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Zelda Wasserman
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Research Profile (preview)
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Chemicals & Drugs
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Network (preview)
20
Decicco, Carl
15
Covington, Maryanne
10
Liu, Rui-Qin
8
Duan, James J-W
8
Hardman, Karl
7
Cherney, Robert
7
Christ, David
7
Magolda, Ronald
7
Newton, Robert
7
Qian, Mingxin
7
Xue, Chu-Biao
6
Meyer, Dayton
6
Trzaskos, James
6
Arner, Elizabeth
5
Wexler, Ruth
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Geonetwork of Zelda Wasserman (preview)
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All Publications
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2008: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Nelson David J; Lo Yvonne C; Yang Gengjie; Scherle Peggy A; Mandlekar Sandhya; Wasserman Zelda R; Jezak Heather; Solomon Kimberly A; Tebben Andrew J; Carter Percy H; Decicco Carl P
Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Journal of medicinal chemistry 2008;51(4):721-4.
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2008: Yao Wenqing; Zhuo Jincong; Burns David M; Li Yun-Long; Qian Ding-Quan; Zhang Colin; He Chunhong; Xu Meizhong; Shi Eric; Li Yanlong; Marando Cindy A; Covington Maryanne B; Yang Gengjie; Liu Xiangdong; Pan Max; Fridman Jordan S; Scherle Peggy; Wasserman Zelda R; Hollis Gregory; Vaddi Kris; Yeleswaram Swamy; Newton Robert; Friedman Steve; Metcalf Brian
Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.
Bioorganic & medicinal chemistry letters 2008;18(1):159-63.
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2008: Duan James J-W; Chen Lihua; Lu Zhonghui; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Vaddi Krishna; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):241-6.
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2007: Sheppeck James E; Tebben Andrew; Gilmore John L; Yang Anle; Wasserman Zelda R; Decicco Carl P; Duan James J-W
A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE.
Bioorganic & medicinal chemistry letters 2007;17(5):1408-12.
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2006: Ala Paul J; Gonneville Lucie; Hillman Milton C; Becker-Pasha Mary; Wei Min; Reid Brian G; Klabe Ronald; Yue Eddy W; Wayland Brian; Douty Brent; Polam Padmaja; Wasserman Zelda; Bower Michael; Combs Andrew P; Burn Timothy C; Hollis Gregory F; Wynn Richard
Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.
The Journal of biological chemistry 2006;281(43):32784-95.
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2006: Yue Eddy W; Wayland Brian; Douty Brent; Crawley Matthew L; McLaughlin Eric; Takvorian Amy; Wasserman Zelda; Bower Michael J; Wei Min; Li Yanlong; Ala Paul J; Gonneville Lucie; Wynn Richard; Burn Timothy C; Liu Phillip C C; Combs Andrew P
Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold.
Bioorganic & medicinal chemistry 2006;14(17):5833-49.
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2006: Combs Andrew P; Zhu Wenyu; Crawley Matthew L; Glass Brian; Polam Padmaja; Sparks Richard B; Modi Dilip; Takvorian Amy; McLaughlin Erin; Yue Eddy W; Wasserman Zelda; Bower Michael; Wei Min; Rupar Mark; Ala Paul J; Reid Brian M; Ellis Dawn; Gonneville Lucie; Emm Thomas; Taylor Nancy; Yeleswaram Swamy; Li Yanlong; Wynn Richard; Burn Timothy C; Hollis Gregory; Liu Phillip C C; Metcalf Brian
Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.
Journal of medicinal chemistry 2006;49(13):3774-89.
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2005: Han Wei; Jiang Xiangjun; Hu Zilun; Wasserman Zelda R; Decicco Carl P
Investigation of glycine alpha-ketoamide HCV NS3 protease inhibitors: effect of carboxylic acid isosteres.
Bioorganic & medicinal chemistry letters 2005;15(15):3487-90.
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2005: Duan James J-W; Lu Zhonghui; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Decicco Carl P
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.
Bioorganic & medicinal chemistry letters 2005;15(12):2970-3.
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2005: Wasserman Zelda R
Making a new turn in matrix metalloprotease inhibition.
Chemistry & biology 2005;12(2):143-4.
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2004: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(12):2981-3.
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2003: Pan Weijun; Arnone Marc; Kendall Marvin; Grafstrom Robert H; Seitz Steven P; Wasserman Zelda R; Albright Charles F
Identification of peptide substrates for human MMP-11 (stromelysin-3) using phage display.
The Journal of biological chemistry 2003;278(30):27820-7.
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2003: Duan James J-W; Lu Zhonghui; Xue Chu-Biao; He Xiaohua; Seng Jennifer L; Roderick John J; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Magolda Ronald L; Newton Robert C; Trzaskos James M; Decicco Carl P
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2003;13(12):2035-40.
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2003: Cherney Robert J; Duan James J-W; Voss Matthew E; Chen Lihua; Wang Li; Meyer Dayton T; Wasserman Zelda R; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Mandlekar Sandhya; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Journal of medicinal chemistry 2003;46(10):1811-23.
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2003: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Wang Li; Yao Wenqing; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Tortorella Micky D; Arner Elizabeth C; Qian Mingxin; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ron L; Decicco Carl P
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Bioorganic & medicinal chemistry letters 2003;13(7):1297-300.
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2003: Wasserman Zelda R; Duan James J-W; Voss Matthew E; Xue Chu Biao; Cherney Robert J; Nelson David J; Hardman Karl D; Decicco Carl P
Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.
Chemistry & biology 2003;10(3):215-23.
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2003: Zhang Xiaojun; Schmitt Aaron C; Jiang Wen; Wasserman Zelda; Decicco Carl P
Design and synthesis of potent, non-peptide inhibitors of HCV NS3 protease.
Bioorganic & medicinal chemistry letters 2003;13(6):1157-60.
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2003: Han Wei; Hu Zilun; Jiang Xiangjun; Wasserman Zelda R; Decicco Carl P
Glycine alpha-ketoamides as HCV NS3 protease inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(6):1111-4.
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2002: Duan James J-W; Chen Lihua; Wasserman Zelda R; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Hardman Karl D; Magolda Ronald L; Newton Robert C; Christ David D; Wexler Ruth R; Decicco Carl P
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
Journal of medicinal chemistry 2002;45(23):4954-7.
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2002: Archer Sharon J; Camac Daniel M; Wu Zhongren J; Farrow Neil A; Domaille Peter J; Wasserman Zelda R; Bukhtiyarova Marina; Rizzo Christopher; Jagannathan Sharada; Mersinger Lawrence J; Kettner Charles A
Hepatitis C virus NS3 protease requires its NS4A cofactor peptide for optimal binding of a boronic acid inhibitor as shown by NMR.
Chemistry & biology 2002;9(1):79-92.
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2002: Yao Wenqing; Chao Michael; Wasserman Zelda R; Liu Rui Qin; Covington Maryanne B; Newton Robert; Christ David; Wexler Ruth R; Decicco Carl P
Potent P1' biphenylmethyl substituted aggrecanase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(1):101-4.
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2001: Xue C B; He X; Corbett R L; Roderick J; Wasserman Z R; Liu R Q; Jaffee B D; Covington M B; Qian M; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Journal of medicinal chemistry 2001;44(21):3351-4.
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2001: Yao W; Wasserman Z R; Chao M; Reddy G; Shi E; Liu R Q; Covington M B; Arner E C; Pratta M A; Tortorella M; Magolda R L; Newton R; Qian M; Ribadeneira M D; Christ D; Wexler R R; Decicco C P
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Journal of medicinal chemistry 2001;44(21):3347-50.
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1999: Duan J J; Chen L; Xue C B; Wasserman Z R; Hardman K D; Covington M B; Copeland R R; Arner E C; Decicco C P
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(10):1453-8.
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1999: Cherney R J; Wang L; Meyer D T; Xue C B; Arner E C; Copeland R A; Covington M B; Hardman K D; Wasserman Z R; Jaffee B D; Decicco C P
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Bioorganic & medicinal chemistry letters 1999;9(9):1279-84.
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1998: Cherney R J; Wang L; Meyer D T; Xue C B; Wasserman Z R; Hardman K D; Welch P K; Covington M B; Copeland R A; Arner E C; DeGrado W F; Decicco C P
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Journal of medicinal chemistry 1998;41(11):1749-51.
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1998: Jacobson I C; Reddy P G; Wasserman Z R; Hardman K D; Covington M B; Arner E C; Copeland R A; Decicco C P; Magolda R L
Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(7):837-42.
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1992: Anthony-Cahill S J; Benfield P A; Fairman R; Wasserman Z R; Brenner S L; Stafford W F; Altenbach C; Hubbell W L; DeGrado W F
Molecular characterization of helix-loop-helix peptides.
Science (New York, N.Y.) 1992;255(5047):979-83.
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1990: Wasserman Z R; Salemme F R
A molecular dynamics investigation of the elastomeric restoring force in elastin.
Biopolymers 1990;29(12-13):1613-31.
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1989: DeGrado W F; Wasserman Z R; Lear J D
Protein design, a minimalist approach.
Science (New York, N.Y.) 1989;243(4891):622-8.
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1988: Lear J D; Wasserman Z R; DeGrado W F
Synthetic amphiphilic peptide models for protein ion channels.
Science (New York, N.Y.) 1988;240(4856):1177-81.
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1988: Wendoloski J J; Wasserman Z R; Salemme F R
Computer simulation of biological interactions and reactivity.
Journal of computer-aided molecular design 1988;1(4):313-22.
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1982: DeGrado W F; Wasserman Z R; Chowdhry V
Sequence and structural homologies among type I and type II interferons.
Nature 1982;300(5890):379-81.
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