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Shengdian Wang

Research Profile

Living Beings

Chemicals & Drugs

Anatomy

Physiology

Lymphocyte Activation

Disorders

Hepatitis B, Chronic

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Publications

TOP 3
Eric D Mortenson; SaeGwang Park; Shengdian Wang; Zhujun Jiang; Yang-Xin Fu
Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells.
James Tysome; Pengju Wang; Shengdian Wang; Ming Yuan; Ghassan Alusi; Louisa S Chard; Dong Chen; Pan Du; Rathi Gangeswaran; Dongling Gao; Nick Lemoine; Xiaozhu Li; Yaohe Wang
A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity.
Meng Xu; Xuexiang Du; Yang-Xin Fu; Sirui Li; Xiaozhu Li; Mingyue Liu; Shengdian Wang
The tumor immunosuppressive microenvironment impairs the therapy of anti-HER2/neu antibody.

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All Publications

2013: Eric D Mortenson; SaeGwang Park; Shengdian Wang; Zhujun Jiang; Yang-Xin Fu
Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(6):1476-86.
2012: James Tysome; Pengju Wang; Shengdian Wang; Ming Yuan; Ghassan Alusi; Louisa S Chard; Dong Chen; Pan Du; Rathi Gangeswaran; Dongling Gao; Nick Lemoine; Xiaozhu Li; Yaohe Wang
A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(24):6679-89.
2012: Meng Xu; Xuexiang Du; Yang-Xin Fu; Sirui Li; Xiaozhu Li; Mingyue Liu; Shengdian Wang
The tumor immunosuppressive microenvironment impairs the therapy of anti-HER2/neu antibody.
Protein & cell 2012;3(6):441-9.
2012: Y Luan; J Wang; Z Zhang; F-S Wang; L Cheng; S-Y Zhang; L Luo; Lieping Chen; D-M Zhu; J Ju; Shengdian Wang
Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection.
Journal of viral hepatitis 2012;19(1):23-31.
2011: Dallas B Flies; Shengdian Wang; Haiying Xu; Lieping Chen
Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):1537-41.
2011: M Ying; C R Goodwin; Hugo Guerrero-Cazares; Bachchu Lal; John Laterra; A QUINONES-HINOJOSA; Y Sang; P Sun; Shengdian Wang; SHULI XIA
Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition.
Oncogene 2011;30(31):3454-67.
2011: Xue Han; Yang Liu; Liqun Luo; Peiying Ye; Linghua Zheng; Lieping Chen; Shengdian Wang
The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope.
Cellular & molecular immunology 2011;8(4):333-40.
2011: SHENG YAO; Yuwen Zhu; Gefeng Zhu; Mathew Augustine; Linghua Zheng; Diana J Goode; Megan Broadwater; William Ruff; Sarah Flies; Haiying Xu; Dallas Flies; Liqun Luo; Shengdian Wang; Lieping Chen
B7-h2 is a costimulatory ligand for CD28 in human.
Immunity 2011;34(5):729-40.
2011: Liang Cheng; Jun Wang; Xiaozhu Li; Qiao Xing; Peishuang Du; Lishan Su; Shengdian Wang
Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cell-mediated liver injury in mice.
PloS one 2011;6(3):e17631.
2011: Shengdian Wang; Lieping Chen
Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways.
Current topics in microbiology and immunology 2011;344():245-67.
2010: Jun Wang; Wenxia Zhao; Liang Cheng; Mingzhou Guo; Dongling Li; Xiaozhu Li; Yi Tan; Suping Ma; Suyun Li; Yunsheng Yang; Lieping Chen; Shengdian Wang
CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7654-62.
2010: Linghua Zheng; Dongling Li; Fusheng Wang; Hao Wu; Xiaozhu Li; Junliang Fu; Xinyue Chen; Lizhong Wang; Yang Liu; Shengdian Wang
Association between hepatitis B viral burden in chronic infection and a functional single nucleotide polymorphism of the PDCD1 gene.
Journal of clinical immunology 2010;30(6):855-60.
2010: Xiangqun Li; Xue Han; Shengdian Wang; Ziyuan Duan
Development and characterization of monoclonal antibodies against mouse TSLP.
Hybridoma (2005) 2010;29(5):425-30.
2010: Liufu Deng; Haizeng Zhang; Yan Luan; Jianfeng Zhang; Qiao Xing; Shuxiao Dong; Xiaoran Wu; Mingyue Liu; Shengdian Wang
Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(16):4105-12.
2010: SaeGwang Park; Zhujun Jiang; Eric D Mortenson; Liufu Deng; Olga Radkevich-Brown; Xuanming Yang; Husain Sattar; Yang Wang; Nicholas K Brown; Mark Greene; Yang Liu; Jie Tang; Shengdian Wang; Yang-Xin Fu
The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity.
Cancer cell 2010;18(2):160-70.
2010: G Guo; X Qiu; Shengdian Wang; Y Chen; P B Rothman; Zijian Wang; Y Chen; G Wang; J-L Chen
Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells.
Oncogene 2010;29(26):3845-53.
2010: Shengdian Wang; Lieping Chen
Structural immunology of costimualtory and coinhibitory molecules.
Science China. Life sciences 2010;53(2):183-9.
2009: Dongling Li; Linghua Zheng; Lei Jin; Yuesu Zhou; Haiying Li; Junliang Fu; Ming Shi; Peishuang Du; Lizhong Wang; Hao Wu; Guoyun Chen; Pan Zheng; Yang Liu; Fu-Sheng Wang; Shengdian Wang
CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection.
Hepatology (Baltimore, Md.) 2009;50(3):735-42.
2009: SHENG YAO; Shengdian Wang; Yuwen Zhu; Liqun Luo; Gefeng Zhu; Sarah Flies; Haiying Xu; William Ruff; Megan Broadwater; In-Hak Choi; Koji Tamada; Lieping Chen
PD-1 on dendritic cells impedes innate immunity against bacterial infection.
Blood 2009;113(23):5811-8.
2007: Ning Li; Hanjun Qin; Xiaozhu Li; Chunxia Zhou; Dongmei Wang; Wenbo Ma; Chen Lin; Youhui Zhang; Shengdian Wang; Shuren Zhang
Synergistic antitumor effect of chemotactic-prostate tumor-associated antigen gene-modified tumor cell vaccine and anti-CTLA-4 mAb in murine tumor model.
Immunology letters 2007;113(2):90-8.
2007: Lieping Chen; Zheng Zhang; Weiwei Chen; Zhidong Zhang; Yonggang Li; Ming Shi; Jiyuan Zhang; Lieping Chen; Shengdian Wang; Fu-Sheng Wang
B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6634-41.
2007: Ning Li; Hanjun Qin; Xiaozhu Li; Chunxia Zhou; Dongmei Wang; Wenbo Ma; Chen Lin; Youhui Zhang; Shengdian Wang; Shuren Zhang
Potent systemic antitumor immunity induced by vaccination with chemotactic-prostate tumor associated antigen gene-modified tumor cell and blockade of B7-H1.
Journal of clinical immunology 2007;27(1):117-30.
2006: Xiaoyan Lin; Chunxia Zhou; Shengdian Wang; Dongmei Wang; Wenbo Ma; Xiao Liang; Chen Lin; Zheng Wang; Jie Li; Sujuan Guo; Youhui Zhang; Shuren Zhang
Enhanced antitumor effect against human telomerase reverse transcriptase (hTERT) by vaccination with chemotactic-hTERT gene-modified tumor cell and the combination with anti-4-1BB monoclonal antibodies.
International journal of cancer. Journal international du cancer 2006;119(8):1886-96.
2005: Hideto Tamura; Kazuo Dan; Koji Tamada; Kyoko Nakamura; Yumiko Shioi; Hideya Hyodo; Shengdian Wang; Haidong Dong; Lieping Chen; Kiyoyuki Ogata
Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5708-17.
2005: Fumiya Hirano; Katsumi Kaneko; Hideto Tamura; Haidong Dong; Shengdian Wang; Masao Ichikawa; Cecilia Rietz; Dallas B Flies; Julie S Lau; Gefeng Zhu; Koji Tamada; Lieping Chen
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
Cancer research 2005;65(3):1089-96.
2004: Liqun Luo; Andrei I Chapoval; Dallas B Flies; Gefeng Zhu; Fumiya Hirano; Shengdian Wang; Julie S Lau; Haidong Dong; Koji Tamada; Andrew S Flies; Yang Liu; Lieping Chen
B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5445-50.
2004: Shengdian Wang; Lieping Chen
Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses.
Microbes and infection / Institut Pasteur 2004;6(8):759-66.
2004: Shengdian Wang; Lieping Chen
T lymphocyte co-signaling pathways of the B7-CD28 family.
Cellular & molecular immunology 2004;1(1):37-42.
2003: Gabriel L Sica; In-Hak Choi; Gefeng Zhu; Koji Tamada; Shengdian Wang; Hideto Tamura; Andrei I Chapoval; Dallas B Flies; Jürgen Bajorath; Lieping Chen
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Immunity 2003;18(6):849-61.
2003: Shengdian Wang; Jürgen Bajorath; Dallas B Flies; Haidong Dong; Tasuku Honjo; Lieping Chen
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.
The Journal of experimental medicine 2003;197(9):1083-91.
2003: Shin Kurosawa; Allen C Myers; Lieping Chen; Shengdian Wang; Jian Ni; James R Plitt; Nicola M Heller; Bruce S Bochner; Robert P Schleimer
Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells.
American journal of respiratory cell and molecular biology 2003;28(5):563-73.
2002: Shengdian Wang; Gefeng Zhu; Koji Tamada; Lieping Chen; Jürgen Bajorath
Ligand binding sites of inducible costimulator and high avidity mutants with improved function.
The Journal of experimental medicine 2002;195(8):1033-41.
2000: Shengdian Wang; Gefeng Zhu; Andrei I Chapoval; Haidong Dong; Koji Tamada; J Ni; Lieping Chen
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.
Blood 2000;96(8):2808-13.