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Lee-Ho Wang

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Chemicals & Drugs

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Amino Acid Sequences

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Publications

TOP 3
Wei-Chih Chao; Steven Chun-Wei Chou; Jyh-Feng Lu; Tai-An Pan; Jinn-Shyan Wang; Lee-Ho Wang; Hsiao-Ching Yang; Pi-Tai Chou
Probing ligand binding to thromboxane synthase.
Chung-Ying K Chen; Richard J Kulmacz; Elizabeth M Poole; Cornelia M Ulrich; Lee-Ho Wang
Functional analysis of human thromboxane synthase polymorphic variants.
Wei-Chih Chao; Hsiao-Hui Chen; Pi-Tai Chou; Yi-Kang Lan; Jyh-Feng Lu; Jinn-Shyan Wang; Hsiao-Ching Yang; Ya-Chien Yu; Lee-Ho Wang
Probing the interaction between prostacyclin synthase and prostaglandin H2 analogues or inhibitors via a combination of resonance Raman spectroscopy and molecular dynamics simulation approaches.

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All Publications

2013: Wei-Chih Chao; Steven Chun-Wei Chou; Jyh-Feng Lu; Tai-An Pan; Jinn-Shyan Wang; Lee-Ho Wang; Hsiao-Ching Yang; Pi-Tai Chou
Probing ligand binding to thromboxane synthase.
Biochemistry 2013;52(6):1113-21.
2012: Chung-Ying K Chen; Richard J Kulmacz; Elizabeth M Poole; Cornelia M Ulrich; Lee-Ho Wang
Functional analysis of human thromboxane synthase polymorphic variants.
Pharmacogenetics and genomics 2012;22(9):653-8.
2011: Wei-Chih Chao; Hsiao-Hui Chen; Pi-Tai Chou; Yi-Kang Lan; Jyh-Feng Lu; Jinn-Shyan Wang; Hsiao-Ching Yang; Ya-Chien Yu; Lee-Ho Wang
Probing the interaction between prostacyclin synthase and prostaglandin H2 analogues or inhibitors via a combination of resonance Raman spectroscopy and molecular dynamics simulation approaches.
Journal of the American Chemical Society 2011;133(46):18870-9.
2009: Hui-Chun Yeh; Gary J Gerfen; Jinn-Shyan Wang; Ah-Lim Tsai; Lee-Ho Wang
Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate.
Biochemistry 2009;48(5):917-28.
2008: Hui-Chun Yeh; Pei-Yung Hsu; Ah-Lim Tsai; Lee-Ho Wang
Spectroscopic characterization of the oxyferrous complex of prostacyclin synthase in solution and in trapped sol-gel matrix.
The FEBS journal 2008;275(9):2305-14.
2008: Yi-Ching Li; Chia-Wang Chiang; Hui-Chun Yeh; Pei-Yung Hsu; Frank G Whitby; Lee-Ho Wang; Nei-Li Chan
Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.
The Journal of biological chemistry 2008;283(5):2917-26.
2008: Vladimir Berka; Lee-Ho Wang; Ah-Lim Tsai
Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.
Biochemistry 2008;47(1):405-20.
2007: Hui-Chun Yeh; Ah-Lim Tsai; Lee-Ho Wang
Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.
Archives of biochemistry and biophysics 2007;461(2):159-68.
2006: Chia-Wang Chiang; Hui-Chun Yeh; Lee-Ho Wang; Nei-Li Chan
Crystal structure of the human prostacyclin synthase.
Journal of molecular biology 2006;364(3):266-74.
2006: Hui-Chun Yeh; Lee-Ho Wang
Profiling of prostanoids in zebrafish embryonic development.
Prostaglandins, leukotrienes, and essential fatty acids 2006;75(6):397-402.
2005: Hui-Chun Yeh; Pei-Yung Hsu; Jinn-Shyan Wang; Ah-Lim Tsai; Lee-Ho Wang
Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase.
Biochimica et biophysica acta 2005;1738(1-3):121-32.
2005: Ke-He Ruan; Jiaxin Wu; Lee-Ho Wang
Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique.
Archives of biochemistry and biophysics 2005;444(2):165-73.
2005: Cornelia M Ulrich; Christopher S Carlson; Justin G Sibert; Elizabeth M Poole; Joon-Ho Yu; Lee-Ho Wang; Rachel Sparks; John D Potter; Jeannette Bigler
Thromboxane synthase (TBXAS1) polymorphisms in African-American and Caucasian populations: evidence for selective pressure.
Human mutation 2005;26(4):394-5.
2004: I-Shing Yu; Shu-Rung Lin; Chin-Chin Huang; Hui-Yu Tseng; Pei-Hsing Huang; Guey-Yueh Shi; Hua-Lin Wu; Chi-Lu Tang; Pao-Hsien Chu; Lee-Ho Wang; Kenneth K Wu; Shu-Wha Lin
TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death.
Blood 2004;104(1):135-42.
2004: Corina E Rogge; Wen Liu; Gang Wu; Lee-Ho Wang; Richard J Kulmacz; Ah-Lim Tsai
Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2.
Biochemistry 2004;43(6):1560-8.
2003: Masahiro Yaekashiwa; Lee-Ho Wang
Nrf2 regulates thromboxane synthase gene expression in human lung cells.
DNA and cell biology 2003;22(8):479-87.
2003: Pei-Yung Hsu; Lee-Ho Wang
Protein engineering of thromboxane synthase: conversion of membrane-bound to soluble form.
Archives of biochemistry and biophysics 2003;416(1):38-46.
2003: Zhucheng Chen; Lee-Ho Wang; Johannes P M Schelvis
Resonance Raman investigation of the interaction of thromboxane synthase with substrate analogues.
Biochemistry 2003;42(9):2542-51.
2003: Mei Du; Hui-Chun Yeh; Vladimir Berka; Lee-Ho Wang; Ah-Lim Tsai
Redox properties of human endothelial nitric-oxide synthase oxygenase and reductase domains purified from yeast expression system.
The Journal of biological chemistry 2003;278(8):6002-11.
2002: Kevin R Kozak; Brenda C Crews; Jason D Morrow; Lee-Ho Wang; Y Henry Ma; Rolf Weinander; Per-Johan Jakobsson; Lawrence J Marnett
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.
The Journal of biological chemistry 2002;277(47):44877-85.
2002: Lee-Ho Wang; Richard J Kulmacz
Thromboxane synthase: structure and function of protein and gene.
Prostaglandins & other lipid mediators 2002;68-69():409-22.
2002: Masahiro Yaekashiwa; Lee-Ho Wang
Transcriptional control of the human thromboxane synthase gene in vivo and in vitro.
The Journal of biological chemistry 2002;277(25):22497-508.
2001: Lee-Ho Wang; Ah-Lim Tsai; Pei-Yung Hsu
Substrate binding is the rate-limiting step in thromboxane synthase catalysis.
The Journal of biological chemistry 2001;276(18):14737-43.
2000: Pei-Yung Hsu; Ah-Lim Tsai; Lee-Ho Wang
Identification of thromboxane synthase amino acid residues involved in heme-propionate binding.
Archives of biochemistry and biophysics 2000;383(1):119-27.
1999: Pei-Yung Hsu; Ah-Lim Tsai; Richard J Kulmacz; Lee-Ho Wang
Expression, purification, and spectroscopic characterization of human thromboxane synthase.
The Journal of biological chemistry 1999;274(2):762-9.
1997: X M Xu; JL Tang; X Chen; Lee-Ho Wang; Kenneth K Wu
Involvement of two Sp1 elements in basal endothelial prostaglandin H synthase-1 promoter activity.
The Journal of biological chemistry 1997;272(11):6943-50.
1997: Song-Kun Shyue; Ke-He Ruan; Lee-Ho Wang; Kenneth K Wu
Prostacyclin synthase active sites. Identification by molecular modeling-guided site-directed mutagenesis.
The Journal of biological chemistry 1997;272(6):3657-62.
1996: R Tazawa; Eric Green; Kazuteru Ohashi; Kenneth K Wu; Lee-Ho Wang
Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter.
Archives of biochemistry and biophysics 1996;334(2):349-56.
1996: Lee-Ho Wang; L Chen
Organization of the gene encoding human prostacyclin synthase.
Biochemical and biophysical research communications 1996;226(3):631-7.
1996: Lee-Ho Wang; N Matijevic-Aleksic; P Y Hsu; Ke-He Ruan; Kenneth K Wu; Richard J Kulmacz
Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis.
The Journal of biological chemistry 1996;271(33):19970-5.
1996: Q Guo; Lee-Ho Wang; Ke-He Ruan; Richard J Kulmacz
Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.
The Journal of biological chemistry 1996;271(32):19134-9.
1995: N Matijevic-Aleksic; S K Sanduja; Lee-Ho Wang; Kenneth K Wu
Differential expression of thromboxane A synthase and prostaglandin H synthase in megakaryocytic cell line.
Biochimica et biophysica acta 1995;1269(2):167-75.
1995: Richard J Kulmacz; Lee-Ho Wang
Comparison of hydroperoxide initiator requirements for the cyclooxygenase activities of prostaglandin H synthase-1 and -2.
The Journal of biological chemistry 1995;270(41):24019-23.
1995: X M Xu; A Hajibeige; R Tazawa; D Loose-Mitchell; Lee-Ho Wang; Kenneth K Wu
Characterization of human prostaglandin H synthase genes.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():105-7.
1994: Lee-Ho Wang; R Tazawa; A Q Lang; Kenneth K Wu
Alternate splicing of human thromboxane synthase mRNA.
Archives of biochemistry and biophysics 1994;315(2):273-8.
1994: B Pereira; Kenneth K Wu; Lee-Ho Wang
Molecular cloning and characterization of bovine prostacyclin synthase.
Biochemical and biophysical research communications 1994;203(1):59-66.
1994: R Tazawa; X M Xu; Kenneth K Wu; Lee-Ho Wang
Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene.
Biochemical and biophysical research communications 1994;203(1):190-9.
1993: B Pereira; Kenneth K Wu; Lee-Ho Wang
Bovine prostacyclin synthase: purification and isolation of partial cDNA.
Biochemical and biophysical research communications 1993;197(3):1041-8.
1993: Ke-He Ruan; Lee-Ho Wang; Kenneth K Wu; Richard J Kulmacz
Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum.
The Journal of biological chemistry 1993;268(26):19483-90.
1993: X M Xu; Kazuteru Ohashi; S K Sanduja; Ke-He Ruan; Lee-Ho Wang; Kenneth K Wu
Enhanced prostacyclin synthesis in endothelial cells by retrovirus-mediated transfer of prostaglandin H synthase cDNA.
The Journal of clinical investigation 1993;91(4):1843-9.
1993: Lee-Ho Wang; A Hajibeigi; X M Xu; D Loose-Mitchell; Kenneth K Wu
Characterization of the promoter of human prostaglandin H synthase-1 gene.
Biochemical and biophysical research communications 1993;190(2):406-11.
1992: Kazuteru Ohashi; Ke-He Ruan; Richard J Kulmacz; Kenneth K Wu; Lee-Ho Wang
Primary structure of human thromboxane synthase determined from the cDNA sequence.
The Journal of biological chemistry 1992;267(2):789-93.
1991: Lee-Ho Wang; Kazuteru Ohashi; Kenneth K Wu
Isolation of partial complementary DNA encoding human thromboxane synthase.
Biochemical and biophysical research communications 1991;177(1):286-91.