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Jeffrey Waring

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Daniel Adolfo Llano; Jeffrey F Waring; David G Witte; Viswanath Devanarayan; Teresa Ellis; Jinhe Li; Robert A Lenz
Cerebrospinal fluid cytokine dynamics differ between Alzheimer disease patients and elderly controls.
Jinhe Li; Daniel Adolfo Llano; Anahita Bhathena; Teresa Ellis; Larry Ereshefsky; Stanford S Jhee; David LeBlond; Robert Lenz; Jeffrey F Waring
Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels.
Michael J Liguori; Hong Liu; Kennan C Marsh; Jeffrey F Waring; Mark E Andracki; Eric A G Blomme; Rita Ciurlionis; Amy C Ditewig; Stella Doktor; Gerard Gagne; Murali Gopalakrishnan; Chih-Hung Lee; Yi Yang
AhR activation underlies the CYP1A autoinduction by A-998679 in rats.

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2012: Daniel Adolfo Llano; Jeffrey F Waring; David G Witte; Viswanath Devanarayan; Teresa Ellis; Jinhe Li; Robert A Lenz
Cerebrospinal fluid cytokine dynamics differ between Alzheimer disease patients and elderly controls.
Alzheimer disease and associated disorders 2012;26(4):322-8.
2012: Jinhe Li; Daniel Adolfo Llano; Anahita Bhathena; Teresa Ellis; Larry Ereshefsky; Stanford S Jhee; David LeBlond; Robert Lenz; Jeffrey F Waring
Effect of human cerebrospinal fluid sampling frequency on amyloid-β levels.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(4):295-303.
2012: Michael J Liguori; Hong Liu; Kennan C Marsh; Jeffrey F Waring; Mark E Andracki; Eric A G Blomme; Rita Ciurlionis; Amy C Ditewig; Stella Doktor; Gerard Gagne; Murali Gopalakrishnan; Chih-Hung Lee; Yi Yang
AhR activation underlies the CYP1A autoinduction by A-998679 in rats.
Frontiers in genetics 2012;3():213.
2012: Teresa A Ellis; David Leblond; Jinhe Li; Jeffrey F Waring
The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid.
International journal of Alzheimer's disease 2012;2012():984746.
2011: Jinhe Li; Jens Halvard Gronlien; Kennan C Marsh; Suzanne L Mathieu; Anwar Murtaza; Lisa M Olson; Jeffrey F Waring; David J Anderson; William H Bunnelle; Richard Harris; Jianguo Ji; Murali Gopalakrishnan
Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists.
Journal of neuroimmunology 2011;239(1-2):37-43.
2010: Steven C Cassar; Ann E Tovcimak; Nathan R Rustay; Teresa A Ellis; Bradley A Hooker; David G Witte; Jinhe Li; Wayne R Buck; Dancia Scharf; Uwe Muller; Andreas Jeromin; Kevin K W Wang; Jeffrey F Waring
Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats.
Journal of neuroscience methods 2010;192(2):249-53.
2010: Yi Yang; Annette J Dahly-Vernon; Eric A G Blomme; Jie Lai-Zhang; Dale J Kempf; Kennan Marsh; Yvette A Harrington; Steven H Nye; Darin L Evans; Richard J Roman; Howard J Jacob; Jeffrey F Waring
Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats.
Veterinary journal (London, England : 1997) 2010;185(1):75-82.
2010: Jeffrey F Waring; Rita Ciurlionis; Kennan Marsh; Larry Klein; David A DeGoey; John T Randolph; Brian Spear; Dale J Kempf
Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia.
Archives of toxicology 2010;84(4):263-70.
2010: Nathan R Rustay; Elizabeth A Cronin; Peter Curzon; Stella Markosyan; Robert S Bitner; Teresa A Ellis; Jeffrey F Waring; Michael W Decker; Lynne E Rueter; Kaitlin E Browman
Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease.
Brain research 2010;1311():136-47.
2010: Michael J Liguori; Amy C Ditewig; Jane F Maddox; James P Luyendyk; Lois D Lehman-McKeeman; David M Nelson; Vasanthi M Bhaskaran; Jeffrey F Waring; Patricia E Ganey; Robert A Roth; Eric A G Blomme
Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example.
International journal of molecular sciences 2010;11(11):4697-714.
2009: Eric A G Blomme; Yi Yang; Jeffrey F Waring
Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development.
Toxicology letters 2009;186(1):22-31.
2008: Xiaomin Deng; Michael J Liguori; Erica M Sparkenbaugh; Jeffrey F Waring; Eric A G Blomme; Patricia E Ganey; Robert A Roth
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.
The Journal of pharmacology and experimental therapeutics 2008;327(3):634-44.
2008: Min Hu; Jeffrey F Waring; Murali Gopalakrishnan; Jinhe Li
Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells.
Journal of neurochemistry 2008;106(3):1371-7.
2008: Jeffrey F Waring; Stephen Abel; Jinhe Li; R Scott Bitner; Arthur L Nikkel; Eric A Blomme; David J Anderson; Murali Gopalakrishnan
Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist.
Neuroscience research 2008;60(3):266-74.
2008: Christine Healan-Greenberg; Jeffrey F Waring; Dale J Kempf; Eric A G Blomme; Rommel G Tirona; Richard B Kim
A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(3):500-7.
2008: Jeffrey F Waring; Yi Yang; Christine H Healan-Greenberg; Andrew L Adler; Robert Dickinson; Teresa McNally; Xiaojun Wang; Moshe Weitzberg; Xiangdong Xu; Andrew Lisowski; Scott E Warder; Yu Gui Gu; Bradley A Zinker; Eric A G Blomme; Heidi S Camp
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
The Journal of pharmacology and experimental therapeutics 2008;324(2):507-16.
2008: Michael J Liguori; Eric A G Blomme; Jeffrey F Waring
Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):223-33.
2008: Eric A G Blomme; Rita Ciurlionis; Kennan Marsh; Jeffrey F Waring; Yi Yang
Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats.
Toxicology letters 2008;176(2):138-48.
2008: Wayne R Buck; Jeffrey F Waring; Eric A G Blomme
Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology.
Methods in molecular biology (Clifton, N.J.) 2008;460():23-44.
2007: Venugopalan Cheriyath; Keith B Glaser; Jeffrey F Waring; Rachid Baz; Mohamad A Hussein; Ernest C Borden
G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells.
The Journal of clinical investigation 2007;117(10):3107-17.
2007: Pek Yee Lum; Yudong D He; J Greg Slatter; Jeffrey F Waring; Nicollete Zelinsky; Guy Cavet; Xudong Dai; Olivia Fong; Rebecca J Gum; Lixia Jin; Gary E Adamson; Christopher J Roberts; David B Olsen; Daria J Hazuda; Roger G Ulrich
Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia.
Genomics 2007;90(4):464-73.
2007: Yu Gui Gu; Moshe Weitzberg; Richard F Clark; Xiangdong Xu; Qun Li; Nathan L Lubbers; Yi Yang; David W A Beno; Deborah L Widomski; Tianyuan Zhang; T Matthew Hansen; Robert F Keyes; Jeffrey F Waring; Sherry L Carroll; Xiaojun Wang; Rongqi Wang; Christine H Healan-Greenberg; Eric A G Blomme; Bruce A Beutel; Hing L Sham; Heidi S Camp
N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.
Journal of medicinal chemistry 2007;50(5):1078-82.
2006: Michael J Liguori; Jeffrey F Waring
Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions.
Expert opinion on drug metabolism & toxicology 2006;2(6):835-46.
2006: Xiaomin Deng; Robert F Stachlewitz; Michael J Liguori; Eric A G Blomme; Jeffrey F Waring; James P Luyendyk; Jane F Maddox; Patricia E Ganey; Robert A Roth
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1191-9.
2006: Lysiane Richert; Michael J Liguori; Catherine Abadie; Bruno Heyd; Georges Mantion; Nermin Halkic; Jeffrey F Waring
Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(5):870-9.
2006: Yi Yang; Stephen J Abel; Rita Ciurlionis; Jeffrey F Waring
Development of a toxicogenomics in vitro assay for the efficient characterization of compounds.
Pharmacogenomics 2006;7(2):177-86.
2006: Jeffrey F Waring; Michael J Liguori; James P Luyendyk; Jane F Maddox; Patricia E Ganey; Robert F Stachlewitz; Colin North; Eric A G Blomme; Robert A Roth
Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1080-7.
2006: Dale J Kempf; Jeffrey F Waring; David Morfitt; Paige Werner; Brian Ebert; Michael J Mitten; Bach Nguyen; John T Randolph; David A DeGoey; Larry Klein; Kennan Marsh
Practical preclinical model for assessing the potential for unconjugated hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors.
Antimicrobial agents and chemotherapy 2006;50(2):762-4.
2006: Xudong Dai; Yudong D He; Hongyue Dai; Pek Yee Lum; Christopher J Roberts; Jeffrey F Waring; Roger G Ulrich
Development of an approach for ab initio estimation of compound-induced liver injury based on global gene transcriptional profiles.
Genome informatics. International Conference on Genome Informatics 2006;17(2):77-88.
2005: William J Giardina; Michael J Dart; Richard R Harris; Robert S Bitner; Richard J Radek; Gerard B Fox; Sanjay R Chemburkar; Kennan Marsh; Jeffrey F Waring; Julia Y Hui; Jinhua Chen; Peter Curzon; George Grayson; Victoria A Komater; Yiyin Ku; Mark Lockwood; Holly M Miner; Arthur L Nikkel; Jia Bao Pan; Yu-Ming Pu; Lei Wang; Youssef L Bennani; Niklaus Durmuller; Robert A Jolly; Sylvain Roux; James P Sullivan; Michael W Decker
Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
Epilepsia 2005;46(9):1349-61.
2005: Karol L Thompson; Barry A Rosenzweig; P Scott Pine; Jacques Retief; Yaron Turpaz; Cynthia A Afshari; Hisham K Hamadeh; Michael A Damore; Michael Boedigheimer; Eric Blomme; Rita Ciurlionis; Jeffrey F Waring; James C Fuscoe; Richard S Paules; Charles J Tucker; Thomas Fare; Ernest M Coffey; Yudong He; Patrick J Collins; Kurt Jarnagin; Susan Fujimoto; Brigitte Ganter; Gretchen Kiser; Tamma Kaysser-Kranich; Joseph Sina; Frank D Sistare
Use of a mixed tissue RNA design for performance assessments on multiple microarray formats.
Nucleic acids research 2005;33(22):e187.
2005: Jeffrey F Waring; Mark G Anderson
Idiosyncratic toxicity: mechanistic insights gained from analysis of prior compounds.
Current opinion in drug discovery & development 2005;8(1):59-65.
2005: Michael J Liguori; Mark G Anderson; Stanley Bukofzer; James McKim; Jeffrey Pregenzer; Jacques Retief; Brian B Spear; Jeffrey F Waring
Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin.
Hepatology (Baltimore, Md.) 2005;41(1):177-86.
2004: Yi Yang; Eric A G Blomme; Jeffrey F Waring
Toxicogenomics in drug discovery: from preclinical studies to clinical trials.
Chemico-biological interactions 2004;150(1):71-85.
2004: Robert A Jolly; Rita Ciurlionis; David Morfitt; Mary Helgren; Reid Patterson; Roger G Ulrich; Jeffrey F Waring
Microvesicular steatosis induced by a short chain fatty acid: effects on mitochondrial function and correlation with gene expression.
Toxicologic pathology 2004;32 Suppl 2():19-25.
2004: Jeffrey F Waring; Roger G Ulrich; Nick Flint; David Morfitt; Arno Kalkuhl; Staedtler Frank; Michael Lawton; Johanna M Beekman; Laura Suter
Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene.
Environmental health perspectives 2004;112(4):439-48.
2004: Valerie A Baker; Helen M Harries; Jeffrey F Waring; Colette M Duggan; Hong A Ni; Robert A Jolly; Lawrence W Yoon; Angus T De Souza; Judith E Schmid; Roger H Brown; Roger G Ulrich; John C Rockett
Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays.
Environmental health perspectives 2004;112(4):428-38.
2003: Jeffrey F Waring; Rita Ciurlionis; Robert A Jolly; Matthew Heindel; Gerard Gagne; Jane A Fagerland; Roger G Ulrich
Isolated human hepatocytes in culture display markedly different gene expression patterns depending on attachment status.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(5-6):693-701.
2003: Jeffrey F Waring
Overview of microarrays in drug discovery and development.
Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.] 2003;Chapter 9():Unit9.6.
2003: Rebecca J Gum; Lori L Gaede; Matthew Heindel; Jeffrey F Waring; James M Trevillyan; Bradley A Zinker; Margery E Stark; Denise Wilcox; Michael R Jirousek; cristina Rondinone; Roger G Ulrich
Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):1131-43.
2003: Jeffrey F Waring; Rita Ciurlionis; Jill E Clampit; Sherry Morgan; Rebecca J Gum; Robert A Jolly; Paul Kroeger; Leigh Frost; James M Trevillyan; Bradley A Zinker; Michael R Jirousek; Roger G Ulrich; cristina Rondinone
PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.
Molecular and cellular endocrinology 2003;203(1-2):155-68.
2003: Keith B Glaser; Michael J Staver; Jeffrey F Waring; Joshua Stender; Roger G Ulrich; Steven K Davidsen
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.
Molecular cancer therapeutics 2003;2(2):151-63.
2003: Jeffrey F Waring; Guy Cavet; Robert A Jolly; Jeff McDowell; Hongye Dai; Rita Ciurlionis; Chunsheng Zhang; Roland B Stoughton; Pek Lum; Allan Ferguson; Christopher J Roberts; Roger G Ulrich
Development of a DNA microarray for toxicology based on hepatotoxin-regulated sequences.
EHP toxicogenomics : journal of the National Institute of Environmental Health Sciences 2003;111(1T):53-60.
2002: Jeffrey F Waring; Rebecca J Gum; David Morfitt; Robert A Jolly; Rita Ciurlionis; Matthew Heindel; Lori Gallenberg; Bruno Buratto; Roger G Ulrich
Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor.
Toxicology 2002;181-182():537-50.
2002: Bradley A Zinker; cristina Rondinone; James M Trevillyan; Rebecca J Gum; Jill E Clampit; Jeffrey F Waring; Nancy Xie; Denise Wilcox; Peer Jacobson; Leigh Frost; Paul Kroeger; Regina M Reilly; Sandra Koterski; Terry J Opgenorth; Roger G Ulrich; Seth Crosby; Madeline Butler; Susan F Murray; Robert A McKay; Sanjay Bhanot; Brett P Monia; Michael R Jirousek
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11357-62.
2002: cristina Rondinone; James M Trevillyan; Jill E Clampit; Rebecca J Gum; Cathy Berg; Paul Kroeger; Leigh Frost; Bradley A Zinker; Regina Reilly; Roger Ulrich; Madeline Butler; Brett P Monia; Michael R Jirousek; Jeffrey F Waring
Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis.
Diabetes 2002;51(8):2405-11.
2002: Jeffrey F Waring; Donald N Halbert
The promise of toxicogenomics.
Current opinion in molecular therapeutics 2002;4(3):229-35.
2001: Jeffrey F Waring; Robert A Jolly; Rita Ciurlionis; P Y Lum; J T Praestgaard; David Morfitt; B Buratto; C Roberts; E Schadt; Roger G Ulrich
Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.
Toxicology and applied pharmacology 2001;175(1):28-42.
2001: Jeffrey F Waring; Rita Ciurlionis; Robert A Jolly; Matthew Heindel; Roger G Ulrich
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity.
Toxicology letters 2001;120(1-3):359-68.
2000: Jeffrey F Waring; Roger G Ulrich
The impact of genomics-based technologies on drug safety evaluation.
Annual review of pharmacology and toxicology 2000;40():335-52.