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Qun Wang

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Yu Luo; Zhong-Fei Ni; Yun-Juan Nie; Hai-Rong Shi; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.
Gao-Shang Chai; Xiang-Shu Cheng; Xia Jiang; Zhi-Wei Ma; Zhong-Fei Ni; Jian-Zhi Wang; Qun Wang; Ao-Ji Xie; Gong-Ping Liu
Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine.
Juan Ye; Yanqin Ying; Ruidan Zheng; Qin Ning; Qun Wang; Katherine Cianflone; Lihong Liao; Huiling Lu; Xiaoping Luo
Downregulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth.

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All Publications

2013: Yu Luo; Zhong-Fei Ni; Yun-Juan Nie; Hai-Rong Shi; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
PTPA activates protein phosphatase-2A through reducing its phosphorylation at tyrosine-307 with upregulation of protein tyrosine phosphatase 1B.
Biochimica et biophysica acta 2013;1833(5):1235-43.
2013: Gao-Shang Chai; Xiang-Shu Cheng; Xia Jiang; Zhi-Wei Ma; Zhong-Fei Ni; Jian-Zhi Wang; Qun Wang; Ao-Ji Xie; Gong-Ping Liu
Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine.
Journal of neurochemistry 2013;124(3):388-96.
2012: Juan Ye; Yanqin Ying; Ruidan Zheng; Qin Ning; Qun Wang; Katherine Cianflone; Lihong Liao; Huiling Lu; Xiaoping Luo
Downregulating SOCS3 with siRNA ameliorates insulin signaling and glucose metabolism in hepatocytes of IUGR rats with catch-up growth.
Pediatric research 2012;72(6):550-9.
2012: Xin-An Liu; Jie Song; Qing Tian; Qian Jiang; Qun Wang; Jian-Zhi Wang
Expression of the hyperphosphorylated tau attenuates ER stress-induced apoptosis with upregulation of unfolded protein response.
Apoptosis : an international journal on programmed cell death 2012;17(10):1039-49.
2012: Xiu-Ping Liu; Min Qu; Fu-Yuan Cao; Dan Ke; Gong-Ping Liu; Qun Wang; Yao Zhang; Hong-Yun Zheng; Jian-Zhi Wang
Upregulation of astrocytes protein phosphatase-2A stimulates astrocytes migration via inhibiting p38 MAPK in tg2576 mice.
Glia 2012;60(9):1279-88.
2012: Xiu-Qing Yao; Yang-Yang Yin; Xiao-Xue Zhang; Xia-Chun Li; Bin Liu; Dan-Ju Luo; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.
FEBS letters 2012;586(16):2522-8.
2012: Xu-Ying Sun; Rong Liu; You-Ming Lu; Qun Wang; Xiao-Chuan Wang; Xiu-Lian Wang; Yu-Ping Wei; Ao-Ji Xie; Yan Xiong; Yang Yang; Jian-Zhi Wang
Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A).
The Journal of biological chemistry 2012;287(14):11174-82.
2012: Gong-Ping Liu; Cai-Xia Peng; Hai-Hong Shi; Qun Wang; Wei Wei; Xiu-Qing Yao; Jun Yin; Yao Zhang; Xin Zhou; Juan Hu; Hong-Lian Li; Jian-Zhi Wang
I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis.
Neurobiology of aging 2012;33(2):254-64.
2012: Ning-Ning Chen; Dan-Ju Luo; Jian-Zhi Wang; Qun Wang; Yi Wang; Xiu-Qing Yao; Cong Yu; Gong-Ping Liu
Pesticides induce spatial memory deficits with synaptic impairments and an imbalanced tau phosphorylation in rats.
Journal of Alzheimer's disease : JAD 2012;30(3):585-94.
2011: Xifei Yang; Ying Yang; Qiuyue Zhang; Qun Wang; Jing Feng; Zhengqi Fu; Yin Li; Jinzhuo Luo; Qing Tian
Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.
Journal of psychopharmacology (Oxford, England) 2011;25(8):1118-25.
2011: Xiu-Qing Yao; Yang-Yang Yin; Xiao-Xue Zhang; Ning-Ning Chen; Bin Liu; Dan Liu; Dan-Ju Luo; Zhong-Fei Ni; Jian-Zhi Wang; Qun Wang; Xiong Wang; Gong-Ping Liu
Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.
The Biochemical journal 2011;437(2):335-44.
2011: Qun Wang; L X Ye; H H Zhao; J W Chen; Yi-Kai Zhou
Benchmark dose approach for low-level lead induced haematogenesis inhibition and associations of childhood intelligences with ALAD activity and ALA levels.
The Science of the total environment 2011;409(10):1806-10.
2011: Xiao-Ping Hong; Cai-Xia Peng; Wei Wei; Qing Tian; Ying-Hua Liu; Fu-Yuan Cao; Qun Wang; Jian-Zhi Wang
Relationship of adult neurogenesis with tau phosphorylation and GSK-3β activity in subventricular zone.
Neurochemical research 2011;36(2):288-96.
2011: Wei Wei; Zelan Wei; Chang-E Zhang; Ying-Hua Liu; Darrell D Mousseau; Qing Tian; Jian-Zhi Wang; Qun Wang; Gong-Ping Liu
Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats.
Journal of Alzheimer's disease : JAD 2011;27(3):639-50.
2011: Guang Yu; Yi Li; Qing Tian; Rong Liu; Qun Wang; Jian-Zhi Wang; Xiaochuan Wang
Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.
Journal of Alzheimer's disease : JAD 2011;24(3):525-35.
2010: Dan Liu; Hong-Yun Zheng; Zheng-Zhao Luo; Qun Wang; Ling-Qiang Zhu
Effect of PP-2A on neurite outgrowth in neuronal cells.
In vitro cellular & developmental biology. Animal 2010;46(8):702-7.
2010: Ling-Qiang Zhu; Hong-Yun Zheng; Cai-Xia Peng; Dan Liu; Hong-Lian Li; Qun Wang; Jian-Zhi Wang
Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(10):3839-48.
2010: Ling-Qiang Zhu; Dan Liu; Juan Hu; Jin Cheng; Shao-Hui Wang; Qun Wang; Fang Wang; Jian-Guo Chen; Jian-Zhi Wang
GSK-3 beta inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(10):3624-33.
2010: Zheng-Qi Fu; Ying Yang; Jie Song; Qian Jiang; Zan-Chao Lin; Qun Wang; Ling-Qiang Zhu; Jian-Zhi Wang; Qing Tian
LiCl attenuates thapsigargin-induced tau hyperphosphorylation by inhibiting GSK-3β in vivo and in vitro.
Journal of Alzheimer's disease : JAD 2010;21(4):1107-17.
2010: Hai-Hong Wang; Hong-Lian Li; Rong Liu; Yao Zhang; Kai Liao; Qun Wang; Jian-Zhi Wang; Shi-Jie Liu
Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors.
Journal of Alzheimer's disease : JAD 2010;21(1):167-79.
2010: Xin-An Liu; Kai Liao; Rong Liu; Hai-Hong Wang; Yao Zhang; Qi Zhang; Qun Wang; Hong-Lian Li; Qing Tian; Jian-Zhi Wang
Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.
Journal of Alzheimer's disease : JAD 2010;19(3):953-62.
2010: Yang-Yang Yin; Hao Liu; Xiao-Bin Cong; Zhao Liu; Qun Wang; Jian-Zhi Wang; Ling-Qiang Zhu
Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats.
Journal of Alzheimer's disease : JAD 2010;19(2):735-46.
2009: Ying-Hua Liu; Wei Wei; Jun Yin; Gong-Ping Liu; Qun Wang; Fu-Yuan Cao; Jian-Zhi Wang
Proteasome inhibition increases tau accumulation independent of phosphorylation.
Neurobiology of aging 2009;30(12):1949-61.
2009: Zhi-qun Ling; Qing Tian; Li Wang; Zheng-Qi Fu; Xiao-Chuan Wang; Qun Wang; Jian-Zhi Wang
Constant illumination induces Alzheimer-like damages with endoplasmic reticulum involvement and the protection of melatonin.
Journal of Alzheimer's disease : JAD 2009;16(2):287-300.
2009: Jia-Yu Zhang; Caixia Peng; Hairong Shi; Shaohui Wang; Qun Wang; Jian-Zhi Wang
Inhibition of autophagy causes tau proteolysis by activating calpain in rat brain.
Journal of Alzheimer's disease : JAD 2009;16(1):39-47.
2008: Chang-E Zhang; Qing Tian; Wei Wei; Jun-Hua Peng; Gong-Ping Liu; Xin-Wen Zhou; Qun Wang; Dao Wen Wang; Jian-Zhi Wang
Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus.
Neurobiology of aging 2008;29(11):1654-65.
2008: Gong-Ping Liu; Yao Zhang; Xiu-Qing Yao; Chang-E Zhang; Jiang Fang; Qun Wang; Jian-Zhi Wang
Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
Neurobiology of aging 2008;29(9):1348-58.
2008: Qun Wang; Jia-Yu Zhang; Shi-Jie Liu; Hong-Lian Li
Overactivated mitogen-activated protein kinase by anisomycin induces tau hyperphosphorylation.
Sheng li xue bao : [Acta physiologica Sinica] 2008;60(4):485-91.
2007: Ling-Qiang Zhu; Shao-Hui Wang; Dan Liu; Yang-Yang Yin; Qing Tian; Xiao-Chuan Wang; Qun Wang; Jian-Guo Chen; Jian-Zhi Wang
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(45):12211-20.
2007: Ying Yang; Xi-Fei Yang; Yi-Peng Wang; Qing Tian; Xiao-Chuan Wang; Hong-Lian Li; Qun Wang; Jian-Zhi Wang
Inhibition of protein phosphatases induces transport deficits and axonopathy.
Journal of neurochemistry 2007;102(3):878-86.
2007: Shaohui Wang; Lingqiang Zhu; Hairong Shi; Hongyun Zheng; Qing Tian; Qun Wang; Rong Liu; Jian-Zhi Wang
Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5.
Neurochemical research 2007;32(8):1329-35.
2007: Hong-Lian Li; Hai-Hong Wang; Shi-Jie Liu; Yan-Qiu Deng; Yong-Jie Zhang; Qing Tian; Xiao-Chuan Wang; Xiao-Qian Chen; Ying Yang; Jia-Yu Zhang; Qun Wang; Huaxi Xu; Francesca-Fang Liao; Jian-Zhi Wang
Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3591-6.
2006: Ze-Fen Wang; Hong-Lian Li; Xia-Chun Li; Qi Zhang; Qing Tian; Qun Wang; Huaxi Xu; Jian-Zhi Wang
Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture.
Journal of neurochemistry 2006;98(4):1167-75.
2006: Yong-Jie Zhang; Ya-Fei Xu; Ying-Hua Liu; Jun Yin; Hong-Lian Li; Qun Wang; Jian-Zhi Wang
Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1431-42.
2006: Zhong-sen Qu; Qing Tian; Xin-Wen Zhou; Qun Wang; Qi Zhang; Jian-Zhi Wang
[Mechanism of tau hyperphosphorylation in brain cortex of diabetic rats and effect of LiCl].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2006;28(2):244-8.
2005: Zhong-sen Qu; Qing Tian; Xin-Wen Zhou; Xiao-Chuan Wang; Qun Wang; Qi Zhang; Jian-Zhi Wang
[Alteration of beta-amyloid and glutamate transporter in the brain of diabetes rats and the underlying mechanism].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2005;27(6):708-11.
2005: Ling-Qiang Zhu; Shao-hui Wang; Zhi-qun Ling; Qun Wang; Mao-qiong Hu; Jian-Zhi Wang
Inhibition of melatonin biosynthesis activates protein kinase a and induces Alzheimer-like tau hyperphosphorylation in rats.
Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences 2005;20(2):83-7.
2005: Hai-hong Wang; Ai Hong Zhang; Ling-Qiang Zhu; Qun Wang; Jian-Zhi Wang
Overexpression of dishevelled-1 attenuates wortmannin-induced hyperphosphorylation of cytoskeletal proteins in N2a cell.
Acta pharmacologica Sinica 2005;26(6):679-84.
2005: Xia-Chun Li; Ze-Fen Wang; Jun-Xia Zhang; Qun Wang; Jian-Zhi Wang
Effect of melatonin on calyculin A-induced tau hyperphosphorylation.
European journal of pharmacology 2005;510(1-2):25-30.
2004: Shi Jie Liu; Jia Yu Zhang; Hong Lian Li; Zheng-Yu Fang; Qun Wang; Heng Mei Deng; Cheng-Xin Gong; Inge Grundke-Iqbal; Khalid Iqbal; Jian-Zhi Wang
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain.
The Journal of biological chemistry 2004;279(48):50078-88.
2004: Ying-chun Zhang; Ze-fen Wang; Qun Wang; Yi-peng Wang; Jian-Zhi Wang
Melatonin attenuates beta-amyloid-induced inhibition of neurofilament expression.
Acta pharmacologica Sinica 2004;25(4):447-51.
2003: Shi Jie Liu; Ai Hong Zhang; Hong Lian Li; Qun Wang; Heng Mei Deng; William Netzer; Huaxi Xu; Jian-Zhi Wang
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.
Journal of neurochemistry 2003;87(6):1333-44.
2003: Zheng-Yu Fang; Shi-Jie Liu; Xiao-Chuan Wang; Rong Liu; Qun Wang; Zheng-Yue Chen; Jian-Zhi Wang
[Effect of calpain on the degradation of tau protein in rat brain cortex extracts].
Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 2003;35(7):629-34.
2003: Li Sun; S Y Liu; Xin-Wen Zhou; Xiao-Chuan Wang; Rong Liu; Qun Wang; Jian-Zhi Wang
Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats.
Neuroscience 2003;118(4):1175-82.
2002: Yipeng Wang; Qun Wang; Jianzhi Wang
[Detection of level and mutation of neurofilament mRNA in Alzheimer's disease].
Zhonghua yi xue za zhi 2002;82(8):519-22.
2001: Yi-peng Wang; Z L Wei; Xiao-Chuan Wang; Qun Wang; Jian-Zhi Wang
[Comparative study of the expression and phosphorylation of neurofilament proteins of brain gray matter in Alzheimer's disease].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2001;23(5):445-9.
2001: X T Li; Qun Wang; Z L Wei; Y H Yuan; Jian-Zhi Wang
[Alzheimer-like protein phosphatase deficiency leads to abnormal phosphorylation and accumulation of neurofilaments].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2001;23(5):439-44.
2000: Jianzhi Wang; Z Wei; Qun Wang; Inge Grundke-Iqbal; Khalid Iqbal
[Association of microtubule promoting and binding activity of tau with its phosphorylation sites].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2000;22(2):120-3.