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Cord Brakebusch

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Krishna C Vadodaria; Ueli Suter; Cord Brakebusch; Sebastian Jessberger
Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis.
Nancy Luckashenak; Anna Wähe; Cord Brakebusch; Katharina Breit; Thomas Brocker
Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
Sebastian A Wagner; Brian T Weinert; Clifford Young; Petra Beli; Cord Brakebusch; Christian D Kelstrup; Michael L Nielsen; Jesper V Olsen; Christian Schölz; Chunaram Choudhary
Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.

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All Publications

2013: Krishna C Vadodaria; Ueli Suter; Cord Brakebusch; Sebastian Jessberger
Stage-specific functions of the small Rho GTPases Cdc42 and Rac1 for adult hippocampal neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(3):1179-89.
2013: Nancy Luckashenak; Anna Wähe; Cord Brakebusch; Katharina Breit; Thomas Brocker
Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(1):27-35.
2012: Sebastian A Wagner; Brian T Weinert; Clifford Young; Petra Beli; Cord Brakebusch; Christian D Kelstrup; Michael L Nielsen; Jesper V Olsen; Christian Schölz; Chunaram Choudhary
Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Molecular & cellular proteomics : MCP 2012;11(12):1578-85.
2012: Esben Pedersen; Karine Peyrollier; Fabio Quondamatteo; Lennart M Rösner; Alanna Stanley; Zhipeng Wang; Thomas Werfel; Cord Brakebusch
RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1.
Journal of cell science 2012;125(Pt 22):5379-90.
2012: Esben Pedersen; Cord Brakebusch
Rho GTPase function in development: how in vivo models change our view.
Experimental cell research 2012;318(14):1779-87.
2012: Rizaldy P Scott; Julie Ruston; Cord Brakebusch; Jianmei Du; Steve P Hawley; Nina Jones; Tony Pawson
Podocyte-specific loss of Cdc42 leads to congenital nephropathy.
Journal of the American Society of Nephrology : JASN 2012;23(7):1149-54.
2012: Christina M Baker; Cord Brakebusch; Hung-Li Chung; William A Comrie; Christine A Fedorchuk; Young-Min Hyun; Kihong Lim; James L McGrath; Martin Meier-Schellersheim; Richard E Waugh; Minsoo Kim
Opposing roles for RhoH GTPase during T-cell migration and activation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10474-9.
2012: Jennifer Block; Cord Brakebusch; Dennis Breitsprecher; Patrick Duwe; Jan Faix; Robert Geffers; Matthias Geyer; Frieda Kage; Sonja Kühn; Jennifer L Rohn; Theresia E B Stradal; Moritz Winterhoff; Buzz Baum; Klemens Rottner
FMNL2 drives actin-based protrusion and migration downstream of Cdc42.
Current biology : CB 2012;22(11):1005-12.
2012: Silvia Cappello; Karl-Klaus Conzelmann; Alexander Ghanem; Manuela Allegra; Paola Arlotta; Matteo Bergami; Christian R J Böhringer; Cord Brakebusch; Matteo Caleo; Marco Mainardi; Giulio Srubek Tomassy; Jolanda van Hengel; Magdalena Götz
A radial glia-specific role of RhoA in double cortex formation.
Neuron 2012;73(5):911-24.
2012: Ryotaro Sakamori; Ewa Stypulkowski; Waixing Tang; Shiyan Yu; Cord Brakebusch; Soumyashree Das; Veronique Douard; Shanshan Feng; Ronaldo P Ferraris; Yinzheng Guan; Wei Guo; Akihiro Harada; Nan Gao
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
The Journal of clinical investigation 2012;122(3):1052-65.
2012: Kristina Behrendt; Wilhelm Bloch; Cord Brakebusch; Jennifer Klatte; Thomas Krieg; Catherin Niemann; Carien M Niessen; Ralf Paus; Ruth Pofahl; Neil Smyth; Michael Tscharntke; Ingo Haase
A function for Rac1 in the terminal differentiation and pigmentation of hair.
Journal of cell science 2012;125(Pt 4):896-905.
2012: Irina Pleines; Jolanda van Hengel; Stefan Offermanns; Cord Brakebusch; Lidija Chakarova; Shuchi Gupta; Ina Hagedorn; Christoph Kleinschnitz; Georg Krohne; Frauke May; Bernhard Nieswandt
Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis.
Blood 2012;119(4):1054-63.
2012: Tommi Anttonen; Ilya Belevich; Cord Brakebusch; Eija Jokitalo; Anna Kirjavainen; Maarja Laos; William D Richardson; Ulla Pirvola
Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood.
Scientific reports 2012;2():978.
2012: Esben Pedersen; Karine Peyrollier; Astrid Basse; Tine Lefever; Cord Brakebusch
Rho GTPase knockout induction in primary keratinocytes from adult mice.
Methods in molecular biology (Clifton, N.J.) 2012;827():157-66.
2011: Stefanie Robel; Alexandra Lepier; Sophia Bardehle; Cord Brakebusch; Magdalena Götz
Genetic deletion of cdc42 reveals a crucial role for astrocyte recruitment to the injury site in vitro and in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(35):12471-82.
2011: Yanmei Qi; Xunwei Wu; Jie Liu; Stephen F Lowry; Cord Brakebusch; Siobhan A Corbett; Alan M Graham; Yaling Han; Michael Leitges; Shaohua Li
Cdc42 controls vascular network assembly through protein kinase Cι during embryonic vasculogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(8):1861-70.
2011: Dominik Herzog; Pirmin Loetscher; Jolanda van Hengel; Sebastian Knüsel; Cord Brakebusch; Verdon Taylor; Ueli Suter; João B Relvas
The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(13):5120-30.
2011: Ben Jackson; Karine Peyrollier; Esben Pedersen; Astrid Basse; Richard Karlsson; Zhipeng Wang; Tine Lefever; Alexandra M Ochsenbein; Gudula Schmidt; Klaus Aktories; Alanna Stanley; Fabio Quondamatteo; Markus Ladwein; Klemens Rottner; Jolanda van Hengel; Cord Brakebusch
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes.
Molecular biology of the cell 2011;22(5):593-605.
2011: Stefan Porubsky; Shijun Wang; Eva Kiss; Stefan Dehmel; Mahnaz Bonrouhi; Tatjana Dorn; Bruno Luckow; Cord Brakebusch; Hermann-Josef Gröne
Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.
European journal of immunology 2011;41(1):76-88.
2010: Dino P Leone; Karpagam Srinivasan; Cord Brakebusch; Susan K McConnell
The rho GTPase Rac1 is required for proliferation and survival of progenitors in the developing forebrain.
Developmental neurobiology 2010;70(9):659-78.
2010: Xiaowen He; Jie Liu; Yanmei Qi; Cord Brakebusch; Anna Chrostek-Grashoff; David Edgar; Peter D Yurchenco; Siobhan A Corbett; Stephen F Lowry; Alan M Graham; Yaling Han; Shaohua Li
Rac1 is essential for basement membrane-dependent epiblast survival.
Molecular and cellular biology 2010;30(14):3569-81.
2010: Sabina Tahirovic; farida hellal; Dorothee Neukirchen; Robert Hindges; Boyan K Garvalov; Kevin C Flynn; Theresia E Stradal; Anna Chrostek-Grashoff; Cord Brakebusch; Frank Bradke
Rac1 regulates neuronal polarization through the WAVE complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(20):6930-43.
2010: Tine Lefever; Esben Pedersen; Astrid Basse; Ralf Paus; Fabio Quondamatteo; Alanna C Stanley; Lutz Langbein; Xunwei Wu; Jürgen Wehland; Silvia Lommel; Cord Brakebusch
N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways.
Journal of cell science 2010;123(Pt 1):128-40.
2009: R Karlsson; E D Pedersen; Z Wang; Cord Brakebusch
Rho GTPase function in tumorigenesis.
Biochimica et biophysica acta 2009;1796(2):91-8.
2009: Gokul Kesavan; Fredrik Wolfhagen Sand; Thomas Uwe Greiner; Jenny Johansson; Sune Kobberup; Xunwei Wu; Cord Brakebusch; Henrik Semb
Cdc42-mediated tubulogenesis controls cell specification.
Cell 2009;139(4):791-801.
2009: Ursula Haditsch; Dino P Leone; Mélissa Farinelli; Anna Chrostek-Grashoff; Cord Brakebusch; Isabelle M Mansuy; Susan K McConnell; Theo D Palmer
A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory.
Molecular and cellular neurosciences 2009;41(4):409-19.
2009: Tim Lämmermann; Jörg Renkawitz; Xunwei Wu; Karin Hirsch; Cord Brakebusch; Michael Sixt
Cdc42-dependent leading edge coordination is essential for interstitial dendritic cell migration.
Blood 2009;113(23):5703-10.
2009: Elena Vasyutina; Benedetta Martarelli; Cord Brakebusch; Hagen Wende; Carmen Birchmeier
The small G-proteins Rac1 and Cdc42 are essential for myoblast fusion in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(22):8935-40.
2009: Dan Du; Esben Pedersen; Zhipeng Wang; Richard Karlsson; Zhengjun Chen; Xunwei Wu; Cord Brakebusch
Cdc42 is crucial for the maturation of primordial cell junctions in keratinocytes independent of Rac1.
Experimental cell research 2009;315(8):1480-9.
2009: Sebastian Fuchs; Dominik Herzog; Grzegorz Sumara; Stine Büchmann-Møller; Gianluca Civenni; Xunwei Wu; Anna Chrostek-Grashoff; Ueli Suter; Romeo Ricci; João B Relvas; Cord Brakebusch; Lukas Sommer
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.
Cell stem cell 2009;4(3):236-47.
2009: Irina Pleines; Margitta Elvers; Amrei Strehl; Miroslava Pozgajova; David Varga-Szabo; Frauke May; Anna Chrostek-Grashoff; Cord Brakebusch; Bernhard Nieswandt
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Pflügers Archiv : European journal of physiology 2009;457(5):1173-85.
2009: Martina Bauer; Cord Brakebusch; Caroline Coisne; Michael Sixt; Hartmut Wekerle; Britta Engelhardt; Reinhard Fässler
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1920-5.
2009: Aleksandra Piwko-Czuchra; Heidi Koegel; Hannelore Meyer; Martina Bauer; Sabine Werner; Cord Brakebusch; Reinhard Fässler
Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.
PloS one 2009;4(5):e5488.
2009: Haixin Yuan; Hong Zhang; Xunwei Wu; Zhe Zhang; Dan Du; Wenchao Zhou; Shuhua Zhou; Cord Brakebusch; Zhengjun Chen
Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice.
Hepatology (Baltimore, Md.) 2009;49(1):240-9.
2008: Jolanda van Hengel; Petra D'Hooge; Bart Hooghe; Xunwei Wu; Louis Libbrecht; Rita De Vos; Fabio Quondamatteo; Martina Klempt; Cord Brakebusch; Frans van Roy
Continuous cell injury promotes hepatic tumorigenesis in cdc42-deficient mouse liver.
Gastroenterology 2008;134(3):781-92.
2007: Boyan K Garvalov; Kevin C Flynn; Dorothee Neukirchen; Liane Meyn; Nicole Teusch; Xunwei Wu; Cord Brakebusch; James R Bamburg; Frank Bradke
Cdc42 regulates cofilin during the establishment of neuronal polarity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(48):13117-29.
2007: Xunwei Wu; Shaohua Li; Anna Chrostek-Grashoff; Aleksandra Czuchra; Hannelore Meyer; Peter D Yurchenco; Cord Brakebusch
Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(10):2767-78.
2007: Tanja Bosse; Julia Ehinger; Aleksandra Czuchra; Stefanie Benesch; Anika Steffen; Xunwei Wu; Kathrin Schloen; Hartmut H Niemann; Giorgio Scita; Theresia E B Stradal; Cord Brakebusch; Klemens Rottner
Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways.
Molecular and cellular biology 2007;27(19):6615-28.
2007: Yves Benninger; Tina Thurnherr; Jorge A Pereira; Sven Krause; Xunwei Wu; Anna Chrostek-Grashoff; Dominik Herzog; Klaus-Armin Nave; Robin J M Franklin; Dies Meijer; Cord Brakebusch; Ueli Suter; João B Relvas
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.
The Journal of cell biology 2007;177(6):1051-61.
2007: Michael Tscharntke; Ruth Pofahl; Anna Chrostek-Grashoff; Neil Smyth; Carien M Niessen; Catherin Niemann; Benedikt Hartwig; Volker Herzog; Helmut W Klein; Thomas Krieg; Cord Brakebusch; Ingo Haase
Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1.
Journal of cell science 2007;120(Pt 8):1480-90.
2007: Tatjana Dorn; Ursula Kuhn; Gerd Bungartz; Sebastian Stiller; Martina Bauer; Joachim W Ellwart; Thorsten Peters; Karin Scharffetter-Kochanek; Monika Semmrich; Melanie Laschinger; Bernhard Holzmann; Wolfgang E F Klinkert; Per thor Straten; Tania Køllgaard; Michael Sixt; Cord Brakebusch
RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Blood 2007;109(6):2346-55.
2006: Tina Thurnherr; Yves Benninger; Xunwei Wu; Anna Chrostek; Sven M Krause; Klaus-Armin Nave; Robin J M Franklin; Cord Brakebusch; Ueli Suter; João B Relvas
Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(40):10110-9.
2006: Xunwei Wu; Fabio Quondamatteo; Cord Brakebusch
Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(8):466-74.
2006: Gerd Bungartz; Sebastian Stiller; Martina Bauer; Werner Müller; Angela Schippers; Norbert Wagner; Reinhard Fässler; Cord Brakebusch
Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.
Blood 2006;108(6):1857-64.
2006: Aleksandra Czuchra; Hannelore Meyer; Kyle Legate; Cord Brakebusch; Reinhard Fässler
Genetic analysis of beta1 integrin "activation motifs" in mice.
The Journal of cell biology 2006;174(6):889-99.
2006: Anna Chrostek; Xunwei Wu; Fabio Quondamatteo; Rong Hu; Anna Sanecka; Catherin Niemann; Lutz Langbein; Ingo Haase; Cord Brakebusch
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis.
Molecular and cellular biology 2006;26(18):6957-70.
2006: Silvia Cappello; Alessio Attardo; Xunwei Wu; Takuji Iwasato; Shigeyoshi Itohara; Michaela Wilsch-Bräuninger; Hanna M Eilken; Michael A Rieger; Timm Schroeder; Wieland B Huttner; Cord Brakebusch; Magdalena Götz
The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface.
Nature neuroscience 2006;9(9):1099-107.
2006: Marie A Breau; Thomas PIETRI; Olivier Eder; Martine Blanche; Cord Brakebusch; Reinhard Fässler; Jean Paul Thiery; Sylvie Dufour
Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.
Development (Cambridge, England) 2006;133(9):1725-34.
2006: Stina Nilsson; Dorota Kaniowska; Cord Brakebusch; Reinhard Fässler; Staffan Johansson
Threonine 788 in integrin subunit beta1 regulates integrin activation.
Experimental cell research 2006;312(6):844-53.
2006: Nils Cordes; J Seidler; R Durzok; H Geinitz; Cord Brakebusch
beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.
Oncogene 2006;25(9):1378-90.
2006: Xunwei Wu; Fabio Quondamatteo; Tine Lefever; Aleksandra Czuchra; Hannelore Meyer; Anna Chrostek; Ralf Paus; Lutz Langbein; Cord Brakebusch
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Genes & development 2006;20(5):571-85.
2005: Aleksandra Czuchra; Xunwei Wu; Hannelore Meyer; Jolanda van Hengel; Timm Schroeder; Robert Geffers; Klemens Rottner; Cord Brakebusch
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.
Molecular biology of the cell 2005;16(10):4473-84.
2005: Cord Brakebusch; Reinhard Fässler
beta 1 integrin function in vivo: adhesion, migration and more.
Cancer metastasis reviews 2005;24(3):403-11.
2005: Julia Seidler; Rita Durzok; Cord Brakebusch; Nils Cordes
Interactions of the integrin subunit beta1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2005;76(2):129-34.
2005: Dino P Leone; João B Relvas; Lia S Campos; Silvio Hemmi; Cord Brakebusch; Reinhard Fässler; Charles ffrench-Constant; Ueli Suter
Regulation of neural progenitor proliferation and survival by beta1 integrins.
Journal of cell science 2005;118(Pt 12):2589-99.
2005: Jan Marsal; Cord Brakebusch; Gerd Bungartz; Reinhard Fässler; William W Agace
beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.
European journal of immunology 2005;35(6):1805-11.
2004: Sofia Xanthoulea; Manolis Pasparakis; Stavroula Kousteni; Cord Brakebusch; David Wallach; Jan Bauer; Hans Lassmann; george kollias
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.
The Journal of experimental medicine 2004;200(3):367-76.
2004: Thomas PIETRI; Olivier Eder; Marie Anne Breau; Piotr Topilko; Martine Blanche; Cord Brakebusch; Reinhard Fässler; Jean Paul Thiery; Sylvie Dufour
Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.
Development (Cambridge, England) 2004;131(16):3871-83.
2004: Lia S Campos; Dino P Leone; João B Relvas; Cord Brakebusch; Reinhard Fässler; Ueli Suter; Charles ffrench-Constant
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance.
Development (Cambridge, England) 2004;131(14):3433-44.
2003: Sabine Grüner; Miroslava Prostredna; Valerie Schulte; Thomas Krieg; Beate Eckes; Cord Brakebusch; Bernhard Nieswandt
Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.
Blood 2003;102(12):4021-7.
2003: Ewa Sitnicka; Cord Brakebusch; Inga-Lill Martensson; Marcus Svensson; William W Agace; Mikael Sigvardsson; Natalija Buza-Vidas; David Bryder; Corrado M Cilio; Henrik Ahlenius; Eugene Maraskovsky; Jacques J Peschon; Sten Eirik W Jacobsen
Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.
The Journal of experimental medicine 2003;198(10):1495-506.
2003: Attila Aszodi; Ernst B Hunziker; Cord Brakebusch; Reinhard Fässler
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Genes & development 2003;17(19):2465-79.
2003: Cord Brakebusch; Reinhard Fässler
The integrin-actin connection, an eternal love affair.
The EMBO journal 2003;22(10):2324-33.
2003: Marijke J E Kuijpers; Valerie Schulte; Wolfgang Bergmeier; Theo Lindhout; Cord Brakebusch; Stefan Offermanns; Reinhard Fässler; Johan W M Heemskerk; Bernhard Nieswandt
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):685-7.
2003: Wilko D Altrock; Susanne tom Dieck; Maxim Sokolov; Alexander C Meyer; Albrecht Sigler; Cord Brakebusch; Reinhard Fässler; Karin Richter; Tobias M Boeckers; Heidrun Potschka; Claudia Brandt; Wolfgang Löscher; Dörte Grimberg; Thomas Dresbach; Anne Hempelmann; Hadir Hassan; Detlef Balschun; Julietta U Frey; Johann Helmut Brandstätter; Craig C Garner; christian rosenmund; Eckart D Gundelfinger
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.
Neuron 2003;37(5):787-800.
2003: Zhi-Yong He; Cord Brakebusch; Reinhard Fässler; Jordan A Kreidberg; Paul Primakoff; Diana G Myles
None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion.
Developmental biology 2003;254(2):226-37.
2002: Erik H J Danen; Petra Sonneveld; Cord Brakebusch; Reinhard Fassler; Arnoud Sonnenberg
The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis.
The Journal of cell biology 2002;159(6):1071-86.
2002: Cord Brakebusch; Constanze I Seidenbecher; Fredrik Asztely; Uwe Rauch; Henry Matthies; Hannelore Meyer; Manfred Krug; Tobias M Böckers; Xiaohong Zhou; Michael R Kreutz; Dirk Montag; Eckart D Gundelfinger; Reinhard Fässler
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory.
Molecular and cellular biology 2002;22(21):7417-27.
2002: Anna Gustavsson; Annika Armulik; Cord Brakebusch; Reinhard Fässler; Staffan Johansson; Maria Fällman
Role of the beta1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia.
Journal of cell science 2002;115(Pt 13):2669-78.
2002: Richard Grose; Caroline Hutter; Wilhelm Bloch; Irmgard S Thorey; Fiona M Watt; Reinhard Fässler; Cord Brakebusch; Sabine Werner
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.
Development (Cambridge, England) 2002;129(9):2303-15.
2002: Cord Brakebusch; Daniel Bouvard; Fabio Stanchi; Takao Sakai; Reinhard Fässler
Integrins in invasive growth.
The Journal of clinical investigation 2002;109(8):999-1006.
2002: Cord Brakebusch; Simon Fillatreau; Alexandre J Potocnik; Gerd Bungartz; Patricia Wilhelm; Marcus Svensson; Phil Kearney; Heinrich Korner; David Gray; Reinhard Fässler
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
Immunity 2002;16(3):465-77.
2001: Martyn A J Chidgey; Cord Brakebusch; Erika Elisabet Gustafsson; A Cruchley; C Hail; S Kirk; Anita J Merritt; AJ North; C Tselepis; J Hewitt; Carolyn Byrne; Reinhard Fassler; David R Garrod
Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation.
The Journal of cell biology 2001;155(5):821-32.
2001: Xiao-Hong Zhou; Cord Brakebusch; Henry Matthies; Toshitaka Oohashi; E Hirsch; M Moser; Manfred Krug; Constanze I Seidenbecher; Tobias M Boeckers; Uwe Rauch; R Buettner; Eckart D Gundelfinger; Reinhard Fässler
Neurocan is dispensable for brain development.
Molecular and cellular biology 2001;21(17):5970-8.
2001: Daniel Bouvard; Cord Brakebusch; Erika Elisabet Gustafsson; Attila Aszódi; T Bengtsson; A Berna; Reinhard Fässler
Functional consequences of integrin gene mutations in mice.
Circulation research 2001;89(3):211-23.
2001: Wolfgang Bergmeier; Daniel Bouvard; J A Eble; R Mokhtari-Nejad; Valerie Schulte; Hubert Zirngibl; Cord Brakebusch; Reinhard Fässler; Bernhard Nieswandt
Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha.
The Journal of biological chemistry 2001;276(27):25121-6.
2001: Bernhard Nieswandt; Cord Brakebusch; Wolfgang Bergmeier; Valerie Schulte; Daniel Bouvard; R Mokhtari-Nejad; Theo Lindhout; Johan W M Heemskerk; Hubert Zirngibl; Reinhard Fässler
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
The EMBO journal 2001;20(9):2120-30.
2001: Michael Henry; Jakob S Satz; Cord Brakebusch; Mercedes Costell; Erika Elisabet Gustafsson; Reinhard Fässler; Kevin P Campbell
Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.
Journal of cell science 2001;114(Pt 6):1137-44.
2001: Erika Elisabet Gustafsson; Cord Brakebusch; K Hietanen; Reinhard Fässler
Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice.
Journal of cell science 2001;114(Pt 4):671-6.
2000: Cord Brakebusch; Richard Grose; Fabio Quondamatteo; A Ramirez; J L Jorcano; A Pirro; M Svensson; Rainer Herken; T Sasaki; Rupert Timpl; Sabine Werner; Reinhard Fässler
Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes.
The EMBO journal 2000;19(15):3990-4003.
2000: Jill Dixon; Cord Brakebusch; R Fässler; Michael J Dixon
Increased levels of apoptosis in the prefusion neural folds underlie the craniofacial disorder, Treacher Collins syndrome.
Human molecular genetics 2000;9(10):1473-80.
2000: Alexandre J Potocnik; Cord Brakebusch; Reinhard Fässler
Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow.
Immunity 2000;12(6):653-63.
2000: K Iba; Reidar Albrechtsen; BJ Gilpin; Camilla Fröhlich; Frosty Loechel; A Zolkiewska; K Ishiguro; T Kojima; Wei Liu; J Kevin Langford; Ralph D Sanderson; Cord Brakebusch; Reinhard Fässler; Ulla M Wewer
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.
The Journal of cell biology 2000;149(5):1143-56.
1999: C Gimond; Arjan van der Flier; S van Delft; Cord Brakebusch; Ingrid Kuikman; John G Collard; R Fässler; Arnoud Sonnenberg
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function.
The Journal of cell biology 1999;147(6):1325-40.
1999: Cord Brakebusch; K Wennerberg; Hans-Willi Krell; UH Weidle; A Sallmyr; S Johansson; Reinhard Fässler
Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.
Oncogene 1999;18(26):3852-61.
1999: Cord Brakebusch; Irmi Sures; Bahija Jallal; K Mossie; O Fusco; Stefano Iacobelli; Axel Ullrich
Isolation and functional characterization of the human 90K promoter.
Genomics 1999;57(2):268-78.
1999: Jan F Talts; Cord Brakebusch; Reinhard Fässler
Integrin gene targeting.
Methods in molecular biology (Clifton, N.J.) 1999;129():153-87.
1997: Cord Brakebusch; E Hirsch; Alexandre J Potocnik; Reinhard Fässler
Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.
Journal of cell science 1997;110 ( Pt 23)():2895-904.
1997: Wilhelm Bloch; E Forsberg; S Lentini; Cord Brakebusch; K Martin; Hans-Willi Krell; UH Weidle; Klaus Addicks; Reinhard Fässler
Beta 1 integrin is essential for teratoma growth and angiogenesis.
The Journal of cell biology 1997;139(1):265-78.
1997: Uwe Rauch; Hannelore Meyer; Cord Brakebusch; Constanze I Seidenbecher; Eckart D Gundelfinger; David Beier; Reinhard Fässler
Sequence and chromosomal localization of the mouse brevican gene.
Genomics 1997;44(1):15-21.
1997: Cord Brakebusch; Bahija Jallal; O Fusco; Stefano Iacobelli; Axel Ullrich
Expression of the 90K immunostimulator gene is controlled by a promoter with unique features.
The Journal of biological chemistry 1997;272(6):3674-82.
1995: Bahija Jallal; J Powell; J Zachwieja; Cord Brakebusch; L Germain; J Jacobs; S Iacobelli; A Ullrich
Suppression of tumor growth in vivo by local and systemic 90K level increase.
Cancer research 1995;55(15):3223-7.