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Shiro Watanabe

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Chemicals & Drugs

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Shiro Watanabe; Koichi tsuneyama
Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet.
Ken Tanaka; Yasuhiro Tezuka; Shiro Watanabe; Nobuo Kawahara; Feng Li; Hiroaki Kida
Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis.
Shiro Watanabe; Koichi tsuneyama
Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid.

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2013: Shiro Watanabe; Koichi tsuneyama
Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet.
The Journal of toxicological sciences 2013;38(3):379-90.
2013: Ken Tanaka; Yasuhiro Tezuka; Shiro Watanabe; Nobuo Kawahara; Feng Li; Hiroaki Kida
Evaluation of the quality of Chinese and Vietnamese cassia using LC-MS and multivariate analysis.
Natural product communications 2013;8(1):75-8.
2012: Shiro Watanabe; Koichi tsuneyama
Cattle bile but not bear bile or pig bile induces lipid profile changes and fatty liver injury in mice: mediation by cholic acid.
The Journal of toxicological sciences 2012;37(1):105-21.
2011: Hironori Ishikawa; Shiro Watanabe
Cattle bile aggravates diclofenac sodium-induced small intestinal injury in mice.
Evidence-based complementary and alternative medicine : eCAM 2011;2011():315858.
2009: Shiro Watanabe; Takashi Kamei; Ken Tanaka; Kunio Kawasuji; Tsuyoshi Yoshioka; Masahiro Ohno
Roles of bile acid conjugates and phospholipids in in vitro activation of pancreatic lipase by bear bile and cattle bile.
Journal of ethnopharmacology 2009;125(2):203-6.
2008: Masataka Saito; Shiro Watanabe
Differential modulation of lipopolysaccharide- and zymosan-induced hypophagia by dexamethasone treatment.
Pharmacology, biochemistry, and behavior 2008;90(3):428-33.
2006: Kazuhisa Naoi; Suguru Kogure; Masataka Saito; Tomohito Hamazaki; Shiro Watanabe
Differential effects of selective cyclooxygenase (COX)-1 and COX-2 inhibitors on anorexic response and prostaglandin generation in various tissues induced by zymosan.
Biological & pharmaceutical bulletin 2006;29(7):1319-24.
2005: Mizuki Takenaka; Satoko Kanada; Tomohito Hamazaki; Shiro Watanabe
Dietary supplementation with n-3 polyunsaturated fatty acids attenuates the depression of food-motivated behavior during zymosan-induced peritonitis.
Biological & pharmaceutical bulletin 2005;28(7):1291-3.
2005: Kei Hamazaki; Miho Itomura; Mingming Huan; Hiroto Nishizawa; Shigeki Sawazaki; Masatoshi Tanouchi; Shiro Watanabe; Tomohito Hamazaki; Katsutoshi Terasawa; Kazunaga Yazawa
Effect of omega-3 fatty acid-containing phospholipids on blood catecholamine concentrations in healthy volunteers: a randomized, placebo-controlled, double-blind trial.
Nutrition (Burbank, Los Angeles County, Calif.) 2005;21(6):705-10.
2005: Miho Itomura; Kei Hamazaki; Shigeki Sawazaki; Makoto Kobayashi; Katsutoshi Terasawa; Shiro Watanabe; Tomohito Hamazaki
The effect of fish oil on physical aggression in schoolchildren--a randomized, double-blind, placebo-controlled trial.
The Journal of nutritional biochemistry 2005;16(3):163-71.
2005: Masashi Morita; Ikuko Takahashi; Mariko Kanai; Fumito Okafuji; Makoto Iwashima; Toshimitsu Hayashi; Shiro Watanabe; Tomohito Hamazaki; Nobuyuki Shimozawa; Yasuyuki Suzuki; Hirokazu Furuya; Takeshi Yamada; Tsuneo Imanaka
Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid beta-oxidation in skin fibroblasts of X-linked adrenoleukodystrophy.
FEBS letters 2005;579(2):409-14.
2004: Mingming Huan; Kei Hamazaki; Yueji Sun; Miho Itomura; Hongyan Liu; Wei Kang; Shiro Watanabe; Katsutoshi Terasawa; Tomohito Hamazaki
Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China.
Biological psychiatry 2004;56(7):490-6.
2004: Shiro Watanabe; Satoko Kanada; Mizuki Takenaka; Tomohito Hamazaki
Dietary n-3 fatty acids selectively attenuate LPS-induced behavioral depression in mice.
Physiology & behavior 2004;81(4):605-13.
2004: Masaru Doshi; Shiro Watanabe; Tsuyoshi Niimoto; Hiroshi Kawashima; Yoshiyuki Ishikura; Yoshinobu Kiso; Tomohito Hamazaki
Effect of dietary enrichment with n-3 polyunsaturated fatty acids (PUFA) or n-9 PUFA on arachidonate metabolism in vivo and experimentally induced inflammation in mice.
Biological & pharmaceutical bulletin 2004;27(3):319-23.
2003: Shiro Watanabe; Masaru Doshi; Tomohito Hamazaki
n-3 Polyunsaturated fatty acid (PUFA) deficiency elevates and n-3 PUFA enrichment reduces brain 2-arachidonoylglycerol level in mice.
Prostaglandins, leukotrienes, and essential fatty acids 2003;69(1):51-9.
2003: Chunyan Du; Akira Sato; Shiro Watanabe; Chun-Zheng Wu; Atsushi Ikemoto; Ken Ando; Kiyomi Kikugawa; Yoichi Fujii; Harumi Okuyama
Cholesterol synthesis in mice is suppressed but lipofuscin formation is not affected by long-term feeding of n-3 fatty acid-enriched oils compared with lard and n-6 fatty acid-enriched oils.
Biological & pharmaceutical bulletin 2003;26(6):766-70.
2003: Kei Hamazaki; Miho Itomura; Mingming Huan; Hiroto Nishizawa; Shiro Watanabe; Tomohito Hamazaki; Shigeki Sawazaki; Katsutoshi Terasawa; Shuuji Nakajima; Takashi Terano; Yoshiya Hata; Seiichi Fujishiro
n-3 long-chain FA decrease serum levels of TG and remnant-like particle-cholesterol in humans.
Lipids 2003;38(4):353-8.
2002: Tomohito Hamazaki; Alice Thienprasert; Kanit Kheovichai; Suched Samuhaseneetoo; Tetsuro Nagasawa; Shiro Watanabe
The effect of docosahexaenoic acid on aggression in elderly Thai subjects--a placebo-controlled double-blind study.
Nutritional neuroscience 2002;5(1):37-41.
2001: Shiro Watanabe; Masaru Doshi; K Akimoto; Y Kiso; Tomohito Hamazaki
Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells.
Prostaglandins & other lipid mediators 2001;66(2):109-20.
2001: Tomohito Hamazaki; Shigeki Sawazaki; Miho Itomura; Y Nagao; A Thienprasert; Tetsuro Nagasawa; Shiro Watanabe
Effect of docosahexaenoic acid on hostility.
World review of nutrition and dietetics 2001;88():47-52.
2000: Shiro Watanabe; K Katagiri; K Onozaki; N Hata; Y Misawa; Tomohito Hamazaki; H Okuyama
Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes.
Prostaglandins, leukotrienes, and essential fatty acids 2000;62(3):147-52.
2000: M Miyazaki; Naoya Takemura; Shiro Watanabe; N Hata; Y Misawa; Harumi Okuyama
Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin.
Biochimica et biophysica acta 2000;1483(1):101-10.
1999: Akira Sato; T Osakabe; Atsushi Ikemoto; Shiro Watanabe; T Kobayashi; Harumi Okuyama
Long-term n-3 fatty acid deficiency induces no substantial change in the rate of protein synthesis in rat brain and liver.
Biological & pharmaceutical bulletin 1999;22(8):775-9.
1999: Atsushi Ikemoto; T Kobayashi; K Emoto; M Umeda; Shiro Watanabe; Harumi Okuyama
Effects of docosahexaenoic and arachidonic acids on the synthesis and distribution of aminophospholipids during neuronal differentiation of PC12 cells.
Archives of biochemistry and biophysics 1999;364(1):67-74.
1999: S Yasuda; Shiro Watanabe; T Kobayashi; N Hata; Y Misawa; H Utsumi; Harumi Okuyama
Dietary docosahexaenoic acid enhances ferric nitrilotriacetate-induced oxidative damage in mice but not when additional alpha-tocopherol is supplemented.
Free radical research 1999;30(3):199-205.
1999: K Oh-hashi; T Takahashi; A Tanabe; Shiro Watanabe; Harumi Okuyama
Dietary alpha-linolenate suppresses endotoxin-induced platelet-activating factor production in rat kidney.
Lipids 1999;34(1):31-7.
1998: Akira Sato; MZ Huang; Shiro Watanabe; Harumi Okuyama; H Nakamoto; Z Radák; S Goto
Protein carbonyl content roughly reflects the unsaturation of lipids in muscle but not in other tissues of stroke-prone spontaneously hypertensive strain (SHRSP) rats fed different fats and oils.
Biological & pharmaceutical bulletin 1998;21(12):1271-6.
1998: S Matsuba; Makoto Itoh; T Joh; H Takeyama; Natsuki Dohi; Shiro Watanabe; Harumi Okuyama
Effect of dietary linoleate/alpha-linolenate balance on experimentally induced gastric injury in rats.
Prostaglandins, leukotrienes, and essential fatty acids 1998;59(5):317-23.
1998: S Yasuda; Shiro Watanabe; T Kobayashi; Harumi Okuyama
Effects of dietary unsaturated fatty acid and chronic carbon tetrachloride treatment on the accumulation of oxidation products, alpha-tocopherol and liver injury in mice.
Biological & pharmaceutical bulletin 1998;21(10):1050-6.
1998: M Miyazaki; MZ Huang; Naoya Takemura; Shiro Watanabe; Harumi Okuyama
Free fatty acid fractions from some vegetable oils exhibit reduced survival time-shortening activity in stroke-prone spontaneously hypertensive rats.
Lipids 1998;33(7):655-61.
1998: K Ohhashi; T Takahashi; Shiro Watanabe; T Kobayashi; Harumi Okuyama; N Hata; Y Misawa
Effect of replacing a high linoleate oil with a low linoleate, high alpha-linolenate oil, as compared with supplementing EPA or DHA, on reducing lipid mediator production in rat polymorphonuclear leukocytes.
Biological & pharmaceutical bulletin 1998;21(6):558-64.
1998: Shiro Watanabe; T Kobayashi; Harumi Okuyama
Absence of relation between the expression of cyclooxygenase isoforms and the synthesis of prostaglandin E2 in resident and thioglycollate-elicited macrophages in rats.
Prostaglandins & other lipid mediators 1998;56(1):7-18.
1997: K Oh-hashi; T Takahashi; Shiro Watanabe; T Kobayashi; Harumi Okuyama
Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes.
Journal of lipid mediators and cell signalling 1997;17(3):207-20.
1997: S Yasuda; Shiro Watanabe; T Kobayashi; Harumi Okuyama
Docosahexaenoic acid-rich fish oil does not enhance the elevation of serum transaminase and liver triacylglycerol induced by carbon tetrachloride in mice.
Lipids 1997;32(12):1249-55.
1997: MZ Huang; Shiro Watanabe; T Kobayashi; Akito Nagatsu; Jinsaku Sakakibara; Harumi Okuyama
Unusual effects of some vegetable oils on the survival time of stroke-prone spontaneously hypertensive rats.
Lipids 1997;32(7):745-51.
1997: Atsushi Ikemoto; T Kobayashi; Shiro Watanabe; Harumi Okuyama
Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release.
Neurochemical research 1997;22(6):671-8.
1997: K Oh-hashi; Shiro Watanabe; T Kobayashi; Harumi Okuyama
Reevaluation of the effect of a high alpha-linolenate and a high linoleate diet on antigen-induced antibody and anaphylactic responses in mice.
Biological & pharmaceutical bulletin 1997;20(3):217-23.
1997: Shiro Watanabe; C Yoshida; T Kobayashi; Harumi Okuyama
An enzyme immunoassay for prostaglandin E2 using biotin-prostaglandin B2 conjugate as a tracer.
Biological & pharmaceutical bulletin 1997;20(1):101-3.
1996: Harumi Okuyama; T Kobayashi; Shiro Watanabe
Dietary fatty acids--the N-6/N-3 balance and chronic elderly diseases. Excess linoleic acid and relative N-3 deficiency syndrome seen in Japan.
Progress in lipid research 1996;35(4):409-57.
1996: M Z Huang; Y Naito; Shiro Watanabe; T Kobayashi; H Kanai; H Nagai; Harumi Okuyama
Effect of rapeseed and dietary oils on the mean survival time of stroke-prone spontaneously hypertensive rats.
Biological & pharmaceutical bulletin 1996;19(4):554-7.
1996: Y Okaniwa; S Yuasa; N Yamamoto; Shiro Watanabe; T Kobayashi; Harumi Okuyama; M Nomura; Y Nagata
A high linoleate and a high alpha-linolenate diet induced changes in learning behavior of rats. Effects of a shift in diets and reversal of training stimuli.
Biological & pharmaceutical bulletin 1996;19(4):536-40.
1995: T Tsutsumi; E Yamauchi; E Suzuki; Shiro Watanabe; T Kobayashi; Harumi Okuyama
Effect of a high alpha-linolenate and high linoleate diet on membrane-associated enzyme activities in rat brain--modulation of Na+, K+- ATPase activity at suboptimal concentrations of ATP.
Biological & pharmaceutical bulletin 1995;18(5):664-70.
1995: A Ishihara; A Ito; K Sakai; Shiro Watanabe; T Kobayashi; Harumi Okuyama
Dietary high-linoleate safflower oil is not hypocholesterolemic in aged mice after a long-term feeding--comparison with lard, perilla oil and fish oil.
Biological & pharmaceutical bulletin 1995;18(4):485-90.
1995: T Tsutsumi; T Kobayashi; M Miyashita; Shiro Watanabe; Y Homma; Harumi Okuyama
A lysophosphoinositide-specific phospholipase C distinct from other phospholipase C families in rat brain.
Archives of biochemistry and biophysics 1995;317(2):331-6.
1994: Shiro Watanabe; N Sakai; Y Yasui; Y Kimura; T Kobayashi; T Mizutani; Harumi Okuyama
A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice.
The Journal of nutrition 1994;124(9):1566-73.
1994: Shiro Watanabe; T Kobayashi; Harumi Okuyama
Regulation of lipopolysaccharide-induced tumor necrosis factor alpha production by endogenous prostaglandin E2 in rat resident and thioglycollate-elicited macrophages.
Journal of lipid mediators and cell signalling 1994;10(3):283-94.
1994: T Tsutsumi; T Kobayashi; H Ueda; E Yamauchi; Shiro Watanabe; Harumi Okuyama
Lysophosphoinositide-specific phospholipase C in rat brain synaptic plasma membranes.
Neurochemical research 1994;19(4):399-406.
1993: H Ueda; T Kobayashi; M Kishimoto; T Tsutsumi; Shiro Watanabe; Harumi Okuyama
The presence of Ca(2+)-independent phospholipase A1 highly specific for phosphatidylinositol in bovine brain.
Biochemical and biophysical research communications 1993;195(3):1272-9.
1993: Shiro Watanabe; K Onozaki; S Yamamoto; Harumi Okuyama
Regulation by dietary essential fatty acid balance of tumor necrosis factor production in mouse macrophages.
Journal of leukocyte biology 1993;53(2):151-6.
1991: Shiro Watanabe; Harumi Okuyama
Effect of dietary alpha-linolenate/linoleate balance on endotoxin-induced hepatitis in mice.
Lipids 1991;26(6):467-71.
1991: Shiro Watanabe; Harumi Okuyama
[Physiological significance of n-3 fatty acid-containing phospholipids].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1991;36(3):584-8.
1991: Shiro Watanabe; H Hayashi; K Onozaki; Harumi Okuyama
Effect of dietary alpha-linolenate/linoleate balance on lipopolysaccharide-induced tumor necrosis factor production in mouse macrophages.
Life sciences 1991;48(21):2013-20.
1990: Shiro Watanabe; E Suzuki; R Kojima; Y Suzuki; Harumi Okuyama
Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats.
Lipids 1990;25(5):267-72.