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Michael Waring

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Chemicals & Drugs

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Robin C K Yang; Michael J Waring; Jia-Rong Wu; Yen-Chung Chen; Yu-Ling Chen; Shih-Chuan Chien; Jonathan T B Huang; Roy Huang; Chia-Chun Hung; Wei-Kang Hung; Kee-Ching G Jeng; Mokai Liao; Leung Sheh
Energetic studies on DNA-peptide interaction in relation to the enthalpy-entropy compensation paradox.
Jonathan T B Huang; Yen-Chung Chen; Jung-Cheng Chang; Kee-Ching G Jeng; Karen K L Kao; Robin C K Yang; Lou-Sing Kan; Ming-Tsair Wey; Michael J Waring; Chee-Shan Chen; Wei-Jyun Chien; Leung Sheh
Novel DNA-peptide interaction networks.
Liisa D Van Vliet; Tom Ellis; Patrick J Foley; Ligong Liu; Frederick M Pfeffer; Richard A Russell; Ronald N Warrener; Florian Hollfelder; Michael J Waring
Molecular recognition of DNA by rigid [N]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties.

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2013: Robin C K Yang; Michael J Waring; Jia-Rong Wu; Yen-Chung Chen; Yu-Ling Chen; Shih-Chuan Chien; Jonathan T B Huang; Roy Huang; Chia-Chun Hung; Wei-Kang Hung; Kee-Ching G Jeng; Mokai Liao; Leung Sheh
Energetic studies on DNA-peptide interaction in relation to the enthalpy-entropy compensation paradox.
Organic & biomolecular chemistry 2013;11(1):48-61.
2010: Jonathan T B Huang; Yen-Chung Chen; Jung-Cheng Chang; Kee-Ching G Jeng; Karen K L Kao; Robin C K Yang; Lou-Sing Kan; Ming-Tsair Wey; Michael J Waring; Chee-Shan Chen; Wei-Jyun Chien; Leung Sheh
Novel DNA-peptide interaction networks.
Bioorganic & medicinal chemistry 2010;18(7):2575-85.
2007: Liisa D Van Vliet; Tom Ellis; Patrick J Foley; Ligong Liu; Frederick M Pfeffer; Richard A Russell; Ronald N Warrener; Florian Hollfelder; Michael J Waring
Molecular recognition of DNA by rigid [N]-polynorbornane-derived bifunctional intercalators: synthesis and evaluation of their binding properties.
Journal of medicinal chemistry 2007;50(10):2326-40.
2006: Geoff Wells; Christopher R H Martin; Philip W Howard; Zara A Sands; Charles A Laughton; Arnaud Tiberghien; Chi Kit Woo; Luke A Masterson; Marissa J Stephenson; John A Hartley; Terence C Jenkins; Steven D Shnyder; Paul M Loadman; Michael J Waring; David E Thurston
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.
Journal of medicinal chemistry 2006;49(18):5442-61.
2006: Chia-Hung Yang; Kee-Ching G Jeng; Wan-Hsu Yang; Yu-Ling Chen; Chia-Chun Hung; Juey-Wen Lin; Shui-Tein Chen; Simon Richardson; Christopher R H Martin; Michael J Waring; Leung Sheh
Unusually strong positive cooperativity in binding of peptides to latent membrane protein-1 DNA fragments of the Epstein-Barr viral gene.
Chembiochem : a European journal of chemical biology 2006;7(8):1187-96.
2005: Chris Martin; Tom Ellis; Claire J McGurk; Terence C Jenkins; John A Hartley; Michael J Waring; David E Thurston
Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
Biochemistry 2005;44(11):4135-47.
2005: Yolanda D Tseng; Haifang Ge; Xiuzhu Wang; J Michael Edwardson; Michael J Waring; William J Fitzgerald; Robert Henderson
Atomic force microscopy study of the structural effects induced by echinomycin binding to DNA.
Journal of molecular biology 2005;345(4):745-58.
2004: Johanna Virstedt; Torunn Berge; Robert Henderson; Michael J Waring; Andrew Travers
The influence of DNA stiffness upon nucleosome formation.
Journal of structural biology 2004;148(1):66-85.
2004: Chia-Hung Yang; Wen-Fu Chen; Ming-Chu Jong; Boh-Jun Jong; Jung-Cheng Chang; Michael J Waring; Lin Ma; Leung Sheh
Semiquinone footprinting.
Journal of the American Chemical Society 2004;126(26):8104-5.
2004: Laurence G May; Mark A Madine; Michael J Waring
Echinomycin inhibits chromosomal DNA replication and embryonic development in vertebrates.
Nucleic acids research 2004;32(1):65-72.
2003: Chia-Hung Yang; Ping-Jen Chou; Zhen Long Luo; I Chun Chou; Jung-Cheng Chang; Chien-Chung Cheng; Christopher R H Martin; Michael J Waring; Leung Sheh
Preferential binding to DNA sequences of peptides related to a novel XPRK motif.
Bioorganic & medicinal chemistry 2003;11(15):3279-88.
2003: Torunn Berge; E Lucy Haken; Michael J Waring; Robert Henderson
The binding mode of the DNA bisintercalator luzopeptin investigated using atomic force microscopy.
Journal of structural biology 2003;142(2):241-6.
2002: Stephen D G Crow; Christian Bailly; Christiane Garbay-Jaureguiberry; Bernard Roques; Barbara Ramsay Shaw; Michael J Waring
DNA sequence recognition by the antitumor drug ditercalinium.
Biochemistry 2002;41(27):8672-82.
2002: Torunn Berge; Nigel S Jenkins; Richard B Hopkirk; Michael J Waring; J Michael Edwardson; Robert Henderson
Structural perturbations in DNA caused by bis-intercalation of ditercalinium visualised by atomic force microscopy.
Nucleic acids research 2002;30(13):2980-6.
2001: A Minnock; L S Lin; J Morgan; S D Crow; Michael J Waring; Leung Sheh
Sequence-specific DNA cleavage by dipeptides disubstituted with chlorambucil and 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid.
Bioconjugate chemistry 2001;12(6):870-82.
2000: Michael J Waring
Facilitating structural transitions in DNA.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):11685-7.
2000: Christian Bailly; S Crow; A Minnock; Michael J Waring
DNA recognition by quinoline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of luzopeptin.
Nucleosides, nucleotides & nucleic acids 2000;19(8):1337-53.
1999: A Minnock; S Crow; Christian Bailly; Michael J Waring
The influence of the exocyclic pyrimidine 5-methyl group on DNAse I cleavage and sequence recognition by drugs.
Biochimica et biophysica acta 1999;1489(2-3):233-48.
1999: Christian Bailly; S Crow; A Minnock; Michael J Waring
Demethylation of thymine residues affects DNA cleavage by endonucleases but not sequence recognition by drugs.
Journal of molecular biology 1999;291(3):561-73.
1998: Michael J Waring
Genetic medicine comes out of the cold in Sweden. Report on Nobel Workshop. 'Gene-Targeted Drugs: Function and Delivery' held at Stockholm, 3 April 1998, and Friiberghs Herrgård, 4-5 April, 1998.
Biochimica et biophysica acta 1998;1378(3):R63-5.
1998: M J Guo; S Hildbrand; C J Leumann; L W McLaughlin; Michael J Waring
Inhibition of DNA polymerase reactions by pyrimidine nucleotide analogues lacking the 2-keto group.
Nucleic acids research 1998;26(8):1863-9.
1997: Michael J Waring; Christian Bailly
The influence of the exocyclic amino group characteristic of GC base pairs on molecular recognition of specific nucleotide sequences in DNA by berenil and DAPI.
Journal of molecular recognition : JMR 1997;10(3):121-7.
1997: S Jennewein; Michael J Waring
Footprinting of echinomycin and actinomycin D on DNA molecules asymmetrically substituted with inosine and/or 2,6-diaminopurine.
Nucleic acids research 1997;25(8):1502-10.
1996: Christian Bailly; D Payet; A A Travers; Michael J Waring
PCR-based development of DNA substrates containing modified bases: an efficient system for investigating the role of the exocyclic groups in chemical and structural recognition by minor groove binding drugs and proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13623-8.
1996: Christian Bailly; M Braña; Michael J Waring
Sequence-selective intercalation of antitumour bis-naphthalimides into DNA. Evidence for an approach via the major groove.
European journal of biochemistry / FEBS 1996;240(1):195-208.
1996: C Marchand; Christian Bailly; Chi Hung Nguyen; Emile Bisagni; Thérèse Garestier; Claude Hélène; Michael J Waring
Stabilization of triple helical DNA by a benzopyridoquinoxaline intercalator.
Biochemistry 1996;35(15):5022-32.
1996: C Bourdouxhe-Housiaux; Pierre Colson; Claude Houssier; Michael J Waring; Christian Bailly
Interaction of a DNA-threading netropsin-amsacrine combilexin with DNA and chromatin.
Biochemistry 1996;35(14):4251-64.
1996: Christian Bailly; F Hamy; Michael J Waring
Cooperativity in the binding of echinomycin to DNA fragments containing closely spaced CpG sites.
Biochemistry 1996;35(4):1150-61.
1995: Christian Bailly; Michael J Waring; A A Travers
Effects of base substitutions on the binding of a DNA-bending protein.
Journal of molecular biology 1995;253(1):1-7.
1995: Christian Bailly; C Marchand; C Hung Nguyen; Emile Bisagni; Thérèse Garestier; Claude Hélène; Michael J Waring
Localized chemical reactivity in double-stranded DNA associated with the intercalative binding of benzo[e]pyridoindole and benzo[g]pyridoindole triple-helix-stabilizing ligands.
European journal of biochemistry / FEBS 1995;232(1):66-76.
1995: Christian Bailly; N E Møllegaard; P E Nielsen; Michael J Waring
The influence of the 2-amino group of guanine on DNA conformation. Uranyl and DNase I probing of inosine/diaminopurine substituted DNA.
The EMBO journal 1995;14(9):2121-31.
1995: Christian Bailly; Michael J Waring
Transferring the purine 2-amino group from guanines to adenines in DNA changes the sequence-specific binding of antibiotics.
Nucleic acids research 1995;23(6):885-92.
1995: C Bourdouxhe; Pierre Colson; Claude Houssier; Jean-Pierre Hénichart; Michael J Waring; W A Denny; Christian Bailly
Design of composite drug molecules: mutual effects on binding to DNA of an intercalator, amsacrine, and a minor groove binder, netropsin.
Anti-cancer drug design 1995;10(2):131-54.
1995: Christian Bailly; Michael J Waring
Comparison of different footprinting methodologies for detecting binding sites for a small ligand on DNA.
Journal of biomolecular structure & dynamics 1995;12(4):869-98.
1994: G S Ridge; Christian Bailly; D E Graves; Michael J Waring
Daunomycin modifies the sequence-selective recognition of DNA by actinomycin.
Nucleic acids research 1994;22(24):5241-6.
1994: Michael J Waring; Christian Bailly
The purine 2-amino group as a critical recognition element for binding of small molecules to DNA.
Gene 1994;149(1):69-79.
1994: Christian Bailly; I O Donkor; D Gentle; M Thornalley; Michael J Waring
Sequence-selective binding to DNA of cis- and trans- butamidine analogues of the anti-Pneumocystis carinii pneumonia drug pentamidine.
Molecular pharmacology 1994;46(2):313-22.
1994: Christian Bailly; D E Graves; G Ridge; Michael J Waring
Use of a photoactive derivative of actinomycin to investigate shuffling between binding sites on DNA.
Biochemistry 1994;33(29):8736-45.
1994: Michael J Waring; Christian Bailly
DNA recognition by intercalators and hybrid molecules.
Journal of molecular recognition : JMR 1994;7(2):109-22.
1994: Christian Bailly; D Gentle; F Hamy; M Purcell; Michael J Waring
Localized chemical reactivity in DNA associated with the sequence-specific bisintercalation of echinomycin.
The Biochemical journal 1994;300 ( Pt 1)():165-73.
1994: S Flock; F Bailly; Christian Bailly; Michael J Waring; Jean-Pierre Hénichart; Pierre Colson; Claude Houssier
Interaction of two peptide-acridine conjugates containing the SPKK peptide motif with DNA and chromatin.
Journal of biomolecular structure & dynamics 1994;11(4):881-900.
1993: E W Sayers; Michael J Waring
Footprinting titration studies on the binding of echinomycin to DNA incapable of forming Hoogsteen base pairs.
Biochemistry 1993;32(35):9094-107.
1993: Daniel S Pilch; Michael J Waring; Jian-Sheng Sun; M Rougée; Chi Hung Nguyen; Emile Bisagni; Thérèse Garestier; Claude Hélène
Characterization of a triple helix-specific ligand. BePI (3-methoxy-7H-8-methyl-11- [(3'-amino)propylamino]-benzo[e]pyrido[4,3-b]indole) intercalates into both double-helical and triple-helical DNA.
Journal of molecular biology 1993;232(3):926-46.
1993: Christian Bailly; Michael J Waring
Preferential intercalation at AT sequences in DNA by lucanthone, hycanthone, and indazole analogs. A footprinting study.
Biochemistry 1993;32(23):5985-93.
1993: Christian Bailly; Alan W Cuthbert; D Gentle; Michael Knowles; Michael J Waring
Sequence-selective binding of amiloride to DNA.
Biochemistry 1993;32(10):2514-24.
1992: C Bourdouxhe; Pierre Colson; Claude Houssier; Jian-Sheng Sun; T Montenay-Garestier; Claude Hélène; C Rivalle; Emile Bisagni; Michael J Waring; Jean-Pierre Hénichart
Binding of a distamycin-ellipticine hybrid molecule to DNA and chromatin: spectroscopic, biochemical, and molecular modeling investigations.
Biochemistry 1992;31(49):12385-96.
1992: Michael J Waring
Echinomycin.
Pathologie-biologie 1992;40(10):1022-34.
1992: C Marchand; Christian Bailly; M J McLean; S E Moroney; Michael J Waring
The 2-amino group of guanine is absolutely required for specific binding of the anti-cancer antibiotic echinomycin to DNA.
Nucleic acids research 1992;20(21):5601-6.
1992: Christian Bailly; C O'Huigin; Raymond Houssin; Pierre Colson; Claude Houssier; C Rivalle; Emile Bisagni; J P Henichart; Michael J Waring
DNA-binding properties of a distamycin-ellipticine hybrid molecule.
Molecular pharmacology 1992;41(5):845-55.
1992: F Bailly; Christian Bailly; Michael J Waring; Jean-Pierre Hénichart
Selective binding to AT sequences in DNA by an acridine-linked peptide containing the SPKK motif.
Biochemical and biophysical research communications 1992;184(2):930-7.
1992: Christian Bailly; W A Denny; L E Mellor; L P Wakelin; Michael J Waring
Sequence specificity of the binding of 9-aminoacridine- and amsacrine-4-carboxamides to DNA studied by DNase I footprinting.
Biochemistry 1992;31(13):3514-24.
1990: Christian Bailly; C OhUigin; C Rivalle; Emile Bisagni; Jean-Pierre Hénichart; Michael J Waring
Sequence-selective binding of an ellipticine derivative to DNA.
Nucleic acids research 1990;18(21):6283-91.
1990: N P Bajaj; M J McLean; Michael J Waring; E Smekal
Sequence-selective, pH-dependent binding to DNA of benzophenanthridine alkaloids.
Journal of molecular recognition : JMR 1990;3(1):48-54.
1989: M J McLean; F Seela; Michael J Waring
Echinomycin-induced hypersensitivity to osmium tetroxide of DNA fragments incapable of forming Hoogsteen base pairs.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9687-91.
1989: M J McLean; A Dar; Michael J Waring
Differences between sites of binding to DNA and strand cleavage for complexes of bleomycin with iron or cobalt.
Journal of molecular recognition : JMR 1989;1(4):184-92.
1988: M J McLean; Michael J Waring
Chemical probes reveal no evidence of Hoogsteen base pairing in complexes formed between echinomycin and DNA in solution.
Journal of molecular recognition : JMR 1988;1(3):138-51.
1988: J Portugal; K R Fox; M J McLean; J L Richenberg; Michael J Waring
Diethyl pyrocarbonate can detect a modified DNA structure induced by the binding of quinoxaline antibiotics.
Nucleic acids research 1988;16(9):3655-70.
1988: K R Fox; H Davies; G R Adams; J Portugal; Michael J Waring
Sequence-specific binding of luzopeptin to DNA.
Nucleic acids research 1988;16(6):2489-507.
1988: J Portugal; Michael J Waring
Assignment of DNA binding sites for 4',6-diamidine-2-phenylindole and bisbenzimide (Hoechst 33258). A comparative footprinting study.
Biochimica et biophysica acta 1988;949(2):158-68.
1987: J Portugal; Michael J Waring
Hydroxyl radical footprinting of the sequence-selective binding of netropsin and distamycin to DNA.
FEBS letters 1987;225(1-2):195-200.
1987: J Portugal; Michael J Waring
Analysis of the effects of antibiotics on the structure of nucleosome core particles determined by DNAase I cleavage.
Biochimie 1987;69(8):825-40.
1987: K R Fox; G W Grigg; Michael J Waring
Sequence-selective binding of phleomycin to DNA.
The Biochemical journal 1987;243(3):847-51.
1986: C M Low; K R Fox; Michael J Waring
DNA sequence selectivity of three biosynthetic analogues of the quinoxaline antibiotics.
Anti-cancer drug design 1986;1(2):149-60.