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Michael Waterfield

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Chemicals & Drugs

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Danielle Boller; Angela De Laurentiis; Olivier Delattre; Paul Depledge; Kathrin T Doepfner; Sarah Fattet; Karl Frei; Michael A Grotzer; Ana S Guerreiro; Masahiko Hayakawa; Katrin Höland; Hiroyuki Kaizawa; Tomonobu Koizumi; Marin Marinov; Takahide Ohishi; Anthony Robson; Nahid Saghir; Anelia Schweri-Olac; Tarek Shalaby; Olivier Spertini; Michael D Waterfield; Alexandre Arcaro
Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.
Hong-Lin Chan; Hsiu-Chuan Chou; MaCarmen Duran; Jana Gruenewald; Michael D Waterfield; Anne Ridley; John Francis Timms
Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells.
Marketa Zvelebil; Michael D Waterfield; Stephen J Shuttleworth
Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors.

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All Publications

2012: Danielle Boller; Angela De Laurentiis; Olivier Delattre; Paul Depledge; Kathrin T Doepfner; Sarah Fattet; Karl Frei; Michael A Grotzer; Ana S Guerreiro; Masahiko Hayakawa; Katrin Höland; Hiroyuki Kaizawa; Tomonobu Koizumi; Marin Marinov; Takahide Ohishi; Anthony Robson; Nahid Saghir; Anelia Schweri-Olac; Tarek Shalaby; Olivier Spertini; Michael D Waterfield; Alexandre Arcaro
Targeting PI3KC2β impairs proliferation and survival in acute leukemia, brain tumours and neuroendocrine tumours.
Anticancer research 2012;32(8):3015-27.
2010: Hong-Lin Chan; Hsiu-Chuan Chou; MaCarmen Duran; Jana Gruenewald; Michael D Waterfield; Anne Ridley; John Francis Timms
Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells.
The Journal of biological chemistry 2010;285(7):4307-18.
2008: Marketa Zvelebil; Michael D Waterfield; Stephen J Shuttleworth
Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors.
Archives of biochemistry and biophysics 2008;477(2):404-10.
2008: Harold B J Jefferies; Frank T Cooke; Parmjit S Jat; Christine Boucheron; Tomonobu Koizumi; Masahiko Hayakawa; Hiroyuki Kaizawa; Takahide Ohishi; Paul Workman; Michael D Waterfield; Peter J Parker
A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.
EMBO reports 2008;9(2):164-70.
2007: Ali Tiss; Celia Smith; Stephane Camuzeaux; Musarat Kabir; Simon A Gayther; Usha Menon; Michael D Waterfield; John Francis Timms; Ian Jacobs; Rainer Cramer
Serum peptide profiling using MALDI mass spectrometry: avoiding the pitfalls of coated magnetic beads using well-established ZipTip technology.
Proteomics 2007;7 Suppl 1():77-89.
2007: Masahiko Hayakawa; Ken-Ichi Kawaguchi; Hiroyuki Kaizawa; Tomonobu Koizumi; Takahide Ohishi; Mayumi Yamano; Minoru Okada; Mitsuaki Ohta; Shin-ichi Tsukamoto; Florence I Raynaud; Peter Parker; Paul Workman; Michael D Waterfield
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
Bioorganic & medicinal chemistry 2007;15(17):5837-44.
2007: Florence I Raynaud; Suzanne A Eccles; Paul A Clarke; Angela Hayes; Bernard P Nutley; Sonia Alix; Alan Henley; Francesca Di-Stefano; Zahida Ahmad; Sandrine Guillard; Lynn M Bjerke; Lloyd R Kelland; Melanie Valenti; Lisa Patterson; Sharon M Gowan; Alexis de Haven Brandon; Masahiko Hayakawa; Hiroyuki Kaizawa; Tomonubu Koizumi; Takahide Ohishi; Sonal Patel; Nahid Saghir; Peter Parker; Michael D Waterfield; Paul Workman
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.
Cancer research 2007;67(12):5840-50.
2007: Eleonora Jovceva; Martin R Larsen; Michael D Waterfield; Buzz Baum; John Francis Timms
Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis.
Journal of cell science 2007;120(Pt 11):1888-97.
2007: Severine Gharbi; Marketa Zvelebil; Stephen J Shuttleworth; Tim Hancox; Nahid Saghir; John Francis Timms; Michael D Waterfield
Exploring the specificity of the PI3K family inhibitor LY294002.
The Biochemical journal 2007;404(1):15-21.
2007: Masahiko Hayakawa; Hiroyuki Kaizawa; Hiroyuki Moritomo; Tomonobu Koizumi; Takahide Ohishi; Mayumi Yamano; Minoru Okada; Mitsuaki Ohta; Shin-ichi Tsukamoto; Florence I Raynaud; Paul Workman; Michael D Waterfield; Peter Parker
Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(9):2438-42.
2007: Alison Maloney; Paul A Clarke; Soren Naaby-Hansen; Rob Stein; Jens Koopm,ann; Akunna Akpan; Alice Yang; Marketa Zvelebil; Rainer Cramer; Lindsay Stimson; Wynne Aherne; Udai Banerji; Ian Judson; Swee Sharp; Marissa Powers; Emmanuel deBilly; Joanne Salmons; Michael Walton; Al L Burlingame; Michael D Waterfield; Paul Workman
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Cancer research 2007;67(7):3239-53.
2007: Masahiko Hayakawa; Hiroyuki Kaizawa; Ken-Ichi Kawaguchi; Noriko Ishikawa; Tomonobu Koizumi; Takahide Ohishi; Mayumi Yamano; Minoru Okada; Mitsuaki Ohta; Shin-ichi Tsukamoto; Florence I Raynaud; Michael D Waterfield; Peter Parker; Paul Workman
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
Bioorganic & medicinal chemistry 2007;15(1):403-12.
2006: Masahiko Hayakawa; Hiroyuki Kaizawa; Hiroyuki Moritomo; Tomonobu Koizumi; Takahide Ohishi; Minoru Okada; Mitsuaki Ohta; Shin-ichi Tsukamoto; Peter Parker; Paul Workman; Michael D Waterfield
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors.
Bioorganic & medicinal chemistry 2006;14(20):6847-58.
2006: John Sinclair; mark e weeks; Amna Butt; Jessica L Worthington; Akunna Akpan; Nic Jones; Michael D Waterfield; Donald Allanand; John Francis Timms
Proteomic response of Schizosaccharomyces pombe to static and oscillating extremely low-frequency electromagnetic fields.
Proteomics 2006;6(17):4755-64.
2006: Roy M Katso; Olivier E Pardo; Andrea Palamidessi; Clemens M Franz; Marin Marinov; Angela De Laurentiis; Julian Downward; Giorgio Scita; Anne J Ridley; Michael D Waterfield; Alexandre Arcaro
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms.
Molecular biology of the cell 2006;17(9):3729-44.
2006: Pedro Cutillas; Asim Khwaja; Mariona Graupera; Wayne Pearce; Severine Gharbi; Michael D Waterfield; Bart Vanhaesebroeck
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):8959-64.
2006: Hong-Lin Chan; Piers R J Gaffney; Michael D Waterfield; Heinz Anderle; H Peter Matthiessen; Hans-Peter Schwarz; Peter L Turecek; John Francis Timms
Proteomic analysis of UVC irradiation-induced damage of plasma proteins: Serum amyloid P component as a major target of photolysis.
FEBS letters 2006;580(13):3229-36.
2006: mark e weeks; John Sinclair; Amna Butt; Yuen-Li Chung; Jessica L Worthington; Caroline R M Wilkinson; John Griffiths; Nic Jones; Michael D Waterfield; John Francis Timms
A parallel proteomic and metabolomic analysis of the hydrogen peroxide- and Sty1p-dependent stress response in Schizosaccharomyces pombe.
Proteomics 2006;6(9):2772-96.
2005: Karin Barnouin; Sarah Hart; Andrew J Thompson; Masahiro Okuyama; Michael D Waterfield; Rainer Cramer
Enhanced phosphopeptide isolation by Fe(III)-IMAC using 1,1,1,3,3,3-hexafluoroisopropanol.
Proteomics 2005;5(17):4376-88.
2005: Pedro Cutillas; Barbara Geering; Michael D Waterfield; Bart Vanhaesebroeck
Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line.
Molecular & cellular proteomics : MCP 2005;4(8):1038-51.
2005: Hong-Lin Chan; Severine Gharbi; Piers R J Gaffney; Rainer Cramer; Michael D Waterfield; John Francis Timms
Proteomic analysis of redox- and ErbB2-dependent changes in mammary luminal epithelial cells using cysteine- and lysine-labelling two-dimensional difference gel electrophoresis.
Proteomics 2005;5(11):2908-26.
2005: mark e weeks; John Sinclair; Richard Jacob; Malcolm Saxton; Susan Kirby; James Jones; Michael D Waterfield; Rainer Cramer; John Francis Timms
Stress-induced changes in the Schizosaccharomyces pombe proteome using two-dimensional difference gel electrophoresis, mass spectrometry and a novel integrated robotics platform.
Proteomics 2005;5(6):1669-85.
2005: Pedro Cutillas; Juerg Biber; Joanne Marks; Richard Jacob; Bruno Stieger; Richard Jacob; Michael D Waterfield; Al L Burlingame; Robert J Unwin
Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex.
Proteomics 2005;5(1):101-12.
2004: Pedro Cutillas; Robert J Chalkley; Kirk Hansen; Rainer Cramer; Anthony G W Norden; Michael D Waterfield; Al L Burlingame; Robert J Unwin
The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells.
American journal of physiology. Renal physiology 2004;287(3):F353-64.
2004: Bart Vanhaesebroeck; Jennifer L Rohn; Michael D Waterfield
Gene targeting: attention to detail.
Cell 2004;118(3):274-6.
2004: Sarah White; Severine Gharbi; M F Bertani; Hong-Lin Chan; Michael D Waterfield; John Francis Timms
Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression.
British journal of cancer 2004;90(1):173-81.
2004: Lindsay K MacDougall; Mary Elizabeth Gagou; Sally J Leevers; Ernst Hafen; Michael D Waterfield
Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways.
Molecular and cellular biology 2004;24(2):796-808.
2002: Alexandre Arcaro; Umme K Khanzada; Bart Vanhaesebroeck; Teresa D Tetley; Michael D Waterfield; Michael J Seckl
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.
The EMBO journal 2002;21(19):5097-108.
2002: John Francis Timms; Sarah White; Michael J O'Hare; Michael D Waterfield
Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells.
Oncogene 2002;21(43):6573-86.
2002: Sarah Hart; Michael D Waterfield; Al L Burlingame; Rainer Cramer
Factors governing the solubilization of phosphopeptides retained on ferric NTA IMAC beads and their analysis by MALDI TOFMS.
Journal of the American Society for Mass Spectrometry 2002;13(9):1042-51.
2002: Klaus Okkenhaug; Antonio Bilancio; Géraldine Farjot; Helen Priddle; Sara Sancho; Emma Peskett; Wayne Pearce; Stephen E Meek; Ashreena Salpekar; Michael D Waterfield; Andrew J H Smith; Bart Vanhaesebroeck
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.
Science (New York, N.Y.) 2002;297(5583):1031-4.
2002: Frederique Verdier; Taras Valovka; Alexander Zhyvoloup; Ludmila B Drobot; Vladimir L Buchman; Michael D Waterfield; Ivan T Gout
Ruk is ubiquitinated but not degraded by the proteasome.
European journal of biochemistry / FEBS 2002;269(14):3402-8.
2002: Silvia Benvenuti; Rainer Cramer; Jim Bruce; Michael D Waterfield; Parmjit S Jat
Identification of novel candidates for replicative senescence by functional proteomics.
Oncogene 2002;21(28):4403-13.
2002: Silvia Benvenuti; Rainer Cramer; Christopher C Quinn; Jim Bruce; Marketa Zvelebil; Steve Corless; Jacquelyn Bond; Alice Yang; Susan Hockfield; Al L Burlingame; Michael D Waterfield; Parmjit S Jat
Differential proteome analysis of replicative senescence in rat embryo fibroblasts.
Molecular & cellular proteomics : MCP 2002;1(4):280-92.
2002: Severine Gharbi; Piers Gaffney; Alice Yang; Marketa Zvelebil; Rainer Cramer; Michael D Waterfield; John Francis Timms
Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system.
Molecular & cellular proteomics : MCP 2002;1(2):91-8.
2002: Robert A Harris; Alice Yang; Robert C Stein; Kevan Lucy; Luc Brusten; Athula Herath; Raj Parekh; Michael D Waterfield; Michael J O'Hare; Munro A Neville; Martin J Page; Marketa Zvelebil
Cluster analysis of an extensive human breast cancer cell line protein expression map database.
Proteomics 2002;2(2):212-23.
2001: Soren Naaby-Hansen; Michael D Waterfield; Rainer Cramer
Proteomics--post-genomic cartography to understand gene function.
Trends in pharmacological sciences 2001;22(7):376-84.
2001: Luciano Pirola; Marketa Zvelebil; G Bulgarelli-Leva; Emmanuel Van Obberghen; Michael D Waterfield; Matthias P Wymann
Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.
The Journal of biological chemistry 2001;276(24):21544-54.
2001: Roy M Katso; Klaus Okkenhaug; Kourosh R Ahmadi; S White; John Francis Timms; Michael D Waterfield
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.
Annual review of cell and developmental biology 2001;17():615-75.
2001: Bart Vanhaesebroeck; Sally J Leevers; Kourosh R Ahmadi; John Francis Timms; Roy M Katso; Paul C Driscoll; R Woscholski; Peter J Parker; Michael D Waterfield
Synthesis and function of 3-phosphorylated inositol lipids.
Annual review of biochemistry 2001;70():535-602.
2000: DB Parekh; Roy M Katso; N R Leslie; C Peter Downes; Katarzyna Joanna Procyk; Michael D Waterfield; Peter J Parker
Beta1-integrin and PTEN control the phosphorylation of protein kinase C.
The Biochemical journal 2000;352 Pt 2():425-33.
2000: Robert C Stein; Michael D Waterfield
PI3-kinase inhibition: a target for drug development?
Molecular medicine today 2000;6(9):347-57.
2000: Ivan T Gout; G Middleton; J Adu; Natalia Ninkina; Ludmila B Drobot; Valeriy Filonenko; Genadiy Matsuka; Alun M Davies; Michael D Waterfield; Vladimir L Buchman
Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.
The EMBO journal 2000;19(15):4015-25.
2000: Alexandre Arcaro; Marketa Zvelebil; C Wallasch; A Ullrich; Michael D Waterfield; J Domin
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.
Molecular and cellular biology 2000;20(11):3817-30.
2000: J Domin; Ibragim Gaidarov; M E Smith; James H Keen; Michael D Waterfield
The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles.
The Journal of biological chemistry 2000;275(16):11943-50.
1999: Martin J Page; B Amess; R R Townsend; Raj Parekh; Athula Herath; L Brusten; Marketa Zvelebil; Robert C Stein; Michael D Waterfield; S C Davies; Michael J O'Hare
Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12589-94.
1999: David Weinkove; T P Neufeld; T Twardzik; Michael D Waterfield; Sally J Leevers
Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor.
Current biology : CB 1999;9(18):1019-29.
1999: Paola Lo Surdo; Matthew J Bottomley; Alexandre Arcaro; Gregg Siegal; George Panayotou; Andrew Sankar; Piers R J Gaffney; Andrew M Riley; Barry V L Potter; Michael D Waterfield; Paul C Driscoll
Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates.
The Journal of biological chemistry 1999;274(22):15678-85.
1999: R A Brown; J Domin; Alexandre Arcaro; Michael D Waterfield; Peter R Shepherd
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase.
The Journal of biological chemistry 1999;274(21):14529-32.
1999: AG Harpur; MJ Layton; P Das; Matthew J Bottomley; George Panayotou; Paul C Driscoll; Michael D Waterfield
Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1999;274(18):12323-32.
1999: Sally J Leevers; Bart Vanhaesebroeck; Michael D Waterfield
Signalling through phosphoinositide 3-kinases: the lipids take centre stage.
Current opinion in cell biology 1999;11(2):219-25.
1999: Bart Vanhaesebroeck; K Higashi; C Raven; Melanie J Welham; S Anderson; Paul Brennan; Stephen G Ward; Michael D Waterfield
Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo.
The EMBO journal 1999;18(5):1292-302.
1998: MJ Layton; AG Harpur; George Panayotou; Philippe I H Bastiaens; Michael D Waterfield
Binding of a diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor beta induces oligomerization of phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1998;273(50):33379-85.
1998: Alexandre Arcaro; Stefano Volinia; Marketa Zvelebil; R Stein; S J Watton; MJ Layton; Ivan T Gout; Kourosh R Ahmadi; Julian Downward; Michael D Waterfield
Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity.
The Journal of biological chemistry 1998;273(49):33082-90.
1998: Ivan T Gout; T Minami; K Hara; Y Tsujishita; Valeriy Filonenko; Michael D Waterfield; K Yonezawa
Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.
The Journal of biological chemistry 1998;273(46):30061-4.
1998: S J Turner; J Domin; Michael D Waterfield; Stephen G Ward; John Westwick
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha.
The Journal of biological chemistry 1998;273(40):25987-95.
1998: Gregg Siegal; Ben Davis; Søren M Kristensen; Andrew Sankar; J Linacre; Robert C Stein; George Panayotou; Michael D Waterfield; Paul C Driscoll
Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
Journal of molecular biology 1998;276(2):461-78.
1997: R Uellner; Marketa Zvelebil; J Hopkins; J Jones; Lindsay K MacDougall; B P Morgan; Eckhard R Podack; Michael D Waterfield; Gillian M Griffiths
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.
The EMBO journal 1997;16(24):7287-96.
1997: J Domin; F Pages; Stefano Volinia; Susan E Rittenhouse; Marketa Zvelebil; Robert C Stein; Michael D Waterfield
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin.
The Biochemical journal 1997;326 ( Pt 1)():139-47.
1997: Bart Vanhaesebroeck; Sally J Leevers; George Panayotou; Michael D Waterfield
Phosphoinositide 3-kinases: a conserved family of signal transducers.
Trends in biochemical sciences 1997;22(7):267-72.
1997: J Domin; Michael D Waterfield
Using structure to define the function of phosphoinositide 3-kinase family members.
FEBS letters 1997;410(1):91-5.
1997: David Weinkove; Sally J Leevers; Lindsay K MacDougall; Michael D Waterfield
p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110.
The Journal of biological chemistry 1997;272(23):14606-10.
1997: P Rodriguez-Viciana; PH Warne; A Khwaja; BM Marte; D Pappin; P Das; Michael D Waterfield; A Ridley; Julian Downward
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.
Cell 1997;89(3):457-67.
1997: Bart Vanhaesebroeck; Melanie J Welham; K Kotani; R Stein; PH Warne; Marketa Zvelebil; K Higashi; Stefano Volinia; Julian Downward; Michael D Waterfield
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4330-5.
1997: R Woscholski; PM Finan; E Radley; Nick Totty; AE Sterling; J Justin Hsuan; Michael D Waterfield; Peter J Parker
Synaptojanin is the major constitutively active phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase in rodent brain.
The Journal of biological chemistry 1997;272(15):9625-8.
1997: C Linassier; Lindsay K MacDougall; J Domin; Michael D Waterfield
Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase.
The Biochemical journal 1997;321 ( Pt 3)():849-56.
1997: C Panaretou; J Domin; Shamshad Cockcroft; Michael D Waterfield
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.
The Journal of biological chemistry 1997;272(4):2477-85.
1996: D Renzoni; D J Pugh; Giuliano Siligardi; P Das; CJ Morton; C Rossi; Michael D Waterfield; Iain D Campbell; John E Ladbury
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry 1996;35(49):15646-53.
1996: Sally J Leevers; David Weinkove; Lindsay K MacDougall; Ernst Hafen; Michael D Waterfield
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.
The EMBO journal 1996;15(23):6584-94.
1996: K Salim; Matthew J Bottomley; E Querfurth; Marketa Zvelebil; Ivan T Gout; R Scaife; Robert L Margolis; R Gigg; C I Smith; Paul C Driscoll; Michael D Waterfield; George Panayotou
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.
The EMBO journal 1996;15(22):6241-50.
1996: Lindsay K MacDougall; Michael D Waterfield
Receptor signalling: to sevenless, a daughter.
Current biology : CB 1996;6(10):1250-3.
1996: J Domin; R Dhand; Michael D Waterfield
Binding to the platelet-derived growth factor receptor transiently activates the p85alpha-p110alpha phosphoinositide 3-kinase complex in vivo.
The Journal of biological chemistry 1996;271(35):21614-21.
1996: P Finan; H Koga; Marketa Zvelebil; Michael D Waterfield; S Kellie
The C-terminal SH3 domain of p67phox binds its natural ligand in a reverse orientation.
Journal of molecular biology 1996;261(2):173-80.
1996: S Banin; O Truong; D R Katz; Michael D Waterfield; PM Brickell; Ivan T Gout
Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases.
Current biology : CB 1996;6(8):981-8.
1996: P Rodriguez-Viciana; PH Warne; Bart Vanhaesebroeck; Michael D Waterfield; Julian Downward
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.
The EMBO journal 1996;15(10):2442-51.
1996: Matthias P Wymann; G Bulgarelli-Leva; Marketa Zvelebil; Luciano Pirola; Bart Vanhaesebroeck; Michael D Waterfield; George Panayotou
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.
Molecular and cellular biology 1996;16(4):1722-33.
1996: V Srinivasan; Michael D Waterfield; Tom L Blundell
Comparative analysis of the regions binding beta gamma-subunits in Galpha and PH domains.
Biochemical and biophysical research communications 1996;220(3):697-702.
1995: R Woscholski; Michael D Waterfield; Peter J Parker
Purification and biochemical characterization of a mammalian phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
The Journal of biological chemistry 1995;270(52):31001-7.
1995: Lindsay K MacDougall; J Domin; Michael D Waterfield
A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction.
Current biology : CB 1995;5(12):1404-15.
1995: Christine A Orengo; Mark B Swindells; AD Michie; Marketa Zvelebil; Paul C Driscoll; Michael D Waterfield; Janet M Thornton
Structural similarity between the pleckstrin homology domain and verotoxin: the problem of measuring and evaluating structural similarity.
Protein science : a publication of the Protein Society 1995;4(10):1977-83.
1995: R Woscholski; T Kodaki; R H Palmer; Michael D Waterfield; Peter J Parker
Modulation of the substrate specificity of the mammalian phosphatidylinositol 3-kinase by cholesterol sulfate and sulfatide.
Biochemistry 1995;34(36):11489-93.
1995: Stefano Volinia; R Dhand; Bart Vanhaesebroeck; Lindsay K MacDougall; R Stein; Marketa Zvelebil; J Domin; C Panaretou; Michael D Waterfield
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.
The EMBO journal 1995;14(14):3339-48.
1995: Marketa Zvelebil; George Panayotou; J Linacre; Michael D Waterfield
Prediction and analysis of SH2 domain-phosphopeptide interactions.
Protein engineering 1995;8(6):527-33.
1995: L Guruprasad; Venugopal Dhanaraj; D Timm; Tom L Blundell; Ivan T Gout; Michael D Waterfield
The crystal structure of the N-terminal SH3 domain of Grb2.
Journal of molecular biology 1995;248(4):856-66.
1995: Giuliana Pelicci; silvia giordano; Z Zhen; Anna Elisabetta Salcini; Luisa Lanfrancone; Alberto Bardelli; G Panayotou; Michael D Waterfield; Carola Ponzetto; Pier Giuseppe Pelicci
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein.
Oncogene 1995;10(8):1631-8.
1994: A Kauffmann-Zeh; Reinhard Klinger; G Endemann; Michael D Waterfield; Reinhard Wetzker; J Justin Hsuan
Regulation of human type II phosphatidylinositol kinase activity by epidermal growth factor-dependent phosphorylation and receptor association.
The Journal of biological chemistry 1994;269(49):31243-51.
1994: Stefano Volinia; I Hiles; E Ormondroyd; D Nizetic; R Antonacci; M Rocchi; Michael D Waterfield
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.
Genomics 1994;24(3):472-7.
1994: D Timm; K Salim; Ivan T Gout; L Guruprasad; Michael D Waterfield; Tom L Blundell
Crystal structure of the pleckstrin homology domain from dynamin.
Nature structural biology 1994;1(11):782-8.
1994: R Woscholski; R Dhand; M J Fry; Michael D Waterfield; Peter J Parker
Biochemical characterization of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha.p85 alpha forms of the mammalian phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1994;269(40):25067-72.
1994: A Kristina Downing; Paul C Driscoll; Ivan T Gout; K Salim; Marketa Zvelebil; Michael D Waterfield
Three-dimensional solution structure of the pleckstrin homology domain from dynamin.
Current biology : CB 1994;4(10):884-91.
1994: P Rodriguez-Viciana; PH Warne; R Dhand; Bart Vanhaesebroeck; Ivan T Gout; M J Fry; Michael D Waterfield; Julian Downward
Phosphatidylinositol-3-OH kinase as a direct target of Ras.
Nature 1994;370(6490):527-32.
1994: S Roche; R Dhand; Michael D Waterfield; Sara A Courtneidge
The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes.
The Biochemical journal 1994;301 ( Pt 3)():703-11.
1994: M Hensmann; G W Booker; George Panayotou; J Boyd; J Linacre; Michael D Waterfield; Iain D Campbell
Phosphopeptide binding to the N-terminal SH2 domain of the p85 alpha subunit of PI 3'-kinase: a heteronuclear NMR study.
Protein science : a publication of the Protein Society 1994;3(7):1020-30.
1994: R Scaife; Ivan T Gout; Michael D Waterfield; Robert L Margolis
Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences.
The EMBO journal 1994;13(11):2574-82.
1994: P Finan; Y Shimizu; Ivan T Gout; J Justin Hsuan; O Truong; C Butcher; P Bennett; Michael D Waterfield; S Kellie
An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex.
The Journal of biological chemistry 1994;269(19):13752-5.
1994: R Woscholski; T Kodaki; M McKinnon; Michael D Waterfield; Peter J Parker
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.
FEBS letters 1994;342(2):109-14.
1994: R Dhand; K Hara; I Hiles; B Bax; Ivan T Gout; George Panayotou; M J Fry; K Yonezawa; M Kasuga; Michael D Waterfield
PI 3-kinase: structural and functional analysis of intersubunit interactions.
The EMBO journal 1994;13(3):511-21.
1994: T Kodaki; R Woscholski; S Emr; Michael D Waterfield; Paul Nurse; Peter J Parker
Mammalian phosphatidylinositol 3'-kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product.
European journal of biochemistry / FEBS 1994;219(3):775-80.
1993: George Panayotou; Michael D Waterfield; P End
Riding the evanescent wave.
Current biology : CB 1993;3(12):913-5.
1993: M J Fry; George Panayotou; G W Booker; Michael D Waterfield
New insights into protein-tyrosine kinase receptor signaling complexes.
Protein science : a publication of the Protein Society 1993;2(11):1785-97.
1993: A D Goodearl; J B Davis; K Mistry; L Minghetti; M Otsu; Michael D Waterfield; P Stroobant
Purification of multiple forms of glial growth factor.
The Journal of biological chemistry 1993;268(24):18095-102.
1993: Carola Ponzetto; Alberto Bardelli; Flavio Maina; Paola Longati; G Panayotou; R Dhand; Michael D Waterfield; paolo comoglio
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.
Molecular and cellular biology 1993;13(8):4600-8.
1993: M J Fry; Michael D Waterfield
Structure and function of phosphatidylinositol 3-kinase: a potential second messenger system involved in growth control.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):337-44.
1993: George Panayotou; G Gish; P End; O Truong; Ivan T Gout; R Dhand; M J Fry; I Hiles; T Pawson; Michael D Waterfield
Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.
Molecular and cellular biology 1993;13(6):3567-76.
1993: G W Booker; Ivan T Gout; A Kristina Downing; Paul C Driscoll; J Boyd; Michael D Waterfield; Iain D Campbell
Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase.
Cell 1993;73(4):813-22.
1993: P End; Ivan T Gout; M J Fry; George Panayotou; R Dhand; K Yonezawa; M Kasuga; Michael D Waterfield
A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex.
The Journal of biological chemistry 1993;268(14):10066-75.
1993: F Ruiz-Larrea; P Vicendo; P Yaish; P End; George Panayotou; M J Fry; S J Morgan; A Thompson; Peter J Parker; Michael D Waterfield
Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex.
The Biochemical journal 1993;290 ( Pt 2)():609-16.
1993: Sara A Courtneidge; R Dhand; D Pilat; G M Twamley; Michael D Waterfield; M F Roussel
Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.
The EMBO journal 1993;12(3):943-50.
1992: Ivan T Gout; R Dhand; George Panayotou; M J Fry; I Hiles; M Otsu; Michael D Waterfield
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.
The Biochemical journal 1992;288 ( Pt 2)():395-405.
1992: George Panayotou; B Bax; Ivan T Gout; M Federwisch; B Wroblowski; R Dhand; M J Fry; T L Blundell; Axel Wollmer; Michael D Waterfield
Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes.
The EMBO journal 1992;11(12):4261-72.
1992: M J Fry; George Panayotou; R Dhand; F Ruiz-Larrea; Ivan T Gout; O Nguyen; S A Courtneidge; Michael D Waterfield
Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns.
The Biochemical journal 1992;288 ( Pt 2)():383-93.
1992: P End; George Panayotou; A Entwistle; Michael D Waterfield; Matthias Chiquet
Tenascin: a modulator of cell growth.
European journal of biochemistry / FEBS 1992;209(3):1041-51.
1992: Alberto Bardelli; Flavio Maina; Ivan T Gout; M J Fry; Michael D Waterfield; paolo comoglio; Carola Ponzetto
Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains.
Oncogene 1992;7(10):1973-8.
1992: N F Totty; Michael D Waterfield; J J Hsuan
Accelerated high-sensitivity microsequencing of proteins and peptides using a miniature reaction cartridge.
Protein science : a publication of the Protein Society 1992;1(9):1215-24.
1992: G W Booker; A L Breeze; A Kristina Downing; George Panayotou; Ivan T Gout; Michael D Waterfield; Iain D Campbell
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.
Nature 1992;358(6388):684-7.
1992: Stefano Volinia; P Patracchini; M Otsu; I Hiles; Ivan T Gout; E Calzolari; F Bernardi; L Rooke; Michael D Waterfield
Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.
Oncogene 1992;7(4):789-93.
1992: George Panayotou; M J Fry; Michael D Waterfield
Multi-enzyme complexes associated with receptors during signal transduction.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1992;314(9 Suppl):11-20.
1991: Reinhard Wetzker; Reinhard Klinger; J Justin Hsuan; M J Fry; A Kauffmann-Zeh; E Müller; H Frunder; Michael D Waterfield
Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes.
European journal of biochemistry / FEBS 1991;200(1):179-85.
1991: J D Haley; Michael D Waterfield
Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis.
The Journal of biological chemistry 1991;266(3):1746-53.
1990: Michael D Waterfield; C Greenfield; I Hiles; M Federwisch; Axel Wollmer; T L Blundell; N McDonald
The use of optical techniques to detect conformational changes associated with the interaction of epidermal growth factor and its receptor.
Advances in second messenger and phosphoprotein research 1990;24():301-6.
1989: C Greenfield; I Hiles; Michael D Waterfield; M Federwisch; Axel Wollmer; T L Blundell; N McDonald
Epidermal growth factor binding induces a conformational change in the external domain of its receptor.
The EMBO journal 1989;8(13):4115-23.
1989: J Justin Hsuan; N Totty; Michael D Waterfield
Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor.
The Biochemical journal 1989;262(2):659-63.
1989: J Justin Hsuan; Julian Downward; S Clark; Michael D Waterfield
Proteolytic generation of constitutive tyrosine kinase activity of the human insulin receptor.
The Biochemical journal 1989;259(2):519-27.
1989: G Panayotou; Michael D Waterfield
Cell surface receptors for polypeptide hormones, growth factors and neuropeptides.
Current opinion in cell biology 1989;1(2):167-76.
1989: J D Haley; J J Hsuan; Michael D Waterfield
Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.
Oncogene 1989;4(3):273-83.
1988: Mark Noble; K Murray; P Stroobant; Michael D Waterfield; P Riddle
Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell.
Nature 1988;333(6173):560-2.
1988: S Clark; D J Cheng; J J Hsuan; J D Haley; Michael D Waterfield
Loss of three major auto phosphorylation sites in the EGF receptor does not block the mitogenic action of EGF.
Journal of cellular physiology 1988;134(3):421-8.
1988: M R Crompton; R J Owens; N F Totty; S E Moss; Michael D Waterfield; M J Crumpton
Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family.
The EMBO journal 1988;7(1):21-7.
1988: C Greenfield; G Patel; S Clark; N Jones; Michael D Waterfield
Expression of the human EGF receptor with ligand-stimulatable kinase activity in insect cells using a baculovirus vector.
The EMBO journal 1988;7(1):139-46.
1987: M Bajaj; Michael D Waterfield; J Schlessinger; W R Taylor; T Blundell
On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.
Biochimica et biophysica acta 1987;916(2):220-6.
1987: F Tata; M E Chaves; A F Markham; G D Scrace; Michael D Waterfield; N McIntyre; R Williamson; S E Humphries
The isolation and characterisation of cDNA and genomic clones for human lecithin: cholesterol acyltransferase.
Biochimica et biophysica acta 1987;910(2):142-8.