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Timothy Wang

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Reidar Alexander Vigen; Trond Viset; Helge Waldum; Timothy C Wang; Duan Chen; Reidar Fossmark; Mark Kidd; Yosuke Kodama; Irvin M Modlin; Chunmei Zhao
Immunohistochemical evidence for an impairment of autophagy in tumorigenesis of gastric carcinoids and adenocarcinomas in rodent models and patients.
Wataru Shibata; Christoph Benedikt Westphalen; Daniel L Worthley; Hiroshi Ariyama; Samuel Asfaha; Zinaida Dubeykovskaya; James G Fox; SureshKumar Muthupalani; Michael Quante; Timothy C Wang
Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors.
Reena Shakya; Matthias Szabolcs; Benjamin Tycko; Timothy C Wang; Jenna Brooks; Angelica Cullo; Justine Davies; Tamas Gonda; Steffen Hirsch; Samuel Kim; Kenneth Olive; Michael Quante; Martha Salas; Thomas Ludwig
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

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2013: Reidar Alexander Vigen; Trond Viset; Helge Waldum; Timothy C Wang; Duan Chen; Reidar Fossmark; Mark Kidd; Yosuke Kodama; Irvin M Modlin; Chunmei Zhao
Immunohistochemical evidence for an impairment of autophagy in tumorigenesis of gastric carcinoids and adenocarcinomas in rodent models and patients.
Histology and histopathology 2013;28(4):531-42.
2013: Wataru Shibata; Christoph Benedikt Westphalen; Daniel L Worthley; Hiroshi Ariyama; Samuel Asfaha; Zinaida Dubeykovskaya; James G Fox; SureshKumar Muthupalani; Michael Quante; Timothy C Wang
Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors.
Gut 2013;62(2):192-200.
2013: Reena Shakya; Matthias Szabolcs; Benjamin Tycko; Timothy C Wang; Jenna Brooks; Angelica Cullo; Justine Davies; Tamas Gonda; Steffen Hirsch; Samuel Kim; Kenneth Olive; Michael Quante; Martha Salas; Thomas Ludwig
Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.
Cancer research 2013;73(2):885-96.
2013: Christoph B Westphalen; Frederic Marrache; Timothy C Wang
Analysis of transplanted bone marrow-derived cells in chronic pancreatitis.
Methods in molecular biology (Clifton, N.J.) 2013;980():291-300.
2013: Samuel Asfaha; Zinaida A Dubeykovskaya; Alexander N Dubeykovskiy; Russell Ericksen; James G Fox; Richard A Friedman; Harold Frucht; SureshKumar Muthupalani; Wataru Shibata; Sarah Stokes; Hiroyuki Tomita; Hiroshi Ariyama; Xiangdong Yang; Timothy C Wang
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.
Gastroenterology 2013;144(1):155-66.
2012: Mark A Glaire; Timothy C Wang; Emad M El-Omar; Daniel L Worthley
The mesenchyme in malignancy: a partner in the initiation, progression and dissemination of cancer.
Pharmacology & therapeutics 2012;136(2):131-41.
2012: Robert F Schwabe; Timothy C Wang
Cancer. Bacteria deliver a genotoxic hit.
Science (New York, N.Y.) 2012;338(6103):52-3.
2012: Vigneshwaran Ramanathan; Shigeo Takaishi; Alexander Dubeykovskiy; Guangchun Jin; Christoph Benedikt Westphalen; Ashley Whelan; Timothy C Wang
P53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in mice.
Cancer investigation 2012;30(4):275-86.
2012: Tamas A Gonda; Young-In Kim; SureshKumar Muthupalani; Martha C Salas; Wataru Shibata; Kyoung-Jin Sohn; Julian A Abrams; James G Fox; Mary V Gamble; Timothy C Wang; Benjamin Tycko
Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.
Gastroenterology 2012;142(4):824-833.e7.
2012: Michael Quante; Anil K Rustgi; Carrie Shawber; Julian A Abrams; Samuel Asfaha; Govind Bhagat; Zinaida Dubeykovskaya; Jose-Luiz Figueiredo; Richard Friedman; Pamela Good; Jan Kitajewski; Michele D Lee; Yoomi Lee; Charles J Lightdale; Umar Mahmood; Frederic Marache; Timothy C Wang
Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.
Cancer cell 2012;21(1):36-51.
2011: Alexander Sheh; Timothy C Wang; Rebecca Fry; Zhongming Ge; Amanda F McCabe; Melissa W Mobley; SureshKumar Muthupalani; Nicola M A Parry; Arkadiusz R Raczynski; Julia E Rager; James G Fox
17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice.
Cancer prevention research (Philadelphia, Pa.) 2011;4(9):1426-35.
2011: Masahiro Ohtani; Arlin Rogers; Nancy S Taylor; Timothy C Wang; Koichiro Watanabe; Mark T Whary; Shilu Xu; Alexis García; Zhongming Ge; Robert P Marini; SureshKumar Muthupalani; Yan Feng; James G Fox
17 β-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice.
Carcinogenesis 2011;32(8):1244-50.
2011: Shui Ping Tu; Xiang Dong Yang; Govind Bhagat; Guanglin Cui; James G Fox; Sureshkumar Muthuplani; D Mark Pritchard; Michael Quante; Wataru Shibata; Shigeo Takaishi; Timothy C Wang
IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis.
Cancer research 2011;71(12):4247-59.
2011: Hiroyuki Tomita; Shigeo Takaishi; Treve Menheniott; Xiangdong Yang; Wataru Shibata; Guangchun Jin; Kelly S Betz; Kazuyuki Kawakami; Toshinari Minamoto; Catherine Tomasetto; Marie-Christine Rio; Nataporn Lerkowit; Andrea Varro; Andrew S Giraud; Timothy C Wang
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.
Gastroenterology 2011;140(3):879-91.
2011: Michael Quante; Shui Ping Tu; Hiroyuki Tomita; Tamas Gonda; Sophie S W Wang; Shigeo Takashi; Gwang Ho Baik; Wataru Shibata; Bethany Diprete; Kelly S Betz; Richard Friedman; Andrea Varro; Benjamin Tycko; Timothy C Wang
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.
Cancer cell 2011;19(2):257-72.
2011: Shigeo Takaishi; Wataru Shibata; Hiroyuki Tomita; Guangchun Jin; Xiangdong Yang; Russell Ericksen; Zinaida Dubeykovskaya; Samuel Asfaha; Michael Quante; Kelly S Betz; Arthur Shulkes; Timothy C Wang
In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice.
American journal of physiology. Gastrointestinal and liver physiology 2011;300(2):G334-44.
2011: Lauren E Grosberg; Andrew J Radosevich; Samuel Asfaha; Timothy C Wang; Elizabeth M C Hillman
Spectral characterization and unmixing of intrinsic contrast in intact normal and diseased gastric tissues using hyperspectral two-photon microscopy.
PloS one 2011;6(5):e19925.
2011: Xiang Dong Yang; Wandong Ai; Samuel Asfaha; Govind Bhagat; Richard A Friedman; Guangchun Jin; Heuijoon Park; Benjamin Shykind; Thomas G Diacovo; Andras Falus; Timothy C Wang
Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells.
Nature medicine 2011;17(1):87-95.
2011: Jennifer L Lofgren; Mark T Whary; Zhongming Ge; SureshKumar Muthupalani; Nancy S Taylor; Melissa Mobley; Amanda Potter; Andrea Varro; Daniel Eibach; Sebastian Suerbaum; Timothy C Wang; James G Fox
Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia.
Gastroenterology 2011;140(1):210-20.
2010: Michael Quante; Frederic Marrache; James R Goldenring; Timothy C Wang
TFF2 mRNA transcript expression marks a gland progenitor cell of the gastric oxyntic mucosa.
Gastroenterology 2010;139(6):2018-2027.e2.
2010: Benjamin Lebwohl; Timothy C Wang; Alfred I Neugut
Socioeconomic and other predictors of colonoscopy preparation quality.
Digestive diseases and sciences 2010;55(7):2014-20.
2010: Zhigang Song; Govind Bhagat; Michael Quante; Gwang Ho Baik; Frederic Marrache; Shui Ping Tu; Chun-Mei Zhao; Duan Chen; Andrew J Dannenberg; Timothy C Wang
Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis.
Laboratory investigation; a journal of technical methods and pathology 2010;90(3):426-35.
2010: Wataru Shibata; Shigeo Takaishi; SureshKumar Muthupalani; D Mark Pritchard; Mark T Whary; Arlin Rogers; James G Fox; Kelly S Betz; Klaus H Kaestner; Michael Karin; Timothy C Wang
Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia.
Gastroenterology 2010;138(3):1022-34.e1-10.
2010: Tamas A Gonda; Andrea Varro; Timothy C Wang; Benjamin Tycko
Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?
Seminars in cell & developmental biology 2010;21(1):2-10.
2009: Michael Quante; Timothy C Wang
Stem cells in gastroenterology and hepatology.
Nature reviews. Gastroenterology & hepatology 2009;6(12):724-37.
2009: Tomoyuki Okumura; Sophie S W Wang; Shigeo Takaishi; Shui Ping Tu; Vivian Ng; Russell E Ericksen; Anil K Rustgi; Timothy C Wang
Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium.
Laboratory investigation; a journal of technical methods and pathology 2009;89(12):1410-22.
2009: Chung-Wei Lee; Barry Rickman; Arlin Rogers; SureshKumar Muthupalani; Shigeo Takaishi; Peiying Yang; Timothy C Wang; James G Fox
Combination of sulindac and antimicrobial eradication of Helicobacter pylori prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.
Cancer research 2009;69(20):8166-74.
2009: Guangchun Jin; Vigneshwaran Ramanathan; Michael Quante; Gwang Ho Baik; Xiangdong Yang; Sophie S W Wang; Shuiping Tu; Shanisha A K Gordon; David Mark Pritchard; Andrea Varro; Arthur Shulkes; Timothy C Wang
Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.
The Journal of clinical investigation 2009;119(9):2691-701.
2009: Sophie S W Wang; Samuel Asfaha; Tomoyuki Okumura; Kelly S Betz; SureshKumar Muthupalani; Arlin Rogers; Shuiping Tu; Shigeo Takaishi; Guangchun Jin; Xiangdong Yang; deng-chyang wu; James G Fox; Timothy C Wang
Fibroblastic colony-forming unit bone marrow cells delay progression to gastric dysplasia in a helicobacter model of gastric tumorigenesis.
Stem cells (Dayton, Ohio) 2009;27(9):2301-11.
2009: Hanchen Li; Xueli Fan; Calin Stoicov; Jian Hua Liu; Sharif Zubair; Elena Tsai; Ronald Ste Marie; Timothy C Wang; Stephen Lyle; Evelyn A Kurt-Jones; JeanMarie Houghton
Human and mouse colon cancer utilizes CD95 signaling for local growth and metastatic spread to liver.
Gastroenterology 2009;137(3):934-44, 944.e1-4.
2009: Shigeo Takaishi; Shuiping Tu; Zinaida A Dubeykovskaya; Mark T Whary; SureshKumar Muthupalani; Barry H Rickman; Arlin Rogers; Nantaporn Lertkowit; Andrea Varro; James G Fox; Timothy C Wang
Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice.
The American journal of pathology 2009;175(1):365-75.
2009: Tamas A Gonda; Shuiping Tu; Timothy C Wang
Chronic inflammation, the tumor microenvironment and carcinogenesis.
Cell cycle (Georgetown, Tex.) 2009;8(13):2005-13.
2009: Shigeo Takaishi; Tomoyuki Okumura; Shuiping Tu; Sophie S W Wang; Wataru Shibata; Ramanathan Vigneshwaran; Shanisha A K Gordon; Yutaka Shimada; Timothy C Wang
Identification of gastric cancer stem cells using the cell surface marker CD44.
Stem cells (Dayton, Ohio) 2009;27(5):1006-20.
2009: Zinaida Dubeykovskaya; Alexander Dubeykovskiy; Joel cohen-solal; Timothy C Wang
Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines.
The Journal of biological chemistry 2009;284(6):3650-62.
2008: Le Jiang; Tamas A Gonda; Mary V Gamble; Martha Salas; Venkatraman E Seshan; Shuiping Tu; William S Twaddell; Peter Hegyi; Gyorgy Lazar; Islay Steele; Andrea Varro; Timothy C Wang; Benjamin Tycko
Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.
Cancer research 2008;68(23):9900-8.
2008: Alexander Dubeykovskiy; Thomas Nguyen; Zinaida Dubeykovskaya; Shi Lei; Timothy C Wang
Flow cytometric detection of progastrin interaction with gastrointestinal cells.
Regulatory peptides 2008;151(1-3):106-14.
2008: Shuiping Tu; Govind Bhagat; Guanglin Cui; Shigeo Takaishi; Evelyn A Kurt-Jones; Barry Rickman; Kelly S Betz; Melitta Penz-Oesterreicher; Olle Bjorkdahl; James G Fox; Timothy C Wang
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.
Cancer cell 2008;14(5):408-19.
2008: Frederic Marrache; Shui Ping Tu; Govind Bhagat; Swaroop Pendyala; Christoph H Osterreicher; Shanisha Gordon; Vigneshwaran Ramanathan; Melitta Penz-Osterreicher; Kelly S Betz; Zhigang Song; Timothy C Wang
Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis.
Gastroenterology 2008;135(4):1277-87.
2008: F Marrache; S Pendyala; Govind Bhagat; K S Betz; Z Song; Timothy C Wang
Role of bone marrow-derived cells in experimental chronic pancreatitis.
Gut 2008;57(8):1113-20.
2008: Shigeo Takaishi; Tomoyuki Okumura; Timothy C Wang
Gastric cancer stem cells.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(17):2876-82.
2008: Chung-Wei Lee; Barry Rickman; Arlin Rogers; Zhongming Ge; Timothy C Wang; James G Fox
Helicobacter pylori eradication prevents progression of gastric cancer in hypergastrinemic INS-GAS mice.
Cancer research 2008;68(9):3540-8.
2008: Chung-Wei Lee; Xiang Wang; Kuo-Liong Chien; Zhongming Ge; Barry Rickman; Arlin Rogers; Andrea Varro; Mark T Whary; Timothy C Wang; James G Fox
Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy.
International journal of cancer. Journal international du cancer 2008;122(5):1068-76.
2008: Timothy C Wang; David E Fleischer; Peter Kaufman; Juan-R Malagelada; Walter J McDonald; Kenneth R McQuaid; Marshall Montrose; Pankaj J Pasricha; Don W Powell; Suzanne Rose; William A Rowe; Andrea Todisco
The best of times and the worst of times: sustaining the future of academic gastroenterology in the United States--Report of a Consensus Conference Conducted by the AGA Institute Future Trends Committee.
Gastroenterology 2008;134(2):597-616.
2008: Thorsten Cramer; Stefan Jüttner; Thomas Plath; Stefan Mergler; Thomas Seufferlein; Timothy C Wang; Juanita L Merchant; Michael Höcker
Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB.
Cellular signalling 2008;20(1):60-72.
2007: Masahiro Ohtani; Alexis García; Arlin Rogers; Zhongming Ge; Nancy S Taylor; Shilu Xu; Koichiro Watanabe; Robert P Marini; Mark T Whary; Timothy C Wang; James G Fox
Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice.
Carcinogenesis 2007;28(12):2597-604.
2007: James G Fox; Arlin Rogers; Mark T Whary; Zhongming Ge; Masa Ohtani; Evelyn Kurt Jones; Timothy C Wang
Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice.
The American journal of pathology 2007;171(5):1520-8.
2007: Shuiping Tu; Alfred L Chi; Seonhee Lim; Guanglin Cui; Zina Dubeykovskaya; Wandong Ai; John V Fleming; Shigeo Takaishi; Timothy C Wang
Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(6):G1726-37.
2007: JeanMarie Houghton; Alexei Morozov; Iva Smirnova; Timothy C Wang
Stem cells and cancer.
Seminars in cancer biology 2007;17(3):191-203.
2007: Shigeo Takaishi; Timothy C Wang
Gene expression profiling in a mouse model of Helicobacter-induced gastric cancer.
Cancer science 2007;98(3):284-93.
2007: Wandong Ai; Hai Zheng; Xiangdong Yang; Ying Liu; Timothy C Wang
Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity.
Nucleic acids research 2007;35(18):6137-49.
2007: James G Fox; Timothy C Wang
Inflammation, atrophy, and gastric cancer.
The Journal of clinical investigation 2007;117(1):60-9.
2007: Evelyn A Kurt-Jones; LuCheng Cao; Frantisek Sandor; Arlin Rogers; Mark T Whary; Prashant R Nambiar; Anna M Cerny; Glennice Bowen; Jing Yan; Shigeo Takaishi; Alfred L Chi; George Reed; JeanMarie Houghton; James G Fox; Timothy C Wang
Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses.
Infection and immunity 2007;75(1):471-80.
2006: Guanglin Cui; Shigeo Takaishi; Wandong Ai; Kelly S Betz; Jon Florholmen; Theodore J Koh; JeanMarie Houghton; D Mark Pritchard; Timothy C Wang
Gastrin-induced apoptosis contributes to carcinogenesis in the stomach.
Laboratory investigation; a journal of technical methods and pathology 2006;86(10):1037-51.
2006: Wandong Ai; Ying Liu; Timothy C Wang
Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(6):G1096-104.
2006: Wandong Ai; Shigeo Takaishi; Timothy C Wang; John V Fleming
Regulation of L-histidine decarboxylase and its role in carcinogenesis.
Progress in nucleic acid research and molecular biology 2006;81():231-70.
2005: Arlin Rogers; Nancy S Taylor; Mark T Whary; Erinn D Stefanich; Timothy C Wang; James G Fox
Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice.
Cancer research 2005;65(23):10709-15.
2005: Abhijit Chakladar; Alexander Dubeykovskiy; Lindsay J Wojtukiewicz; Jitesh Pratap; Shi Lei; Timothy C Wang
Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment.
Biochemical and biophysical research communications 2005;336(1):190-6.
2005: Shigeo Takaishi; Guanglin Cui; Dana M Frederick; Jane E Carlson; JeanMarie Houghton; Andrea Varro; Graham J Dockray; Zhongming Ge; Mark T Whary; Arlin Rogers; James G Fox; Timothy C Wang
Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.
Gastroenterology 2005;128(7):1965-83.
2005: Xun Cai; Jane Carlson; Calin Stoicov; Hanchen Li; Timothy C Wang; JeanMarie Houghton
Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice.
Gastroenterology 2005;128(7):1937-52.
2005: JeanMarie Houghton; Timothy C Wang
Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers.
Gastroenterology 2005;128(6):1567-78.
2004: JeanMarie Houghton; Calin Stoicov; Sachiyo Nomura; Arlin Rogers; Jane Carlson; Hanchen Li; Xun Cai; James G Fox; James R Goldenring; Timothy C Wang
Gastric cancer originating from bone marrow-derived cells.
Science (New York, N.Y.) 2004;306(5701):1568-71.
2004: Guanglin Cui; Theodore J Koh; Duan Chen; Chunmei Zhao; Shigeo Takaishi; Graham J Dockray; Andrea Varro; Arlin Rogers; James G Fox; Timothy C Wang
Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach.
Cancer research 2004;64(22):8160-6.
2004: Leisa Mandell; Anthony P Moran; Andrew Cocchiarella; JeanMarie Houghton; Nancy Taylor; James G Fox; Timothy C Wang; Evelyn A Kurt-Jones
Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4.
Infection and immunity 2004;72(11):6446-54.
2004: Shi Lei; Alexander Dubeykovskiy; Abhijit Chakladar; Lindsay Wojtukiewicz; Timothy C Wang
The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.
The Journal of biological chemistry 2004;279(41):42492-502.
2004: John V Fleming; Ignacio Fajardo; Michael R Langlois; Francisca Sánchez-Jiménez; Timothy C Wang
The C-terminus of rat L-histidine decarboxylase specifically inhibits enzymic activity and disrupts pyridoxal phosphate-dependent interactions with L-histidine substrate analogues.
The Biochemical journal 2004;381(Pt 3):769-78.
2004: Natalie F Sinclair; Wandong Ai; Raktima Raychowdhury; Meixia Bi; Timothy C Wang; Theodore J Koh; John T McLaughlin
Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanism.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(6):G992-9.
2004: John V Fleming; Francisca Sánchez-Jiménez; Aurelio A Moya-García; Michael R Langlois; Timothy C Wang
Mapping of catalytically important residues in the rat L-histidine decarboxylase enzyme using bioinformatic and site-directed mutagenesis approaches.
The Biochemical journal 2004;379(Pt 2):253-61.
2004: Wandong Ai; Ying Liu; Michael Langlois; Timothy C Wang
Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements.
The Journal of biological chemistry 2004;279(10):8684-93.
2004: Evelyn A Kurt-Jones; Frantisek Sandor; Yasdel Ortiz; Glennice N Bowen; Stacy L Counter; Timothy C Wang; Robert W Finberg
Use of murine embryonic fibroblasts to define Toll-like receptor activation and specificity.
Journal of endotoxin research 2004;10(6):419-24.
2004: Theodore J Koh; John Field; Andrea Varro; Triantafillos Liloglou; Pat Fielding; Guanglin Cui; JeanMarie Houghton; Graham J Dockray; Timothy C Wang
Glycine-extended gastrin promotes the growth of lung cancer.
Cancer research 2004;64(1):196-201.
2004: John T McLaughlin; Wandong Ai; Natalie F Sinclair; Rocchina Colucci; Raktima Raychowdhury; Theodore J Koh; Timothy C Wang
PACAP and gastrin regulate the histidine decarboxylase promoter via distinct mechanisms.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(1):G51-9.
2003: Hanchen Li; Calin Stoicov; Xun Cai; Timothy C Wang; JeanMarie Houghton
Helicobacter and gastric cancer disease mechanisms: host response and disease susceptibility.
Current gastroenterology reports 2003;5(6):459-67.
2003: James G Fox; Timothy C Wang; Arlin Rogers; Theofilos Poutahidis; Zhongming Ge; Nancy Taylor; Charles A Dangler; Dawn A Israel; Uma Krishna; Kristen Gaus; Richard M Peek
Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia.
Gastroenterology 2003;124(7):1879-90.
2003: Jaroslav Zivny; Timothy C Wang; Rhonda Yantiss; Kyung H Kim; JeanMarie Houghton
Role of therapy or monitoring in preventing progression to gastric cancer.
Journal of clinical gastroenterology 2003;36(5 Suppl):S50-60; discussion S61-2.
2003: James G Fox; Arlin Rogers; Melanie M Ihrig; Nancy S Taylor; Mark T Whary; Graham J Dockray; Andrea Varro; Timothy C Wang
Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific.
Cancer research 2003;63(5):942-50.
2003: John V Fleming; Timothy C Wang
The production of 53-55-kDa isoforms is not required for rat L-histidine decarboxylase activity.
The Journal of biological chemistry 2003;278(1):686-94.
2002: Raktima Raychowdhury; Georgia Schäfer; John Fleming; Stefan Rosewicz; Bertram Wiedenmann; Timothy C Wang; Michael Höcker
Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromogranin A promoter.
Molecular endocrinology (Baltimore, Md.) 2002;16(12):2802-18.
2002: Raktima Raychowdhury; John V Fleming; John T McLaughlin; Clemens J Bulitta; Timothy C Wang
Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter.
Biochemical and biophysical research communications 2002;297(5):1089-95.
2002: Clemens J Bulitta; John V Fleming; Raktima Raychowdhury; Douglas Taupin; Ian Rosenberg; Timothy C Wang
Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element.
Biochemical and biophysical research communications 2002;293(1):366-74.
2002: JeanMarie Houghton; James G Fox; Timothy C Wang
Gastric cancer: laboratory bench to clinic.
Journal of gastroenterology and hepatology 2002;17(4):495-502.
2002: James G Fox; Barbara J Sheppard; Charles A Dangler; Mark T Whary; Melanie M Ihrig; Timothy C Wang
Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses.
Cancer research 2002;62(3):696-702.
2002: James G Fox; Timothy C Wang
Helicobacter pylori infection: pathogenesis.
Current opinion in gastroenterology 2002;18(1):15-25.
2002: James Farrell; Douglas Taupin; Theodore J Koh; Duan Chen; Chunmei Zhao; Daniel K Podolsky; Timothy C Wang
TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury.
The Journal of clinical investigation 2002;109(2):193-204.
2001: R Colucci; John V Fleming; Ramnik Xavier; Timothy C Wang
L-histidine decarboxylase decreases its own transcription through downregulation of ERK activity.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(4):G1081-91.
2001: Michael Höcker; Thorsten Cramer; Daniel O'Connor; Stefan Rosewicz; Bertram Wiedenmann; Timothy C Wang
Neuroendocrine-specific and gastrin-dependent expression of a chromogranin A-luciferase fusion gene in transgenic mice.
Gastroenterology 2001;121(1):43-55.
2000: Duan Chen; Chunmei Zhao; Graham J Dockray; Andrea Varro; A Van Hoek; Natalie F Sinclair; Timothy C Wang; Theodore J Koh
Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice.
Gastroenterology 2000;119(3):756-65.
2000: Theodore J Koh; Clemens J Bulitta; John V Fleming; Graham J Dockray; Andrea Varro; Timothy C Wang
Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis.
The Journal of clinical investigation 2000;106(4):533-9.
2000: John V Fleming; Timothy C Wang
Amino- and carboxy-terminal PEST domains mediate gastrin stabilization of rat L-histidine decarboxylase isoforms.
Molecular and cellular biology 2000;20(13):4932-47.
1999: James G Fox; Charles A Dangler; Nancy S Taylor; A King; Theodore J Koh; Timothy C Wang
High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice.
Cancer research 1999;59(19):4823-8.
1999: Thomas Plath; Michael Höcker; Ernst-Otto Riecken; Timothy C Wang; Bertram Wiedenmann; Stefan Rosewicz
Interferon-alpha inhibits chromogranin A promoter activity in neuroendocrine pancreatic cancer cells.
FEBS letters 1999;458(3):378-82.
1999: Raktima Raychowdhury; Z Zhang; Michael Höcker; Timothy C Wang
Activation of human histidine decarboxylase gene promoter activity by gastrin is mediated by two distinct nuclear factors.
The Journal of biological chemistry 1999;274(30):20961-9.
1999: Douglas Taupin; Du-Chu Wu; W K Jeon; K Devaney; Timothy C Wang; Daniel K Podolsky
The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation.
The Journal of clinical investigation 1999;103(9):R31-8.
1999: Theodore J Koh; Graham J Dockray; Andrea Varro; R J Cahill; Charles A Dangler; James G Fox; Timothy C Wang
Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation.
The Journal of clinical investigation 1999;103(8):1119-26.
1998: Michael Höcker; Raktima Raychowdhury; Thomas Plath; H Wu; Daniel O'Connor; Bertram Wiedenmann; Stefan Rosewicz; Timothy C Wang
Sp1 and CREB mediate gastrin-dependent regulation of chromogranin A promoter activity in gastric carcinoma cells.
The Journal of biological chemistry 1998;273(51):34000-7.
1998: Michael Höcker; I Rosenberg; R Xavier; R J Henihan; Bertram Wiedenmann; Stefan Rosewicz; D K Podolsky; Timothy C Wang
Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells.
The Journal of biological chemistry 1998;273(36):23046-54.
1998: Timothy C Wang; JR Goldenring; Charles A Dangler; S Ito; A Mueller; W K Jeon; Theodore J Koh; James G Fox
Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection.
Gastroenterology 1998;114(4):675-89.
1997: James G Fox; Charles A Dangler; Mark T Whary; W Edelman; R Kucherlapati; Timothy C Wang
Mice carrying a truncated Apc gene have diminished gastric epithelial proliferation, gastric inflammation, and humoral immunity in response to Helicobacter felis infection.
Cancer research 1997;57(18):3972-8.
1997: Theodore J Koh; JR Goldenring; S Ito; Hiroshi Mashimo; A S Kopin; Andrea Varro; Graham J Dockray; Timothy C Wang
Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice.
Gastroenterology 1997;113(3):1015-25.
1997: M Höcker; Z Zhang; Juanita L Merchant; Timothy C Wang
Gastrin regulates the human histidine decarboxylase promoter through an AP-1-dependent mechanism.
The American journal of physiology 1997;272(4 Pt 1):G822-30.
1996: Timothy C Wang; Theodore J Koh; Andrea Varro; R J Cahill; Charles A Dangler; James G Fox; Graham J Dockray
Processing and proliferative effects of human progastrin in transgenic mice.
The Journal of clinical investigation 1996;98(8):1918-29.
1996: TSANYANG LIANG; AE Reid; R Xavier; Robert Cardiff; Timothy C Wang
Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.
The Journal of clinical investigation 1996;97(12):2872-7.
1996: Z Zhang; Michael Höcker; T J Koh; Timothy C Wang
The human histidine decarboxylase promoter is regulated by gastrin and phorbol 12-myristate 13-acetate through a downstream cis-acting element.
The Journal of biological chemistry 1996;271(24):14188-97.
1996: Michael Höcker; Z Zhang; D A Fenstermacher; S Tågerud; M Chulak; David R Joseph; Timothy C Wang
Rat histidine decarboxylase promoter is regulated by gastrin through a protein kinase C pathway.
The American journal of physiology 1996;270(4 Pt 1):G619-33.
1996: Michael Höcker; Z Zhang; T J Koh; Timothy C Wang
The regulation of histidine decarboxylase gene expression.
The Yale journal of biology and medicine 1996;69(1):21-33.
1996: James G Fox; X Li; R J Cahill; Karl A Andrutis; A K Rustgi; Robert D Odze; Timothy C Wang
Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice.
Gastroenterology 1996;110(1):155-66.
1995: T J Koh; Timothy C Wang
Molecular cloning and sequencing of the murine gastrin gene.
Biochemical and biophysical research communications 1995;216(1):34-41.
1995: Timothy C Wang; M W Babyatsky; P S Oates; Z Zhang; L Tillotson; M Chulak; S J Brand; E V Schmidt
A rat gastrin-human gastrin chimeric transgene directs antral G cell-specific expression in transgenic mice.
The American journal of physiology 1995;268(6 Pt 1):G1025-36.
1995: Richard Sharp; M W Babyatsky; H Takagi; S Tågerud; Timothy C Wang; DE Bockman; S J Brand; Glenn Merlino
Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice.
Development (Cambridge, England) 1995;121(1):149-61.
1994: Timothy C Wang; Robert Cardiff; Lawrence R Zukerberg; E Lees; A Arnold; E V Schmidt
Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice.
Nature 1994;369(6482):669-71.
1994: G P Jeffrey; P S Oates; Timothy C Wang; M W Babyatsky; S J Brand
Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric mucous cells.
Gastroenterology 1994;106(2):336-45.
1994: L G Tillotson; Timothy C Wang; S J Brand
Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein.
The Journal of biological chemistry 1994;269(3):2234-40.
1993: Timothy C Wang; S Bonner-Weir; P S Oates; M Chulak; B Simon; G T Merlino; E V Schmidt; S J Brand
Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells.
The Journal of clinical investigation 1993;92(3):1349-56.
1992: Timothy C Wang; S J Brand
Function and regulation of gastrin in transgenic mice: a review.
The Yale journal of biology and medicine 1992;65(6):705-13; discussion 737-40.
1990: R M Strauss; Timothy C Wang; P B Kelsey; Carolyn Corlies Compton; M J Ferraro; G Perez-Perez; Julie Parsonnet; Martin Blaser
Association of Helicobacter pylori infection with dyspeptic symptoms in patients undergoing gastroduodenoscopy.
The American journal of medicine 1990;89(4):464-9.
1990: Timothy C Wang; S J Brand
Islet cell-specific regulatory domain in the gastrin promoter contains adjacent positive and negative DNA elements.
The Journal of biological chemistry 1990;265(15):8908-14.