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Elias Aizenman

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Tuan D Nguyen; Matthias J Schnell; Peter L Strick; Christoph Wirblich; Elias Aizenman; Karl Kandler
Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracing.
Callie A Norris; Mitchell G Springer; Karen A Hartnett; Kai He; John P Horn; Elias Aizenman
Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A.
R A Saadi; Karen A Hartnett; Kai He; Michal Hershfinkel; Karl Kandler; Elias Aizenman
SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.

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All Publications

2012: Tuan D Nguyen; Matthias J Schnell; Peter L Strick; Christoph Wirblich; Elias Aizenman; Karl Kandler
Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracing.
Journal of neuroscience methods 2012;209(2):367-70.
2012: Callie A Norris; Mitchell G Springer; Karen A Hartnett; Kai He; John P Horn; Elias Aizenman
Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(26):8865-70.
2012: R A Saadi; Karen A Hartnett; Kai He; Michal Hershfinkel; Karl Kandler; Elias Aizenman
SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.
Neuroscience 2012;210():38-46.
2011: Mandar A Aras; Elias Aizenman
Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons.
Antioxidants & redox signaling 2011;15(8):2249-63.
2010: Kai He; Elias Aizenman
ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity.
Journal of neurochemistry 2010;114(2):452-61.
2009: Mandar A Aras; Robert A Saadi; Elias Aizenman
Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia.
The European journal of neuroscience 2009;30(12):2250-7.
2009: Patrick T Redman; Karen A Hartnett; Mandar A Aras; Edwin S Levitan; Elias Aizenman
Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling.
The Journal of physiology 2009;587(Pt 18):4393-404.
2009: Mandar A Aras; Hirokazu Hara; Karen A Hartnett; Karl Kandler; Elias Aizenman
Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.
Journal of neurochemistry 2009;110(1):106-17.
2008: Yeung Ho; Ranmal Samarasinghe; Megan E Knoch; Marcia Lewis; Elias Aizenman; Donald B DeFranco
Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death.
Molecular pharmacology 2008;74(4):1141-51.
2008: Mandar A Aras; Karen A Hartnett; Elias Aizenman
Assessment of cell viability in primary neuronal cultures.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] 2008;Chapter 7():Unit 7.18.
2008: Megan E Knoch; Karen A Hartnett; Hirokazu Hara; Karl Kandler; Elias Aizenman
Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge.
Glia 2008;56(1):89-96.
2007: Yumin Zhang; Elias Aizenman; Donald B DeFranco; Paul A Rosenberg
Intracellular zinc release, 12-lipoxygenase activation and MAPK dependent neuronal and oligodendroglial death.
Molecular medicine (Cambridge, Mass.) 2007;13(7-8):350-5.
2007: Patrick T Redman; Kai He; Karen A Hartnett; Bahiyya S Jefferson; Linda Hu; Paul A Rosenberg; Edwin S Levitan; Elias Aizenman
Apoptotic surge of potassium currents is mediated by p38 phosphorylation of Kv2.1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3568-73.
2006: P T Redman; B S Jefferson; C B Ziegler; Ole V Mortensen; Gonzalo E Torres; Edwin S Levitan; Elias Aizenman
A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity.
Neuroscience 2006;143(1):1-6.
2006: Kai He; Jason Huang; Carl F Lagenaur; Elias Aizenman
Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons.
The Journal of pharmacology and experimental therapeutics 2006;317(3):1320-9.
2006: S K Pal; K Takimoto; Elias Aizenman; Edwin S Levitan
Apoptotic surface delivery of K+ channels.
Cell death and differentiation 2006;13(4):661-7.
2005: Mandar A Aras; Elias Aizenman
Obligatory role of ASK1 in the apoptotic surge of K+ currents.
Neuroscience letters 2005;387(3):136-40.
2005: Hanmi Lee; Carol Xiu-Qing Chen; Yong-Jian Liu; Elias Aizenman; Karl Kandler
KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses.
The European journal of neuroscience 2005;21(9):2593-9.
2005: Peter W Land; Elias Aizenman
Zinc accumulation after target loss: an early event in retrograde degeneration of thalamic neurons.
The European journal of neuroscience 2005;21(3):647-57.
2004: Yumin Zhang; Hong Wang; Jianrong Li; Daniel A Jimenez; Edwin S Levitan; Elias Aizenman; Paul A Rosenberg
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(47):10616-27.
2004: Greta Ann Herin; Elias Aizenman
Amino terminal domain regulation of NMDA receptor function.
European journal of pharmacology 2004;500(1-3):101-11.
2004: Hirokazu Hara; Elias Aizenman
A molecular technique for detecting the liberation of intracellular zinc in cultured neurons.
Journal of neuroscience methods 2004;137(2):175-80.
2004: Sumon Pal; Kai He; Elias Aizenman
Nitrosative stress and potassium channel-mediated neuronal apoptosis: is zinc the link?
Pflügers Archiv : European journal of physiology 2004;448(3):296-303.
2004: Yin Lu; Ya Li; Greta Ann Herin; Elias Aizenman; Paul M Epstein; Paul A Rosenberg
Elevation of intracellular cAMP evokes activity-dependent release of adenosine in cultured rat forebrain neurons.
The European journal of neuroscience 2004;19(10):2669-81.
2004: Elena Zaks-Makhina; Yonjung Kim; Elias Aizenman; Edwin S Levitan
Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast.
Molecular pharmacology 2004;65(1):214-9.
2003: Sumon Pal; Karen A Hartnett; Jeanne M Nerbonne; Edwin S Levitan; Elias Aizenman
Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(12):4798-802.
2003: Daniel N Leszkiewicz; Elias Aizenman
Reversible modulation of GABA(A) receptor-mediated currents by light is dependent on the redox state of the receptor.
The European journal of neuroscience 2003;17(10):2077-83.
2003: BethAnn McLaughlin; Karen A Hartnett; Joseph A Erhardt; Jeffrey J Legos; Ray F White; Frank C Barone; Elias Aizenman
Caspase 3 activation is essential for neuroprotection in preconditioning.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(2):715-20.
2002: Daniel N Leszkiewicz; Beth Ann McLaughlin; Elias Aizenman
Protein kinases and light: unlikely partners in a receptor localization puzzle.
Physiology & behavior 2002;77(4-5):533-6.
2002: Daniel N Leszkiewicz; Elias Aizenman
A role for the redox site in the modulation of the NMDA receptor by light.
The Journal of physiology 2002;545(Pt 2):435-40.
2002: Shen Du; BethAnn McLaughlin; Sumon Pal; Elias Aizenman
In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(17):7408-16.
2002: Jeffrey J Legos; BethAnn McLaughlin; Stephen Skaper; Paul J L M Strijbos; Andrew A Parsons; Elias Aizenman; Greta Ann Herin; Frank C Barone; Joseph A Erhardt
The selective p38 inhibitor SB-239063 protects primary neurons from mild to moderate excitotoxic injury.
European journal of pharmacology 2002;447(1):37-42.
2002: Elias Aizenman; Michael C Sanguinetti
Channels gone bad. Reflections from a Tapas bar.
Neuron 2002;34(5):679-83.
2002: S Santos; Elias Aizenman
Functional expression of muscle-type nicotinic acetylcholine receptors in rat forebrain neurons in vitro.
Methods and findings in experimental and clinical pharmacology 2002;24(2):63-6.
2001: Greta Ann Herin; S Du; Elias Aizenman
The neuroprotective agent ebselen modifies NMDA receptor function via the redox modulatory site.
Journal of neurochemistry 2001;78(6):1307-14.
2001: BethAnn McLaughlin; Sumon Pal; M P Tran; Andrew A Parsons; Frank C Barone; Joseph A Erhardt; Elias Aizenman
p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(10):3303-11.
2000: JD Sinor; S Du; Sriram Venneti; R C Blitzblau; Daniel N Leszkiewicz; Paul A Rosenberg; Elias Aizenman
NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(23):8831-7.
2000: Elias Aizenman; JD Sinor; JC Brimecombe; Greta Ann Herin
Alterations of N-methyl-D-aspartate receptor properties after chemical ischemia.
The Journal of pharmacology and experimental therapeutics 2000;295(2):572-7.
2000: Elias Aizenman; AK Stout; Karen A Hartnett; Kirk E Dineley; BethAnn McLaughlin; Ian J Reynolds
Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release.
Journal of neurochemistry 2000;75(5):1878-88.
2000: Daniel N Leszkiewicz; Karl Kandler; Elias Aizenman
Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro.
The Journal of physiology 2000;524 Pt 2():365-74.
2000: Russell M Sanchez; Chunhe Wang; G Gardner; L Orlando; David L Tauck; Paul A Rosenberg; Elias Aizenman; Frances E Jensen
Novel role for the NMDA receptor redox modulatory site in the pathophysiology of seizures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(6):2409-17.
2000: Y Li-Smerin; Elias Aizenman; Jon W Johnson
Inhibition by intracellular Mg(2+) of recombinant N-methyl-D-aspartate receptors expressed in Chinese hamster ovary cells.
The Journal of pharmacology and experimental therapeutics 2000;292(3):1104-10.
1999: JC Brimecombe; WK Potthoff; Elias Aizenman
A critical role of the N-methyl-D-aspartate (NMDA) receptor subunit (NR) 2A in the expression of redox sensitivity of NR1/NR2A recombinant NMDA receptors.
The Journal of pharmacology and experimental therapeutics 1999;291(2):785-92.
1999: Elias Aizenman; WK Potthoff
Lack of interaction between nitric oxide and the redox modulatory site of the NMDA receptor.
British journal of pharmacology 1999;126(1):296-300.
1998: S R Arden; JD Sinor; WK Potthoff; Elias Aizenman
Subunit-specific interactions of cyanide with the N-methyl-D-aspartate receptor.
The Journal of biological chemistry 1998;273(34):21505-11.
1998: G J Wang; H J Chung; J Schnuer; E Lea; Michael B Robinson; WK Potthoff; Elias Aizenman; Paul A Rosenberg
Dihydrokainate-sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate.
The European journal of neuroscience 1998;10(8):2523-31.
1998: JC Brimecombe; MJ Gallagher; David R Lynch; Elias Aizenman
An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors.
The Journal of pharmacology and experimental therapeutics 1998;286(2):627-34.
1998: K Hoyt; S R Arden; Elias Aizenman; Ian J Reynolds
Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons.
Molecular pharmacology 1998;53(4):742-9.
1998: Elias Aizenman; JC Brimecombe; WK Potthoff; Paul A Rosenberg
Why is the role of nitric oxide in NMDA receptor function and dysfunction so controversial?
Progress in brain research 1998;118():53-71.
1997: JC Brimecombe; FA Boeckman; Elias Aizenman
Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):11019-24.
1997: Joelle M Scanlon; Elias Aizenman; Ian J Reynolds
Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons.
European journal of pharmacology 1997;326(1):67-74.
1997: Karen A Hartnett; AK Stout; S Rajdev; Paul A Rosenberg; Ian J Reynolds; Elias Aizenman
NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro.
Journal of neurochemistry 1997;68(5):1836-45.
1997: JD Sinor; FA Boeckman; Elias Aizenman
Intrinsic redox properties of N-methyl-D-aspartate receptor can determine the developmental expression of excitotoxicity in rat cortical neurons in vitro.
Brain research 1997;747(2):297-303.
1997: Thomas A Blanpied; FA Boeckman; Elias Aizenman; Jon W Johnson
Trapping channel block of NMDA-activated responses by amantadine and memantine.
Journal of neurophysiology 1997;77(1):309-23.
1996: F A Boeckman; Elias Aizenman
Pharmacological properties of acquired excitotoxicity in Chinese hamster ovary cells transfected with N-methyl-D-aspartate receptor subunits.
The Journal of pharmacology and experimental therapeutics 1996;279(2):515-23.
1995: Elias Aizenman
Modulation of N-methyl-D-aspartate receptors by hydroxyl radicals in rat cortical neurons in vitro.
Neuroscience letters 1995;189(1):57-9.
1995: T A Newcomer; Paul A Rosenberg; Elias Aizenman
Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin.
Journal of neurochemistry 1995;64(4):1742-8.
1995: T A Newcomer; Paul A Rosenberg; Elias Aizenman
TOPA quinone, a kainate-like agonist and excitotoxin is generated by a catecholaminergic cell line.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):3172-7.
1994: E K Speliotes; K A Hartnett; R C Blitzblau; Elias Aizenman; Paul A Rosenberg
Comparison of the potency of competitive NMDA antagonists against the neurotoxicity of glutamate and NMDA.
Journal of neurochemistry 1994;63(3):879-85.
1994: Frances E Jensen; G J Gardner; A P Williams; P M Gallop; Elias Aizenman; Paul A Rosenberg
The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury.
Neuroscience 1994;62(2):399-406.
1994: F A Boeckman; Elias Aizenman
Stable transfection of the NR1 subunit in Chinese hamster ovary cells fails to produce a functional N-methyl-D-aspartate receptor.
Neuroscience letters 1994;173(1-2):189-92.
1994: Elias Aizenman; Frances E Jensen; P M Gallop; Paul A Rosenberg; L H Tang
Further evidence that pyrroloquinoline quinone interacts with the N-methyl-D-aspartate receptor redox site in rat cortical neurons in vitro.
Neuroscience letters 1994;168(1-2):189-92.
1993: L H Tang; Elias Aizenman
Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitro.
Neuron 1993;11(5):857-63.
1993: T A Newcomer; Alan Palmer; Paul A Rosenberg; Elias Aizenman
Nonenzymatic conversion of 3,4-dihydroxyphenylalanine to 2,4,5-trihydroxyphenylalanine and 2,4,5-trihydroxyphenylalanine quinone in physiological solutions.
Journal of neurochemistry 1993;61(3):911-20.
1993: L H Tang; Elias Aizenman
Long-lasting modification of the N-methyl-D-aspartate receptor channel by a voltage-dependent sulfhydryl redox process.
Molecular pharmacology 1993;44(2):473-8.
1993: L H Tang; Elias Aizenman
The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro.
The Journal of physiology 1993;465():303-23.
1993: Ian J Reynolds; D M Zeleski; K D Rothermund; K A Hartnett; R Tidwell; Elias Aizenman
Studies on the effects of several pentamidine analogues on the NMDA receptor.
European journal of pharmacology 1993;244(2):175-9.
1992: K Hoyt; L H Tang; Elias Aizenman; Ian J Reynolds
Nitric oxide modulates NMDA-induced increases in intracellular Ca2+ in cultured rat forebrain neurons.
Brain research 1992;592(1-2):310-6.
1992: Elias Aizenman; F A Boeckman; Paul A Rosenberg
Glutathione prevents 2,4,5-trihydroxyphenylalanine excitotoxicity by maintaining it in a reduced, non-active form.
Neuroscience letters 1992;144(1-2):233-6.
1992: Elias Aizenman; K A Hartnett
The action of CGS-19755 on the redox enhancement of NMDA toxicity in rat cortical neurons in vitro.
Brain research 1992;585(1-2):28-34.
1992: Elias Aizenman; K A Hartnett; C Zhong; P M Gallop; Paul A Rosenberg
Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(6):2362-9.
1992: Elias Aizenman; Ian J Reynolds
Modulation of NMDA excitotoxicity by redox reagents.
Annals of the New York Academy of Sciences 1992;648():125-31.
1992: Ian J Reynolds; Elias Aizenman
Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1992;12(3):970-5.
1991: K R Gilbert; Elias Aizenman; Ian J Reynolds
Oxidized glutathione modulates N-methyl-D-aspartate- and depolarization-induced increases in intracellular Ca2+ in cultured rat forebrain neurons.
Neuroscience letters 1991;133(1):11-4.
1991: Elias Aizenman; L H Tang; Ian J Reynolds
Effects of nicotinic agonists on the NMDA receptor.
Brain research 1991;551(1-2):355-7.
1991: Paul A Rosenberg; R Loring; Y Xie; V Zaleskas; Elias Aizenman
2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(11):4865-9.
1991: N J Sucher; Elias Aizenman; S A Lipton
N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(4):966-71.
1991: D W Schulz; R H Loring; Elias Aizenman; Richard E Zigmond
Autoradiographic localization of putative nicotinic receptors in the rat brain using 125I-neuronal bungarotoxin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(1):287-97.
1990: Elias Aizenman; K A Hartnett; Ian J Reynolds
Oxygen free radicals regulate NMDA receptor function via a redox modulatory site.
Neuron 1990;5(6):841-6.
1990: Ian J Reynolds; E A Rush; Elias Aizenman
Reduction of NMDA receptors with dithiothreitol increases [3H]-MK-801 binding and NMDA-induced Ca2+ fluxes.
British journal of pharmacology 1990;101(1):178-82.
1990: Elias Aizenman; W F White; R H Loring; Paul A Rosenberg
A 3,4-dihydroxyphenylalanine oxidation product is a non-N-methyl-D-aspartate glutamatergic agonist in rat cortical neurons.
Neuroscience letters 1990;116(1-2):168-71.
1990: Elias Aizenman; R H Loring; S A Lipton
Blockade of nicotinic responses in rat retinal ganglion cells by neuronal bungarotoxin.
Brain research 1990;517(1-2):209-14.
1989: Elias Aizenman; A Karschin; S A Lipton
Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro.
European journal of pharmacology 1989;174(1):9-22.
1989: Paul A Rosenberg; Elias Aizenman
Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex.
Neuroscience letters 1989;103(2):162-8.
1989: R H Loring; Elias Aizenman; S A Lipton; Richard E Zigmond
Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(7):2423-31.
1989: Elias Aizenman; S A Lipton; R H Loring
Selective modulation of NMDA responses by reduction and oxidation.
Neuron 1989;2(3):1257-63.
1988: J S Hahn; Elias Aizenman; S A Lipton
Central mammalian neurons normally resistant to glutamate toxicity are made sensitive by elevated extracellular Ca2+: toxicity is blocked by the N-methyl-D-aspartate antagonist MK-801.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6556-60.
1988: A Karschin; Elias Aizenman; S A Lipton
The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(8):2895-906.
1988: S A Lipton; M P Frosch; M D Phillips; David L Tauck; Elias Aizenman
Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture.
Science (New York, N.Y.) 1988;239(4845):1293-6.
1988: Elias Aizenman; M P Frosch; S A Lipton
Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat.
The Journal of physiology 1988;396():75-91.
1987: S A Lipton; Elias Aizenman; R H Loring
Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells.
Pflügers Archiv : European journal of physiology 1987;410(1-2):37-43.