachdev; Monica Bhanot; Mai-Thao Le; Joseph L-K Chan; Lu-Hai Wang
The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.
The Journal of biological chemistry 2002;277(13):11107-15.
2001: Ulrich Hermanto; Cong S Zong; Lu-Hai Wang
ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth.
Oncogene 2001;20(51):7551-62.
2001: C L Sadowski; Thomas T Wheeler; Lu-Hai Wang; Henry B Sadowski
GH regulation of IGF-I and suppressor of cytokine signaling gene expression in C2C12 skeletal muscle cells.
Endocrinology 2001;142(9):3890-900.
2001: Pallavi Sachdev; Y X Jiang; Weiqun Li; Toru Miki; Hiroshi Maruta; MS Nur-E-Kamal; Lu-Hai Wang
Differential requirement for Rho family GTPases in an oncogenic insulin-like growth factor-I receptor-induced cell transformation.
The Journal of biological chemistry 2001;276(28):26461-71.
2001: C L Sadowski; T S Choi; M Le; Thomas T Wheeler; Lu-Hai Wang; Henry B Sadowski
Insulin Induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 Skeletal Muscle Cells Is Mediated by Stat5*.
The Journal of biological chemistry 2001;276(23):20703-10.
2000: Ulrich Hermanto; Cong S Zong; Lu-Hai Wang
Inhibition of mitogen-activated protein kinase kinase selectively inhibits cell proliferation in human breast cancer cells displaying enhanced insulin-like growth factor I-mediated mitogen-activated protein kinase activation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(12):655-64.
2000: Liyu Zeng; Pallavi Sachdev; L Yan; Joseph L-K Chan; T Trenkle; Michael McClelland; John Welsh; Lu-Hai Wang
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.
Molecular and cellular biology 2000;20(24):9212-24.
2000: K T Nguyen; W J Wang; Joseph L-K Chan; Lu-Hai Wang
Differential requirements of the MAP kinase and PI3 kinase signaling pathways in Src- versus insulin and IGF-1 receptors-induced growth and transformation of rat intestinal epithelial cells.
Oncogene 2000;19(47):5385-97.
2000: Cong S Zong; J Chan; David E Levy; Curt M Horvath; Henry B Sadowski; Lu-Hai Wang
Mechanism of STAT3 activation by insulin-like growth factor I receptor.
The Journal of biological chemistry 2000;275(20):15099-105.
1998: Cong S Zong; Liyu Zeng; Y Jiang; Henry B Sadowski; Lu-Hai Wang
Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth.
The Journal of biological chemistry 1998;273(43):28065-72.
1997: J Chen; Henry B Sadowski; Ronald A Kohanski; Lu-Hai Wang
Stat5 is a physiological substrate of the insulin receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2295-300.
1997: Cong S Zong; Joseph L-K Chan; S K Yang; Lu-Hai Wang
Mutations of Ros differentially effecting signal transduction pathways leading to cell growth versus transformation.
The Journal of biological chemistry 1997;272(3):1500-6.
1997: Joseph L-K Chan; M Lai; Lu-Hai Wang
Effect of dimerization on signal transduction and biological function of oncogenic Ros, insulin, and insulin-like growth factor I receptors.
The Journal of biological chemistry 1997;272(1):146-53.
1996: Q Xiong; Joseph L-K Chan; Cong S Zong; Lu-Hai Wang
Two chimeric receptors of epidermal growth factor receptor and c-Ros that differ in their transmembrane domains have opposite effects on cell growth.
Molecular and cellular biology 1996;16(4):1509-18.
1996: Y Jiang; Joseph L-K Chan; Cong S Zong; Lu-Hai Wang
Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor.
The Journal of biological chemistry 1996;271(1):160-7.
1995: J Chen; J Tong; I Tanaka-Sukegawa; Lu-Hai Wang
Cloning and functional characterization of the chicken c-ros promoter.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1523-30.
1994: Cong S Zong; Lu-Hai Wang
Modulatory effect of the transmembrane domain of the protein-tyrosine kinase encoded by oncogene ros: biological function and substrate interaction.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10982-6.
1994: J Chen; Cong S Zong; Lu-Hai Wang
Tissue and epithelial cell-specific expression of chicken proto-oncogene c-ros in several organs suggests that it may play roles in their development and mature functions.
Oncogene 1994;9(3):773-80.
1994: J Chen; T Hanafusa; Lu-Hai Wang
Ala-->Gly mutation in the putative catalytic loop confers temperature sensitivity on Ros, insulin receptor, and insulin-like growth factor I receptor protein-tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(1):321-5.
1993: Cong S Zong; B Poon; J Chen; Lu-Hai Wang
Molecular and biochemical bases for activation of the transforming potential of the proto-oncogene c-ros.
Journal of virology 1993;67(11):6453-62.
1993: D Liu; Cong S Zong; Lu-Hai Wang
Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions.
Journal of virology 1993;67(11):6835-40.
1993: D Liu; W J Rutter; Lu-Hai Wang
Modulating effects of the extracellular sequence of the human insulinlike growth factor I receptor on its transforming and tumorigenic potential.
Journal of virology 1993;67(1):9-18.
1992: S M Jong; Cong S Zong; T Dorai; Lu-Hai Wang
Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.
Journal of virology 1992;66(8):4909-18.
1992: D Liu; W J Rutter; Lu-Hai Wang
Enhancement of transforming potential of human insulinlike growth factor 1 receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence.
Journal of virology 1992;66(1):374-85.
1991: T Dorai; J B Levy; L Kang; Joan S Brugge; Lu-Hai Wang
Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src.
Molecular and cellular biology 1991;11(8):4165-76.
1991: J M Chen; D Heller; B Poon; L Kang; Lu-Hai Wang
The proto-oncogene c-ros codes for a transmembrane tyrosine protein kinase sharing sequence and structural homology with sevenless protein of Drosophila melanogaster.
Oncogene 1991;6(2):257-64.
1991: B Poon; D Dixon; L Ellis; R A Roth; W J Rutter; Lu-Hai Wang
Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):877-81.
1991: S M Jong; Lu-Hai Wang
Two point mutations in the transmembrane domain of P68gag-ros inactive its transforming activity and cause a delay in membrane association.
Journal of virology 1991;65(1):180-9.
1990: S M Jong; Lu-Hai Wang
Role of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion protein.
Journal of virology 1990;64(12):5997-6009.
1990: T Dorai; Lu-Hai Wang
An alternative non-tyrosine protein kinase product of the c-src gene in chicken skeletal muscle.
Molecular and cellular biology 1990;10(8):4068-79.
1987: J B Levy; T Dorai; Lu-Hai Wang; Joan S Brugge
The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA.
Molecular and cellular biology 1987;7(11):4142-5.