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Peter Warn

Research Profile

Chemicals & Drugs

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Physiology

Fungal Drug Resistance

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Publications

TOP 3
Ajay Sudan; Peter A Warn; Zaid Al-Nakeeb; Tim W Felton; Joanne Goodwin; Lea Gregson; Thomas S Harrison; Susan J Howard; Joanne Livermore; John R Perfect; Andrew Sharp; William W Hope
Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints.
J L Livermore; Andrew Sharp; Peter A Warn; Susan J Howard; J Abbott; T W Felton; J Goodwin; L Gregson; William W Hope
Pharmacokinetics and pharmacodynamics of anidulafungin for experimental Candida endophthalmitis: insights into the utility of echinocandins for treatment of a potentially sight-threatening infection.
Adam R Jeans; Peter A Warn; Susan J Howard; Zaid Al-Nakeeb; Joanne Goodwin; Lea Gregson; William W Hope
Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis.

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All Publications

2013: Ajay Sudan; Peter A Warn; Zaid Al-Nakeeb; Tim W Felton; Joanne Goodwin; Lea Gregson; Thomas S Harrison; Susan J Howard; Joanne Livermore; John R Perfect; Andrew Sharp; William W Hope
Pharmacokinetics and pharmacodynamics of fluconazole for cryptococcal meningoencephalitis: implications for antifungal therapy and in vitro susceptibility breakpoints.
Antimicrobial agents and chemotherapy 2013;57(6):2793-800.
2013: J L Livermore; Andrew Sharp; Peter A Warn; Susan J Howard; J Abbott; T W Felton; J Goodwin; L Gregson; William W Hope
Pharmacokinetics and pharmacodynamics of anidulafungin for experimental Candida endophthalmitis: insights into the utility of echinocandins for treatment of a potentially sight-threatening infection.
Antimicrobial agents and chemotherapy 2013;57(1):281-8.
2012: Adam R Jeans; Peter A Warn; Susan J Howard; Zaid Al-Nakeeb; Joanne Goodwin; Lea Gregson; William W Hope
Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis.
Antimicrobial agents and chemotherapy 2012;56(10):5180-5.
2012: Adam R Jeans; Cornelia Lass-Flörl; Jayesh B Majithiya; Peter A Warn; Zaid Al-Nakeeb; Maiken Cavling Arendrup; Manuel Cuenca Estrella; Joanne Goodwin; Lea Gregson; Susan J Howard; William W Hope
Pharmacodynamics of voriconazole in a dynamic in vitro model of invasive pulmonary aspergillosis: implications for in vitro susceptibility breakpoints.
The Journal of infectious diseases 2012;206(3):442-52.
2012: Zaid Al-Nakeeb; Timothy W Felton; Joanne Goodwin; Lea Gregson; Susan J Howard; Adam R Jeans; Ajay Sudan; Peter A Warn; William W Hope
Pharmacodynamics of itraconazole against Aspergillus fumigatus in an in vitro model of the human alveolus: perspectives on the treatment of triazole-resistant infection and utility of airway administration.
Antimicrobial agents and chemotherapy 2012;56(8):4146-53.
2012: Peter A Warn; Daniel K Benjamin; Michael Cohen-Wolkowiez; Timothy W Felton; Joanne Goodwin; Lea Gregson; Susan Howard; Joanne Livermore; Ruta Petraitiene; Vidmantas Petraitis; Andrew Sharp; THOMAS WALSH; William W Hope
Anidulafungin for neonatal hematogenous Candida meningoencephalitis: identification of candidate regimens for humans using a translational pharmacological approach.
Antimicrobial agents and chemotherapy 2012;56(2):708-14.
2012: Jason D Oliver; Danny Tuckwell; Peter A Warn; Mike Birch; Anna E Johns; Sarah J Kaye; Joanne Livermore; Darel A Macdonald; Michael J Bromley
The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence.
PloS one 2012;7(9):e43559.
2011: Ahmed M Albarrag; Michael J Anderson; Susan J Howard; Geoff D Robson; Dominique Sanglard; Peter A Warn; David W Denning
Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter.
Antimicrobial agents and chemotherapy 2011;55(11):5113-21.
2011: Susan J Howard; Joanne Livermore; David Perlin; Andrew Sharp; Peter A Warn; A Alastruey-Izquierdo; Joanne Goodwin; Lea Gregson; William W Hope
Pharmacodynamics of echinocandins against Candida glabrata: requirement for dosage escalation to achieve maximal antifungal activity in neutropenic hosts.
Antimicrobial agents and chemotherapy 2011;55(10):4880-7.
2011: J L Slater; Peter A Warn; Susan J Howard; David Perlin; Andrew Sharp; A Alastruey-Izquierdo; Maiken Cavling Arendrup; J Goodwin; L M Gregson; William W Hope
Disseminated Candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin.
Antimicrobial agents and chemotherapy 2011;55(7):3075-83.
2011: Susan J Howard; Jodi M Lestner; Andrew Sharp; Lea Gregson; Joanne Goodwin; Joanne Slater; Jayesh B Majithiya; Peter A Warn; William W Hope
Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapy.
The Journal of infectious diseases 2011;203(9):1324-32.
2011: J L Slater; L Gregson; David W Denning; Peter A Warn
Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice.
Medical mycology : official publication of the International Society for Human and Animal Mycology 2011;49 Suppl 1():S107-13.
2010: Peter A Warn; Andrew Sharp; Graham Morrissey; David W Denning
Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus.
International journal of antimicrobial agents 2010;35(2):146-51.
2009: Peter A Warn; Andrew Sharp; Arvind Parmar; Jayesh Majithiya; David W Denning; William W Hope
Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effect.
Antimicrobial agents and chemotherapy 2009;53(8):3453-61.
2007: William W Hope; Peter A Warn; Andrew Sharp; Paul Reed; Brian Keevil; Arnold Louie; THOMAS WALSH; David W Denning; George L Drusano
Optimization of the dosage of flucytosine in combination with amphotericin B for disseminated candidiasis: a pharmacodynamic rationale for reduced dosing.
Antimicrobial agents and chemotherapy 2007;51(10):3760-2.
2007: Juan L Rodriguez-Tudela; J Peter Donnelly; Michael A Pfaller; Erja Chryssantou; Peter A Warn; David W Denning; Ana Espinel-Ingroff; Francesco Barchiesi; Manuel Cuenca Estrella
Statistical analyses of correlation between fluconazole MICs for Candida spp. assessed by standard methods set forth by the European Committee on Antimicrobial Susceptibility Testing (E.Dis. 7.1) and CLSI (M27-A2).
Journal of clinical microbiology 2007;45(1):109-11.
2007: William W Hope; George L Drusano; Caroline B Moore; Andrew Sharp; Arnold Louie; THOMAS WALSH; David W Denning; Peter A Warn
Effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis.
Antimicrobial agents and chemotherapy 2007;51(1):285-95.
2006: Peter A Warn; Andrew Sharp; Juan Mosquera; Jochen Spickermann; Anne Schmitt-Hoffmann; Markus Heep; David W Denning
Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus.
The Journal of antimicrobial chemotherapy 2006;58(6):1198-207.
2006: William W Hope; Peter A Warn; Andrew Sharp; Susan Howard; Miki Kasai; Arnold Louie; THOMAS WALSH; George L Drusano; David W Denning
Derivation of an in vivo drug exposure breakpoint for flucytosine against Candida albicans and Impact of the MIC, growth rate, and resistance genotype on the antifungal effect.
Antimicrobial agents and chemotherapy 2006;50(11):3680-8.
2006: Peter A Warn; Andrew Sharp; David W Denning
In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp.
The Journal of antimicrobial chemotherapy 2006;57(1):135-8.
2005: Peter A Warn; Andrew Sharp; Graham Morrissey; David W Denning
Activity of aminocandin (IP960) compared with amphotericin B and fluconazole in a neutropenic murine model of disseminated infection caused by a fluconazole-resistant strain of Candida tropicalis.
The Journal of antimicrobial chemotherapy 2005;56(3):590-3.
2005: William W Hope; Peter A Warn; Andrew Sharp; Paul Reed; Brian Keevil; Arnold Louie; David W Denning; George L Drusano
Surface response modeling to examine the combination of amphotericin B deoxycholate and 5-fluorocytosine for treatment of invasive candidiasis.
The Journal of infectious diseases 2005;192(4):673-80.
2005: Won Hee Jung; Peter A Warn; Enrico Ragni; Laura Popolo; Christopher D Nunn; Michael P Turner; Lubomira Stateva
Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans.
Yeast (Chichester, England) 2005;22(4):285-94.
2004: Peter A Warn; Andrew Sharp; J Guinea; David W Denning
Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida.
The Journal of antimicrobial chemotherapy 2004;53(5):743-9.
2003: Peter A Warn; M W Brampton; Andrew Sharp; Graham Morrissey; N Steel; David W Denning; T Priest
Infrared body temperature measurement of mice as an early predictor of death in experimental fungal infections.
Laboratory animals 2003;37(2):126-31.
2003: Peter A Warn; Graham Morrissey; J Morrissey; David W Denning
Activity of micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistance to amphotericin B.
The Journal of antimicrobial chemotherapy 2003;51(4):913-9.
2002: Peter A Warn; Andrew Sharp; Graham Morrissey; David W Denning
In vivo activity of micafungin in a persistently neutropenic murine model of disseminated infection caused by Candida tropicalis.
The Journal of antimicrobial chemotherapy 2002;50(6):1071-4.
2002: Juan Mosquera; Andrew Sharp; Caroline B Moore; Peter A Warn; David W Denning
In vitro interaction of terbinafine with itraconazole, fluconazole, amphotericin B and 5-flucytosine against Aspergillus spp.
The Journal of antimicrobial chemotherapy 2002;50(2):189-94.
2001: Juan Mosquera; Peter A Warn; Juan L Rodriguez-Tudela; David W Denning
Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole.
The Journal of antimicrobial chemotherapy 2001;48(4):583-6.
2001: Juan Mosquera; Peter A Warn; J Morrissey; Caroline B Moore; Cristina Gil-Lamaignere; David W Denning
Susceptibility testing of Aspergillus flavus: inoculum dependence with itraconazole and lack of correlation between susceptibility to amphotericin B in vitro and outcome in vivo.
Antimicrobial agents and chemotherapy 2001;45(5):1456-62.
2000: Peter A Warn; J Morrissey; Caroline B Moore; David W Denning
In vivo activity of amphotericin B lipid complex in immunocompromised mice against fluconazole-resistant or fluconazole-susceptible Candida tropicalis.
Antimicrobial agents and chemotherapy 2000;44(10):2664-71.
2000: Elizabeth M Johnson; KL Oakley; SA Radford; Caroline B Moore; Peter A Warn; DW Warnock; David W Denning
Lack of correlation of in vitro amphotericin B susceptibility testing with outcome in a murine model of Aspergillus infection.
The Journal of antimicrobial chemotherapy 2000;45(1):85-93.
1999: David W Denning; Peter A Warn
Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B.
Antimicrobial agents and chemotherapy 1999;43(11):2592-9.