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Axel Brakhage

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Aspergillosis

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Claudia C König; Sandor Nietzsche; Kirstin Scherlach; Volker Schroeckh; Axel A Brakhage; Fabian Horn; Christian Hertweck
Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic Fungus Aspergillus fumigatus.
Petra Bacher; Axel A Brakhage; Olaf Kniemeyer; Christian Schink; Janka Teutschbein; Mario Assenmacher; Alexander Scheffold
Antigen-reactive T cell enrichment for direct, high-resolution analysis of the human naive and memory Th cell repertoire.
Daniel H Scharf; Axel A Brakhage
Engineering fungal secondary metabolism: a roadmap to novel compounds.

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2013: Claudia C König; Sandor Nietzsche; Kirstin Scherlach; Volker Schroeckh; Axel A Brakhage; Fabian Horn; Christian Hertweck
Bacterium Induces Cryptic Meroterpenoid Pathway in the Pathogenic Fungus Aspergillus fumigatus.
Chembiochem : a European journal of chemical biology 2013;14(8):938-42.
2013: Petra Bacher; Axel A Brakhage; Olaf Kniemeyer; Christian Schink; Janka Teutschbein; Mario Assenmacher; Alexander Scheffold
Antigen-reactive T cell enrichment for direct, high-resolution analysis of the human naive and memory Th cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):3967-76.
2013: Daniel H Scharf; Axel A Brakhage
Engineering fungal secondary metabolism: a roadmap to novel compounds.
Journal of biotechnology 2013;163(2):179-83.
2013: Laetitia Muszkieta; Vera Pähtz; Antonis Rokas; Kazutoshi Shibuya; Véronique Anton Leberre; Rémi Beau; Anne Beauvais; Axel A Brakhage; Jean M Francois; John G Gibbons; Olaf Kniemeyer; Jean P Latgé
Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches.
Frontiers in microbiology 2013;4():13.
2013: Axel A Brakhage
Regulation of fungal secondary metabolism.
Nature reviews. Microbiology 2013;11(1):21-32.
2012: Eva M Huber; Daniel H Scharf; Michael Groll; Peter Hortschansky; Axel A Brakhage
DNA minor groove sensing and widening by the CCAAT-binding complex.
Structure (London, England : 1993) 2012;20(10):1757-68.
2012: Daniel H Scharf; Kirstin Scherlach; Martin Roth; Axel A Brakhage; Pranatchareeya Chankhamjon; Thorsten Heinekamp; Christian Hertweck
Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway.
Angewandte Chemie (International ed. in English) 2012;51(40):10064-8.
2012: Christian Gil Girol; Stefan Günther; Thorsten Heinekamp; Wolfgang Hüttel; Axel A Brakhage; Katja Maria Fisch; Jörn Piel; Michael Müller
Regio- and stereoselective oxidative phenol coupling in Aspergillus niger.
Angewandte Chemie (International ed. in English) 2012;51(39):9788-91.
2012: Anindita Sarkar; Kirstin Scherlach; Volker Schroeckh; Martin Westermann; Axel A Brakhage; Pranatchareeya Chankhamjon; Alexander N Funk; Christian Hertweck; Fabian Horn; Martin Roth; Uwe Horn
Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans.
Journal of biotechnology 2012;160(1-2):64-71.
2012: Dirk Wartenberg; Mirko Weide; Robert Winkler; Daniela Albrecht-Eckardt; Olaf Kniemeyer; Kirstin Scherlach; Martin Vödisch; Axel A Brakhage
Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.
Journal of proteomics 2012;75(13):4038-49.
2012: Christiane Wallwey; Xiulan Xie; Axel A Brakhage; Christoph Heddergott; Shu-Ming Li
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
Microbiology (Reading, England) 2012;158(Pt 6):1634-44.
2012: Christoph Heddergott; Olaf Kniemeyer; Oliver Kurzai; Ines Leonhardt; Sandor Nietzsche; Sandra Bruns; Axel A Brakhage
The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and influences recognition by human immune effector cells.
Eukaryotic cell 2012;11(5):673-82.
2012: Maria Cândida Monteiro; Catalina Moreno; José R Tormo; Vito Valiante; Francisco Asensio; Axel A Brakhage; Juan Cantizani; Mercedes de la Cruz; J Ramón De Lucas; Olga Genilloud; Jean-Paul Latgé; Emilia Mellado; FRANCISCA VCICENTE
A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin.
Journal of biomolecular screening 2012;17(4):542-9.
2012: Thorsten Heinekamp; Sophia Keller; Juliane Macheleidt; Andreas Thywißen; Vito Valiante; Axel A Brakhage
Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence.
Frontiers in microbiology 2012;3():440.
2012: Hans-Wilhelm Nützmann; Volker Schroeckh; Axel A Brakhage
Regulatory cross talk and microbial induction of fungal secondary metabolite gene clusters.
Methods in enzymology 2012;517():325-41.
2012: Sebastian Müller; Clara Baldin; Axel A Brakhage; Marco Groth; Reinhard Guthke; Olaf Kniemeyer; Vito Valiante
Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression.
BMC genomics 2012;13():519.
2012: Diego A Martinez; Nilce M Martinez-Rossi; Michel Monod; Brian G Oliver; Antonio Rossi; Sakina Saif; Marketa Samalova; Charles W Saunders; Terrance Shea; Ekaterina Shelest; Richard C Summerbell; Richard C Barton; Elizabeth Birch; Bruce W Birren; Axel A Brakhage; Zehua Chen; Christina A Cuomo; Jonathan M Goldberg; Yvonne Gräser; Sarah J Gurr; David Heiman; Joseph Heitman; Idit Kosti; Wenjun Li; Jun Xu; Sarah Young; Qiandong Zeng; Theodore C White
Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection.
mBio 2012;3(5):e00259-12.
2012: Fabian Horn; Olaf Kniemeyer; Johannes Pollmächer; Vito Valiante; Thorsten Heinekamp; Axel A Brakhage
Systems biology of fungal infection.
Frontiers in microbiology 2012;3():108.
2012: Jörg Linde; Peter Hortschansky; Axel A Brakhage; Eugen Fazius; Reinhard Guthke; Hubertus Haas
Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach.
BMC systems biology 2012;6():6.
2011: Dirk Wartenberg; Hans-Martin Dahse; Thorsten Heinekamp; Ilse Jacobsen; Olaf Kniemeyer; Katrin Lapp; Axel A Brakhage
Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein.
International journal of medical microbiology : IJMM 2011;301(7):602-11.
2011: Kirstin Scherlach; Volker Schroeckh; Axel A Brakhage; Hans-Martin Dahse; Hans-Wilhelm Nützmann; Christian Hertweck
Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification.
Angewandte Chemie (International ed. in English) 2011;50(42):9843-7.
2011: Radhika Jain; Nicole Remme; Vito Valiante; Teresa Docimo; Jonathan Gershenzon; Hubertus Haas; Thorsten Heinekamp; Christian Hertweck; Axel A Brakhage
The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus.
Molecular microbiology 2011;82(1):39-53.
2011: Hans-Wilhelm Nützmann; Yazmid Reyes-Dominguez; Kirstin Scherlach; Volker Schroeckh; Julia Schümann; Joseph Strauss; Agnieszka Gacek; Christian Hertweck; Fabian Horn; Axel A Brakhage
Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):14282-7.
2011: Daniel H Scharf; Kirstin Scherlach; Peter Hortschansky; Nicole Remme; Axel A Brakhage; Pranatchareeya Chankhamjon; Andreas Habel; Thorsten Heinekamp; Christian Hertweck
A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis.
Journal of the American Chemical Society 2011;133(32):12322-5.
2011: Kirstin Scherlach; Volker Schroeckh; Axel A Brakhage; Hans-Martin Dahse; Uwe Horn; Martin Roth; Anindita Sarkar; Christian Hertweck
Two induced fungal polyketide pathways converge into antiproliferative spiroanthrones.
Chembiochem : a European journal of chemical biology 2011;12(12):1836-9.
2011: Katrin Volling; Andreas Thywissen; Axel A Brakhage; Hans-Peter Saluz
Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling.
Cellular microbiology 2011;13(8):1130-48.
2011: Mike Hasenberg; Judith Behnsen; Sven Krappmann; Axel A Brakhage; Matthias Gunzer
Phagocyte responses towards Aspergillus fumigatus.
International journal of medical microbiology : IJMM 2011;301(5):436-44.
2011: Olaf Kniemeyer; André D Schmidt; Martin Vödisch; Dirk Wartenberg; Axel A Brakhage
Identification of virulence determinants of the human pathogenic fungi Aspergillus fumigatus and Candida albicans by proteomics.
International journal of medical microbiology : IJMM 2011;301(5):368-77.
2011: Axel A Brakhage; Uwe Gross; Joachim Morschhäuser
Pathobiology of human-pathogenic fungi.
International journal of medical microbiology : IJMM 2011;301(5):367.
2011: Daniela Albrecht-Eckardt; Olaf Kniemeyer; Franziska Mech; Matthias Gunzer; Axel A Brakhage; Reinhard Guthke
On the way toward systems biology of Aspergillus fumigatus infection.
International journal of medical microbiology : IJMM 2011;301(5):453-9.
2011: Martin Vödisch; Ernst R Werner; Robert Winkler; Martin Roth; Kirstin Scherlach; Axel A Brakhage; Hans-Peter Braun; Hubertus Haas; Christian Hertweck; Olaf Kniemeyer
Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia.
Journal of proteome research 2011;10(5):2508-24.
2011: Steffen Priebe; Jörg Linde; Daniela Albrecht-Eckardt; Reinhard Guthke; Axel A Brakhage
FungiFun: a web-based application for functional categorization of fungal genes and proteins.
Fungal genetics and biology : FG & B 2011;48(4):353-8.
2011: Sophia Keller; Juliane Macheleidt; Kirstin Scherlach; Jeannette Schmaler-Ripcke; Thorsten Heinekamp; Ilse D Jacobsen; Axel A Brakhage
Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence.
PloS one 2011;6(10):e26604.
2011: Andreas Thywißen; Peter F Zipfel; Hans-Martin Dahse; Thorsten Heinekamp; Sandor Nietzsche; Jeannette Schmaler-Ripcke; Axel A Brakhage
Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway.
Frontiers in microbiology 2011;2():96.
2011: Franziska Mech; Andreas Thywissen; Axel A Brakhage; Reinhard Guthke; Marc Thilo Figge
Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus.
PloS one 2011;6(5):e19591.
2011: Anke Burmester; Marius Felder; Marc Feuermann; Gernot Glöckner; Marco Groth; Reinhard Guthke; Christoph Heddergott; Andrew Heidel; Joseph Heitman; Christian Hertweck; Bernhard Hube; Olaf Kniemeyer; Wenjun Li; Michel Monod; Ivo Pedruzzi; Andreas Petzold; Matthias Platzer; Steffen Priebe; Susann Schindler; Volker Schroeckh; Ekaterina Shelest; Peter Staib; Karol Szafranski; Theodore C White; Robert Winkler; Johannes Wöstemeyer; Peter F Zipfel; Axel A Brakhage
Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi.
Genome biology 2011;12(1):R7.
2011: Axel A Brakhage; Volker Schroeckh
Fungal secondary metabolites - strategies to activate silent gene clusters.
Fungal genetics and biology : FG & B 2011;48(1):15-22.
2010: Sebastian Bergmann; Alexander N Funk; Kirstin Scherlach; Volker Schroeckh; Ekaterina Shelest; Uwe Horn; Christian Hertweck; Axel A Brakhage
Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster.
Applied and environmental microbiology 2010;76(24):8143-9.
2010: Sandra Bruns; Marc Seidler; Daniela Albrecht-Eckardt; Stefanie Salvenmoser; Nicole Remme; Christian Hertweck; Axel A Brakhage; Olaf Kniemeyer; Frank-Michael C Müller
Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin.
Proteomics 2010;10(17):3097-107.
2010: Axel A Brakhage; Sandra Bruns; Andreas Thywissen; Peter F Zipfel; Judith Behnsen
Interaction of phagocytes with filamentous fungi.
Current opinion in microbiology 2010;13(4):409-15.
2010: Judith Behnsen; Franziska Lessing; Susann Schindler; Dirk Wartenberg; Ilse Jacobsen; Marcel Thoen; Peter F Zipfel; Axel A Brakhage
Secreted Aspergillus fumigatus protease Alp1 degrades human complement proteins C3, C4, and C5.
Infection and immunity 2010;78(8):3585-94.
2010: Daniel H Scharf; Nicole Remme; Thorsten Heinekamp; Peter Hortschansky; Axel A Brakhage; Christian Hertweck
Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus.
Journal of the American Chemical Society 2010;132(29):10136-41.
2010: Janka Teutschbein; Daniela Albrecht-Eckardt; Maria Pötsch; Reinhard Guthke; Vishukumar Aimanianda; Cécile Clavaud; Jean-Paul Latgé; Axel A Brakhage; Olaf Kniemeyer
Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus.
Journal of proteome research 2010;9(7):3427-42.
2010: Alexander Gehrke; Thorsten Heinekamp; Ilse Jacobsen; Axel A Brakhage
Heptahelical receptors GprC and GprD of Aspergillus fumigatus Are essential regulators of colony growth, hyphal morphogenesis, and virulence.
Applied and environmental microbiology 2010;76(12):3989-98.
2010: Isabelle Mouyna; Olaf Kniemeyer; Thomas Jank; Céline Loussert; Emilia Mellado; Vishukumar Aimanianda; Anne Beauvais; Dirk Wartenberg; Jacqueline Sarfati; Jagadeesh Bayry; Marie-Christine Prévost; Axel A Brakhage; Sabine Strahl; Michel Huerre; Jean-Paul Latgé
Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability.
Molecular microbiology 2010;76(5):1205-21.
2010: Sandra Bruns; Olaf Kniemeyer; Mike Hasenberg; Vishukumar Aimanianda; Sandor Nietzsche; Andreas Thywissen; Andreas Jeron; Jean-Paul Latgé; Axel A Brakhage; Matthias Gunzer
Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA.
PLoS pathogens 2010;6(4):e1000873.
2010: Daniela Albrecht-Eckardt; Olaf Kniemeyer; Axel A Brakhage; Reinhard Guthke
Missing values in gel-based proteomics.
Proteomics 2010;10(6):1202-11.
2010: Marcel Thön; Qusai Al Abdallah; Peter Hortschansky; Daniel H Scharf; Martin Eisendle; Hubertus Haas; Axel A Brakhage
The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes.
Nucleic acids research 2010;38(4):1098-113.
2010: Markus Schrettl; Nicola Beckmann; John Joseph Varga; Thorsten Heinekamp; Ilse Jacobsen; Christoph Jöchl; Tarek A. A. Moussa; Shaohua Wang; Fabio Gsaller; Michael Blatzer; Ernst R Werner; William C Niermann; Axel A Brakhage; Hubertus Haas
HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus.
PLoS pathogens 2010;6(9):e1001124.
2010: Daniela Albrecht-Eckardt; Reinhard Guthke; Axel A Brakhage; Olaf Kniemeyer
Integrative analysis of the heat shock response in Aspergillus fumigatus.
BMC genomics 2010;11():32.
2009: Vito Valiante; Radhika Jain; Thorsten Heinekamp; Axel A Brakhage
The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus.
Fungal genetics and biology : FG & B 2009;46(12):909-18.
2009: Axel A Brakhage; Marcel Thön; Petra Spröte; Daniel H Scharf; Qusai Al Abdallah; Sandra M Wolke; Peter Hortschansky
Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors.
Phytochemistry 2009;70(15-16):1801-11.
2009: Vishukumar Aimanianda; Jagadeesh Bayry; Silvia Bozza; Olaf Kniemeyer; Katia Perruccio; Sri Ramulu Elluru; Cécile Clavaud; Sophie Paris; Axel A Brakhage; Srini V Kaveri; Luigina Romani; Jean-Paul Latgé
Surface hydrophobin prevents immune recognition of airborne fungal spores.
Nature 2009;460(7259):1117-21.
2009: Volker Schroeckh; Kirstin Scherlach; Hans-Wilhelm Nützmann; Ekaterina Shelest; Wolfgang Schmidt-Heck; Julia Schuemann; Karin Martin; Christian Hertweck; Axel A Brakhage
Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14558-63.
2009: Nicolas Rispail; Darren M Soanes; Cemile Ant; Robert Czajkowski; Anke Grünler; Romain Huguet; Elena Perez-Nadales; Anna Poli; Elodie Sartorel; Vito Valiante; Meng Yang; Roland Beffa; Axel A Brakhage; Neil A R Gow; Regine Kahmann; Marc-Henri Lebrun; Helena Lenasi; José Perez-Martin; Nicholas J Talbot; Jürgen Wendland; Antonio Di Pietro
Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi.
Fungal genetics and biology : FG & B 2009;46(4):287-98.
2009: Martin Vödisch; Daniela Albrecht-Eckardt; Franziska Lessing; André D Schmidt; Robert Winkler; Reinhard Guthke; Axel A Brakhage; Olaf Kniemeyer
Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus.
Proteomics 2009;9(5):1407-15.
2009: Petra Spröte; Axel A Brakhage; Michael J Hynes
Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans.
Eukaryotic cell 2009;8(3):421-3.
2009: Jeannette Schmaler-Ripcke; Venelina Sugareva; Peter Gebhardt; Robert Winkler; Olaf Kniemeyer; Thorsten Heinekamp; Axel A Brakhage
Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus.
Applied and environmental microbiology 2009;75(2):493-503.
2009: Olaf Kniemeyer; Franziska Lessing; Axel A Brakhage
Proteome analysis for pathogenicity and new diagnostic markers for Aspergillus fumigatus.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2009;47 Suppl 1():S248-54.
2008: André Oliveira Mota Júnior; Iran Malavazi; Frederico M Soriani; Thorsten Heinekamp; Ilse Jacobsen; Axel A Brakhage; Marcela Savoldi; Maria Helena S Goldman; Márcia Eliana da Silva Ferreira; Gustavo H Goldman
Molecular characterization of the Aspergillus fumigatus NCS-1 homologue, NcsA.
Molecular genetics and genomics : MGG 2008;280(6):483-95.
2008: Petra Spröte; Michael J Hynes; Peter Hortschansky; Ekaterina Shelest; Daniel H Scharf; Sandra M Wolke; Axel A Brakhage
Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster.
Molecular microbiology 2008;70(2):445-61.
2008: Markus Schrettl; Heenam Stanley Kim; Martin Eisendle; Claudia Kragl; William C Nierman; Thorsten Heinekamp; Ernst R Werner; Ilse Jacobsen; Paul Illmer; Hyojeong Yi; Axel A Brakhage; Hubertus Haas
SreA-mediated iron regulation in Aspergillus fumigatus.
Molecular microbiology 2008;70(1):27-43.
2008: Christina Grosse; Thorsten Heinekamp; Olaf Kniemeyer; Alexander Gehrke; Axel A Brakhage
Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus.
Applied and environmental microbiology 2008;74(15):4923-33.
2008: Vito Valiante; Thorsten Heinekamp; Radhika Jain; Albert Härtl; Axel A Brakhage
The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response.
Fungal genetics and biology : FG & B 2008;45(5):618-27.
2008: Marcel Erhard; Uta-Christina Hipler; Anke Burmester; Axel A Brakhage; Johannes Wöstemeyer
Identification of dermatophyte species causing onychomycosis and tinea pedis by MALDI-TOF mass spectrometry.
Experimental dermatology 2008;17(4):356-61.
2008: Judith Behnsen; Andrea Hartmann; Jeannette Schmaler; Alexander Gehrke; Axel A Brakhage; Peter F Zipfel
The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system.
Infection and immunity 2008;76(2):820-7.
2008: Axel A Brakhage; Julia Schuemann; Sebastian Bergmann; Kirstin Scherlach; Volker Schroeckh; Christian Hertweck
Activation of fungal silent gene clusters: a new avenue to drug discovery.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2008;66():1, 3-12.
2008: Oumaïma Ibrahim-Granet; Marc Dubourdeau; Jean-Paul Latgé; Patrick Ave; Michel Huerre; Axel A Brakhage; Matthias Brock
Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis.
Cellular microbiology 2008;10(1):134-48.
2007: Franziska Lessing; Olaf Kniemeyer; Iwona Wozniok; Juergen Loeffler; Oliver Kurzai; Albert Haertl; Axel A Brakhage
The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model.
Eukaryotic cell 2007;6(12):2290-302.
2007: Katrin Volling; Axel A Brakhage; Hans-Peter Saluz
Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatus.
FEMS microbiology letters 2007;275(2):250-4.
2007: Marcel Thön; Qusai Al Abdallah; Peter Hortschansky; Axel A Brakhage
The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response.
The Journal of biological chemistry 2007;282(37):27259-69.
2007: Peter Hortschansky; Martin Eisendle; Qusai Al Abdallah; André D Schmidt; Sebastian Bergmann; Marcel Thön; Olaf Kniemeyer; Beate Abt; Birgit Seeber; Ernst R Werner; Masashi Kato; Axel A Brakhage; Hubertus Haas
Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron.
The EMBO journal 2007;26(13):3157-68.
2007: Petra Spröte; Axel A Brakhage
The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis.
Archives of microbiology 2007;188(1):69-79.
2007: Sebastian Bergmann; Julia Schümann; Kirstin Scherlach; Corinna Lange; Axel A Brakhage; Christian Hertweck
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans.
Nature chemical biology 2007;3(4):213-7.
2007: Felicitas Schöbel; Oumaïma Ibrahim-Granet; Patrick Avé; Jean-Paul Latgé; Axel A Brakhage; Matthias Brock
Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis.
Infection and immunity 2007;75(3):1237-44.
2007: Márcia Eliana da Silva Ferreira; Thorsten Heinekamp; Albert Härtl; Axel A Brakhage; Camile P Semighini; Steven D Harris; Marcela Savoldi; Paula Fagundes de Gouvêa; Maria Helena de Souza Goldman; Gustavo H Goldman
Functional characterization of the Aspergillus fumigatus calcineurin.
Fungal genetics and biology : FG & B 2007;44(3):219-30.
2007: Judith Behnsen; Priyanka Narang; Mike Hasenberg; Frank Gunzer; Ursula Bilitewski; Nina Klippel; Manfred Rohde; Matthias Brock; Axel A Brakhage; Matthias Gunzer
Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans.
PLoS pathogens 2007;3(2):e13.
2007: Kathrin Luther; Antonella Torosantucci; Axel A Brakhage; Jürgen Heesemann; Frank Ebel
Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2.
Cellular microbiology 2007;9(2):368-81.
2006: Venelina Sugareva; Albert Härtl; Matthias Brock; Katrin Hübner; Manfred Rohde; Thorsten Heinekamp; Axel A Brakhage
Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus.
Archives of microbiology 2006;186(5):345-55.
2006: Claudio Kupfahl; Thorsten Heinekamp; Gernot Geginat; Thomas Ruppert; Albert Härtl; Holger Hof; Axel A Brakhage
Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model.
Molecular microbiology 2006;62(1):292-302.
2006: Márcia Eliana da Silva Ferreira; Iran Malavazi; Marcela Savoldi; Axel A Brakhage; Maria Helena S Goldman; Heenam Stanley Kim; William C Nierman; Gustavo H Goldman
Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole.
Current genetics 2006;50(1):32-44.
2006: Frank Ebel; Monika Schwienbacher; Jennifer Beyer; Jürgen Heesemann; Axel A Brakhage; Matthias Brock
Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development.
Fungal genetics and biology : FG & B 2006;43(7):476-89.
2006: Martina Herrmann; Petra Spröte; Axel A Brakhage
Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production.
Applied and environmental microbiology 2006;72(4):2957-70.
2006: Olaf Kniemeyer; Franziska Lessing; Olaf Scheibner; Christian Hertweck; Axel A Brakhage
Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus.
Current genetics 2006;49(3):178-89.
2006: Márcia Eliana da Silva Ferreira; Marcia R V Z Kress; Marcela Savoldi; Maria Helena S Goldman; Albert Härtl; Thorsten Heinekamp; Axel A Brakhage; Gustavo H Goldman
The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus.
Eukaryotic cell 2006;5(1):207-11.
2005: Axel A Brakhage
Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants.
Current drug targets 2005;6(8):875-86.
2005: Hideya Goda; Takashi Nagase; Shinjiro Tanoue; Junya Sugiyama; Stefan Steidl; André Tüncher; Tetsuo Kobayashi; Norihiro Tsukagoshi; Axel A Brakhage; Masashi Kato
Nuclear translocation of the heterotrimeric CCAAT binding factor of Aspergillus oryzae is dependent on two redundant localising signals in a single subunit.
Archives of microbiology 2005;184(2):93-100.
2005: André Tüncher; Petra Spröte; Alexander Gehrke; Axel A Brakhage
The CCAAT-binding complex of eukaryotes: evolution of a second NLS in the HapB subunit of the filamentous fungus Aspergillus nidulans despite functional conservation at the molecular level between yeast, A.nidulans and human.
Journal of molecular biology 2005;352(3):517-33.
2005: Claudia Maerker; Manfred Rohde; Axel A Brakhage; Matthias Brock
Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia.
The FEBS journal 2005;272(14):3615-30.
2005: Axel A Brakhage; Qusai Al Abdallah; André Tüncher; Petra Spröte
Evolution of beta-lactam biosynthesis genes and recruitment of trans-acting factors.
Phytochemistry 2005;66(11):1200-10.
2005: André D Schmidt; Thorsten Heinekamp; Markus Matuschek; Burghard Liebmann; Claus Bollschweiler; Axel A Brakhage
Analysis of mating-dependent transcription of Blakeslea trispora carotenoid biosynthesis genes carB and carRA by quantitative real-time PCR.
Applied microbiology and biotechnology 2005;67(4):549-55.
2005: Axel A Brakhage; Burghard Liebmann
Aspergillus fumigatus conidial pigment and cAMP signal transduction: significance for virulence.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2005;43 Suppl 1():S75-82.
2004: Stefan Steidl; André Tüncher; Hideya Goda; Corina Guder; Natalia Papadopoulou; Tetsuo Kobayashi; Norihiro Tsukagoshi; Masashi Kato; Axel A Brakhage
A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: piggy back transport of the pre-assembled complex to the nucleus.
Journal of molecular biology 2004;342(2):515-24.
2004: Burghard Liebmann; Meike Müller; Armin Braun; Axel A Brakhage
The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus.
Infection and immunity 2004;72(9):5193-203.
2004: Burghard Liebmann; Thomas W Mühleisen; Meike Müller; Matthias Hecht; Gerhard Weidner; Armin Braun; Matthias Brock; Axel A Brakhage
Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis.
Archives of microbiology 2004;181(5):378-83.
2004: André Tüncher; Hans Reinke; Goran Martic; Maria Louise Caruso; Axel A Brakhage
A basic-region helix-loop-helix protein-encoding gene (devR) involved in the development of Aspergillus nidulans.
Molecular microbiology 2004;52(1):227-41.
2004: Axel A Brakhage; Petra Spröte; Qusai Al Abdallah; Alexander Gehrke; Hans Plattner; André Tüncher
Regulation of penicillin biosynthesis in filamentous fungi.
Advances in biochemical engineering/biotechnology 2004;88():45-90.
2003: Burghard Liebmann; S Gattung; Bernhard Jahn; Axel A Brakhage
cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages.
Molecular genetics and genomics : MGG 2003;269(3):420-35.
2003: Kim Langfelder; Martin Streibel; Bernhard Jahn; Gerhard Haase; Axel A Brakhage
Biosynthesis of fungal melanins and their importance for human pathogenic fungi.
Fungal genetics and biology : FG & B 2003;38(2):143-58.
2003: Silke Busch; Helge B Bode; Axel A Brakhage; Gerhard H Braus
Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans.
Current genetics 2003;42(4):209-19.
2002: Bernhard Jahn; Kim Langfelder; Ulrike Schneider; Christine Schindel; Axel A Brakhage
PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages.
Cellular microbiology 2002;4(12):793-803.
2002: Maria Louise Caruso; Olivier Litzka; Goran Martic; Friedrich Lottspeich; Axel A Brakhage
Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis gene.
Journal of molecular biology 2002;323(3):425-39.
2002: Kim Langfelder; Stephanie Gattung; Axel A Brakhage
A novel method used to delete a new Aspergillus fumigatus ABC transporter-encoding gene.
Current genetics 2002;41(4):268-74.
2002: Axel A Brakhage; Kim Langfelder
Menacing mold: the molecular biology of Aspergillus fumigatus.
Annual review of microbiology 2002;56():433-55.
2002: Oscar Bañuelos; Javier Casqueiro; S Steidl; Santiago Gutiérrez; Axel A Brakhage; Juan F Martín
Subcellular localization of the homocitrate synthase in Penicillium chrysogenum.
Molecular genetics and genomics : MGG 2002;266(5):711-9.
2001: Kim Langfelder; Bruno Philippe; Bernhard Jahn; Jean-Paul Latgé; Axel A Brakhage
Differential expression of the Aspergillus fumigatus pksP gene detected in vitro and in vivo with green fluorescent protein.
Infection and immunity 2001;69(10):6411-8.
2001: Akimitsu Tanaka; Ken-ichi Kamei; Shinjiro Tanoue; P Papagiannopoulos; Stefan Steidl; Axel A Brakhage; Meryl A Davis; Michael J Hynes; Masashi Kato; Takeshi Kobayashi; Norihiro Tsukagoshi
AoHapB, AoHapC and AoHapE, subunits of the Aspergillus oryzae CCAAT-binding complex, are functionally interchangeable with the corresponding subunits in Aspergillus nidulans.
Current genetics 2001;39(3):175-82.
2001: Stefan Steidl; Michael J Hynes; Axel A Brakhage
The Aspergillus nidulans multimeric CCAAT binding complex AnCF is negatively autoregulated via its hapB subunit gene.
Journal of molecular biology 2001;306(4):643-53.
2001: Gerhard Weidner; Stefan Steidl; Axel A Brakhage
The Aspergillus nidulans homoaconitase gene lysF is negatively regulated by the multimeric CCAAT-binding complex AnCF and positively regulated by GATA sites.
Archives of microbiology 2001;175(2):122-32.
2000: Werner Heinz; Oliver Kurzai; Axel A Brakhage; WA Fonzi; Hans Christian Korting; Matthias Frosch; Fritz A Mühlschlegel
Molecular responses to changes in the environmental pH are conserved between the fungal pathogens Candida dubliniensis and Candida albicans.
International journal of medical microbiology : IJMM 2000;290(3):231-8.
2000: Bernhard Jahn; Fatima Boukhallouk; J Lotz; Kim Langfelder; G Wanner; Axel A Brakhage
Interaction of human phagocytes with pigmentless Aspergillus conidia.
Infection and immunity 2000;68(6):3736-9.
1999: J Van Den Brulle; Stefan Steidl; Axel A Brakhage
Cloning and characterization of an Aspergillus nidulans gene involved in the regulation of penicillin biosynthesis.
Applied and environmental microbiology 1999;65(12):5222-8.
1999: Axel A Brakhage; Alex Andrianopoulos; Masashi Kato; Stefan Steidl; Meryl A Davis; Norihiro Tsukagoshi; Michael J Hynes
HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology.
Fungal genetics and biology : FG & B 1999;27(2-3):243-52.
1999: Axel A Brakhage; Kim Langfelder; G Wanner; Annette Schmidt; Bernhard Jahn
Pigment biosynthesis and virulence.
Contributions to microbiology 1999;2():205-15.
1999: C d'Enfert; Gerhard Weidner; P C Mol; Axel A Brakhage
Transformation systems of Aspergillus fumigatus. New tools to investigate fungal virulence.
Contributions to microbiology 1999;2():149-66.
1999: Olivier Litzka; K Then Bergh; J Van den Brulle; Stefan Steidl; Axel A Brakhage
Transcriptional control of expression of fungal beta-lactam biosynthesis genes.
Antonie van Leeuwenhoek 1999;75(1-2):95-105.
1999: Stefan Steidl; P Papagiannopoulos; Olivier Litzka; Alex Andrianopoulos; Meryl A Davis; Axel A Brakhage; Michael J Hynes
AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR.
Molecular and cellular biology 1999;19(1):99-106.
1998: Kim Langfelder; Bernhard Jahn; H Gehringer; Annette Schmidt; G Wanner; Axel A Brakhage
Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence.
Medical microbiology and immunology 1998;187(2):79-89.
1998: Axel A Brakhage
Molecular regulation of beta-lactam biosynthesis in filamentous fungi.
Microbiology and molecular biology reviews : MMBR 1998;62(3):547-85.
1998: Gerhard Weidner; C d'Enfert; A Koch; P C Mol; Axel A Brakhage
Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine 5'-monophosphate decarboxylase.
Current genetics 1998;33(5):378-85.
1998: K Then Bergh; Axel A Brakhage
Regulation of the Aspergillus nidulans penicillin biosynthesis gene acvA (pcbAB) by amino acids: implication for involvement of transcription factor PACC.
Applied and environmental microbiology 1998;64(3):843-9.
1998: Olivier Litzka; P Papagiannopolous; Meryl A Davis; Michael J Hynes; Axel A Brakhage
The penicillin regulator PENR1 of Aspergillus nidulans is a HAP-like transcriptional complex.
European journal of biochemistry / FEBS 1998;251(3):758-67.
1997: Bernhard Jahn; A Koch; Annette Schmidt; G Wanner; H Gehringer; Sucharit Bhakdi; Axel A Brakhage
Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence.
Infection and immunity 1997;65(12):5110-7.
1997: Gerhard Weidner; B Steffan; Axel A Brakhage
The Aspergillus nidulans lysF gene encodes homoaconitase, an enzyme involved in the fungus-specific lysine biosynthesis pathway.
Molecular & general genetics : MGG 1997;255(3):237-47.
1997: Axel A Brakhage
Molecular regulation of penicillin biosynthesis in Aspergillus (Emericella) nidulans.
FEMS microbiology letters 1997;148(1):1-10.
1996: K T Bergh; Olivier Litzka; Axel A Brakhage
Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans.
Journal of bacteriology 1996;178(13):3908-16.
1996: Olivier Litzka; K Then Bergh; Axel A Brakhage
The Aspergillus nidulans penicillin-biosynthesis gene aat (penDE) is controlled by a CCAAT-containing DNA element.
European journal of biochemistry / FEBS 1996;238(3):675-82.
1995: Olivier Litzka; K T Bergh; Axel A Brakhage
Analysis of the regulation of the Aspergillus nidulans penicillin biosynthesis gene aat (penDE), which encodes acyl coenzyme A:6-aminopenicillanic acid acyltransferase.
Molecular & general genetics : MGG 1995;249(5):557-69.
1995: Axel A Brakhage; J Van den Brulle
Use of reporter genes to identify recessive trans-acting mutations specifically involved in the regulation of Aspergillus nidulans penicillin biosynthesis genes.
Journal of bacteriology 1995;177(10):2781-8.
1994: Axel A Brakhage; P Browne; G Turner
Analysis of the regulation of penicillin biosynthesis in Aspergillus nidulans by targeted disruption of the acvA gene.
Molecular & general genetics : MGG 1994;242(1):57-64.
1992: Axel A Brakhage; Geoffrey Turner
L-lysine repression of penicillin biosynthesis and the expression of penicillin biosynthesis genes acvA and ipnA in Aspergillus nidulans.
FEMS microbiology letters 1992;77(1-3):123-7.
1992: Axel A Brakhage; P Browne; Geoffrey Turner
Regulation of Aspergillus nidulans penicillin biosynthesis and penicillin biosynthesis genes acvA and ipnA by glucose.
Journal of bacteriology 1992;174(11):3789-99.