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Mansukh Wani

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Tamam El-Elimat; Mario Figueroa; Tyler N Graf; David J Kroll; Audrey F Adcock; Cynthia S Day; Cedric J Pearce; Huzefa A Raja; Mansukh C Wani; Nicholas H. Oberlies
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
Arlene A Sy-Cordero; Mansukh C Wani; Mary F Paine; Stephen J Polyak; Scott P Runyon; Rajesh Agarwal; Scott J Brantley; Tyler N Graf; David J Kroll; Nicholas H. Oberlies
Enhanced bioactivity of silybin B methylation products.
Mario Figueroa; Tyler N Graf; David J Kroll; Ulyana Munoz-Acuna; Audrey F Adcock; Rajesh Agrawal; Sloan Ayers; Esperanza J Carcache de Blanco; Blaise A Darveaux; Cedric J Pearce; Steven M Swanson; Mansukh C Wani; Jilai Yang; Nicholas H. Oberlies
Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.

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All Publications

2013: Tamam El-Elimat; Mario Figueroa; Tyler N Graf; David J Kroll; Audrey F Adcock; Cynthia S Day; Cedric J Pearce; Huzefa A Raja; Mansukh C Wani; Nicholas H. Oberlies
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
Journal of natural products 2013;76(3):382-7.
2013: Arlene A Sy-Cordero; Mansukh C Wani; Mary F Paine; Stephen J Polyak; Scott P Runyon; Rajesh Agarwal; Scott J Brantley; Tyler N Graf; David J Kroll; Nicholas H. Oberlies
Enhanced bioactivity of silybin B methylation products.
Bioorganic & medicinal chemistry 2013;21(3):742-7.
2012: Mario Figueroa; Tyler N Graf; David J Kroll; Ulyana Munoz-Acuna; Audrey F Adcock; Rajesh Agrawal; Sloan Ayers; Esperanza J Carcache de Blanco; Blaise A Darveaux; Cedric J Pearce; Steven M Swanson; Mansukh C Wani; Jilai Yang; Nicholas H. Oberlies
Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.
The Journal of antibiotics 2012;65(11):559-64.
2012: Sloan Ayers; Esperanza J Carcache de Blanco; Brandie M Ehrmann; Joseph O Falkinham; David J Kroll; Sheila M Mitchell; Cedric J Pearce; Qi Shen; Steven M Swanson; Mansukh C Wani; Audrey F Adcock; Nicholas H. Oberlies
Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.
Journal of peptide science : an official publication of the European Peptide Society 2012;18(8):500-10.
2012: Cedric J Pearce; Qi Shen; Djaja D Soejarto; Mansukh C Wani; Xiaoli Zhang; Esperanza J Carcache de Blanco; Norman R Farnsworth; James R Fuchs; David Jarjoura; A Douglas Kinghorn; David J Kroll; Daniel D Lantvit; Nicholas H. Oberlies; Jimmy Orjala; Steven M Swanson
Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.
Methods in molecular biology (Clifton, N.J.) 2012;944():267-77.
2012: Sloan Ayers; Esperanza J Carcache de Blanco; Blaise A Darveaux; Tyler N Graf; David J Kroll; Susan Matthew; Cedric J Pearce; Qi Shen; Steven M Swanson; Mansukh C Wani; Audrey F Adcock; Nicholas H. Oberlies
Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022).
The Journal of antibiotics 2012;65(1):3-8.
2011: Arlene A Sy-Cordero; Mansukh C Wani; Cedric J Pearce; Qi Shen; Steven M Swanson; Audrey F Adcock; Tyler N Graf; David J Kroll; Nicholas H. Oberlies
Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).
Journal of natural products 2011;74(10):2137-42.
2011: Sloan Ayers; Tyler N Graf; Audrey F Adcock; David J Kroll; Susan Matthew; Esperanza J Carcache de Blanco; Qi Shen; Steven M Swanson; Mansukh C Wani; Cedric J Pearce; Nicholas H Oberlies
Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.
Journal of natural products 2011;74(5):1126-31.
2011: David J Adams; William R Waud; Mansukh C Wani; Govindarajan Manikumar; James L Flowers; Timothy A Driscoll; Lee Roy Morgan
BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.
Cancer chemotherapy and pharmacology 2011;67(4):855-65.
2010: Arlene A Sy-Cordero; Tyler N Graf; Mansukh C Wani; David J Kroll; Cedric J Pearce; Nicholas H Oberlies
Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles.
The Journal of antibiotics 2010;63(9):539-44.
2010: Arlene Sy-Cordero; Tyler N Graf; Yuka Nakanishi; Mansukh C Wani; Rajesh Agarwal; David Kroll; Nicholas H. Oberlies
Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.
Planta medica 2010;76(6):644-7.
2009: Chen Li; Dongho Lee; Tyler N Graf; Sharnelle S Phifer; Yuka Nakanishi; Soedarsono Riswan; Fransisca M Setyowati; Achmad M Saribi; D Doel Soejarto; Norman R Farnsworth; Joseph O Falkinham; David Kroll; A Douglas Kinghorn; Mansukh C Wani; Nicholas H. Oberlies
Bioactive constituents of the stem bark of Mitrephora glabra.
Journal of natural products 2009;72(11):1949-53.
2009: Patrick J Burke; Peter D Senter; David W Meyer; Jamie B Miyamoto; Martha Anderson; Brian E Toki; Govindarajan Manikumar; Mansukh C Wani; David J Kroll; Scott C Jeffrey
Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.
Bioconjugate chemistry 2009;20(6):1242-50.
2009: Qiuwen Mi; John M Pezzuto; Norman R Farnsworth; Mansukh C Wani; A Douglas Kinghorn; Steven M Swanson
Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.
Journal of natural products 2009;72(3):573-80.
2007: Tyler N Graf; Mansukh C Wani; Rajesh Agarwal; David Kroll; Nicholas H. Oberlies
Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention.
Planta medica 2007;73(14):1495-501.
2007: Sharnelle S Phifer; Dongho Lee; Eun-Kyoung Seo; Nam-Cheol Kim; Tyler N Graf; David Kroll; Hernán A Navarro; Robert A Izydore; Francisco Jiménez; Ricardo Garcia; William C Rose; Craig R Fairchild; Robert Wild; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Nicholas H. Oberlies; Monroe E Wall; Mansukh C Wani
Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.
Journal of natural products 2007;70(6):954-61.
2007: Tyler N Graf; Keith E Levine; Margaret E Andrews; Jason M Perlmutter; Samara Joy Nielsen; Jeanine M Davis; Mansukh C Wani; Nicholas H. Oberlies
Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).
Journal of agricultural and food chemistry 2007;55(4):1205-11.
2006: Meredith T Morgan; Yuka Nakanishi; David Kroll; Aaron P Griset; Michael A Carnahan; Michel Wathier; Nicholas H. Oberlies; Govindarajan Manikumar; Mansukh C Wani; Mark W Grinstaff
Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.
Cancer research 2006;66(24):11913-21.
2006: William C Rose; Punit Marathe; Graham R Jang; Thomas M Monticello; Balu N Balasubramanian; Byron Long; Craig R Fairchild; Monroe E Wall; Mansukh C Wani
Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization.
Cancer chemotherapy and pharmacology 2006;58(1):73-85.
2006: Feras Q Alali; Khaled Tawaha; Tamam El-Elimat; Rana M Qasaymeh; Chen Li; Jason Burgess; Yuka Nakanishi; David Kroll; Mansukh C Wani; Nicholas H. Oberlies
Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons.
Natural product research 2006;20(6):558-66.
2006: David J Adams; Mateus Webba da Silva; James L Flowers; Glenda Kohlhagen; Yves Pommier; O Michael Colvin; Govindarajan Manikumar; Mansukh C Wani
Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.
Cancer chemotherapy and pharmacology 2006;57(2):135-44.
2006: David J Adams; Miriam L Wahl; James L Flowers; Banalata Sen; Michael Colvin; Mark Dewhirst; Govindarajan Manikumar; Mansukh C Wani
Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.
Cancer chemotherapy and pharmacology 2006;57(2):145-54.
2005: Chen Li; Dongho Lee; Tyler N Graf; Sharnelle S Phifer; Yuka Nakanishi; Jason P Burgess; Soedarsono Riswan; Fransisca M Setyowati; Achmad M Saribi; D Doel Soejarto; Norman R Farnsworth; Joseph O Falkinham; David Kroll; A Douglas Kinghorn; Mansukh C Wani; Nicholas H. Oberlies
A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.
Organic letters 2005;7(25):5709-12.
2005: Dongho Lee; Chen Li; Tyler N Graf; Jose Schunke Vigo; James G Graham; Fernando Cabieses; Norman R Farnsworth; Patrick Jonas; A Douglas Kinghorn; David Kroll; Mansukh C Wani; Nicholas H. Oberlies
Diterpene glycosides from Egletes viscosa.
Planta medica 2005;71(8):792-4.
2005: Paula R Davis-Searles; Yuka Nakanishi; Nam-Cheol Kim; Tyler N Graf; Nicholas H. Oberlies; Mansukh C Wani; Monroe E Wall; Rajesh Agarwal; David Kroll
Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.
Cancer research 2005;65(10):4448-57.
2005: Qiuwen Mi; Daniel D Lantvit; Eulenia Reyes-Lim; Heebyung Chai; Sharnelle S Phifer; Mansukh C Wani; Monroe E Wall; Ghee Teng Tan; Patrick Jonas; Norman R Farnsworth; A Douglas Kinghorn; John M Pezzuto
Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis.
Anticancer research 2005;25(2A):779-87.
2005: Feras Q Alali; Tamam El-Elimat; Chen Li; Amjad Qandil; Ahmad S Alkofahi; Khaled Tawaha; Jason P Burgess; Yuka Nakanishi; David Kroll; Hernán A Navarro; Joseph O Falkinham; Mansukh C Wani; Nicholas H. Oberlies
New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.
Journal of natural products 2005;68(2):173-8.
2004: Govindarajan Manikumar; Randy M Wadkins; David J Bearss; Daniel Von Hoff; Mansukh C Wani; Monroe E Wall
Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
Bioorganic & medicinal chemistry letters 2004;14(21):5377-81.
2004: Nicholas H. Oberlies; Nam-Cheol Kim; Dolores R Brine; Bradley J Collins; Robert W Handy; Charles M Sparacino; Mansukh C Wani; Monroe E Wall
Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids.
Public health nutrition 2004;7(7):919-24.
2004: Randy M Wadkins; David J Bearss; Govindarajan Manikumar; Mansukh C Wani; Monroe E Wall; Daniel Von Hoff
Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I.
Cancer research 2004;64(18):6679-83.
2004: Randy M Wadkins; David J Bearss; Govindarajan Manikumar; Mansukh C Wani; Monroe E Wall; Daniel Von Hoff
Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity.
Current medicinal chemistry. Anti-cancer agents 2004;4(4):327-34.
2004: Jian-Qiao Gu; Tyler N Graf; Dongho Lee; Hee-Byung Chai; Qiuwen Mi; Leonardus B S Kardono; Fransisca M Setyowati; Rachman Ismail; Soedarsono Riswan; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; David Kroll; Joseph O Falkinham; Monroe E Wall; Mansukh C Wani; A Douglas Kinghorn; Nicholas H. Oberlies
Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.
Journal of natural products 2004;67(7):1156-61.
2003: James L Flowers; Robert M Hoffman; Timothy A Driscoll; Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; Henry S Friedman; Mark Dewhirst; O Michael Colvin; David J Adams
The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.
Cancer chemotherapy and pharmacology 2003;52(3):253-61.
2003: Cody C Cain; Dongho Lee; Robert H Waldo; Alexis T Henry; Earl J Casida; Mansukh C Wani; Monroe E Wall; Nicholas H. Oberlies; Joseph O Falkinham
Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator.
Antimicrobial agents and chemotherapy 2003;47(7):2113-7.
2003: Nam-Cheol Kim; Tyler N Graf; Charles M Sparacino; Mansukh C Wani; Monroe E Wall
Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).
Organic & biomolecular chemistry 2003;1(10):1684-9.
2003: Prakash Sampath; Eric Amundson; Monroe E Wall; Betty M. Tyler; Mansukh C Wani; Lloyd M Alderson; Michael Colvin; Henry Brem; Jon D Weingart
Camptothecin analogs in malignant gliomas: comparative analysis and characterization.
Journal of neurosurgery 2003;98(3):570-7.
2003: Eun-Kyoung Seo; Dongho Lee; Young Geun Shin; Hee-Byung Chai; Hernán A Navarro; Leonardus B S Kardono; Ismail Rahman; Patrick Jonas; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn; Mansukh C Wani; Monroe E Wall
Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.
Archives of pharmacal research 2003;26(2):124-7.
2002: Eun-Kyoung Seo; Nam-Cheol Kim; Mansukh C Wani; Monroe E Wall; Hernán A Navarro; Jason P Burgess; Kazuko Kawanishi; Leonardus B S Kardono; Soedarsono Riswan; William C Rose; Craig R Fairchild; Norman R Farnsworth; A Douglas Kinghorn
Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.
Journal of natural products 2002;65(3):299-305.
2002: Nicholas H. Oberlies; Jason P Burgess; Hernán A Navarro; Rosa Elena Pinos; Craig R Fairchild; Russell W Peterson; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Mansukh C Wani; Monroe E Wall
Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.
Journal of natural products 2002;65(2):95-9.
2001: Eun-Kyoung Seo; Nam-Cheol Kim; Qiuwen Mi; Heebyung Chai; Monroe E Wall; Mansukh C Wani; Hernán A Navarro; Jason P Burgess; James G Graham; Fernando Cabieses; Ghee Teng Tan; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum.
Journal of natural products 2001;64(11):1483-5.
2001: Nicholas H. Oberlies; Jason P Burgess; Hernán A Navarro; Rosa Elena Pinos; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Mansukh C Wani; Monroe E Wall
Bioactive constituents of the roots of Licania intrapetiolaris.
Journal of natural products 2001;64(4):497-501.
2001: Nam-Cheol Kim; Nicholas H. Oberlies; Dolores R Brine; R W Handy; Mansukh C Wani; Monroe E Wall
Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography.
Journal of natural products 2001;64(2):251-3.
2001: B S Burns; ML Edin; G E Lester; H G Tuttle; M E Wall; Mansukh C Wani; Gary Bos
Selective drug resistant human osteosarcoma cell lines.
Clinical orthopaedics and related research 2001;(383):259-67.
2000: Eun-Kyoung Seo; Mansukh C Wani; Monroe E Wall; Hernán A Navarro; R Mukherjee; Norman R Farnsworth; A Douglas Kinghorn
New bioactive aromatic compounds from Vismia guianensis.
Phytochemistry 2000;55(1):35-42.
2000: B Vladu; Jan Woynarowski; Govindarajan Manikumar; Mansukh C Wani; Monroe E Wall; Daniel Von Hoff; Randy M Wadkins
7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents.
Molecular pharmacology 2000;57(2):243-51.
2000: David J Adams; Mark Dewhirst; James L Flowers; Michael P Gamcsik; O Michael Colvin; Govindarajan Manikumar; Mansukh C Wani; Monroe E Wall
Camptothecin analogues with enhanced antitumor activity at acidic pH.
Cancer chemotherapy and pharmacology 2000;46(4):263-71.
1999: Maurizio Del Poeta; S F Chen; Daniel Von Hoff; Christine C Dykstra; Mansukh C Wani; Govindarajan Manikumar; Joseph Heitman; Monroe E Wall; John R Perfect
Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.
Antimicrobial agents and chemotherapy 1999;43(12):2862-8.
1999: Eun-Kyoung Seo; L Huang; Monroe E Wall; Mansukh C Wani; Hernán A Navarro; R Mukherjee; Norman R Farnsworth; A Douglas Kinghorn
New biphenyl compounds with DNA strand-scission activity from Clusia paralicola.
Journal of natural products 1999;62(11):1484-7.
1999: Darrel P Cohen; David J Adams; James L Flowers; Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; O Michael Colvin; R Silber
Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes.
Leukemia research 1999;23(11):1061-70.
1999: Eun-Kyoung Seo; Monroe E Wall; Mansukh C Wani; Hernán A Navarro; R Mukherjee; Norman R Farnsworth; A Douglas Kinghorn
Cytotoxic constituents from the roots of Tovomita brevistaminea.
Phytochemistry 1999;52(4):669-74.
1999: Joseph A Holden; Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar
Human DNA topoisomerase I: quantitative analysis of the effects of camptothecin analogs and the benzophenanthridine alkaloids nitidine and 6-ethoxydihydronitidine on DNA topoisomerase I-induced DNA strand breakage.
Archives of biochemistry and biophysics 1999;370(1):66-76.
1999: Randy M Wadkins; Philip Potter; B Vladu; Jennifer Marty; Gina L Mangold; Steven D Weitman; Govindarajan Manikumar; Mansukh C Wani; Monroe E Wall; Daniel Von Hoff
Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts.
Cancer research 1999;59(14):3424-8.
1998: L Huang; Monroe E Wall; Mansukh C Wani; Hernán A Navarro; Thawatchai Santisuk; Vichai Reutrakul; Eun-Kyoung Seo; Norman R Farnsworth; A Douglas Kinghorn
New compounds with DNA strand-scission activity from the combined leaf and stem of Uvaria hamiltonii.
Journal of natural products 1998;61(4):446-50.
1997: M Valenti; W Nieves-Neira; Glenda Kohlhagen; Kurt W Kohn; Monroe E Wall; Mansukh C Wani; Yves Pommier
Novel 7-alkyl methylenedioxy-camptothecin derivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells.
Molecular pharmacology 1997;52(1):82-7.
1997: S W Carrigan; P C Fox; Monroe E Wall; Mansukh C Wani; J P Bowen
Comparative molecular field analysis and molecular modeling studies of 20-(S)-camptothecin analogs as inhibitors of DNA topoisomerase I and anticancer/antitumor agents.
Journal of computer-aided molecular design 1997;11(1):71-8.
1996: Monroe E Wall; Mansukh C Wani
Camptothecin. Discovery to clinic.
Annals of the New York Academy of Sciences 1996;803():1-12.
1996: F Fullas; Mansukh C Wani; Monroe E Wall; J C Tucker; Christopher W Beecher; A Douglas Kinghorn
Triterpenes from the combined leaf and stem of Lithospermum caroliniense.
Phytochemistry 1996;43(6):1303-5.
1996: BL Wagner; G Pollio; S Leonhardt; Mansukh C Wani; D Y Lee; M O Imhof; D P Edwards; C E Cook; Donald P McDonnell
16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8739-44.
1996: S K Chaudhuri; F Fullas; Mansukh C Wani; Monroe E Wall; J C Tucker; Christopher W Beecher; A Douglas Kinghorn
Two isoflavones from the bark of Petalostemon purpureus.
Phytochemistry 1996;42(6):1709.
1996: Monroe E Wall; Mansukh C Wani
Camptothecin and taxol: from discovery to clinic.
Journal of ethnopharmacology 1996;51(1-3):239-53; discussion 253-4.
1996: S K Chaudhuri; F Fullas; Mansukh C Wani; Monroe E Wall; J C Tucker; Christopher W Beecher; A Douglas Kinghorn
Two isoflavones from the bark of Petalostemon purpureus.
Phytochemistry 1996;41(6):1625-7.
1996: L Huang; F Fullas; R J McGivney; D M Brown; Mansukh C Wani; Monroe E Wall; J C Tucker; Christopher W Beecher; John M Pezzuto; A Douglas Kinghorn
A new prenylated flavonol from the root of Petalostemon purpureus.
Journal of natural products 1996;59(3):290-2.
1996: F Fullas; L J Kornberg; Mansukh C Wani; Monroe E Wall; Norman R Farnsworth; T E Chagwedera; A Douglas Kinghorn
Two new aromatic constitutents from the rootwood of Aeschynomene mimosifolia.
Journal of natural products 1996;59(2):190-2.
1996: S K Chaudhuri; F Fullas; Mansukh C Wani; Monroe E Wall; J C Tucker; Christopher W Beecher; A Douglas Kinghorn
Two isoflavones from the bark of Petalostemon purpureus.
Phytochemistry 1996;41(3):945-6.
1995: S K Chaudhuri; L Huang; F Fullas; D M Brown; Mansukh C Wani; Monroe E Wall
Isolation and structure identification of an active DNA strand-scission agent, (+)-3,4-di-hydroxy-8,9-methylenedioxypterocarpan.
Journal of natural products 1995;58(12):1966-9.
1995: F Fullas; D M Brown; Mansukh C Wani; Monroe E Wall; T E Chagwedera; Norman R Farnsworth; John M Pezzuto; A Douglas Kinghorn
Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera.
Journal of natural products 1995;58(10):1625-8.
1995: C E Cook; Mansukh C Wani; J M Jump; Y W Lee; Patricia A Fail; S A Anderson; Y Q Gu; V Petrow
Structure-activity studies of 2,3,4,4a,5,9b-hexahydroindeno[1,2-c]pyridines as antispermatogenic agents for male contraception.
Journal of medicinal chemistry 1995;38(5):753-63.
1995: Monroe E Wall; Mansukh C Wani
Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture.
Cancer research 1995;55(4):753-60.
1995: S K Chaudhuri; F Fullas; D M Brown; Mansukh C Wani; Monroe E Wall; L Cai; W Mar; S K Lee; Y Luo; K Zaw
Isolation and structural elucidation of pentacyclic triterpenoids from Maprounea africana.
Journal of natural products 1995;58(1):1-9.
1994: C E Cook; Y W Lee; Mansukh C Wani; Patricia A Fail; V Petrow
Effects of D-ring substituents on antiprogestational (antagonist) and progestational (agonist) activity of 11 beta-aryl steroids.
Human reproduction (Oxford, England) 1994;9 Suppl 1():32-9.
1994: Monroe E Wall; Mansukh C Wani; F Fullas; J B Oswald; D M Brown; Thawatchai Santisuk; Vichai Reutrakul; Andrew T McPhail; Norman R Farnsworth; John M Pezzuto
Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines.
Journal of medicinal chemistry 1994;37(10):1465-70.
1993: Monroe E Wall; Mansukh C Wani; A W Nicholas; Govindarajan Manikumar; C Tele; L Moore; A Truesdale; P Leitner; J M Besterman
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
Journal of medicinal chemistry 1993;36(18):2689-700.
1993: C E Cook; Mansukh C Wani; Y W Lee; Patricia A Fail; V Petrow
Reversal of activity profile in analogs of the antiprogestin RU 486: effect of a 16 alpha-substituent on progestational (agonist) activity.
Life sciences 1993;52(2):155-62.
1993: Monroe E Wall; Mansukh C Wani
Antimutagenic agents from natural products of terrestrial and marine origin.
Basic life sciences 1993;61():87-97.
1991: A Y Chen; C Yu; Milan Potmesil; Monroe E Wall; Mansukh C Wani; L F Liu
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.
Cancer research 1991;51(22):6039-44.
1990: A W Nicholas; Mansukh C Wani; Govindarajan Manikumar; Monroe E Wall; K W Kohn; Y Pommier
Plant antitumor agents. 29. Synthesis and biological activity of ring D and ring E modified analogues of camptothecin.
Journal of medicinal chemistry 1990;33(3):972-8.
1990: Monroe E Wall; Mansukh C Wani; T J Hughes; H Taylor
Plant antimutagens.
Basic life sciences 1990;52():61-78.
1989: Beppino C Giovanella; John S Stehlin; Monroe E Wall; Mansukh C Wani; A W Nicholas; L F Liu; R Silber; Milan Potmesil
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts.
Science (New York, N.Y.) 1989;246(4933):1046-8.
1989: Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; H Taylor; T J Hughes; K Gaetano; H W Gerwick; Andrew T McPhail; D R McPhail
Plant antimutagenic agents, 7. Structure and antimutagenic properties of cymobarbatol and 4-isocymobarbatol, new cymopols from green alga (Cymopolia barbata).
Journal of natural products 1989;52(5):1092-9.
1989: Y H Hsiang; L F Liu; Monroe E Wall; Mansukh C Wani; A W Nicholas; Govindarajan Manikumar; S Kirschenbaum; R Silber; Milan Potmesil
DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.
Cancer research 1989;49(16):4385-9.
1989: Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; H Taylor; R McGivney
Plant antimutagens, 6. Intricatin and intricatinol, new antimutagenic homoisoflavonoids from Hoffmanosseggia intricata.
Journal of natural products 1989;52(4):774-8.
1989: Govindarajan Manikumar; K Gaetano; Mansukh C Wani; H Taylor; T J Hughes; J Warner; R McGivney; Monroe E Wall
Plant antimutagenic agents, 5. Isolation and structure of two new isoflavones, fremontin and fremontone from Psorothamnus fremontii.
Journal of natural products 1989;52(4):769-73.
1989: Andrew T McPhail; D R McPhail; Mansukh C Wani; Monroe E Wall; A W Nicholas
Identity of maprounic acid with aleuritolic acid. Revision of the structure of maprounic acid: X-ray crystal structure of p-bromobenzyl acetylmaprounate.
Journal of natural products 1989;52(1):212-6.
1988: Monroe E Wall; Mansukh C Wani; K Gaetano; Govindarajan Manikumar; H Taylor; R McGivney
Plant antimutagenic agents, 4. Isolation and structure elucidation of maesol, an inactive constituent of Maesa spp.
Journal of natural products 1988;51(6):1226-31.
1988: Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; T J Hughes; H Taylor; R McGivney; J Warner
Plant antimutagenic agents, 3. Coumarins.
Journal of natural products 1988;51(6):1148-52.
1988: Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; P Abraham; H Taylor; T J Hughes; J Warner; R McGivney
Plant antimutagenic agents, 2. Flavonoids.
Journal of natural products 1988;51(6):1084-91.
1988: Monroe E Wall; Mansukh C Wani; T J Hughes; H Taylor
Plant antimutagenic agents, 1. General bioassay and isolation procedures.
Journal of natural products 1988;51(5):866-73.
1988: Monroe E Wall; H Taylor; P Perera; Mansukh C Wani
Indoles in edible members of the Cruciferae.
Journal of natural products 1988;51(1):129-35.
1987: Mansukh C Wani; A W Nicholas; Monroe E Wall
Plant antitumor agents. 28. Resolution of a key tricyclic synthon, 5'(RS)-1,5-dioxo-5'-ethyl-5'-hydroxy-2'H,5'H,6'H-6'-oxopyrano[3' ,4'- f]delta 6,8-tetrahydro-indolizine: total synthesis and antitumor activity of 20(S)- and 20(R)-camptothecin.
Journal of medicinal chemistry 1987;30(12):2317-9.
1987: Monroe E Wall; Mansukh C Wani; B N Meyer; H Taylor
Plant antitumor agents, 26. Isolation, structure, and antitumor activity of alkaloids from Anopterus glandulosus.
Journal of natural products 1987;50(6):1152-5.
1987: Monroe E Wall; Mansukh C Wani; H Taylor
Plant antitumor agents, 27. Isolation, structure, and structure activity relationships of alkaloids from Fagara macrophylla.
Journal of natural products 1987;50(6):1095-9.
1987: Mansukh C Wani; A W Nicholas; Govindarajan Manikumar; Monroe E Wall
Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogues. Structure-activity correlations.
Journal of medicinal chemistry 1987;30(10):1774-9.
1987: Monroe E Wall; H Taylor; Mansukh C Wani
Plant antitumor agents, 24. Rapid 9-KB assay.
Journal of natural products 1987;50(4):764-6.
1986: Mansukh C Wani; A W Nicholas; Monroe E Wall
Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogues.
Journal of medicinal chemistry 1986;29(11):2358-63.
1986: Monroe E Wall; Mansukh C Wani; S M Natschke; A W Nicholas
Plant antitumor agents. 22. Isolation of 11-hydroxycamptothecin from Camptotheca acuminata Decne: total synthesis and biological activity.
Journal of medicinal chemistry 1986;29(8):1553-5.
1983: Mansukh C Wani; B R Vishnuvajjala; W E Swain; D H Rector; C E Cook; V Petrow; Jerry Reel; K M Allen; S G Levine
Synthesis and biological activity of zoapatanol analogues.
Journal of medicinal chemistry 1983;26(3):426-30.