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Scott Watkins

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Chafiq Hamdouchi; Boyu Zhong; Jose Mendoza; Elizabeth Collins; Carlos Jaramillo; Jose Eugenio De Diego; Daniel Robertson; Charles D Spencer; Bryan D Anderson; Scott A Watkins; Faming Zhang; Harold B Brooks
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases.
Sheng-Bin Peng; Lei Yan; Xiaoling Xia; Scott A Watkins; Harold B Brooks; Douglas Beight; David K Herron; Michael L Jones; John W Lampe; William T McMillen; Nicholas Mort; J Scott Sawyer; Jonathan M Yingling
Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition.
Carlos Jaramillo; Jose Eugenio De Diego; Chafiq Hamdouchi; Elizabeth Collins; Heather Keyser; Concha Sánchez-Martínez; Miriam del Prado; Bryan Norman; Harold B Brooks; Scott A Watkins; Charles D Spencer; Jack A Dempsey; Bryan D Anderson; Robert M Campbell; Tellie Leggett; Bharvin Patel; Richard M Schultz; Juan Espinosa; Michal Vieth; Faming Zhang; David Timm
Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.

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All Publications

2005: Chafiq Hamdouchi; Boyu Zhong; Jose Mendoza; Elizabeth Collins; Carlos Jaramillo; Jose Eugenio De Diego; Daniel Robertson; Charles D Spencer; Bryan D Anderson; Scott A Watkins; Faming Zhang; Harold B Brooks
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases.
Bioorganic & medicinal chemistry letters 2005;15(7):1943-7.
2005: Sheng-Bin Peng; Lei Yan; Xiaoling Xia; Scott A Watkins; Harold B Brooks; Douglas Beight; David K Herron; Michael L Jones; John W Lampe; William T McMillen; Nicholas Mort; J Scott Sawyer; Jonathan M Yingling
Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition.
Biochemistry 2005;44(7):2293-304.
2004: Carlos Jaramillo; Jose Eugenio De Diego; Chafiq Hamdouchi; Elizabeth Collins; Heather Keyser; Concha Sánchez-Martínez; Miriam del Prado; Bryan Norman; Harold B Brooks; Scott A Watkins; Charles D Spencer; Jack A Dempsey; Bryan D Anderson; Robert M Campbell; Tellie Leggett; Bharvin Patel; Richard M Schultz; Juan Espinosa; Michal Vieth; Faming Zhang; David Timm
Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.
Bioorganic & medicinal chemistry letters 2004;14(24):6095-9.
2004: Rima S Al-Awar; James E Ray; Kyle A Hecker; Sajan Joseph; Jianping Huang; Chuan Shih; Harold B Brooks; Charles D Spencer; Scott A Watkins; Richard M Schultz; Eileen L Considine; Margaret M Faul; Kevin A Sullivan; Stanley P Kolis; Michael A Carr; Faming Zhang
Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(15):3925-8.
2004: Rima S Al-Awar; James E Ray; Kyle A Hecker; Jianping Huang; Philip P Waid; Chuan Shih; Harold B Brooks; Charles D Spencer; Scott A Watkins; Bharvin R Patel; Nancy B Stamm; Catherine A Ogg; Richard M Schultz; Eileen L Considine; Margaret M Faul; Kevin A Sullivan; Stanley P Kolis; John L Grutsch; Sajan Joseph
1,7-annulated indolocarbazoles as cyclin-dependent kinase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(12):3217-20.
2004: Guoxin Zhu; Scott E Conner; Xun Zhou; Ho-Kit Chan; Chuan Shih; Thomas A Engler; Rima S Al-Awar; Harold B Brooks; Scott A Watkins; Charles D Spencer; Richard M Schultz; Jack A Dempsey; Eileen L Considine; Bharvin R Patel; Catherine A Ogg; Vasu Vasudevan; Michelle L Lytle
Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(12):3057-61.
2004: Chafiq Hamdouchi; Heather Keyser; Elizabeth Collins; Carlos Jaramillo; Jose Eugenio De Diego; Charles D Spencer; Jack A Dempsey; Bryan D Anderson; Tillie Leggett; Nancy B Stamm; Richard M Schultz; Scott A Watkins; Kim Cocke; Stephanie Lemke; Teresa F Burke; Richard P Beckmann; Jeffrey T Dixon; Thomas M Gurganus; Nancy B Rankl; Keith A Houck; Faming Zhang; Michal Vieth; Juan Espinosa; David Timm; Robert M Campbell; Bharvin K R Patel; Harold B Brooks
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.
Molecular cancer therapeutics 2004;3(1):1-9.
2003: Concha Sanchez-Martinez; Chuan Shih; Guoxin Zhu; Tiechao Li; Harold B Brooks; Bharvin K R Patel; Richard M Schultz; Tammy B DeHahn; Charles D Spencer; Scott A Watkins; Catherine A Ogg; Eileen L Considine; Jack A Dempsey; Faming Zhang
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.
Bioorganic & medicinal chemistry letters 2003;13(21):3841-6.
2003: Concha Sanchez-Martinez; Chuan Shih; Margaret M Faul; Guoxin Zhu; Michael Paal; Carmen Somoza; Tiechao Li; Christine A Kumrich; Leonard L Winneroski; Zhou Xun; Harold B Brooks; Bharvin K R Patel; Richard M Schultz; Tammy B DeHahn; Charles D Spencer; Scott A Watkins; Eileen L Considine; Jack A Dempsey; Catherine A Ogg; Robert M Campbell; Bryan A Anderson; Jill Wagner
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(21):3835-9.
2003: Thomas A Engler; Kelly Furness; Sushant Malhotra; Concha Sanchez-Martinez; Chuan Shih; Walter Xie; Guoxin Zhu; Xun Zhou; Scott E Conner; Margaret M Faul; Kevin A Sullivan; Stanley P Kolis; Harold B Brooks; Bharvin Patel; Richard M Schultz; Tammy B DeHahn; Kashif Kirmani; Charles D Spencer; Scott A Watkins; Eileen L Considine; Jack A Dempsey; Catherine A Ogg; Nancy B Stamm; Bryan D Anderson; Robert M Campbell; Vasu Vasudevan; Michelle L Lytle
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
Bioorganic & medicinal chemistry letters 2003;13(14):2261-7.
2003: Guoxin Zhu; Scott E Conner; Xun Zhou; Chuan Shih; Tiechao Li; Bryan D Anderson; Harold B Brooks; Robert M Campbell; Eileen L Considine; Jack A Dempsey; Margaret M Faul; Catherine A Ogg; Bharvin Patel; Richard M Schultz; Charles D Spencer; Beverly A Teicher; Scott A Watkins
Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.
Journal of medicinal chemistry 2003;46(11):2027-30.
2003: Guoxin Zhu; Scott E Conner; Xun Zhou; Chuan Shih; Harold B Brooks; Eileen L Considine; Jack A Dempsey; Catherine A Ogg; Bharvin Patel; Richard M Schultz; Charles D Spencer; Beverly A Teicher; Scott A Watkins
Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(7):1231-5.
1999: RN Rao; Nancy B Stamm; K Otto; Steven Kovacevic; Scott A Watkins; P Rutherford; Stephanie Lemke; Kim Cocke; Richard P Beckmann; Keith A Houck; D Johnson; B J Skidmore
Conditional transformation of rat embryo fibroblast cells by a cyclin D1-cdk4 fusion gene.
Oncogene 1999;18(46):6343-56.