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Stephen Ward

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Louise La Pensée; Sunil Sabbani; Raman Sharma; Emma Shore; Paul A Stocks; Stephen A Ward; Yi Hang Wu; Nuna C Araujo; Cerys Bateman; Neil G Berry; Inder Bhamra; Lília Cabral; Amy E Chadwick; Richard Cosstick; M Lurdes S Cristiano; James Firman; Adelina Gavrila; Afthab Hussain; Omar Janneh; Paul M O'Neill
Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
Gemma L Nixon; Paul M O'Neill; Alison E Shone; Stephen A Ward; Nicholas Fisher; David Lalloo; Darren M Moss; Giancarlo A Biagini
Antimalarial pharmacology and therapeutics of atovaquone.
Ashley J Warman; Neil G Berry; Nicholas E Fisher; Darren M Moss; Paul M O'Neill; Teresa S Rito; Stephen A Ward; Giancarlo A Biagini
Antitubercular pharmacodynamics of phenothiazines.

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2013: Louise La Pensée; Sunil Sabbani; Raman Sharma; Emma Shore; Paul A Stocks; Stephen A Ward; Yi Hang Wu; Nuna C Araujo; Cerys Bateman; Neil G Berry; Inder Bhamra; Lília Cabral; Amy E Chadwick; Richard Cosstick; M Lurdes S Cristiano; James Firman; Adelina Gavrila; Afthab Hussain; Omar Janneh; Paul M O'Neill
Artemisinin-polypyrrole conjugates: synthesis, DNA binding studies and preliminary antiproliferative evaluation.
ChemMedChem 2013;8(5):709-18.
2013: Gemma L Nixon; Paul M O'Neill; Alison E Shone; Stephen A Ward; Nicholas Fisher; David Lalloo; Darren M Moss; Giancarlo A Biagini
Antimalarial pharmacology and therapeutics of atovaquone.
The Journal of antimicrobial chemotherapy 2013;68(5):977-85.
2013: Ashley J Warman; Neil G Berry; Nicholas E Fisher; Darren M Moss; Paul M O'Neill; Teresa S Rito; Stephen A Ward; Giancarlo A Biagini
Antitubercular pharmacodynamics of phenothiazines.
The Journal of antimicrobial chemotherapy 2013;68(4):869-80.
2012: Abhishek Srivastava; Alison Ardrey; David Waterhouse; Stephen A Ward
Quantification of rifampicin in human plasma and cerebrospinal fluid by a highly sensitive and rapid liquid chromatographic-tandem mass spectrometric method.
Journal of pharmaceutical and biomedical analysis 2012;70():523-8.
2012: Raman Sharma; Joanne Shearer; Alison E Shone; Paul Stocks; Stephen A Ward; Ashley J Warman; Richard K Amewu; Giancarlo A Biagini; James Chadwick; David Cronk; Nicholas E Fisher; Peter Gibbons; Ian Gowers; Alasdair Hill; David W Hong; Alexandre S Lawrenson; Suet Leung; Alison Mbekeani; Gemma L Nixon; Paul M O'Neill; Serge P Parel; Chandrakala Pidathala; Neil G Berry
Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.
Journal of medicinal chemistry 2012;55(7):3144-54.
2012: Nicholas Fisher; David J Johnson; Alexandre S Lawrenson; Paul M O'Neill; Hilary Ranson; Stephen A Ward; Ashley J Warman; Roslaini Abd Majid; Mohammed Al-Helal; Thomas Antoine; Giancarlo A Biagini
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.
The Journal of biological chemistry 2012;287(13):9731-41.
2012: Suet C Leung; Alison Mbekeani; Gemma L Nixon; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Bénédicte Pacorel; Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Paul M O'Neill
Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal of medicinal chemistry 2012;55(5):1844-57.
2012: Chandrakala Pidathala; Raman Sharma; Alison E Shone; Abhishek Srivastava; Paul A Stocks; Lee Taylor; Stephen A Ward; Ashley J Warman; Richard Amewu; Olivier Berger; Neil G Berry; Giancarlo A Biagini; Sitthivut Charoensutthivarakul; Nicholas E Fisher; Peter Gibbons; Alasdair Hill; W David Hong; Suet C Leung; Alison Mbekeani; Gemma L Nixon; Bénédicte Pacorel; Paul M O'Neill
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).
Journal of medicinal chemistry 2012;55(5):1831-43.
2012: U R Goonetilleke; S Hussain; Aras Kadioglu; Matthew Scarborough; Stephen A Ward; Stephen B Gordon
Death is associated with complement C3 depletion in cerebrospinal fluid of patients with pneumococcal meningitis.
mBio 2012;3(2):.
2011: Olivier Berger; Giancarlo A Biagini; Patrick G Bray; Archana Kaniti; Christophe Tran van Ba; Henri Vial; Stephen A Ward; Paul M O'Neill
Synthesis and antimalarial activities of a diverse set of triazole-containing furamidine analogues.
ChemMedChem 2011;6(11):2094-108.
2011: Fatima Bousejra-El Garah; James Chadwick; James L Maggs; Sant Muangnoicharoen; B Kevin Park; Jean-Luc Stigliani; Stephen A Ward; Michael He-Long Wong; Richard K Amewu; Paul M O'Neill
Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
Journal of medicinal chemistry 2011;54(19):6443-55.
2011: James Chadwick; Fatima Bousejra-El Garah; Francesc Marti; Richard K Amewu; Neil G Berry; Reto Brun; Hollie Burrell-Saward; Silvia Parapini; Matthias Rottmann; Raman Sharma; Paul A Stocks; Donatella Taramelli; Stephen A Ward; Sergio Wittlin; Paul M O'Neill
Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.
ChemMedChem 2011;6(8):1357-61.
2011: Evelyn N Gitau; Gilbert O Kokwaro; Charles Rjc Newton; Stephen A Ward
Global proteomic analysis of plasma from mice infected with Plasmodium berghei ANKA using two dimensional gel electrophoresis and matrix assisted laser desorption ionization-time of flight mass spectrometry.
Malaria journal 2011;10():205.
2010: Peter Gibbons; Edite Verissimo; Nuna C Araujo; Victoria Barton; Gemma L Nixon; Richard K Amewu; James Chadwick; Paul A Stocks; Giancarlo A Biagini; Abhishek Srivastava; Philip J Rosenthal; Jiri Gut; Rita C Guedes; Rui Moreira; Raman Sharma; Neil Berry; M Lurdes S Cristiano; Alison E Shone; Stephen A Ward; Paul M O'Neill
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.
Journal of medicinal chemistry 2010;53(22):8202-6.
2010: Upali R Goonetilleke; Matthew Scarborough; Stephen A Ward; Stephen B Gordon
Proteomic analysis of cerebrospinal fluid in pneumococcal meningitis reveals potential biomarkers associated with survival.
The Journal of infectious diseases 2010;202(4):542-50.
2010: Paul M O'Neill; Richard K Amewu; Gemma L Nixon; Fatima Bousejra ElGarah; Mathirut Mungthin; James Chadwick; Alison E Shone; Livia Vivas; Hollie Lander; Victoria Barton; Sant Muangnoicharoen; Patrick G Bray; Jill Davies; B Kevin Park; Sergio Wittlin; Reto Brun; Michael Preschel; Kesheng Zhang; Stephen A Ward
Identification of a 1,2,4,5-tetraoxane antimalarial drug-development candidate (RKA 182) with superior properties to the semisynthetic artemisinins.
Angewandte Chemie (International ed. in English) 2010;49(33):5693-7.
2010: Victoria Barton; Nicholas Fisher; Giancarlo A Biagini; Stephen A Ward; Paul M O'Neill
Inhibiting Plasmodium cytochrome bc1: a complex issue.
Current opinion in chemical biology 2010;14(4):440-6.
2010: Richard Amewu; Peter Gibbons; Amira Mukhtar; Andrew V Stachulski; Stephen A Ward; Charlotte Hall; Karen Rimmer; Jill Davies; Livia Vivas; John Bacsa; Amy Mercer; Gemma Nixon; Paul A Stocks; Paul M O'Neill
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Organic & biomolecular chemistry 2010;8(9):2068-77.
2010: James Chadwick; Michael Jones; Amy Mercer; Paul A Stocks; Stephen A Ward; B Kevin Park; Paul M O'Neill
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines.
Bioorganic & medicinal chemistry 2010;18(7):2586-97.
2010: Paul M O'Neill; Victoria E Barton; Stephen A Ward
The molecular mechanism of action of artemisinin--the debate continues.
Molecules (Basel, Switzerland) 2010;15(3):1705-21.
2010: Bénédicte Pacorel; Suet C Leung; Andrew V Stachulski; Jill Davies; Livia Vivas; Hollie Lander; Stephen A Ward; Marcel Kaiser; Reto Brun; Paul M O'Neill
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.
Journal of medicinal chemistry 2010;53(2):633-40.
2010: J Brian de Souza; Uduak Okomo; Neal D Alexander; Naveed Aziz; Benjamin Owens; Harparkash Kaur; Momodou Jasseh; Sant Muangnoicharoen; Percy F Sumariwalla; david charles warhurst; Stephen A Ward; David J Conway; Luis Ulloa; Kevin Tracey; Brian M J Foxwell; Paul M Kaye; Michael Walther
Oral activated charcoal prevents experimental cerebral malaria in mice and in a randomized controlled clinical trial in man did not interfere with the pharmacokinetics of parenteral artesunate.
PloS one 2010;5(4):e9867.
2009: Paul M O'Neill; Alison E Shone; Deborah Stanford; Gemma Nixon; Eghbaleh Asadollahy; B Kevin Park; James L Maggs; Phil Roberts; Paul A Stocks; Giancarlo Biagini; Patrick G Bray; Jill Davies; Neil Berry; Charlotte Hall; Karen Rimmer; Peter A Winstanley; Stephen Hindley; Ramesh B Bambal; Charles B Davis; Martin Bates; Stephanie L Gresham; Richard A Brigandi; Federico M Gomez-de-Las-Heras; Domingo V Gargallo; Silvia Parapini; Livia Vivas; Hollie Lander; Donatella Taramelli; Stephen A Ward
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
Journal of medicinal chemistry 2009;52(7):1828-44.
2009: Alisa P Alker; Jonathan Juliano; Steven R Meshnick; Andrew Owen; Edwin Ochong; David J Bell; David J Johnson; Umberto D'Alessandro; Modest Mulenga; Sant Muangnoicharoen; Jean-Pierre Van geertruyden; Peter A Winstanley; Patrick G Bray; Stephen A Ward
Plasmodium falciparum and dihydrofolate reductase I164L mutations in Africa.
Antimicrobial agents and chemotherapy 2009;53(4):1722; author reply 1722-3.
2009: Nuna C P Araújo; Victoria Barton; Michael Jones; Paul A Stocks; Stephen A Ward; Jill Davies; Patrick G Bray; Alison E Shone; M Lurdes S Cristiano; Paul M O'Neill
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates.
Bioorganic & medicinal chemistry letters 2009;19(7):2038-43.
2009: Michael Jones; Amy Mercer; Paul A Stocks; Louise J I La Pensée; Richard Cosstick; B Kevin Park; Miriam E Kennedy; Ivo Piantanida; Stephen A Ward; Jill Davies; Patrick G Bray; Sarah L Rawe; Jonathan Baird; Tafadzwa Charidza; Omar Janneh; Paul M O'Neill
Antitumour and antimalarial activity of artemisinin-acridine hybrids.
Bioorganic & medicinal chemistry letters 2009;19(7):2033-7.
2009: Sant Muangnoicharoen; David J Johnson; Sornchai Looareesuwan; Srivicha Krudsood; Stephen A Ward
Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.
Antimicrobial agents and chemotherapy 2009;53(4):1362-6.
2009: Paul M O'Neill; B Kevin Park; Alison E Shone; James L Maggs; Phillip Roberts; Paul A Stocks; Giancarlo A Biagini; Patrick G Bray; Peter Gibbons; Neil Berry; Peter A Winstanley; Amira Mukhtar; Richard Bonar-Law; Stephen Hindley; Ramesh B Bambal; Charles B Davis; Martin Bates; Timothy K Hart; Stephanie L Gresham; Ron M Lawrence; Richard A Brigandi; Federico M Gomez-delas-Heras; Domingo V Gargallo; Stephen A Ward
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
Journal of medicinal chemistry 2009;52(5):1408-15.
2009: Nicholas Fisher; Ashley J Warman; Stephen A Ward; Giancarlo A Biagini
Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays.
Methods in enzymology 2009;456():303-20.
2009: Lu-Yun Lian; Mohammed Al-Helal; Abd Majid Roslaini; Nicholas Fisher; Patrick G Bray; Stephen A Ward; Giancarlo A Biagini
Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite.
Malaria journal 2009;8():38.
2008: Omar Janneh; Ruben C Hartkoorn; E Jones; Andrew Owen; Stephen A Ward; R Davey; David J Back; Saye H Khoo
Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir.
British journal of pharmacology 2008;155(6):875-83.
2008: Sunil Sabbani; Paul A Stocks; Gemma L Ellis; Jill Davies; Erik Hedenstrom; Stephen A Ward; Paul M O'Neill
Piperidine dispiro-1,2,4-trioxane analogues.
Bioorganic & medicinal chemistry letters 2008;18(21):5804-8.
2008: Edwin Ochong; David J Bell; David J Johnson; Umberto D'Alessandro; Modest Mulenga; Sant Muangnoicharoen; Jean-Pierre Van geertruyden; Peter A Winstanley; Patrick G Bray; Stephen A Ward; Andrew Owen
Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure.
Antimicrobial agents and chemotherapy 2008;52(11):3883-8.
2008: Edite Verissimo; Neil Berry; Peter Gibbons; M Lurdes S Cristiano; Philip J Rosenthal; Jiri Gut; Stephen A Ward; Paul M O'Neill
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(14):4210-4.
2008: Giancarlo A Biagini; Nicholas Fisher; Neil Berry; Paul A Stocks; Brigitte Meunier; Dominic P Williams; Richard Bonar-Law; Patrick G Bray; Andrew Owen; Paul M O'Neill; Stephen A Ward
Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.
Molecular pharmacology 2008;73(5):1347-55.
2008: Gemma L Ellis; Richard Amewu; Sunil Sabbani; Paul A Stocks; Alison Shone; Deborah Stanford; Peter Gibbons; Jill Davies; Livia Vivas; Sarah Charnaud; Emily Bongard; Charlotte Hall; Karen Rimmer; Sonia Lozanom; María Jesús; Domingo Gargallo; Stephen A Ward; Paul M O'Neill
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Journal of medicinal chemistry 2008;51(7):2170-7.
2008: David J Johnson; Andrew Owen; Nick Plant; Patrick G Bray; Stephen A Ward
Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.
Antimicrobial agents and chemotherapy 2008;52(4):1438-45.
2008: Gemma L Ellis; Richard Amewu; Charlotte Hall; Karen Rimmer; Stephen A Ward; Paul M O'Neill
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity.
Bioorganic & medicinal chemistry letters 2008;18(5):1720-4.
2008: Nicholas Fisher; Patrick G Bray; Stephen A Ward; Giancarlo A Biagini
Malaria-parasite mitochondrial dehydrogenases as drug targets: too early to write the obituary.
Trends in parasitology 2008;24(1):9-10.
2007: Ruben C Hartkoorn; Saye Khoo; David J Back; John F Tjia; Catriona J Waitt; Masautso Chaponda; Geraint Davies; Alison Ardrey; Samantha Ashleigh; Stephen A Ward
A rapid and sensitive HPLC-MS method for the detection of plasma and cellular rifampicin.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;857(1):76-82.
2007: Nicholas Fisher; Patrick G Bray; Stephen A Ward; Giancarlo A Biagini
The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.
Trends in parasitology 2007;23(7):305-10.
2007: Ruben C Hartkoorn; Becky Chandler; Andrew Owen; Stephen A Ward; S Bertel Squire; David J Back; Saye H Khoo
Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein.
Tuberculosis (Edinburgh, Scotland) 2007;87(3):248-55.
2007: Stephen A Ward; Esperanca J P Sevene; Ian M Hastings; François Nosten; Rose McGready
Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance.
The Lancet infectious diseases 2007;7(2):136-44.
2007: Paul A Stocks; Patrick G Bray; Victoria E Barton; Mohammed Al-Helal; Michael Jones; Nuna C Araujo; Peter Gibbons; Stephen A Ward; Ruth H Hughes; Giancarlo A Biagini; Jill Davies; Richard Amewu; Amy Mercer; Gemma Ellis; Paul M O'Neill
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.
Angewandte Chemie (International ed. in English) 2007;46(33):6278-83.
2006: Richard Amewu; Andrew V Stachulski; Stephen A Ward; Neil G Berry; Patrick G Bray; Jill Davies; Gael Labat; Livia Vivas; Paul M O'Neill
Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.
Organic & biomolecular chemistry 2006;4(24):4431-6.
2006: Richard Amewu; Andrew V Stachulski; Neil G Berry; Stephen A Ward; Jill Davies; Gael Labat; Jean-François Rossignol; Paul M O'Neill
Synthesis of 1,2,4-trioxepanes via application of thiol-olefin co-oxygenation methodology.
Bioorganic & medicinal chemistry letters 2006;16(23):6124-30.
2006: Eric RICHIER; Giancarlo A Biagini; Sharon Wein; Frederic Boudou; Patrick G Bray; Stephen A Ward; Eric Precigout; Michèle Calas; Jean-François Dubremetz; Henri VIAL
Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp.
Antimicrobial agents and chemotherapy 2006;50(10):3381-8.
2006: Patrick G Bray; Mathirut Mungthin; Ian M Hastings; Giancarlo A Biagini; Dauda K Saidu; Viswanathan Lakshmanan; David J Johnson; Ruth H Hughes; Paul A Stocks; Paul M O'Neill; Fidock David; david charles warhurst; Stephen A Ward
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
Molecular microbiology 2006;62(1):238-51.
2006: Paul M O'Neill; Edite Verissimo; Stephen A Ward; Jill Davies; Edward E Korshin; Nuna C Araujo; Matthew D Pugh; M Lurdes S Cristiano; Paul A Stocks; Mario D Bachi
Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore.
Bioorganic & medicinal chemistry letters 2006;16(11):2991-5.
2006: Giancarlo A Biagini; Parnpen Viriyavejakul; Paul M O'Neill; Patrick G Bray; Stephen A Ward
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria.
Antimicrobial agents and chemotherapy 2006;50(5):1841-51.
2006: Paul M O'Neill; Stephen A Ward; Neil G Berry; J Prince Jeyadevan; Giancarlo A Biagini; Egbaleh Asadollaly; B Kevin Park; Patrick G Bray
A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs.
Current topics in medicinal chemistry 2006;6(5):479-507.
2005: Omar Janneh; Andrew Owen; Becky Chandler; Ruben C Hartkoorn; C Anthony Hart; Patrick G Bray; Stephen A Ward; David J Back; Saye H Khoo
Modulation of the intracellular accumulation of saquinavir in peripheral blood mononuclear cells by inhibitors of MRP1, MRP2, P-gp and BCRP.
AIDS (London, England) 2005;19(18):2097-102.
2005: Giancarlo A Biagini; Fidock David; Patrick G Bray; Stephen A Ward
Mutations conferring drug resistance in malaria parasite drug transporters Pgh1 and PfCRT do not affect steady-state vacuolar Ca2+.
Antimicrobial agents and chemotherapy 2005;49(11):4807-8.
2005: Paul M O'Neill; Sarah L Rawe; Kristina Borstnik; Alison Miller; Stephen A Ward; Patrick G Bray; Jill Davies; Chang Ho Oh; Gary H Posner
Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins.
Chembiochem : a European journal of chemical biology 2005;6(11):2048-54.
2005: Giancarlo A Biagini; Paul M O'Neill; Patrick G Bray; Stephen A Ward
Current drug development portfolio for antimalarial therapies.
Current opinion in pharmacology 2005;5(5):473-8.
2005: Andrew Owen; Omar Janneh; Ruben C Hartkoorn; Becky Chandler; Patrick G Bray; Phillip Martin; Stephen A Ward; C Anthony Hart; Saye H Khoo; David J Back
In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1202-9.
2005: Viswanathan Lakshmanan; Patrick G Bray; Dominik Verdier-Pinard; David J Johnson; Paul Horrocks; Rebecca A Muhle; George E Alakpa; Ruth H Hughes; Stephen A Ward; Donald J Krogstad; Amar Bir Singh Sidhu; Fidock David
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.
The EMBO journal 2005;24(13):2294-305.
2005: Alexis Nzila; Stephen A Ward; Kevin Marsh; Paul F G Sims; John E Hyde
Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium.
Trends in parasitology 2005;21(7):334-9.
2005: Giancarlo A Biagini; Stephen A Ward; Patrick G Bray
Malaria parasite transporters as a drug-delivery strategy.
Trends in parasitology 2005;21(7):299-301.
2005: Alexis Nzila; Stephen A Ward; Kevin Marsh; Paul F G Sims; John E Hyde
Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.
Trends in parasitology 2005;21(6):292-8.
2005: Michael Makanga; Patrick G Bray; Paul Horrocks; Stephen A Ward
Towards a proteomic definition of CoArtem action in Plasmodium falciparum malaria.
Proteomics 2005;5(7):1849-58.
2005: Patrick G Bray; Rowena E Martin; Leann Tilley; Stephen A Ward; Kiaran Kirk; Fidock David
Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance.
Molecular microbiology 2005;56(2):323-33.
2005: Patrick G Bray; Stephen A Ward; Paul M O'Neill
Quinolines and artemisinin: chemistry, biology and history.
Current topics in microbiology and immunology 2005;295():3-38.
2004: Giancarlo A Biagini; Erica M Pasini; Ruth Hughes; Harry P De Koning; Henri VIAL; Paul M O'Neill; Stephen A Ward; Patrick G Bray
Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial drugs.
Blood 2004;104(10):3372-7.
2004: Andrew Owen; Becky Chandler; Patrick G Bray; Stephen A Ward; C Anthony Hart; David J Back; Saye H Khoo
Functional correlation of P-glycoprotein expression and genotype with expression of the human immunodeficiency virus type 1 coreceptor CXCR4.
Journal of virology 2004;78(21):12022-9.
2004: David J Johnson; Fidock David; Mathirut Mungthin; Viswanathan Lakshmanan; Amar Bir Singh Sidhu; Patrick G Bray; Stephen A Ward
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.
Molecular cell 2004;15(6):867-77.
2004: Paul M O'Neill; Amira Mukhtar; Stephen A Ward; Jamie F Bickley; Jill Davies; Mario D Bachi; Paul A Stocks
Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore.
Organic letters 2004;6(18):3035-8.
2004: Paul M O'Neill; Paul A Stocks; Matthew D Pugh; Nuna C Araujo; Edward E Korshin; Jamie F Bickley; Stephen A Ward; Patrick G Bray; Erica Pasini; Jill Davies; Edite Verissimo; Mario D Bachi
Design and synthesis of endoperoxide antimalarial prodrug models.
Angewandte Chemie (International ed. in English) 2004;43(32):4193-7.
2004: Alexis Nzila; Gilbert O Kokwaro; Peter A Winstanley; Kevin Marsh; Stephen A Ward
Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.
Trends in parasitology 2004;20(3):109-12.
2004: J Prince Jeyadevan; Patrick G Bray; James Chadwick; Amy Mercer; Aoife Byrne; Stephen A Ward; B Kevin Park; Dominic P Williams; Richard Cosstick; Jill Davies; Adrian P Higson; Ed Irving; Gary H Posner; Paul M O'Neill
Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin.
Journal of medicinal chemistry 2004;47(5):1290-8.
2003: Paul M O'Neill; Amira Mukhtar; Paul A Stocks; Laura E Randle; Stephen Hindley; Stephen A Ward; Richard C Storr; Jamie F Bickley; Ian A O'Neil; James L Maggs; Ruth H Hughes; Peter A Winstanley; Patrick G Bray; B Kevin Park
Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
Journal of medicinal chemistry 2003;46(23):4933-45.
2003: Giancarlo A Biagini; Paul M O'Neill; Alexis Nzila; Stephen A Ward; Patrick G Bray
Antimalarial chemotherapy: young guns or back to the future?
Trends in parasitology 2003;19(11):479-87.
2003: Giancarlo A Biagini; Eric RICHIER; Patrick G Bray; Michèle Calas; Henri VIAL; Stephen A Ward
Heme binding contributes to antimalarial activity of bis-quaternary ammoniums.
Antimicrobial agents and chemotherapy 2003;47(8):2584-9.
2003: Giancarlo A Biagini; Patrick G Bray; David G Spiller; Michael R H White; Stephen A Ward
The digestive food vacuole of the malaria parasite is a dynamic intracellular Ca2+ store.
The Journal of biological chemistry 2003;278(30):27910-5.
2003: Patrick G Bray; Michael P Barrett; Stephen A Ward; Harry P De Koning
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future.
Trends in parasitology 2003;19(5):232-9.
2002: Paul A Stocks; Kaylene J Raynes; Patrick G Bray; B Kevin Park; Paul M O'Neill; Stephen A Ward
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
Journal of medicinal chemistry 2002;45(23):4975-83.
2002: Ian M Hastings; Patrick G Bray; Stephen A Ward
Parasitology. A requiem for chloroquine.
Science (New York, N.Y.) 2002;298(5591):74-5.
2002: David G Spiller; Patrick G Bray; Ruth H Hughes; Stephen A Ward; Michael R H White
The pH of the Plasmodium falciparum digestive vacuole: holy grail or dead-end trail?
Trends in parasitology 2002;18(10):441-4.
2002: Kevin Jones; Stephen A Ward
Biguanide-atovaquone synergy against Plasmodium falciparum in vitro.
Antimicrobial agents and chemotherapy 2002;46(8):2700-3.
2002: Stephen Hindley; Stephen A Ward; Richard C Storr; Natalie L Searle; Patrick G Bray; B Kevin Park; Jill Davies; Paul M O'Neill
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
Journal of medicinal chemistry 2002;45(5):1052-63.
2002: Patrick G Bray; Kevin Saliba; Jill D Davies; David G Spiller; Michael R H White; Kiaran Kirk; Stephen A Ward
Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH.
Molecular and biochemical parasitology 2002;119(2):301-4; discussion 307-9, 311-3.
2001: Kevin Jones; Patrick G Bray; Saye H Khoo; R A Davey; E Rhiannon Meaden; Stephen A Ward; David J Back
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?
AIDS (London, England) 2001;15(11):1353-8.
2001: A M Stead; Patrick G Bray; I G Edwards; H P DeKoning; B C Elford; Paul A Stocks; Stephen A Ward
Diamidine compounds: selective uptake and targeting in Plasmodium falciparum.
Molecular pharmacology 2001;59(5):1298-306.
2001: Stephen A Ward; Patrick G Bray
Is reversal of chloroquine resistance ready for the clinic?
Lancet 2001;357(9260):904.
2001: S L Smith; C J Sadler; Charlotte C Dodd; Geoffrey Edwards; Stephen A Ward; B Kevin Park; W Graham McLean
The role of glutathione in the neurotoxicity of artemisinin derivatives in vitro.
Biochemical pharmacology 2001;61(4):409-16.
2001: Paul M O'Neill; A Miller; Laurence P D Bishop; Stephen Hindley; James L Maggs; Stephen A Ward; S M Roberts; Feodor Scheinmann; Andrew V Stachulski; G H Posner; B Kevin Park
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
Journal of medicinal chemistry 2001;44(1):58-68.
2000: Paul M O'Neill; Laurence P D Bishop; Natalie L Searle; James L Maggs; Richard C Storr; Stephen A Ward; B Kevin Park; F Mabbs
Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical.
The Journal of organic chemistry 2000;65(5):1578-82.
2000: James L Maggs; Laurence P D Bishop; Geoffrey Edwards; Paul M O'Neill; Stephen A Ward; Peter A Winstanley; B Kevin Park
Biliary metabolites of beta-artemether in rats: biotransformations of an antimalarial endoperoxide.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):209-17.
1999: Paul M O'Neill; Natalie L Searle; K W Kan; Richard C Storr; James L Maggs; Stephen A Ward; Kaylene J Raynes; B Kevin Park
Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether.
Journal of medicinal chemistry 1999;42(26):5487-93.
1999: Patrick G Bray; Stephen A Ward; Hagai Ginsburg
Na+/H+ antiporter, chloroquine uptake and drug resistance: inconsistencies in a newly proposed model.
Parasitology today (Personal ed.) 1999;15(9):360-3.
1999: Kaylene J Raynes; Paul A Stocks; Paul M O'Neill; B Kevin Park; Stephen A Ward
New 4-aminoquinoline Mannich base antimalarials. 1. Effect of an alkyl substituent in the 5'-position of the 4'-hydroxyanilino side chain.
Journal of medicinal chemistry 1999;42(15):2747-51.
1999: Patrick G Bray; Omar Janneh; Kaylene J Raynes; Mathirut Mungthin; H Ginsburg; Stephen A Ward
Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum.
The Journal of cell biology 1999;145(2):363-76.
1999: Mathirut Mungthin; Patrick G Bray; Stephen A Ward
Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand.
The American journal of tropical medicine and hygiene 1999;60(3):469-74.
1999: Patrick G Bray; Omar Janneh; Stephen A Ward
Chloroquine uptake and activity is determined by binding to ferriprotoporphyrin IX in Plasmodium falciparum.
Novartis Foundation symposium 1999;226():252-60; discussion 260-4.
1998: Mathirut Mungthin; Patrick G Bray; R G Ridley; Stephen A Ward
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.
Antimicrobial agents and chemotherapy 1998;42(11):2973-7.
1998: J E Ruscoe; MD Tingle; Paul M O'Neill; Stephen A Ward; B Kevin Park
Effect of disposition of mannich antimalarial agents on their pharmacology and toxicology.
Antimicrobial agents and chemotherapy 1998;42(9):2410-6.
1998: Patrick G Bray; Mathirut Mungthin; R G Ridley; Stephen A Ward
Access to hematin: the basis of chloroquine resistance.
Molecular pharmacology 1998;54(1):170-9.
1998: J Fishwick; Geoffrey Edwards; Stephen A Ward; W Graham McLean
Binding of dihydroartemisinin to differentiating neuroblastoma cells and rat cortical homogenate.
Neurotoxicology 1998;19(3):405-12.
1998: J Fishwick; Geoffrey Edwards; Stephen A Ward; W Graham McLean
Morphological and immunocytochemical effects of dihydroartemisinin on differentiating NB2a neuroblastoma cells.
Neurotoxicology 1998;19(3):393-403.
1998: N A Helsby; Stephen A Ward; Richard Parslew; Peter S Friedmann; Lesley E Rhodes
Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound.
Acta dermato-venereologica 1998;78(2):81-3.
1998: W Graham McLean; Stephen A Ward
In vitro neurotoxicity of artemisinin derivatives.
Médecine tropicale : revue du Corps de santé colonial 1998;58(3 Suppl):28-31.
1998: Paul M O'Neill; Patrick G Bray; S R Hawley; Stephen A Ward; B Kevin Park
4-Aminoquinolines--past, present, and future: a chemical perspective.
Pharmacology & therapeutics 1998;77(1):29-58.
1998: Patrick G Bray; Stephen A Ward
A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum.
Pharmacology & therapeutics 1998;77(1):1-28.
1997: Paul M O'Neill; D J Willock; S R Hawley; Patrick G Bray; Richard C Storr; Stephen A Ward; B Kevin Park
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues.
Journal of medicinal chemistry 1997;40(4):437-48.
1997: S L Smith; J Fishwick; W Graham McLean; Geoffrey Edwards; Stephen A Ward
Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin.
Biochemical pharmacology 1997;53(1):5-10.
1997: Stephen A Ward; Patrick G Bray; S R Hawley
Quinoline resistance mechanisms in Plasmodium falciparum: the debate goes on.
Parasitology 1997;114 Suppl():S125-36.
1996: G Y Ritchie; Mathirut Mungthin; J E Green; Patrick G Bray; S R Hawley; Stephen A Ward
In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1.
Molecular and biochemical parasitology 1996;83(1):35-46.
1996: Patrick G Bray; S R Hawley; Mathirut Mungthin; Stephen A Ward
Physicochemical properties correlated with drug resistance and the reversal of drug resistance in Plasmodium falciparum.
Molecular pharmacology 1996;50(6):1559-66.
1996: Patrick G Bray; S R Hawley; Stephen A Ward
4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake.
Molecular pharmacology 1996;50(6):1551-8.
1996: Paul M O'Neill; Laurence P D Bishop; Richard C Storr; S R Hawley; James L Maggs; Stephen A Ward; B Kevin Park
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of benzylamino and alkylamino ether analogues of artemisinin.
Journal of medicinal chemistry 1996;39(22):4511-4.
1996: S R Hawley; Patrick G Bray; Paul M O'Neill; Dean J Naisbitt; B Kevin Park; Stephen A Ward
Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component.
Antimicrobial agents and chemotherapy 1996;40(10):2345-9.
1996: S R Hawley; Patrick G Bray; Paul M O'Neill; B Kevin Park; Stephen A Ward
The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties.
Biochemical pharmacology 1996;52(5):723-33.
1996: S R Hawley; Patrick G Bray; B Kevin Park; Stephen A Ward
Amodiaquine accumulation in Plasmodium falciparum as a possible explanation for its superior antimalarial activity over chloroquine.
Molecular and biochemical parasitology 1996;80(1):15-25.
1995: J Fishwick; W Graham McLean; Geoffrey Edwards; Stephen A Ward
The toxicity of artemisinin and related compounds on neuronal and glial cells in culture.
Chemico-biological interactions 1995;96(3):263-71.
1995: J E Ruscoe; H Jewell; James L Maggs; Paul M O'Neill; Richard C Storr; Stephen A Ward; B Kevin Park
The effect of chemical substitution on the metabolic activation, metabolic detoxication, and pharmacological activity of amodiaquine in the mouse.
The Journal of pharmacology and experimental therapeutics 1995;273(1):393-404.
1995: J D Wright; N A Helsby; Stephen A Ward
The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides.
British journal of clinical pharmacology 1995;39(4):441-4.
1995: Stephen A Ward; Patrick G Bray; Mathirut Mungthin; S R Hawley
Current views on the mechanisms of resistance to quinoline-containing drugs in Plasmodium falciparum.
Annals of tropical medicine and parasitology 1995;89(2):121-4.
1994: K Haruki; Patrick G Bray; Stephen A Ward; Marcel Hommel; G Y Ritchie
Chloroquine resistance of Plasmodium falciparum: further evidence for a lack of association with mutations of the pfmdr1 gene.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1994;88(6):694.
1994: D K Muhia; C G Thomas; Stephen A Ward; G Edwards; Edward K Mberu; William M Watkins
Ferriprotoporphyrin catalysed decomposition of artemether: analytical and pharmacological implications.
Biochemical pharmacology 1994;48(5):889-95.
1994: Geoffrey Edwards; Peter A Winstanley; Stephen A Ward
Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations.
Clinical pharmacokinetics 1994;27(2):150-65.
1994: Paul M O'Neill; A C Harrison; Richard C Storr; S R Hawley; Stephen A Ward; B Kevin Park
The effect of fluorine substitution on the metabolism and antimalarial activity of amodiaquine.
Journal of medicinal chemistry 1994;37(9):1362-70.
1994: Patrick G Bray; M K Boulter; G Y Ritchie; R E Howells; Stephen A Ward
Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum.
Molecular and biochemical parasitology 1994;63(1):87-94.
1993: G O Kokwaro; I S Szwandt; A P Glazier; Stephen A Ward; Geoffrey Edwards
Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(12):1391-7.
1993: M Nateghpour; Stephen A Ward; R E Howells
Development of halofantrine resistance and determination of cross-resistance patterns in Plasmodium falciparum.
Antimicrobial agents and chemotherapy 1993;37(11):2337-43.
1993: Patrick G Bray; Stephen A Ward
Malaria chemotherapy: resistance to quinoline containing drugs in Plasmodium falciparum.
FEMS microbiology letters 1993;113(1):1-7.
1993: N A Helsby; Geoffrey Edwards; Alasdair M Breckenridge; Stephen A Ward
The multiple dose pharmacokinetics of proguanil.
British journal of clinical pharmacology 1993;35(6):653-6.
1993: A M Ndifor; R E Howells; Patrick G Bray; J L Ngu; Stephen A Ward
Enhancement of drug susceptibility in Plasmodium falciparum in vitro and Plasmodium berghei in vivo by mixed-function oxidase inhibitors.
Antimicrobial agents and chemotherapy 1993;37(6):1318-23.
1993: M K Boulter; Patrick G Bray; R E Howells; Stephen A Ward
The potential of desipramine to reverse chloroquine resistance of Plasmodium falciparum is reduced by its binding to plasma protein.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1993;87(3):303.
1993: G O Kokwaro; S Ismail; A P Glazier; Stephen A Ward; Geoffrey Edwards
Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat.
Biochemical pharmacology 1993;45(6):1243-9.
1993: G O Kokwaro; A P Glazier; Stephen A Ward; Alasdair M Breckenridge; Geoffrey Edwards
Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes.
Biochemical pharmacology 1993;45(6):1235-41.
1993: Geoffrey Edwards; C S McGrath; Stephen A Ward; Wichai Supanaranond; Sasithon Pukrittayakamee; Timothy Davis; N J White
Interactions among primaquine, malaria infection and other antimalarials in Thai subjects.
British journal of clinical pharmacology 1993;35(2):193-8.
1992: C G Thomas; Stephen A Ward; Geoffrey Edwards
Selective determination, in plasma, of artemether and its major metabolite, dihydroartemisinin, by high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography 1992;583(1):131-6.
1992: R David G Theakston; Hui Wen Fan; David A Warrell; Wilmar Dias da Silva; Stephen A Ward; H G Higashi
Use of enzyme immunoassays to compare the effect and assess the dosage regimens of three Brazilian Bothrops antivenoms. The Butantan Institute Antivenom Study Group (BIASG).
The American journal of tropical medicine and hygiene 1992;47(5):593-604.
1992: S Wanwimolruk; Geoffrey Edwards; Stephen A Ward; Alasdair M Breckenridge
The binding of the antimalarial arteether to human plasma proteins in-vitro.
The Journal of pharmacy and pharmacology 1992;44(11):940-2.
1992: Patrick G Bray; R E Howells; G Y Ritchie; Stephen A Ward
Rapid chloroquine efflux phenotype in both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. A correlation of chloroquine sensitivity with energy-dependent drug accumulation.
Biochemical pharmacology 1992;44(7):1317-24.
1992: Geoffrey Edwards; Stephen A Ward
Methods in tropical pharmacology.
British journal of clinical pharmacology 1992;33(6):573-4.
1992: A M Ndifor; R E Howells; Stephen A Ward
Chloroquine sensitivity of Plasmodium falciparum in vivo in a savanna town in Cameroon.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1992;86(3):229-30.
1992: Peter A Winstanley; Charles Newton; G Pasvol; F J Kirkham; Edward K Mberu; Norbert Peshu; Stephen A Ward; J B Were; D A Warrell; Kevin Marsh
Prophylactic phenobarbitone in young children with severe falciparum malaria: pharmacokinetics and clinical effects.
British journal of clinical pharmacology 1992;33(2):149-54.
1991: S M Mansor; Stephen A Ward; Geoffrey Edwards
The effect of fever on quinine and quinidine disposition in the rat.
The Journal of pharmacy and pharmacology 1991;43(10):705-8.
1991: Edward K Mberu; Stephen A Ward; Peter A Winstanley; William M Watkins
Measurement of quinine in filter paper-absorbed blood by high-performance liquid chromatography.
Journal of chromatography 1991;570(1):180-4.
1991: S M Mansor; Malcolm E Molyneux; Terrie E Taylor; Stephen A Ward; J J Wirima; Geoffrey Edwards
Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1-acid glycoprotein and the binding of quinine in Malawian children.
British journal of clinical pharmacology 1991;32(3):317-21.
1991: S M Mansor; Stephen A Ward; Geoffrey Edwards; P E Hoaksey; Alasdair M Breckenridge
The influence of alpha 1-acid glycoprotein on quinine and quinidine disposition in the rat isolated perfused liver preparation.
The Journal of pharmacy and pharmacology 1991;43(9):650-4.
1991: S M Mansor; Geoffrey Edwards; P J Roberts; Stephen A Ward
The effect of malaria infection on paracetamol disposition in the rat.
Biochemical pharmacology 1991;41(11):1707-11.
1991: Stephen A Ward; N A Helsby; E Skjelbo; K Brøsen; L F Gram; Alasdair M Breckenridge
The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study.
British journal of clinical pharmacology 1991;31(6):689-92.
1991: P E Hoaksey; Kwablah Awadzi; Stephen A Ward; P A Coventry; M L Orme; Geoffrey Edwards
Rapid and sensitive method for the determination of albendazole and albendazole sulphoxide in biological fluids.
Journal of chromatography 1991;566(1):244-9.
1991: N A Helsby; William M Watkins; Edward K Mberu; Stephen A Ward
Inter-individual variation in the metabolic activation of the antimalarial biguanides.
Parasitology today (Personal ed.) 1991;7(5):120-3.
1990: N A Helsby; Stephen A Ward; G Edwards; R E Howells; Alasdair M Breckenridge
The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism.
British journal of clinical pharmacology 1990;30(4):593-8.
1990: N A Helsby; Stephen A Ward; R E Howells; Alasdair M Breckenridge
In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.
British journal of clinical pharmacology 1990;30(2):287-91.
1990: William M Watkins; Edward K Mberu; C G Nevill; Stephen A Ward; Alasdair M Breckenridge; Davy K Koech
Variability in the metabolism of proguanil to the active metabolite cycloguanil in healthy Kenyan adults.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(4):492-5.
1990: S M Mansor; Terrie E Taylor; C S McGrath; Geoffrey Edwards; Stephen A Ward; J J Wirima; Malcolm E Molyneux
The safety and kinetics of intramuscular quinine in Malawian children with moderately severe falciparum malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 1990;84(4):482-7.
1990: A M Ndifor; Stephen A Ward; R E Howells
Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance.
Molecular and biochemical parasitology 1990;41(2):251-7.
1990: S M Mansor; Stephen A Ward; Geoffrey Edwards; P E Hoaksey; Alasdair M Breckenridge
The effect of malaria infection on the disposition of quinine and quinidine in the rat isolated perfused liver preparation.
The Journal of pharmacy and pharmacology 1990;42(6):428-32.
1990: K A Milton; P E Hoaksey; Stephen A Ward; Geoffrey Edwards
Lack of effect of halofantrine on hepatic drug metabolism in the rat in vivo and in vitro.
Biochemical pharmacology 1990;39(10):1581-6.
1989: O R Idowu; Stephen A Ward; Geoffrey Edwards
Determination of artelinic acid in blood plasma by high-performance liquid chromatography.
Journal of chromatography 1989;495():167-77.
1989: K A Milton; Geoffrey Edwards; Stephen A Ward; M L Orme; Alasdair M Breckenridge
Pharmacokinetics of halofantrine in man: effects of food and dose size.
British journal of clinical pharmacology 1989;28(1):71-7.
1989: Stephen A Ward; William M Watkins; Edward K Mberu; J E Saunders; Davy K Koech; H M Gilles; R E Howells; Alasdair M Breckenridge
Inter-subject variability in the metabolism of proguanil to the active metabolite cycloguanil in man.
British journal of clinical pharmacology 1989;27(6):781-7.
1988: K A Milton; Stephen A Ward; Geoffrey Edwards
Determination of halofantrine and its principal metabolite desbutylhalofantrine in biological fluids by reversed-phase high-performance liquid chromatography.
Journal of chromatography 1988;433():339-44.
1988: Stephen A Ward; D G May; A J Heath; R A Branch
Carbaryl metabolism is inhibited by cimetidine in the isolated perfused rat liver and in man.
Journal of toxicology. Clinical toxicology 1988;26(5-6):269-81.