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Manus Ward

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Petronela Weisová; Ujval Anilkumar; Caoimhín G Concannon; Jochen H M Prehn; Caitriona Ryan; Manus W Ward
'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.
Beatrice D'Orsi; Heiko Düssmann; Helena Bonner; Michael J Courtney; Liam P Tuffy; Manus W Ward; Ina Woods; Jochen H M Prehn
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.
Petronela Weisová; David Dávila; Liam P Tuffy; Manus W Ward; Caoimhín G Concannon; Jochen H M Prehn
Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.

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All Publications

2012: Petronela Weisová; Ujval Anilkumar; Caoimhín G Concannon; Jochen H M Prehn; Caitriona Ryan; Manus W Ward
'Mild mitochondrial uncoupling' induced protection against neuronal excitotoxicity requires AMPK activity.
Biochimica et biophysica acta 2012;1817(5):744-53.
2012: Beatrice D'Orsi; Heiko Düssmann; Helena Bonner; Michael J Courtney; Liam P Tuffy; Manus W Ward; Ina Woods; Jochen H M Prehn
Calpains are downstream effectors of bax-dependent excitotoxic apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(5):1847-58.
2011: Petronela Weisová; David Dávila; Liam P Tuffy; Manus W Ward; Caoimhín G Concannon; Jochen H M Prehn
Role of 5'-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons.
Antioxidants & redox signaling 2011;14(10):1863-76.
2011: Takuro Tsuchiya; Helena P Bonner; Tobias Engel; Ina Woods; Satoshi Matsushima; Manus W Ward; Waro Taki; David C Henshall; Caoimhín G Concannon; Jochen H M Prehn
Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo.
The European journal of neuroscience 2011;33(3):401-8.
2010: Liam P Tuffy; Caoimhín G Concannon; Beatrice D'Orsi; Matthew A King; Ina Woods; Heinrich J Huber; Manus W Ward; Jochen H M Prehn
Characterization of Puma-dependent and Puma-independent neuronal cell death pathways following prolonged proteasomal inhibition.
Molecular and cellular biology 2010;30(23):5484-501.
2010: Seán M Kilbride; Angela M Farrelly; Caroline Bonner; Manus W Ward; Kristine C Nyhan; Caoimhín G Concannon; Claes B Wollheim; Maria M Byrne; Jochen H M Prehn
AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
The Journal of biological chemistry 2010;285(46):36199-206.
2010: Caroline Bonner; Siobhán Bacon; Caoimhín G Concannon; Syed R Rizvi; Mathurin Baquié; Angela M Farrelly; Seán M Kilbride; Heiko Dussmann; Manus W Ward; Chantal M Boulanger; Claes B Wollheim; Rolf Graf; Maria M Byrne; Jochen H M Prehn
INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.
Diabetes 2010;59(11):2799-808.
2010: Alexander V Zhdanov; Manus W Ward; Cormac T Taylor; Ekaterina A Souslova; Dmitri M Chudakov; Jochen H M Prehn; Dmitri B Papkovsky
Extracellular calcium depletion transiently elevates oxygen consumption in neurosecretory PC12 cells through activation of mitochondrial Na+/Ca2+ exchange.
Biochimica et biophysica acta 2010;1797(9):1627-37.
2010: Helena P Bonner; Caoimhín G Concannon; Caroline Bonner; Ina Woods; Manus W Ward; Jochen H M Prehn
Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability.
Journal of neurochemistry 2010;114(2):606-16.
2010: Caoimhín G Concannon; Liam P Tuffy; Petronela Weisová; Helena P Bonner; David Dávila; Caroline Bonner; Marc C Devocelle; Andreas Strasser; Manus W Ward; Jochen H M Prehn
AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis.
The Journal of cell biology 2010;189(1):83-94.
2010: Manus W Ward; Caoimhín G Concannon; Jacqueline Whyte; Ciara M Walsh; Brian Corley; Jochen H M Prehn
The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics.
Journal of neurochemistry 2010;113(1):275-84.
2010: Manus W Ward
Quantitative analysis of membrane potentials.
Methods in molecular biology (Clifton, N.J.) 2010;591():335-51.
2009: Petronela Weisová; Caoimhín G Concannon; Marc Devocelle; Jochen H M Prehn; Manus W Ward
Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(9):2997-3008.
2008: Niamh Murphy; Helena P Bonner; Manus W Ward; Brona M Murphy; Jochen H M Prehn; David C Henshall
Depletion of 14-3-3 zeta elicits endoplasmic reticulum stress and cell death, and increases vulnerability to kainate-induced injury in mouse hippocampal cultures.
Journal of neurochemistry 2008;106(2):978-88.
2008: Caoimhín G Concannon; Manus W Ward; Helena P Bonner; Katsura Kuroki; Liam Tuffy; Caroline Bonner; Ina Woods; Tobias Engel; David C Henshall; Jochen H M Prehn
NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo occurs in an ER stress and PUMA independent manner.
Journal of neurochemistry 2008;105(3):891-903.
2008: Alexander V Zhdanov; Manus W Ward; Jochen H M Prehn; Dmitri B Papkovsky
Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.
The Journal of biological chemistry 2008;283(9):5650-61.
2007: Manus W Ward; Heinrich J Huber; Petronela Weisová; Heiko Düssmann; David G Nicholls; Jochen H M Prehn
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(31):8238-49.
2007: Caoimhin G Concannon; B F Koehler; Claus Reimertz; B M Murphy; Caroline Bonner; N Thurow; Manus W Ward; Andreas Villunger; A Strasser; Donat Kögel; Jochen H M Prehn
Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway.
Oncogene 2007;26(12):1681-92.
2007: Hans-Georg König; Markus Rehm; Daniel Gudorf; Stan Krajewski; Atan Gross; Manus W Ward; Jochen H M Prehn
Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons.
BMC cell biology 2007;8():7.
2007: Thorsten Müller; Caoimhin G Concannon; Manus W Ward; Ciara M Walsh; Anca L Tirniceriu; Florian Tribl; Donat Kögel; Jochen H M Prehn; Rupert Egensperger
Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).
Molecular biology of the cell 2007;18(1):201-10.
2006: Manus W Ward; Markus Rehm; Heiko Duessmann; Slavomir Kacmar; Caoimhin G Concannon; Jochen H M Prehn
Real time single cell analysis of Bid cleavage and Bid translocation during caspase-dependent and neuronal caspase-independent apoptosis.
The Journal of biological chemistry 2006;281(9):5837-44.
2005: Yulia Kushnareva; Sandra E Wiley; Manus W Ward; Alexander Andreyev; Anne N Murphy
Excitotoxic injury to mitochondria isolated from cultured neurons.
The Journal of biological chemistry 2005;280(32):28894-902.
2005: Manus W Ward; Yulia Kushnareva; Sam Greenwood; Christopher N Connolly
Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons.
Journal of neurochemistry 2005;92(5):1081-90.
2005: Jeremy Copp; Sandra E Wiley; Manus W Ward; Peter van der Geer
Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.
American journal of physiology. Cell physiology 2005;288(2):C403-15.
2004: Manus W Ward; Donat Kögel; Jochen H M Prehn
Neuronal apoptosis: BH3-only proteins the real killers?
Journal of bioenergetics and biomembranes 2004;36(4):295-8.
2002: James A Dykens; Beth Fleck; Soumitra Ghosh; Michelle Lewis; Gonul Velicelebi; Manus W Ward
High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer.
Mitochondrion 2002;1(5):461-73.
2001: A Cristina Rego; Manus W Ward; David G Nicholls
Mitochondria control ampa/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(6):1893-901.
2000: Manus W Ward; A Cristina Rego; Bruno G Frenguelli; David G Nicholls
Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(19):7208-19.
2000: David G Nicholls; Manus W Ward
Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts.
Trends in neurosciences 2000;23(4):166-74.
1999: Roger F Castilho; Manus W Ward; David G Nicholls
Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells.
Journal of neurochemistry 1999;72(4):1394-401.
1999: David G Nicholls; SL Budd; Manus W Ward; Roger F Castilho
Excitotoxicity and mitochondria.
Biochemical Society symposium 1999;66():55-67.
1999: David G Nicholls; SL Budd; Roger F Castilho; Manus W Ward
Glutamate excitotoxicity and neuronal energy metabolism.
Annals of the New York Academy of Sciences 1999;893():1-12.
1998: Roger F Castilho; Oskar Hansson; Manus W Ward; SL Budd; David G Nicholls
Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(24):10277-86.