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Stephen Ward

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Chemicals & Drugs

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John G Foster; Iain Kilty; Amanda B MacKenzie; Edward Carter; Stephen G Ward
Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.
Stephanie J Harris; Loredana Ciuclan; Peter M Finan; Christoph Walker; Stephen G Ward; John Westwick; Matthias P Wymann; Matthew J Thomas
Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
John G Foster; Matthew D Blunt; Edward Carter; Stephen G Ward
Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies.

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All Publications

2013: John G Foster; Iain Kilty; Amanda B MacKenzie; Edward Carter; Stephen G Ward
Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(4):1551-9.
2012: Stephanie J Harris; Loredana Ciuclan; Peter M Finan; Christoph Walker; Stephen G Ward; John Westwick; Matthias P Wymann; Matthew J Thomas
Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
European journal of immunology 2012;42(12):3394-404.
2012: John G Foster; Matthew D Blunt; Edward Carter; Stephen G Ward
Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies.
Pharmacological reviews 2012;64(4):1027-54.
2012: Stephen G Ward; Luke A J O'Neill
Spurs in the hunt for new immunomodulatory drug targets.
Current opinion in pharmacology 2012;12(4):439-43.
2012: Matthew D Blunt; Stephen G Ward
Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia.
Current opinion in pharmacology 2012;12(4):444-51.
2012: Matthew D Blunt; Stephen G Ward
Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities.
Frontiers in immunology 2012;3():226.
2011: Stephen G Ward; John Westwick; Stephanie Harris
Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes.
Immunology letters 2011;138(1):15-8.
2011: Stephanie J Harris; Richard V Parry; John G Foster; Matthew D Blunt; Amu Wang; Federica M Marelli-Berg; John Westwick; Stephen G Ward
Evidence that the lipid phosphatase SHIP-1 regulates T lymphocyte morphology and motility.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(8):4936-45.
2011: Anna Korniejewska; Andrew J McKnight; Zoë Johnson; Malcolm L Watson; Stephen G Ward
Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes.
Immunology 2011;132(4):503-15.
2010: Ian Willox; Irina Mirkina; John Westwick; Stephen G Ward
Evidence for PI3K-dependent CXCR3 agonist-induced degranulation of human cord blood-derived mast cells.
Molecular immunology 2010;47(14):2367-77.
2010: Richard V Parry; Stephen G Ward
Protein arginine methylation: a new handle on T lymphocytes?
Trends in immunology 2010;31(4):164-9.
2010: Li-Rui Sun; Julia Li Zhong; Shu-Xiang Cui; Xun Li; Stephen G Ward; Yan-Qiu Shi; Xiao-Fan Zhang; Yan-Na Cheng; Jian-Jun Gao; Xian-Jun Qu
Modulation of P-glycoprotein activity by the substituted quinoxalinone compound QA3 in adriamycin-resistant K562/A02 cells.
Pharmacological reports : PR 2010;62(2):333-42.
2010: Richard V Parry; Stephanie J Harris; Stephen G Ward
Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1.
Biochimica et biophysica acta 2010;1804(3):592-7.
2009: Stephen G Ward; Randall Mrsny
New insights into mechanisms of gastrointestinal inflammation and cancer.
Current opinion in pharmacology 2009;9(6):677-9.
2009: Benjamin J Colleypriest; Stephen G Ward; David Tosh
How does inflammation cause Barrett's metaplasia?
Current opinion in pharmacology 2009;9(6):721-6.
2009: Stephanie J Harris; John Foster; Stephen G Ward
PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies.
Current opinion in investigational drugs (London, England : 2000) 2009;10(11):1151-62.
2009: Benjamin J Colleypriest; Rebecca M Palmer; Stephen G Ward; David Tosh
Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia.
Trends in molecular medicine 2009;15(7):313-22.
2009: Stephen G Ward
Millipede-like lymphocyte crawling: feeling the way with filopodia.
Immunity 2009;30(3):315-7.
2009: Li-rui Sun; Xun Li; Yan-na Cheng; Hong-yu Yuan; Ming-Hui Chen; Wei Tang; Stephen G Ward; Xian-Jun Qu
Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2009;63(3):202-8.
2009: Stephen G Ward; Federica M Marelli-Berg
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
The Biochemical journal 2009;418(1):13-27.
2008: Ming-Hui Chen; Shu-Xiang Cui; Yan-Na Cheng; Li-Rui Sun; Qian-Bin Li; Wen-Fang Xu; Stephen G Ward; Wei Tang; Xian-Jun Qu
Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity.
Anti-cancer drugs 2008;19(10):957-65.
2008: Adam Webb; Andrew Johnson; Mara Fortunato; Adam Platt; Tom Crabbe; Mark I Christie; Gillian F Watt; Stephen G Ward; Louise A Jopling
Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists.
Journal of leukocyte biology 2008;84(4):1202-12.
2008: Karen Wright; Duncan A F Robertson; Mary Pat Moyer; Stephen G Ward
Long term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer.
International journal of cancer. Journal international du cancer 2008;122(8):1920-1.
2008: Stephen G Ward
New drug targets in inflammation: efforts to expand the anti-inflammatory armoury.
British journal of pharmacology 2008;153 Suppl 1():S5-6.
2008: Stephanie J Harris; Richard V Parry; John Westwick; Stephen G Ward
Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes.
The Journal of biological chemistry 2008;283(5):2465-9.
2007: Laura D Smith; Emma S Hickman; Richard V Parry; John Westwick; Stephen G Ward
PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA.
Cellular signalling 2007;19(12):2528-39.
2007: Tom Crabbe; Melanie J Welham; Stephen G Ward
The PI3K inhibitor arsenal: choose your weapon!
Trends in biochemical sciences 2007;32(10):450-6.
2007: David A Medina-Tato; Stephen G Ward; Malcolm Watson
Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond.
Immunology 2007;121(4):448-61.
2007: L Smith; A Webb; Stephen G Ward
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
Biochemical Society transactions 2007;35(Pt 2):193-8.
2007: Richard V Parry; James L Riley; Stephen G Ward
Signalling to suit function: tailoring phosphoinositide 3-kinase during T-cell activation.
Trends in immunology 2007;28(4):161-8.
2007: Karen Coopman; Laura D Smith; Karen Wright; Stephen G Ward
Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis.
International immunopharmacology 2007;7(3):360-71.
2006: David A Medina-Tato; Malcolm Watson; Stephen G Ward
Leukocyte navigation mechanisms as targets in airway diseases.
Drug discovery today 2006;11(19-20):866-79.
2006: Darran G Cronshaw; Andreas Kouroumalis; Richard Parry; Adam Webb; Zarin Brown; Stephen G Ward
Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22.
Journal of leukocyte biology 2006;79(6):1369-80.
2006: Stephen G Ward
T lymphocytes on the move: chemokines, PI 3-kinase and beyond.
Trends in immunology 2006;27(2):80-7.
2006: Richard V Parry; Gillian C Whittaker; Martin Sims; Christine E Edmead; Melanie J Welham; Stephen G Ward
Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the gab2 pleckstrin homology domain.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):594-602.
2005: Andreas Kouroumalis; Robert J B Nibbs; Hervé APTEL; Karen Wright; George Kolios; Stephen G Ward
The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G alpha i-independent signaling and actin responses in human intestinal myofibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5403-11.
2005: Clare M Wain; John Westwick; Stephen G Ward
Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes.
Cellular signalling 2005;17(10):1194-202.
2005: Kajal M Patel; Karen Wright; Paul Whittaker; Probir Chakravarty; Malcolm Watson; Stephen G Ward
Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma).
Cellular signalling 2005;17(9):1098-110.
2004: George Kolios; Vassilis Valatas; Stephen G Ward
Nitric oxide in inflammatory bowel disease: a universal messenger in an unsolved puzzle.
Immunology 2004;113(4):427-37.
2004: Darran G Cronshaw; Charles Owen; Zarin Brown; Stephen G Ward
Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7761-70.
2004: Karen Wright; Sean A Weaver; Kajal Patel; Karen Coopman; Mark Feeney; George Kolios; Duncan A F Robertson; Stephen G Ward
Differential regulation of prostaglandin E biosynthesis by interferon-gamma in colonic epithelial cells.
British journal of pharmacology 2004;141(7):1091-7.
2004: Stephen G Ward
Do phosphoinositide 3-kinases direct lymphocyte navigation?
Trends in immunology 2004;25(2):67-74.
2004: Adam P Curnock; Yannis Sotsios; Stephen G Ward
Assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling: use of dominant negative mutants controlled by a tetracycline-regulated gene expression system.
Methods in molecular biology (Clifton, N.J.) 2004;239():211-22.
2003: Stephen G Ward; Peter Finan
Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents.
Current opinion in pharmacology 2003;3(4):426-34.
2003: Stephen G Ward; Luke A J O'Neill
Spotlight on new anti-inflammatory drug targets in the immune system.
Current opinion in pharmacology 2003;3(4):391-5.
2003: Adam P Curnock; Yannis Sotsios; Karen Wright; Stephen G Ward
Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class IA and IB phosphoinositide 3-kinases.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):4021-30.
2003: Luke A J O'Neill; Zarin Brown; Stephen G Ward
Toll-like receptors in the spotlight.
Nature immunology 2003;4(4):299.
2003: Adam P Curnock; Stephen G Ward
Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling.
Journal of immunological methods 2003;273(1-2):29-41.
2003: Stephen G Ward; Peter Finan; Melanie J Welham
PI3K comes of age.
Nature immunology 2003;4(1):2.
2002: Robin W Freeburn; Karen Wright; Steven J Burgess; Emmanuelle Astoul; Doreen A Cantrell; Stephen G Ward
Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5441-50.
2002: Adam P Curnock; Marisa K Logan; Stephen G Ward
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
Immunology 2002;105(2):125-36.
2001: Sean A Weaver; Stephen G Ward
Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer?
Trends in molecular medicine 2001;7(10):455-62.
2001: Emmanuelle Astoul; C Edmunds; Doreen A Cantrell; Stephen G Ward
PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.
Trends in immunology 2001;22(9):490-6.
2001: Stephen G Ward; D A Cantrell
Phosphoinositide 3-kinases in T lymphocyte activation.
Current opinion in immunology 2001;13(3):332-8.
2001: Sean A Weaver; Maria P Russo; Karen Wright; George Kolios; Christian Jobin; Duncan A F Robertson; Stephen G Ward
Regulatory role of phosphatidylinositol 3-kinase on TNF-alpha-induced cyclooxygenase 2 expression in colonic epithelial cells.
Gastroenterology 2001;120(5):1117-27.
2001: Yannis Sotsios; Stephen G Ward
Collection, separation, and activation of human T lymphocytes.
Methods in molecular medicine 2001;56():205-15.
2000: Yannis Sotsios; Stephen G Ward
Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines.
Immunological reviews 2000;177():217-35.
2000: Karen Wright; Stephen G Ward
Interactions between phosphatidylinositol 3-kinase and nitric oxide: explaining the paradox.
Molecular cell biology research communications : MCBRC 2000;4(3):137-43.
2000: Yannis Sotsios; Patrick J Blair; John Westwick; Stephen G Ward
Disparate effects of phorbol esters, CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytes.
Immunology 2000;101(1):30-7.
2000: Stephen G Ward
Measurement of phosphoinositide 3-kinase activity.
Methods in molecular biology (Clifton, N.J.) 2000;138():163-72.
1999: Yannis Sotsios; G C Whittaker; John Westwick; Stephen G Ward
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):5954-63.
1999: C Edmunds; Richard V Parry; S J Burgess; Barbara J Reaves; Stephen G Ward
CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP.
European journal of immunology 1999;29(11):3507-15.
1999: Karen Wright; George Kolios; John Westwick; Stephen G Ward
Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism.
The Journal of biological chemistry 1999;274(24):17193-201.
1999: Bart Vanhaesebroeck; K Higashi; C Raven; Melanie J Welham; S Anderson; Paul Brennan; Stephen G Ward; Michael D Waterfield
Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.
The EMBO journal 1999;18(5):1292-302.
1999: Stephen G Ward
The complexities of CD28 and CTLA-4 signalling: PI3K and beyond.
Archivum immunologiae et therapiae experimentalis 1999;47(2):69-75.
1998: S J Turner; J Domin; Michael D Waterfield; Stephen G Ward; John Westwick
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha.
The Journal of biological chemistry 1998;273(40):25987-95.
1998: Stephen G Ward; John Westwick
Chemokines: understanding their role in T-lymphocyte biology.
The Biochemical journal 1998;333 ( Pt 3)():457-70.
1998: Stephen G Ward; K Bacon; John Westwick
Chemokines and T lymphocytes: more than an attraction.
Immunity 1998;9(1):1-11.
1997: Richard V Parry; K Reif; G Smith; David M Sansom; B A Hemmings; Stephen G Ward
Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.
European journal of immunology 1997;27(10):2495-501.
1997: Richard V Parry; D Olive; John Westwick; David M Sansom; Stephen G Ward
Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.
The Biochemical journal 1997;326 ( Pt 1)():249-57.
1997: Karen Wright; Stephen G Ward; George Kolios; John Westwick
Activation of phosphatidylinositol 3-kinase by interleukin-13. An inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29.
The Journal of biological chemistry 1997;272(19):12626-33.
1997: Richard V Parry; G Boulougouris; David M Sansom; Stephen G Ward
Phorbol esters modulate the coupling of the T cell costimulatory molecule CD28 to phosphatidylinositol 3-kinase.
Biochemical Society transactions 1997;25(2):305S.
1997: Stephen G Ward; Richard V Parry; J Matthews; L O'Neill
A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 production.
Biochemical Society transactions 1997;25(2):304S.
1997: Julie D McLeod; Lucy S K Walker; Richard V Parry; Stephen G Ward; David M Sansom
Activation of phosphatidylinositol 3-kinase following Fas engagement is not required for Fas-mediated apoptosis in Jurkat T cells.
Biochemical Society transactions 1997;25(2):241S.
1997: S J Turner; Stephen G Ward; John Westwick
Stimulation of tyrosine phosphorylation and phosphatidylinositol 3-kinase by MCP-1 in THP-1 cells.
Biochemical Society transactions 1997;25(2):216S.
1996: C E Edmead; YI Patel; A Wilson; G Boulougouris; ND Hall; Stephen G Ward; David M Sansom
Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3290-7.
1996: Stephen G Ward
CD28: a signalling perspective.
The Biochemical journal 1996;318 ( Pt 2)():361-77.
1996: Stephen G Ward; C H June; D Olive
PI 3-kinase: a pivotal pathway in T-cell activation?
Immunology today 1996;17(4):187-97.
1996: L Turner; Stephen G Ward; David M Sansom; John Westwick
A role for RANTES in T lymphocyte proliferation.
Biochemical Society transactions 1996;24(1):93S.
1996: Richard V Parry; Stephen G Ward
Involvement of phosphatidylinositol 3-kinase in the activation of p70 S6 kinase by the T cell costimulatory molecule CD28.
Biochemical Society transactions 1996;24(1):88S.
1996: Richard V Parry; John Westwick; Stephen G Ward
Characterisation of a serine/threonine kinase which mediates CD28 phosphorylation following activation by B7.1.
Biochemical Society transactions 1996;24(1):87S.
1996: S J Turner; Stephen G Ward; M McKinnon; John Westwick
Stimulation of signal transduction pathways by MCP-1 in human monocytes and THP-1 cells.
Biochemical Society transactions 1996;24(1):69S.
1996: Stephen G Ward
Phosphoinositide 3-kinase and CD28-mediated T-cell co-stimulation.
Biochemical Society transactions 1996;24(1):240-5.
1995: L Turner; Stephen G Ward; John Westwick
RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2437-44.
1995: Stephen G Ward; Stephen Joseph Mills; C Liu; John Westwick; B V Potter
D-myo-inositol 1,4,5-trisphosphate analogues modified at the 3-position inhibit phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1995;270(20):12075-84.
1995: L Turner; Stephen G Ward; John Westwick
A role for phosphoinositide 3--kinase in RANTES induced chemotaxis of T lymphocytes.
Biochemical Society transactions 1995;23(2):283S.
1995: Stephen G Ward; A Wilson; L Turner; John Westwick; David M Sansom
Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin.
European journal of immunology 1995;25(2):526-32.
1995: Stephen G Ward; R Parry; C LeFeuvre; David M Sansom; John Westwick; A I Lazarovits
Antibody ligation of CD7 leads to association with phosphoinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes.
European journal of immunology 1995;25(2):502-7.
1994: Stephen G Ward; D Lampe; C Liu; B V Potter; John Westwick
Calcium release activity and metabolism of inositol 1,4,5-trisphosphate in T cells. Modulation by novel inositol 1,4,5-trisphosphate 5-phosphatase inhibitors.
European journal of biochemistry / FEBS 1994;222(2):515-23.
1993: Stephen G Ward; John Westwick; ND Hall; David M Sansom
Ligation of CD28 receptor by B7 induces formation of D-3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation.
European journal of immunology 1993;23(10):2572-7.
1992: Stephen G Ward; K Reif; S Ley; M J Fry; M D Waterfield; Doreen A Cantrell
Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases.
The Journal of biological chemistry 1992;267(33):23862-9.
1992: Stephen G Ward; S C Ley; C MacPhee; Doreen A Cantrell
Regulation of D-3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens.
European journal of immunology 1992;22(1):45-9.
1990: Stephen G Ward; Doreen A Cantrell
Heterogeneity of the regulation of phospholipase C by phorbol esters in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3523-8.