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KA Watanabe

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TOP 3
Natalia Dyatkina; Alexander Khorlin; KA Watanabe
Formation and reactivity of 2,4-ditriazolyl pyrimidine C-nucleoside derived from pseudouridine.
D A Brown; W Y Ren; Alexander Khorlin; K Lesiak; D Conklin; KA Watanabe; Michael M Seidman; J George
Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin.
K Lesiak; KA Watanabe; Alokes Majumdar; J Powell; Michael M Seidman; K Vanderveen; Barry M Goldstein; Krzysztof W Pankiewicz
Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.

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All Publications

2000: Natalia Dyatkina; Alexander Khorlin; KA Watanabe
Formation and reactivity of 2,4-ditriazolyl pyrimidine C-nucleoside derived from pseudouridine.
Nucleosides, nucleotides & nucleic acids 2000;19(3):585-91.
1998: D A Brown; W Y Ren; Alexander Khorlin; K Lesiak; D Conklin; KA Watanabe; Michael M Seidman; J George
Aliphatic and alicyclic diols induce melanogenesis in cultured cells and guinea pig skin.
The Journal of investigative dermatology 1998;110(4):428-37.
1998: K Lesiak; KA Watanabe; Alokes Majumdar; J Powell; Michael M Seidman; K Vanderveen; Barry M Goldstein; Krzysztof W Pankiewicz
Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD.
Journal of medicinal chemistry 1998;41(4):618-22.
1997: K Lesiak; KA Watanabe; Alokes Majumdar; Michael M Seidman; K Vanderveen; Barry M Goldstein; Krzysztof W Pankiewicz
Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity.
Journal of medicinal chemistry 1997;40(16):2533-8.
1997: Krzysztof W Pankiewicz; K Lesiak; A Zatorski; Barry M Goldstein; S F Carr; M Sochacki; Alokes Majumdar; Michael M Seidman; KA Watanabe
The practical synthesis of a methylenebisphosphonate analogue of benzamide adenine dinucleotide: inhibition of human inosine monophosphate dehydrogenase (type I and II).
Journal of medicinal chemistry 1997;40(8):1287-91.
1996: Juri Gelovani Tjuvajev; Ronald Finn; KA Watanabe; R Joshi; Takamitsu Oku; J Kennedy; Bradley Beattie; Jason A Koutcher; Steven M Larson; Ronald Blasberg
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.
Cancer research 1996;56(18):4087-95.
1996: J Y Kim; T L Su; Ting-Chao Chou; B Koehler; A Scarborough; Ouathek Ouerfelli; KA Watanabe
Cyclopent[a]anthraquinones as DNA intercalating agents with covalent bond formation potential: synthesis and biological activity.
Journal of medicinal chemistry 1996;39(14):2812-8.
1996: A Zatorski; KA Watanabe; S F Carr; Barry M Goldstein; Krzysztof W Pankiewicz
Chemical synthesis of benzamide adenine dinucleotide: inhibition of inosine monophosphate dehydrogenase (types I and II).
Journal of medicinal chemistry 1996;39(12):2422-6.
1996: Krzysztof W Pankiewicz; A Zatorski; KA Watanabe
NAD-analogues as potential anticancer agents: conformational restrictions as basis for selectivity.
Acta biochimica Polonica 1996;43(1):183-93.
1995: Juri Gelovani Tjuvajev; G Stockhammer; R Desai; H Uehara; KA Watanabe; B Gansbacher; Ronald Blasberg
Imaging the expression of transfected genes in vivo.
Cancer research 1995;55(24):6126-32.
1995: T L Su; Ting-Chao Chou; J Y Kim; J T Huang; G Ciszewska; W Y Ren; G M Otter; Francis M Sirotnak; KA Watanabe
9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.
Journal of medicinal chemistry 1995;38(17):3226-35.
1994: H Li; W H Hallows; J S Punzi; Krzysztof W Pankiewicz; KA Watanabe; Barry M Goldstein
Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes.
Biochemistry 1994;33(39):11734-44.
1994: Barry M Goldstein; H Li; J P Jones; J E Bell; J Zeidler; Krzysztof W Pankiewicz; KA Watanabe
CNAD: a potent and specific inhibitor of alcohol dehydrogenase.
Journal of medicinal chemistry 1994;37(3):392-9.
1994: H Li; W H Hallows; J S Punzi; Victor E Marquez; HL Carrell; Krzysztof W Pankiewicz; KA Watanabe; Barry M Goldstein
Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.
Biochemistry 1994;33(1):23-32.
1993: A Zatorski; P Lipka; N Mollova; Karl Schram; Barry M Goldstein; KA Watanabe; Krzysztof W Pankiewicz
Synthesis of thiazole-4-carboxamide-adenine difluoromethylenediphosphonates substituted with fluorine at C-2' of the adenosine.
Carbohydrate research 1993;249(1):95-108.
1993: Krzysztof W Pankiewicz; J Zeidler; L A Ciszewski; J E Bell; Barry M Goldstein; Hiremagalur N Jayaram; KA Watanabe
Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide.
Journal of medicinal chemistry 1993;36(13):1855-9.
1993: P Kois; KA Watanabe
Oligodeoxynucleotides containing 2'-fluoro-arabino-nucleotide and C-nucleotide.
Nucleic acids symposium series 1993;(29):215-6.
1992: T L Su; B Köhler; Ting-Chao Chou; Moon Woo Chun; KA Watanabe
Synthesis of the acridone alkaloids glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones.
Journal of medicinal chemistry 1992;35(14):2703-10.
1992: X B Kong; Q Y Zhu; P M Vidal; KA Watanabe; B Polsky; Donald Armstrong; M Ostrander; S A Lang; E Muchmore; Ting-Chao Chou
Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.
Antimicrobial agents and chemotherapy 1992;36(4):808-18.
1992: X B Kong; L Rubin; L I Chen; G Ciszewska; KA Watanabe; William P Tong; Francis M Sirotnak; Ting-Chao Chou
Topoisomerase II-mediated DNA cleavage activity and irreversibility of cleavable complex formation induced by DNA intercalator with alkylating capability.
Molecular pharmacology 1992;41(2):237-44.
1991: X B Kong; Q Y Zhu; Ruth Ruprecht; KA Watanabe; J M Zeidler; Jonathan Gold; B Polsky; Donald Armstrong; Ting-Chao Chou
Synergistic inhibition of human immunodeficiency virus type 1 replication in vitro by two-drug and three-drug combinations of 3'-azido-3'-deoxythymidine, phosphonoformate, and 2',3'-dideoxythymidine.
Antimicrobial agents and chemotherapy 1991;35(10):2003-11.
1991: J T Huang; L C Chen; L B Wang; M H Kim; J A Warshaw; Donald Armstrong; Q Y Zhu; Ting-Chao Chou; KA Watanabe; J Matulic-Adamic
Fluorinated sugar analogues of potential anti-HIV-1 nucleosides.
Journal of medicinal chemistry 1991;34(5):1640-6.
1991: I Rosenberg; Z Tocik; KA Watanabe
Synthesis of some oligodeoxynucleotides containing the C-nucleoside and 2'-deoxy-2'-fluoronucleoside moieties.
Nucleic acids symposium series 1991;(24):43-6.
1990: KA Watanabe; K Harada; J Zeidler; J Matulic-Adamic; K Takahashi; W Y Ren; L C Cheng; J J Fox; Ting-Chao Chou; Q Y Zhu
Synthesis and anti-HIV-1 activity of 2'-"up"-fluoro analogues of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC).
Journal of medicinal chemistry 1990;33(8):2145-50.
1990: Elzbieta Sochacka; B Nawrot; Krzysztof W Pankiewicz; KA Watanabe
Synthesis of 1-methyl-5-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)uracil and 1-methyl-5-(3-azido-2,3-dideoxy-2-fluoro-beta-D-arabinofuranosyl)uracil. The C-nucleoside isostere of 3'-azido-3'-deoxythymidine and its 2'-"up"-fluoro analogue.
Journal of medicinal chemistry 1990;33(7):1995-9.
1990: J A Warshaw; KA Watanabe
2'-azido-2',3'-dideoxypyrimidine nucleosides. Synthesis and antiviral activity against human immunodeficiency virus.
Journal of medicinal chemistry 1990;33(6):1663-6.
1989: M Koyama; K Takahashi; Ting-Chao Chou; Zbigniew Darzynkiewicz; J Kapuscinski; T R Kelly; KA Watanabe
Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin.
Journal of medicinal chemistry 1989;32(7):1594-9.
1989: Chung (David) K. Chu; J Matulic-Adamic; J T Huang; Ting-Chao Chou; J H Burchenal; J J Fox; KA Watanabe
Nucleosides. CXXXV. Synthesis of some 9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purines and their biological activities.
Chemical & pharmaceutical bulletin 1989;37(2):336-9.
1988: X B Kong; Adrienne C Scheck; R W Price; P M Vidal; M P Fanucchi; KA Watanabe; J J Fox; Ting-Chao Chou
Incorporation and metabolism of 2'-fluoro-5-substituted arabinosyl pyrimidines and their selective inhibition of viral DNA synthesis in herpes simplex virus type 1 (HSV-1)-infected and mock-infected Vero cells.
Antiviral research 1988;10(4-5):153-66.
1988: J Matulic-Adamic; K Takahashi; Ting-Chao Chou; H Gadler; R W Price; A R Reddy; T I Kalman; KA Watanabe
Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.
Journal of medicinal chemistry 1988;31(8):1642-7.
1988: T L Su; J T Huang; Ting-Chao Chou; G M Otter; Francis M Sirotnak; KA Watanabe
Chemical synthesis and biological activities of 5-deazaaminopterin analogues bearing substituent(s) at the 5- and/or 7-position(s).
Journal of medicinal chemistry 1988;31(6):1209-15.
1988: J Matulic-Adamic; KA Watanabe
Nucleosides. CXLIX. Novel and practical synthesis of alpha-monofluoro- and alpha,alpha-difluorothymidine (F-TDR and F2-TDR).
Chemical & pharmaceutical bulletin 1988;36(4):1554-7.
1988: M Sonenberg; J T Huang; Y F Ren; T L Su; KA Watanabe; H C Haspel; R E Corin; A P Hoffer
Anti-fertility and other actions of gossypol analogues.
Contraception 1988;37(3):247-55.
1988: M Koyama; T R Kelly; KA Watanabe
Novel type of potential anticancer agents derived from chrysophanol and emodin. Some structure-activity relationship studies.
Journal of medicinal chemistry 1988;31(2):283-4.
1987: Krzysztof W Pankiewicz; B Nawrot; H Gadler; R W Price; KA Watanabe
Nucleosides. 146. 1-Methyl-5-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil, the C-nucleoside isostere of the potent antiviral agent 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)thymine (FMAU). Studies directed toward the synthesis of 2'-deoxy-2'-substituted arabino nucleosides. 6.
Journal of medicinal chemistry 1987;30(12):2314-6.
1987: Ting-Chao Chou; X B Kong; M P Fanucchi; Y C Cheng; K Takahashi; KA Watanabe; J J Fox
Synthesis and biological effects of 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil.
Antimicrobial agents and chemotherapy 1987;31(9):1355-8.
1987: Krzysztof W Pankiewicz; B Nawrot; Elzbieta Sochacka; KA Watanabe
Studies directed toward the synthesis of 2'-deoxy-2'-substituted arabino nucleosides.
Nucleic acids symposium series 1987;(18):257-60.
1987: X B Kong; M Andreeff; M P Fanucchi; J J Fox; KA Watanabe; P Vidal; Ting-Chao Chou
Cell differentiation effects of 2'-fluoro-1-beta-D-arabinofuranosyl pyrimidines in HL-60 cells.
Leukemia research 1987;11(11):1031-9.
1987: K Harada; J Matulic-Adamic; R W Price; Ray F Schinazi; KA Watanabe; J J Fox
Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogues of 2'-fluoroarabinosylpyrimidine nucleosides.
Journal of medicinal chemistry 1987;30(1):226-9.
1987: J T Huang; Ray F Schinazi; H Gadler; R W Price; T L Su; KA Watanabe
5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents.
Nucleic acids symposium series 1987;(18):261-4.
1986: T L Su; J T Huang; J H Burchenal; KA Watanabe; J J Fox
Synthesis and biological activities of 5-deaza analogues of aminopterin and folic acid.
Journal of medicinal chemistry 1986;29(5):709-15.
1985: Andrew P Feinberg; Brian Leyland-Jones; M P Fanucchi; C Hancock; J J Fox; KA Watanabe; P M Vidal; L Williams; C W Young; F S Philips
Biotransformation and elimination of [2-14C]-1-(2-deoxy-2'-fluoro-beta-D -arabinofuranosyl)-5-iodocytosine in immunosuppressed patients with herpesvirus infections.
Antimicrobial agents and chemotherapy 1985;27(5):733-8.
1985: M P Fanucchi; Brian Leyland-Jones; C W Young; J H Burchenal; KA Watanabe; J J Fox
Phase I trial of 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-methyluracil (FMAU).
Cancer treatment reports 1985;69(1):55-9.
1984: Andrew P Feinberg; P M Vidal; J J Fox; KA Watanabe; Moon Woo Chun; F H Field; A Bencsath; Brian T Chait; F S Philips
Structures of metabolites isolated from urine of mice treated with the antiviral agent, 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-methyluracil.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(6):784-6.
1984: Ting-Chao Chou; C Lopez; Joseph Colacino; Andrew P Feinberg; KA Watanabe; J J Fox; F S Philips
Metabolic competition studies of 2'-fluoro-5-iodo-1-beta-d-arabinofuranosylcytosine in vero cells and herpes simplex type 1-infected vero cells.
Molecular pharmacology 1984;26(3):587-93.
1984: KA Watanabe; T L Su; U Reichman; N Greenberg; C Lopez; J J Fox
Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.
Journal of medicinal chemistry 1984;27(1):91-4.
1983: C W Young; R Schneider; Brian Leyland-Jones; Donald Armstrong; C T Tan; C Lopez; KA Watanabe; J J Fox; F S Philips
Phase I evaluation of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in immunosuppressed patients with herpesvirus infection.
Cancer research 1983;43(10):5006-9.
1983: F S Philips; Andrew P Feinberg; Ting-Chao Chou; P M Vidal; T L Su; KA Watanabe; J J Fox
Distribution, metabolism, and excretion of 1-(2-fluoro-2-deoxy-beta-D- arabinofuranosyl)thymine and 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5- iodocytosine.
Cancer research 1983;43(8):3619-27.
1983: KA Watanabe; T L Su; R S Klein; Chung (David) K. Chu; A Matsuda; Moon Woo Chun; C Lopez; J J Fox
Nucleosides. 123. Synthesis of antiviral nucleosides: 5-substituted 1-(2-deoxy-2-halogeno-beta-D-arabinofuranosyl)cytosines and -uracils. Some structure-activity relationships.
Journal of medicinal chemistry 1983;26(2):152-6.
1982: Ting-Chao Chou; J H Burchenal; F A Schmid; T J Braun; T L Su; KA Watanabe; J J Fox; F S Philips
Biochemical effects of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil and 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mouse leukemic cells sensitive and resistant to 1-beta-D-arabinofuranosylcytosine.
Cancer research 1982;42(10):3957-63.
1982: Y Saito; R W Price; D A Rottenberg; J J Fox; T L Su; KA Watanabe; F S Philips
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug.
Science (New York, N.Y.) 1982;217(4565):1151-3.
1982: J H Burchenal; Ting-Chao Chou; L Lokys; R S Smith; KA Watanabe; T L Su; J J Fox
Activity of 2-fluoro-5-methylarabinofuranosyluracil against mouse leukemias sensitive to and resistant to 1-beta-D-arabinofuranosylcytosine.
Cancer research 1982;42(7):2598-600.
1982: A J Grant; Andrew P Feinberg; Ting-Chao Chou; KA Watanabe; J J Fox; F S Philips
Incorporation of metabolites of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues.
Biochemical pharmacology 1982;31(6):1103-8.
1981: KA Watanabe; U Reichman; J J Fox; Ting-Chao Chou
Nucleosides. CXIX. Substrate specificity and mechanism of action of cytidine deaminases of monkey plasma and mouse kidney.
Chemico-biological interactions 1981;37(1-2):41-54.
1981: Ting-Chao Chou; Andrew P Feinberg; A J Grant; P Vidal; U Reichman; KA Watanabe; J J Fox; F S Philips
Pharmacological disposition and metabolic fate of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mice and rats.
Cancer research 1981;41(9 Pt 1):3336-42.
1980: KA Watanabe; U Reichman; Chung (David) K. Chu; D H Hollenberg; J J Fox
Nucleosides. 116. 1-(beta-D-Xylofuranosyl)-5-fluorocytosines with a leaving group on the 3' position. Potential double-barreled masked precursors of anticancer nucleosides.
Journal of medicinal chemistry 1980;23(10):1088-94.