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Linda Watkins

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Hutchinson M R; Ramos K M; Loram L C; Wieseler J; Sholar P W; Kearney J J; Lewis M T; Crysdale N Y; Zhang Y; Harrison J A; Maier S F; Rice K C; Watkins L R
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Soderquist Ryan G; Milligan Erin D; Sloane Evan M; Harrison Jacqueline A; Douvas Klarika K; Potter Joseph M; Hughes Travis S; Chavez Raymond A; Johnson Kirk; Watkins Linda R; Mahoney Melissa J
PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution.
Loram Lisa C; Harrison Jacqueline A; Sloane Evan M; Hutchinson Mark R; Sholar Paige; Taylor Frederick R; Berkelhammer Debra; Coats Benjamen D; Poole Stephen; Milligan Erin D; Maier Steven F; Rieger Jayson; Watkins Linda R
Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.

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All Publications

2009: Hutchinson M R; Ramos K M; Loram L C; Wieseler J; Sholar P W; Kearney J J; Lewis M T; Crysdale N Y; Zhang Y; Harrison J A; Maier S F; Rice K C; Watkins L R
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Neuroscience 2009;164(4):1821-32.
2009: Soderquist Ryan G; Milligan Erin D; Sloane Evan M; Harrison Jacqueline A; Douvas Klarika K; Potter Joseph M; Hughes Travis S; Chavez Raymond A; Johnson Kirk; Watkins Linda R; Mahoney Melissa J
PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution.
Journal of biomedical materials research. Part A 2009;91(3):719-29.
2009: Loram Lisa C; Harrison Jacqueline A; Sloane Evan M; Hutchinson Mark R; Sholar Paige; Taylor Frederick R; Berkelhammer Debra; Coats Benjamen D; Poole Stephen; Milligan Erin D; Maier Steven F; Rieger Jayson; Watkins Linda R
Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(44):14015-25.
2009: Watkins Linda R; Hutchinson Mark R; Rice Kenner C; Maier Steven F
The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia.
Trends in pharmacological sciences 2009;30(11):581-91.
2009: Sloane E; Langer S; Jekich B; Mahoney J; Hughes T; Frank M; Seibert W; Huberty G; Coats B; Harrison J; Klinman D; Poole S; Maier S; Johnson K; Chavez R; Watkins L R; Leinwand L; Milligan E
Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
Gene therapy 2009;16(10):1210-22.
2009: Baratta Michael V; Zarza Christina M; Gomez Devan M; Campeau Serge; Watkins Linda R; Maier Steven F
Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress.
The European journal of neuroscience 2009;30(6):1111-6.
2009: Rodgers Krista M; Hutchinson Mark R; Northcutt Alexis; Maier Steven F; Watkins Linda R; Barth Daniel S
The cortical innate immune response increases local neuronal excitability leading to seizures.
Brain : a journal of neurology 2009;132(Pt 9):2478-86.
2009: Hughes Travis S; Langer Stephen J; Virtanen Salla I; Chavez Raymond A; Watkins Linda R; Milligan Erin D; Leinwand Leslie A
Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression.
The journal of gene medicine 2009;11(9):782-90.
2009: Bland Sondra T; Hutchinson Mark R; Maier Steven F; Watkins Linda R; Johnson Kirk W
The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release.
Brain, behavior, and immunity 2009;23(4):492-7.
2009: Barrientos Ruth M; Watkins Linda R; Rudy Jerry W; Maier Steven F
Characterization of the sickness response in young and aging rats following E. coli infection.
Brain, behavior, and immunity 2009;23(4):450-4.
2009: Sloane E M; Soderquist R G; Maier S F; Mahoney M J; Watkins L R; Milligan E D
Long-term control of neuropathic pain in a non-viral gene therapy paradigm.
Gene therapy 2009;16(4):470-5.
2009: Slivka Peter F; Shridhar Mitesh; Lee Gui-in; Sammond Deanne W; Hutchinson Mark R; Martinko Alexander J; Buchanan Madison M; Sholar Page W; Kearney Jeffrey J; Harrison Jacqueline A; Watkins Linda R; Yin Hang
A peptide antagonist of the TLR4-MD2 interaction.
Chembiochem : a European journal of chemical biology 2009;10(4):645-9.
2009: Rozeske Robert R; Der-Avakian Andre; Bland Sondra T; Beckley Jacob T; Watkins Linda R; Maier Steven F
The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2009;34(4):834-43.
2009: Hutchinson Mark R; Lewis Susannah S; Coats Benjamen D; Skyba David A; Crysdale Nicole Y; Berkelhammer Debra L; Brzeski Anita; Northcutt Alexis; Vietz Christine M; Judd Charles M; Maier Steven F; Watkins Linda R; Johnson Kirk W
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
Brain, behavior, and immunity 2009;23(2):240-50.
2009: Hughes Travis S; Langer Stephen J; Johnson Kirk W; Chavez Raymond A; Watkins Linda R; Milligan Erin D; Leinwand Leslie A
Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(1):88-94.
2009: Sloane Evan; Ledeboer A; Seibert W; Coats B; van Strien M; Maier S F; Johnson K W; Chavez R; Watkins L R; Leinwand L; Milligan E D; Van Dam A M
Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.
Brain, behavior, and immunity 2009;23(1):92-100.
2009: Barrientos Ruth M; Frank Matthew G; Hein Amy M; Higgins Emily A; Watkins Linda R; Rudy Jerry W; Maier Steven F
Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.
Brain, behavior, and immunity 2009;23(1):46-54.
2008: Hutchinson Mark R; Northcutt Alexis L; Chao Lindsey W; Kearney Jeffrey J; Zhang Yingning; Berkelhammer Debra L; Loram Lisa C; Rozeske Robert R; Bland Sondra T; Maier Steven F; Gleeson Todd T; Watkins Linda R
Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
Brain, behavior, and immunity 2008;22(8):1248-56.
2008: Hutchinson Mark R; Coats Benjamen D; Lewis Susannah S; Zhang Yingning; Sprunger David B; Rezvani Niloofar; Baker Eric M; Jekich Brian M; Wieseler Julie L; Somogyi Andrew A; Martin David; Poole Stephen; Judd Charles M; Maier Steven F; Watkins Linda R
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Brain, behavior, and immunity 2008;22(8):1178-89.
2008: Christianson John P; Paul Evan D; Irani Myra; Thompson Brittany M; Kubala Kenneth H; Yirmiya Raz; Watkins Linda R; Maier Steven F
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration.
Behavioural brain research 2008;193(1):87-93.
2008: Hutchinson Mark R; Zhang Yingning; Brown Kimberley; Coats Benjamen D; Shridhar Mitesh; Sholar Paige W; Patel Sonica J; Crysdale Nicole Y; Harrison Jacqueline A; Maier Steven F; Rice Kenner C; Watkins Linda R
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
The European journal of neuroscience 2008;28(1):20-9.
2008: Amat J; Paul E; Watkins L R; Maier S F
Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control.
Neuroscience 2008;154(4):1178-86.
2008: Bilbo Staci D; Barrientos Ruth M; Eads Andrea S; Northcutt Alexis; Watkins Linda R; Rudy Jerry W; Maier Steven F
Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood.
Brain, behavior, and immunity 2008;22(4):451-5.
2008: Bilbo Staci D; Yirmiya Raz; Amat Jose; Paul Evan D; Watkins Linda R; Maier Steven F
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats.
Psychoneuroendocrinology 2008;33(3):261-9.
2008: Baratta Michael V; Lucero Thomas R; Amat Jose; Watkins Linda R; Maier Steven F
Role of the ventral medial prefrontal cortex in mediating behavioral control-induced reduction of later conditioned fear.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(2):84-7.
2007: Hein A M; Stutzman D L; Bland S T; Barrientos R M; Watkins L R; Rudy J W; Maier S F
Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus.
Neuroscience 2007;150(4):754-63.
2007: Watkins Linda R; Hutchinson Mark R; Milligan Erin D; Maier Steven F
"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids.
Brain research reviews 2007;56(1):148-69.
2007: Ledeboer Annemarie; Hutchinson Mark R; Watkins Linda R; Johnson Kirk W
Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.
Expert opinion on investigational drugs 2007;16(7):935-50.
2007: Schoeniger-Skinner Diana K; Ledeboer Annemarie; Frank Matthew G; Milligan Erin D; Poole Stephen; Martin David; Maier Steven F; Watkins Linda R
Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Brain, behavior, and immunity 2007;21(5):660-7.
2007: Ledeboer Annemarie; Jekich Brian M; Sloane Evan M; Mahoney John H; Langer Stephen J; Milligan Erin D; Martin David; Maier Steven F; Johnson Kirk W; Leinwand Leslie A; Chavez Raymond A; Watkins Linda R
Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Brain, behavior, and immunity 2007;21(5):686-98.
2007: Wieseler-Frank Julie; Jekich Brian M; Mahoney John H; Bland Sondra T; Maier Steven F; Watkins Linda R
A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
Brain, behavior, and immunity 2007;21(5):711-8.
2007: Baratta M V; Christianson J P; Gomez D M; Zarza C M; Amat J; Masini C V; Watkins L R; Maier S F
Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear.
Neuroscience 2007;146(4):1495-503.
2007: Frank Matthew G; Der-Avakian Andre; Bland Sondra T; Watkins Linda R; Maier Steven F
Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression.
Psychoneuroendocrinology 2007;32(4):376-84.
2007: Der-Avakian Andre; Rozeske Robert R; Bland Sondra T; Watkins Linda R; Maier Steven F
The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats.
Psychopharmacology 2007;191(4):899-907.
2007: Der-Avakian Andre; Bland Sondra T; Rozeske Robert R; Tamblyn Julie P; Hutchinson Mark R; Watkins Linda R; Maier Steven F
The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats.
Psychopharmacology 2007;191(4):909-17.
2007: Holguin Adelina; Frank Matthew G; Biedenkapp Joseph C; Nelson Kristen; Lippert Dylan; Watkins Linda R; Rudy Jerry W; Maier Steven F
Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta.
Journal of neuroscience methods 2007;161(2):265-72.
2007: Bilbo Staci D; Newsum Nicholas J; Sprunger David B; Watkins Linda R; Rudy Jerry W; Maier Steven F
Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood.
Brain, behavior, and immunity 2007;21(3):332-42.
2007: Bland S T; Tamlyn J P; Barrientos R M; Greenwood B N; Watkins L R; Campeau S; Day H E; Maier S F
Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress.
Neuroscience 2007;144(4):1219-28.
2007: Watkins Linda R; Hutchinson Mark R; Ledeboer Annemarie; Wieseler-Frank Julie; Milligan Erin D; Maier Steven F
Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids.
Brain, behavior, and immunity 2007;21(2):131-46.
2007: Frank Matthew G; Baratta Michael V; Sprunger David B; Watkins Linda R; Maier Steven F
Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.
Brain, behavior, and immunity 2007;21(1):47-59.
2007: Hutchinson Mark R; Bland Sondra T; Johnson Kirk W; Rice Kenner C; Maier Steven F; Watkins Linda R
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
TheScientificWorldJournal 2007;7():98-111.
2006: Amat José; Paul Evan; Zarza Christina; Watkins Linda R; Maier Steven F
Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(51):13264-72.
2006: Milligan Erin D; Sloane Evan M; Langer Stephen J; Hughes Travis S; Jekich Brian M; Frank Matthew G; Mahoney John H; Levkoff Lindsay H; Maier Steven F; Cruz Pedro E; Flotte Terence R; Johnson Kirk W; Mahoney Melissa M; Chavez Raymond A; Leinwand Leslie A; Watkins Linda R
Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
Pain 2006;126(1-3):294-308.
2006: Milligan Erin D; Soderquist Ryan G; Malone Stephanie M; Mahoney John H; Hughes Travis S; Langer Stephen J; Sloane Evan M; Maier Steven F; Leinwand Leslie A; Watkins Linda R; Mahoney Melissa J
Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain.
Neuron glia biology 2006;2(4):293-308.
2006: Ledeboer Annemarie; Mahoney John H; Milligan Erin D; Martin David; Maier Steven F; Watkins Linda R
Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.
The journal of pain : official journal of the American Pain Society 2006;7(10):757-67.
2006: Der-Avakian Andre; Bland Sondra T; Schmid Megan J; Watkins Linda R; Spencer Robert L; Maier Steven F
The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine.
Psychoneuroendocrinology 2006;31(5):653-63.
2006: Barrientos Ruth M; Higgins Emily A; Biedenkapp Joseph C; Sprunger David B; Wright-Hardesty Karli J; Watkins Linda R; Rudy Jerry W; Maier Steven F
Peripheral infection and aging interact to impair hippocampal memory consolidation.
Neurobiology of aging 2006;27(5):723-32.
2006: Frank Matthew G; Barrientos Ruth M; Biedenkapp Joseph C; Rudy Jerry W; Watkins Linda R; Maier Steven F
mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.
Neurobiology of aging 2006;27(5):717-22.
2006: Bland Sondra T; Schmid Megan J; Greenwood Benjamin N; Watkins Linda R; Maier Steven F
Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2.
Neuroreport 2006;17(6):593-7.
2006: Bilbo Staci D; Rudy Jerry W; Watkins Linda R; Maier Steven F
A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats.
Behavioural brain research 2006;169(1):39-47.
2006: Frank Matthew G; Wieseler-Frank Julie L; Watkins Linda R; Maier Steven F
Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics.
Journal of neuroscience methods 2006;151(2):121-30.
2006: Watkins Linda R; Wieseler-Frank Julie; Milligan Erin D; Johnston Ian; Maier Steven F
Chapter 22 Contribution of glia to pain processing in health and disease.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2006;81():309-23.
2006: Maier Steven F; Amat Jose; Baratta Michael V; Paul Evan; Watkins Linda R
Behavioral control, the medial prefrontal cortex, and resilience.
Dialogues in clinical neuroscience 2006;8(4):397-406.
2005: Milligan E; Zapata V; Schoeniger D; Chacur M; Green P; Poole S; Martin D; Maier S F; Watkins L R
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
The European journal of neuroscience 2005;22(11):2775-82.
2005: Watkins Linda R; Hutchinson Mark R; Johnston Ian N; Maier Steven F
Glia: novel counter-regulators of opioid analgesia.
Trends in neurosciences 2005;28(12):661-9.
2005: Ledeboer Annemarie; Gamanos Michael; Lai Wenmin; Martin David; Maier Steven F; Watkins Linda R; Quan Ning
Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
The European journal of neuroscience 2005;22(8):1977-86.
2005: Bilbo Staci D; Biedenkapp Joseph C; Der-Avakian Andre; Watkins Linda R; Rudy Jerry W; Maier Steven F
Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(35):8000-9.
2005: Bland Sondra T; Schmid Megan J; Der-Avakian Andre; Watkins Linda R; Spencer Robert L; Maier Steven F
Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress.
Brain research 2005;1051(1-2):90-9.
2005: Takase Luiz F; Nogueira Maria Inês; Bland Sondra T; Baratta Michael; Watkins Linda R; Maier Steven F; Fornal Casimir A; Jacobs Barry L
Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat.
Behavioural brain research 2005;162(2):299-306.
2005: Ledeboer Annemarie; Sloane Evan M; Milligan Erin D; Frank Matthew G; Mahony John H; Maier Steven F; Watkins Linda R
Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
Pain 2005;115(1-2):71-83.
2005: Der-Avakian Andre; Will Matthew J; Bland Sondra T; Deak Terrence; Nguyen Kien T; Schmid Megan J; Spencer Robert L; Watkins Linda R; Maier Steven F
Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats.
Psychopharmacology 2005;179(2):409-17.
2005: Milligan Erin D; Langer Stephen J; Sloane Evan M; He Lin; Wieseler-Frank Julie; O'Connor Kevin; Martin David; Forsayeth John R; Maier Steven F; Johnson Kirk; Chavez Raymond A; Leinwand Leslie A; Watkins Linda R
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
The European journal of neuroscience 2005;21(8):2136-48.
2005: Twining Carin M; Sloane Evan M; Schoeniger Diana K; Milligan Erin D; Martin David; Marsh Henry; Maier Steven F; Watkins Linda R
Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization.
The journal of pain : official journal of the American Pain Society 2005;6(3):174-83.
2005: Amat J; Baratta M V; Paul E; Bland S T; Watkins L R; Maier S F
Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus.
Nature neuroscience 2005;8(3):365-71.
2005: Wieseler-Frank Julie; Maier Steven F; Watkins Linda R
Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences.
Brain, behavior, and immunity 2005;19(2):104-11.
2005: Bilbo Staci D; Levkoff Lindsay H; Mahoney John H; Watkins Linda R; Rudy Jerry W; Maier Steven F
Neonatal infection induces memory impairments following an immune challenge in adulthood.
Behavioral neuroscience 2005;119(1):293-301.
2005: Watkins L R; Maier S F
Immune regulation of central nervous system functions: from sickness responses to pathological pain.
Journal of internal medicine 2005;257(2):139-55.
2005: Wieseler-Frank Julie; Maier Steven F; Watkins Linda R
Central proinflammatory cytokines and pain enhancement.
Neuro-Signals 2005;14(4):166-74.
2005: Maier Steven F; Watkins Linda R
Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor.
Neuroscience and biobehavioral reviews 2005;29(4-5):829-41.
2005: Milligan Erin D; Sloane Evan M; Langer Stephen J; Cruz Pedro E; Chacur Marucia; Spataro Leah; Wieseler-Frank Julie; Hammack Sayamwong E; Maier Steven F; Flotte Terence R; Forsayeth John R; Leinwand Leslie A; Chavez Raymond; Watkins Linda R
Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
Molecular pain 2005;1():9.
2004: Bland Sondra T; Schmid Megan J; Watkins Linda R; Maier Steven F
Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine.
Neuroreport 2004;15(17):2637-41.
2004: Milligan E D; Zapata V; Chacur M; Schoeniger D; Biedenkapp J; O'Connor K A; Verge G M; Chapman G; Green P; Foster A C; Naeve G S; Maier S F; Watkins L R
Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.
The European journal of neuroscience 2004;20(9):2294-302.
2004: Barrientos Ruth M; Sprunger David B; Campeau Serge; Watkins Linda R; Rudy Jerry W; Maier Steven F
BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration.
Journal of neuroimmunology 2004;155(1-2):119-26.
2004: Spataro Leah E; Sloane Evan M; Milligan Erin D; Wieseler-Frank Julie; Schoeniger Diana; Jekich Brian M; Barrientos Ruth M; Maier Steven F; Watkins Linda R
Spinal gap junctions: potential involvement in pain facilitation.
The journal of pain : official journal of the American Pain Society 2004;5(7):392-405.
2004: Verge Gail M; Milligan Erin D; Maier Steve F; Watkins Linda R; Naeve Gregory S; Foster Alan C
Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.
The European journal of neuroscience 2004;20(5):1150-60.
2004: Chacur Marucia; Gutiérrez José Maria; Milligan Erin D; Wieseler-Frank Julie; Britto Luiz R G; Maier Steven F; Watkins Linda R; Cury Yara
Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
Pain 2004;111(1-2):65-76.
2004: Johnston Ian N; Milligan Erin D; Wieseler-Frank Julie; Frank Matthew G; Zapata Varlin; Campisi Jay; Langer Stephen; Martin David; Green Paula; Fleshner M; Leinwand Leslie; Maier Steven F; Watkins Linda R
A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(33):7353-65.
2004: Holguin Adelina; O'Connor Kevin A; Biedenkapp Joseph; Campisi Jay; Wieseler-Frank Julie; Milligan Erin D; Hansen Michael K; Spataro Leah; Maksimova Elena; Bravmann Courtenay; Martin David; Fleshner Monika; Maier Steven F; Watkins Linda R
HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
Pain 2004;110(3):517-30.
2004: Takase Luiz F; Nogueira Maria Ines; Baratta Michael; Bland Sondra T; Watkins Linda R; Maier Steven F; Fornal Casimir A; Jacobs Barry L
Inescapable shock activates serotonergic neurons in all raphe nuclei of rat.
Behavioural brain research 2004;153(1):233-9.
2004: Twining Carin M; Sloane Evan M; Milligan Erin D; Chacur Marucia; Martin David; Poole Stephen; Marsh Henry; Maier Steven F; Watkins Linda R
Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
Pain 2004;110(1-2):299-309.
2004: Wieseler-Frank Julie; Maier Steven F; Watkins Linda R
Glial activation and pathological pain.
Neurochemistry international 2004;45(2-3):389-95.
2004: Day Heidi E W; Greenwood Benjamin N; Hammack Sayamwong E; Watkins Linda R; Fleshner Monika; Maier Steven F; Campeau Serge
Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus.
The Journal of comparative neurology 2004;474(3):364-78.
2004: O'Connor Kevin A; Holguin Adelina; Hansen Michael K; Maier Steven F; Watkins Linda R
A method for measuring multiple cytokines from small samples.
Brain, behavior, and immunity 2004;18(3):274-80.
2004: Hammack Sayamwong E; Richey Kristen J; Watkins Linda R; Maier Steven F
Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress.
Behavioral neuroscience 2004;118(2):443-8.
2004: Chacur Marucia; Milligan Erin D; Sloan Evan M; Wieseler-Frank Julie; Barrientos Ruth M; Martin David; Poole Stephen; Lomonte Brono; Gutiérrez Jose Maria; Maier Steven F; Cury Yara; Watkins Linda R
Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Pain 2004;108(1-2):180-91.
2004: Will Matthew J; Der-Avakian Andre; Bland Sondra T; Grahn Ruth E; Hammack Sayamwong E; Sparks Peter D; Pepin Julie L; Watkins Linda R; Maier Steven F
Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats.
Psychopharmacology 2004;171(2):191-8.
2004: O'Connor Kevin A; Ginsberg Abigail B; Maksimova Elena; Wieseler Frank Julie L; Johnson John D; Spencer Robert L; Campeau Serge; Watkins Linda R; Maier Steven F
Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression.
Neuroendocrinology 2004;80(4):252-63.
2004: Amat J; Tamblyn J P; Paul E D; Bland S T; Amat P; Foster A C; Watkins L R; Maier S F
Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala.
Neuroscience 2004;129(3):509-19.
2004: Johnson J D; O'Connor K A; Watkins L R; Maier S F
The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses.
Neuroscience 2004;127(3):569-77.
2004: Bland S T; Twining C; Schmid M J; Der-Avakian A; Watkins L R; Maier S F
Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus.
Neuroscience 2004;126(3):705-15.
2004: Milligan Erin D; Maier Steven F; Watkins Linda R
Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing.
Methods in molecular medicine 2004;99():67-89.
2003: Gazda Lawrence S; Smith Taro; Watkins Linda R; Maier Steven F; Fleshner Monika
Stressor exposure produces long-term reductions in antigen-specific T and B cell responses.
Stress (Amsterdam, Netherlands) 2003;6(4):259-67.
2003: Hammack Sayamwong E; Pepin Julie L; DesMarteau Jeffrey S; Watkins Linda R; Maier Steven F
Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress.
Behavioural brain research 2003;147(1-2):55-64.
2003: Watkins Linda R; Maier Steven F
Glia: a novel drug discovery target for clinical pain.
Nature reviews. Drug discovery 2003;2(12):973-85.
2003: O'Connor Kevin A; Hansen Michael K; Rachal Pugh C; Deak Molly M; Biedenkapp Joseph C; Milligan Erin D; Johnson John D; Wang Haichao; Maier Steven F; Tracey Kevin J; Watkins Linda R
Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects.
Cytokine 2003;24(6):254-65.
2003: O'Connor Kevin A; Johnson John D; Hansen Michael K; Wieseler Frank Julie L; Maksimova Elena; Watkins Linda R; Maier Steven F
Peripheral and central proinflammatory cytokine response to a severe acute stressor.
Brain research 2003;991(1-2):123-32.
2003: Campisi J; Hansen M K; O'Connor K A; Biedenkapp J C; Watkins L R; Maier S F; Fleshner M
Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(5):1873-82.
2003: Bland Sondra T; Hargrave David; Pepin Julie L; Amat Jose; Watkins Linda R; Maier Steven F
Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(9):1589-96.
2003: Bland Sondra T; Twining Carin; Watkins Linda R; Maier Steven F
Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell.
Synapse (New York, N.Y.) 2003;49(3):206-8.
2003: O'Connor K A; Johnson J D; Hammack S E; Brooks L M; Spencer R L; Watkins L R; Maier S F
Inescapable shock induces resistance to the effects of dexamethasone.
Psychoneuroendocrinology 2003;28(4):481-500.
2003: Maier Steven F; Watkins Linda R
Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment.
Brain, behavior, and immunity 2003;17 Suppl 1():S125-31.
2003: Milligan Erin D; Twining Carin; Chacur Marucia; Biedenkapp Joseph; O'Connor Kevin; Poole Stephen; Tracey Kevin; Martin David; Maier Steven F; Watkins Linda R
Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(3):1026-40.
2003: Hammack Sayamwong E; Schmid Megan J; LoPresti Matthew L; Der-Avakian Andre; Pellymounter Mary Ann; Foster Alan C; Watkins Linda R; Maier Steven F
Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(3):1019-25.
2003: Johnson John D; O'Connor Kevin A; Hansen Michael K; Watkins Linda R; Maier Steven F
Effects of prior stress on LPS-induced cytokine and sickness responses.
American journal of physiology. Regulatory, integrative and comparative physiology 2003;284(2):R422-32.
2003: Barrientos R M; Sprunger D B; Campeau S; Higgins E A; Watkins L R; Rudy J W; Maier S F
Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.
Neuroscience 2003;121(4):847-53.
2003: Watkins Linda R; Milligan Erin D; Maier Steven F
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.
Advances in experimental medicine and biology 2003;521():1-21.
2002: Watkins Linda R; Maier Steven F
Beyond neurons: evidence that immune and glial cells contribute to pathological pain states.
Physiological reviews 2002;82(4):981-1011.
2002: Grahn Ruth E; Hammack S E; Will M J; O'Connor K A; Deak T; Sparks P D; Watkins L R; Maier S F
Blockade of alpha1 adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollable stressor exposure in rats.
Behavioural brain research 2002;134(1-2):387-92.
2002: Barrientos Ruth M; Higgins Emily A; Sprunger David B; Watkins Linda R; Rudy Jerry W; Maier Steven F
Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus.
Behavioural brain research 2002;134(1-2):291-8.
2002: Johnson John D; O'Connor Kevin A; Deak Terrence; Stark Matt; Watkins Linda R; Maier Steven F
Prior stressor exposure sensitizes LPS-induced cytokine production.
Brain, behavior, and immunity 2002;16(4):461-76.
2002: Moraska Albert; Campisi Jay; Nguyen Kien T; Maier Steven F; Watkins Linda R; Fleshner Monika
Elevated IL-1beta contributes to antibody suppression produced by stress.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(1):207-15.
2002: Johnson John D; O'Connor Kevin A; Deak Terrence; Spencer Robert L; Watkins Linda R; Maier Steven F
Prior stressor exposure primes the HPA axis.
Psychoneuroendocrinology 2002;27(3):353-65.
2002: Hammack Sayamwong E; Richey Kristen J; Schmid Megan J; LoPresti Matthew L; Watkins Linda R; Maier Steven F
The role of corticotropin-releasing hormone in the dorsal raphe nucleus in mediating the behavioral consequences of uncontrollable stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):1020-6.
2002: Will Matthew J; Der-Avakian Andre; Pepin Julie L; Durkan Brandice T; Watkins Linda R; Maier Steven F
Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress.
Pharmacology, biochemistry, and behavior 2002;71(1-2):345-51.
2001: Milligan E D; O'Connor K A; Armstrong C B; Hansen M K; Martin D; Tracey K J; Maier S F; Watkins L R
Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats.
The journal of pain : official journal of the American Pain Society 2001;2(6):326-33.
2001: Chacur M; Milligan E D; Gazda L S; Armstrong C; Wang H; Tracey K J; Maier S F; Watkins L R
A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.
Pain 2001;94(3):231-44.
2001: Gazda L S; Milligan E D; Hansen M K; Twining C M; Poulos N M; Chacur M; O'Connor K A; Armstrong C; Maier S F; Watkins L R; Myers R R
Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.
Journal of the peripheral nervous system : JPNS 2001;6(3):111-29.
2001: Watkins L R; Milligan E D; Maier S F
Spinal cord glia: new players in pain.
Pain 2001;93(3):201-5.
2001: Goehler L E; Gaykema R P; Hansen M K; Kleiner J L; Maier S F; Watkins L R
Staphylococcal enterotoxin B induces fever, brain c-Fos expression, and serum corticosterone in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(5):R1434-9.
2001: Milligan E D; O'Connor K A; Nguyen K T; Armstrong C B; Twining C; Gaykema R P; Holguin A; Martin D; Maier S F; Watkins L R
Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(8):2808-19.
2001: Hansen M K; O'Connor K A; Goehler L E; Watkins L R; Maier S F
The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(4):R929-34.
2001: Fleshner M; Deak T; Nguyen K T; Watkins L R; Maier S F
Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3813-9.
2001: Rachal Pugh C; Fleshner M; Watkins L R; Maier S F; Rudy J W
The immune system and memory consolidation: a role for the cytokine IL-1beta.
Neuroscience and biobehavioral reviews 2001;25(1):29-41.
2000: Hansen M K; Daniels S; Goehler L E; Gaykema R P; Maier S F; Watkins L R
Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever.
Autonomic neuroscience : basic & clinical 2000;85(1-3):83-7.
2000: Gaykema R P; Goehler L E; Hansen M K; Maier S F; Watkins L R
Subdiaphragmatic vagotomy blocks interleukin-1beta-induced fever but does not reduce IL-1beta levels in the circulation.
Autonomic neuroscience : basic & clinical 2000;85(1-3):72-7.
2000: Goehler L E; Gaykema R P; Hansen M K; Anderson K; Maier S F; Watkins L R
Vagal immune-to-brain communication: a visceral chemosensory pathway.
Autonomic neuroscience : basic & clinical 2000;85(1-3):49-59.
2000: Hansen M K; Nguyen K T; Goehler L E; Gaykema R P; Fleshner M; Maier S F; Watkins L R
Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats.
Autonomic neuroscience : basic & clinical 2000;85(1-3):119-26.
2000: Van Dam A M; Bol J G; Gaykema R P; Goehler L E; Maier S F; Watkins L R; Tilders F J
Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1beta immunoreactivity in rat brain and pituitary gland.
Neuroscience letters 2000;285(3):169-72.
2000: Milligan E D; Mehmert K K; Hinde J L; Harvey L O; Martin D; Tracey K J; Maier S F; Watkins L R
Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
Brain research 2000;861(1):105-16.
2000: Pugh C R; Johnson J D; Martin D; Rudy J W; Maier S F; Watkins L R
Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
Brain research 2000;861(1):8-15.
2000: Nguyen K T; Deak T; Will M J; Hansen M K; Hunsaker B N; Fleshner M; Watkins L R; Maier S F
Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress.
Brain research 2000;859(2):193-201.
2000: Hansen M K; Nguyen K T; Fleshner M; Goehler L E; Gaykema R P; Maier S F; Watkins L R
Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(2):R331-6.
2000: Watkins L R; Maier S F
The pain of being sick: implications of immune-to-brain communication for understanding pain.
Annual review of psychology 2000;51():29-57.
1999: Deak T; Nguyen K T; Cotter C S; Fleshner M; Watkins L R; Maier S F; Spencer R L
Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.
Brain research 1999;847(2):211-20.
1999: Deak T; Nguyen K T; Fleshner M; Watkins L R; Maier S F
Acute stress may facilitate recovery from a subcutaneous bacterial challenge.
Neuroimmunomodulation 1999;6(5):344-54.
1999: Milligan E D; Hinde J L; Mehmert K K; Maier S F; Watkins L R
A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats.
Journal of neuroscience methods 1999;90(1):81-6.
1999: Hammack S E; Hartley C E; Lea S E; Maier S F; Watkins L R; Sutton L C
Inescapable shock-induced potentiation of morphine analgesia in rats: sites of action.
Behavioral neuroscience 1999;113(4):795-803.
1999: Watkins L R; Maier S F
Implications of immune-to-brain communication for sickness and pain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7710-3.
1999: Grahn R E; Will M J; Hammack S E; Maswood S; McQueen M B; Watkins L R; Maier S F
Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor.
Brain research 1999;826(1):35-43.
1999: Goehler L E; Gaykema R P; Nguyen K T; Lee J E; Tilders F J; Maier S F; Watkins L R
Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(7):2799-806.
1999: Grahn R E; Maswood S; McQueen M B; Watkins L R; Maier S F
Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
Behavioural brain research 1999;99(2):153-67.
1999: Deak T; Nguyen K T; Ehrlich A L; Watkins L R; Spencer R L; Maier S F; Licinio J; Wong M L; Chrousos G P; Webster E; Gold P W
The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.
Endocrinology 1999;140(1):79-86.
1999: Watkins L R; Hansen M K; Nguyen K T; Lee J E; Maier S F
Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists.
Life sciences 1999;65(5):449-81.
1999: Maier S F; Nguyen K T; Deak T; Milligan E D; Watkins L R
Stress, learned helplessness, and brain interleukin-1 beta.
Advances in experimental medicine and biology 1999;461():235-49.
1999: Watkins L R; Nguyen K T; Lee J E; Maier S F
Dynamic regulation of proinflammatory cytokines.
Advances in experimental medicine and biology 1999;461():153-78.
1998: Milligan E D; Nguyen K T; Deak T; Hinde J L; Fleshner M; Watkins L R; Maier S F
The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone.
Brain research 1998;810(1-2):48-58.
1998: Pugh C R; Kumagawa K; Fleshner M; Watkins L R; Maier S F; Rudy J W
Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning.
Brain, behavior, and immunity 1998;12(3):212-29.
1998: Goehler L E; Gaykema R P; Hammack S E; Maier S F; Watkins L R
Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve.
Brain research 1998;804(2):306-10.
1998: Gaykema R P; Goehler L E; Tilders F J; Bol J G; McGorry M; Fleshner M; Maier S F; Watkins L R
Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve.
Neuroimmunomodulation 1998;5(5):234-40.
1998: Fleshner M; Nguyen K T; Cotter C S; Watkins L R; Maier S F
Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity.
The American journal of physiology 1998;275(3 Pt 2):R870-8.
1998: Will M J; Watkins L R; Maier S F
Uncontrollable stress potentiates morphine's rewarding properties.
Pharmacology, biochemistry, and behavior 1998;60(3):655-64.
1998: Fleshner M; Goehler L E; Schwartz B A; McGorry M; Martin D; Maier S F; Watkins L R
Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy.
Journal of neuroimmunology 1998;86(2):134-41.
1998: Maier S F; Goehler L E; Fleshner M; Watkins L R
The role of the vagus nerve in cytokine-to-brain communication.
Annals of the New York Academy of Sciences 1998;840():289-300.
1998: Watkins L R; Wiertelak E P; McGorry M; Martinez J; Schwartz B; Sisk D; Maier S F
Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.
Behavioral neuroscience 1998;112(2):360-78.
1998: Nguyen K T; Deak T; Owens S M; Kohno T; Fleshner M; Watkins L R; Maier S F
Exposure to acute stress induces brain interleukin-1beta protein in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(6):2239-46.
1998: Maier S F; Watkins L R
Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Psychological review 1998;105(1):83-107.
1997: Deak T; Meriwether J L; Fleshner M; Spencer R L; Abouhamze A; Moldawer L L; Grahn R E; Watkins L R; Maier S F
Evidence that brief stress may induce the acute phase response in rats.
The American journal of physiology 1997;273(6 Pt 2):R1998-2004.
1997: Sutton L C; Lea S E; Will M J; Schwartz B A; Hartley C E; Poole J C; Watkins L R; Maier S F
Inescapable shock-induced potentiation of morphine analgesia.
Behavioral neuroscience 1997;111(5):1105-13.
1997: Milligan E D; McGorry M M; Fleshner M; Gaykema R P; Goehler L E; Watkins L R; Maier S F
Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication.
Brain research 1997;766(1-2):240-3.
1997: Sutton L C; Grahn R E; Wiertelak E P; Watkins L R; Maier S F
Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus.
Behavioral neuroscience 1997;111(4):816-24.
1997: Watkins L R; McGorry M; Schwartz B; Sisk D; Wiertelak E P; Maier S F
Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat.
Pain 1997;71(3):237-47.
1997: Watkins L R; Martin D; Ulrich P; Tracey K J; Maier S F
Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
Pain 1997;71(3):225-35.
1997: Wiertelak E P; Roemer B; Maier S F; Watkins L R
Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias.
Brain research 1997;748(1-2):143-50.
1997: Fleshner M; Silbert L; Deak T; Goehler L E; Martin D; Watkins L R; Maier S F
TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
Brain research bulletin 1997;44(6):701-6.
1996: Fleshner M; Brennan F X; Nguyen K; Watkins L R; Maier S F
RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response.
The American journal of physiology 1996;271(5 Pt 2):R1344-52.
1996: Lockwood L L; Silbert L H; Fleshner M R; McNeal C; Watkins L R; Laudenslager M L; Rice K C; Weber R J; Maier S F
Morphine-induced alterations in antibody levels: receptor and immune mechanisms.
The Journal of pharmacology and experimental therapeutics 1996;278(2):689-96.
1996: Brennan F X; Fleshner M; Watkins L R; Maier S F
Macrophage stimulation reduces the cholesterol levels of stressed and unstressed rats.
Life sciences 1996;58(20):1771-6.
1995: Watkins L R; Maier S F; Goehler L E
Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states.
Pain 1995;63(3):289-302.
1995: Fleshner M; Deak T; Spencer R L; Laudenslager M L; Watkins L R; Maier S F
A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure.
Endocrinology 1995;136(12):5336-42.
1995: Grahn R E; Kalman B A; Brennan F X; Watkins L R; Maier S F
The elevated plus-maze is not sensitive to the effect of stressor controllability in rats.
Pharmacology, biochemistry, and behavior 1995;52(3):565-70.
1995: Watkins L R; Goehler L E; Relton J; Brewer M T; Maier S F
Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
Brain research 1995;692(1-2):244-50.
1995: Maier S F; Grahn R E; Maswood S; Watkins L R
The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock.
Psychopharmacology 1995;121(2):250-8.
1995: Maier S F; Busch C R; Maswood S; Grahn R E; Watkins L R
The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM.
Behavioral neuroscience 1995;109(4):759-66.
1995: Maier S F; Grahn R E; Watkins L R
8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.
Behavioral neuroscience 1995;109(3):404-12.
1995: Fleshner M; Hermann J; Lockwood L L; Laudenslager M L; Watkins L R; Maier S F
Stressed rats fail to expand the CD45RC+CD4+ (Th1-like) T cell subset in response to KLH: possible involvement of IFN-gamma.
Brain, behavior, and immunity 1995;9(2):101-12.
1995: Goehler L E; Busch C R; Tartaglia N; Relton J; Sisk D; Maier S F; Watkins L R
Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication.
Neuroscience letters 1995;185(3):163-6.
1995: Fleshner M; Bellgrau D; Watkins L R; Laudenslager M L; Maier S F
Stress-induced reduction in the rat mixed lymphocyte reaction is due to macrophages and not to changes in T cell phenotypes.
Journal of neuroimmunology 1995;56(1):45-52.
1995: Watkins L R; Goehler L E; Relton J K; Tartaglia N; Silbert L; Martin D; Maier S F
Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication.
Neuroscience letters 1995;183(1-2):27-31.
1995: Fleshner M; Goehler L E; Hermann J; Relton J K; Maier S F; Watkins L R
Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated.
Brain research bulletin 1995;37(6):605-10.
1995: Watkins L R; Maier S F; Goehler L E
Cytokine-to-brain communication: a review & analysis of alternative mechanisms.
Life sciences 1995;57(11):1011-26.
1994: Grisel J E; Wiertelak E P; Watkins L R; Maier S F
Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia.
Pharmacology, biochemistry, and behavior 1994;49(4):1029-35.
1994: Maier S F; Watkins L R; Fleshner M
Psychoneuroimmunology. The interface between behavior, brain, and immunity.
The American psychologist 1994;49(12):1004-17.
1994: Wiertelak E P; Furness L E; Watkins L R; Maier S F
Illness-induced hyperalgesia is mediated by a spinal NMDA-nitric oxide cascade.
Brain research 1994;664(1-2):9-16.
1994: Sutton L C; Fleshner M; Mazzeo R; Maier S F; Watkins L R
A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release.
Brain research 1994;663(1):19-29.
1994: Watkins L R; Wiertelak E P; Furness L E; Maier S F
Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.
Brain research 1994;664(1-2):17-24.
1994: Watkins L R; Wiertelak E P; Goehler L E; Smith K P; Martin D; Maier S F
Characterization of cytokine-induced hyperalgesia.
Brain research 1994;654(1):15-26.
1994: Wiertelak E P; Furness L E; Horan R; Martinez J; Maier S F; Watkins L R
Subcutaneous formalin produces centrifugal hyperalgesia at a non-injected site via the NMDA-nitric oxide cascade.
Brain research 1994;649(1-2):19-26.
1994: Watkins L R; Wiertelak E P; Goehler L E; Mooney-Heiberger K; Martinez J; Furness L; Smith K P; Maier S F
Neurocircuitry of illness-induced hyperalgesia.
Brain research 1994;639(2):283-99.
1994: Lockwood L L; Silbert L H; Fleshner M; Laudenslager M L; Watkins L R; Maier S F
Morphine-induced decreases in in vivo antibody responses.
Brain, behavior, and immunity 1994;8(1):24-36.
1994: Wiertelak E P; Smith K P; Furness L; Mooney-Heiberger K; Mayr T; Maier S F; Watkins L R
Acute and conditioned hyperalgesic responses to illness.
Pain 1994;56(2):227-34.
1994: Wiertelak E P; Yang H Y; Mooney-Heiberger K; Maier S F; Watkins L R
The nature of conditioned anti-analgesia: spinal cord opiate and anti-opiate neurochemistry.
Brain research 1994;634(2):214-26.
1993: Fleshner M; Brohm M M; Laudenslager M L; Watkins L R; Maier S F
Modulation of the in vivo antibody response by a benzodiazepine inverse agonist (DMCM) administered centrally or peripherally.
Physiology & behavior 1993;54(6):1149-54.
1993: Maier S F; Wiertelak E P; Martin D; Watkins L R
Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.
Brain research 1993;623(2):321-4.
1993: Lockwood L L; Silbert L H; Laudenslager M L; Watkins L R; Maier S F
Anesthesia-induced modulation of in vivo antibody levels: a study of pentobarbital, chloral hydrate, methoxyflurane, halothane, and ketamine/xylazine.
Anesthesia and analgesia 1993;77(4):769-74.
1993: Grisel J E; Fleshner M; Watkins L R; Maier S F
Opioid and nonopioid interactions in two forms of stress-induced analgesia.
Pharmacology, biochemistry, and behavior 1993;45(1):161-72.
1993: Watkins L R; Wiertelak E P; Maier S F
The amygdala is necessary for the expression of conditioned but not unconditioned analgesia.
Behavioral neuroscience 1993;107(2):402-5.
1993: Maier S F; Grahn R E; Kalman B A; Sutton L C; Wiertelak E P; Watkins L R
The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.
Behavioral neuroscience 1993;107(2):377-88.
1993: Fleshner M; Watkins L R; Lockwood L L; Grahn R E; Gerhardt G; Meaney M J; Laudenslager M L; Maier S F
Blockade of the hypothalamic-pituitary-adrenal response to stress by intraventricular injection of dexamethasone: a method for studying the stress-induced peripheral effects of glucocorticoids.
Psychoneuroendocrinology 1993;18(4):251-63.
1992: Fleshner M; Watkins L R; Lockwood L L; Bellgrau D; Laudenslager M L; Maier S F
Specific changes in lymphocyte subpopulations: a potential mechanism for stress-induced immunomodulation.
Journal of neuroimmunology 1992;41(2):131-42.
1992: Watkins L R; Wiertelak E P; Grisel J E; Silbert L H; Maier S F
Parallel activation of multiple spinal opiate systems appears to mediate 'non-opiate' stress-induced analgesias.
Brain research 1992;594(1):99-108.
1992: Watkins L R; Wiertelak E P; Maier S F
Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
Brain research 1992;582(1):1-9.
1992: Watkins L R; Wiertelak E P; Maier S F
Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
Brain research 1992;582(1):10-21.
1992: Wiertelak E P; Maier S F; Watkins L R
Cholecystokinin antianalgesia: safety cues abolish morphine analgesia.
Science (New York, N.Y.) 1992;256(5058):830-3.
1992: Brennan F X; Job R F; Watkins L R; Maier S F
Total plasma cholesterol levels of rats are increased following only three sessions of tailshock.
Life sciences 1992;50(13):945-50.
1990: Watkins L R; Thurston C L; Fleshner M
Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases.
Brain research 1990;528(2):273-84.

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