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Klaus Brandenburg

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Lena Heinbockel; Mathias Hornef; Yani Kaconis; Guillermo Martinez de Tejada; Sebastian Marwitz; Susana Sánchez-Gómez; Tobias Schürholz; Sabine Dömming; Aline Dupont; Martin Ernst; Torsten Goldmann; Thomas Gutsmann; Julius Brandenburg; Klaus Brandenburg
Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors.
Tobias Schuerholz; Jörg Andrä; Sabine Dömming; Susana Sánchez-Gómez; Sunil David; Aline Dupont; Patrick Garidel; Thomas Gutsmann; Lena Heinbockel; Mathias Hornef; Yani Kaconis; Ina Kowalski; Guillermo Martinez de Tejada; Klaus Brandenburg
Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects.
Guillermo Martinez de Tejada; Iosu Rázquin-Olazaran; Susana Sánchez-Gómez; Tobias Schürholz; Sunil A David; Aline Dupont; Patrick Garidel; Thomas Gutsmann; Lena Heinbockel; Mathias Hornef; Yani Kaconis; Ina Kowalski; Karl Lohner; Jörg Andrä; Klaus Brandenburg
Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines.

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2013: Lena Heinbockel; Mathias Hornef; Yani Kaconis; Guillermo Martinez de Tejada; Sebastian Marwitz; Susana Sánchez-Gómez; Tobias Schürholz; Sabine Dömming; Aline Dupont; Martin Ernst; Torsten Goldmann; Thomas Gutsmann; Julius Brandenburg; Klaus Brandenburg
Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors.
Antimicrobial agents and chemotherapy 2013;57(3):1480-7.
2012: Tobias Schuerholz; Jörg Andrä; Sabine Dömming; Susana Sánchez-Gómez; Sunil David; Aline Dupont; Patrick Garidel; Thomas Gutsmann; Lena Heinbockel; Mathias Hornef; Yani Kaconis; Ina Kowalski; Guillermo Martinez de Tejada; Klaus Brandenburg
Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects.
Current drug targets 2012;13(9):1131-7.
2012: Guillermo Martinez de Tejada; Iosu Rázquin-Olazaran; Susana Sánchez-Gómez; Tobias Schürholz; Sunil A David; Aline Dupont; Patrick Garidel; Thomas Gutsmann; Lena Heinbockel; Mathias Hornef; Yani Kaconis; Ina Kowalski; Karl Lohner; Jörg Andrä; Klaus Brandenburg
Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines.
Current drug targets 2012;13(9):1121-30.
2012: Mateja Mancek-Keber; Gabriela Panter; Kathy Triantafilou; Martha Triantafilou; Jörg Andrä; Mojca Bencina; Klaus Brandenburg; Bostjan Japelj; Roman Jerala
MARCKS as a negative regulator of lipopolysaccharide signaling.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3893-902.
2012: Raquel Conde-Álvarez; Vilma Arce-Gorvel; Elías Barquero-Calvo; José A Bengoechea; Klaus Brandenburg; Carlos Chacón-Díaz; Esteban Chaves-Olarte; María Jesús Grilló; Maite Iriarte; Roman Jerala; Enrique Llobet; Mateja Manček-Keber; Anna Martirosyan; Edgardo Moreno; Ignacio Moriyón; Leyre Palacios-Chaves; Kristine von Bargen; Jean-Pierre Gorvel
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition.
PLoS pathogens 2012;8(5):e1002675.
2012: Tobias Schuerholz; Klaus Brandenburg; Gernot Marx
Antimicrobial peptides and their potential application in inflammation and sepsis.
Critical care (London, England) 2012;16(2):207.
2011: Yani Kaconis; Ina Kowalski; Jörg Howe; Annemarie Brauser; Walter Richter; Iosu Razquin-Olazarán; Melania Iñigo-Pestaña; Patrick Garidel; Manfred Rössle; Guillermo Martinez de Tejada; Thomas Gutsmann; Klaus Brandenburg
Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides.
Biophysical journal 2011;100(11):2652-61.
2011: Klaus Brandenburg; Jörg Andrä; Patrick Garidel; Thomas Gutsmann
Peptide-based treatment of sepsis.
Applied microbiology and biotechnology 2011;90(3):799-808.
2011: Susana Sánchez-Gómez; Bostjan Japelj; Roman Jerala; Ignacio Moriyón; Mirian Fernández Alonso; José Leiva; Sylvie E Blondelle; Jörg Andrä; Klaus Brandenburg; Karl Lohner; Guillermo Martínez de Tejada
Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo.
Antimicrobial agents and chemotherapy 2011;55(1):218-28.
2010: Ina Kowalski; Yani Kaconis; Jörg Andrä; Iosu Razquin-Olazarán; Thomas Gutsmann; Guillermo Martinez de Tejada; Klaus Brandenburg
Physicochemical and biological characterization of anti-endotoxin peptides and their influence on lipid properties.
Protein and peptide letters 2010;17(11):1328-33.
2010: Klaus Brandenburg; Patrick Garidel; Satoshi Fukuoka; Jörg Howe; Michel H J Koch; Thomas Gutsmann; Jörg Andrä
Molecular basis for endotoxin neutralization by amphipathic peptides derived from the alpha-helical cationic core-region of NK-lysin.
Biophysical chemistry 2010;150(1-3):80-7.
2010: Andra B Schromm; Norbert Reiling; Jörg Howe; Karl-Heinz Wiesmüller; Manfred Roessle; Klaus Brandenburg
Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis.
Innate immunity 2010;16(4):213-25.
2010: Thomas Gutsmann; Jörg Howe; Ulrich Zähringer; Patrick Garidel; Andra B Schromm; M H J Koch; Y Fujimoto; Koichi Fukase; I Moriyon; G Martínez-de-Tejada; Klaus Brandenburg
Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells.
Innate immunity 2010;16(1):39-47.
2010: Klaus Brandenburg; Ulrich Seydel
Conformation and supramolecular structure of lipid A.
Advances in experimental medicine and biology 2010;667():25-38.
2009: Andreas Kerth; Patrick Garidel; Jörg Howe; Christian Alexander; Jean-Pierre Mach; Th Waelli; Alfred Blume; Ernst Th Rietschel; Klaus Brandenburg
An infrared reflection-absorption spectroscopic (IRRAS) study of the interaction of lipid A and lipopolysaccharide Re with endotoxin-binding proteins.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2009;5(6):535-42.
2009: I Khatri; Christian Alexander; Klaus Brandenburg; Karin Fournier; Jean-Pierre Mach; Ernst Th Rietschel; Artur J Ulmer; E Terzioglu; Th Waelli; Reginald M Gorczynski
Induction of tolerogenic vs immunogenic dendritic cells (DCs) in the presence of GM-CSF is regulated by the strength of signaling from monophosphoryl lipid A (MPLA) in association with glutathione and fetal hemoglobin gamma-chain.
Immunology letters 2009;124(1):44-9.
2009: Lauren Mashburn-Warren; Jörg Howe; Klaus Brandenburg; Marvin Whiteley
Structural requirements of the Pseudomonas quinolone signal for membrane vesicle stimulation.
Journal of bacteriology 2009;191(10):3411-4.
2009: Sven Gerber; M Wulf; Götz Milkereit; Volkmar Vill; Jörg Howe; M Roessle; P Garidel; T Gutsmann; Klaus Brandenburg
Phase diagrams of monoacylated amide-linked disaccharide glycolipids.
Chemistry and physics of lipids 2009;158(2):118-30.
2009: Klaus Brandenburg; Ulrich Seydel
Conformation and supramolecular structure of lipid A.
Advances in experimental medicine and biology 2009;667():25-38.
2009: Klaus Brandenburg; Jörg Howe; Thomas Gutsman; Patrick Garidel
The expression of endotoxic activity in the Limulus test as compared to cytokine production in immune cells.
Current medicinal chemistry 2009;16(21):2653-60.
2008: Jörg Howe; Walter Richter; Lynn Hawkins; Manfred Rössle; Christian Alexander; Karin Fournier; Jean-Pierre Mach; Th Waelli; Reginald M Gorczynski; Artur J Ulmer; Helmut Brade; Alla Zamyatina; kosma paul; Ernst Th Rietschel; Klaus Brandenburg
Hemoglobin enhances the biological activity of synthetic and natural bacterial (endotoxic) virulence factors: a general principle.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2008;4(6):520-5.
2008: Jörg Howe; Patrick Garidel; Matthias Wulf; Sven Gerber; Götz Milkereit; Volkmar Vill; Manfred Roessle; Klaus Brandenburg
Structural polymorphism of hydrated monoacylated maltose glycolipids.
Chemistry and physics of lipids 2008;155(1):31-7.
2008: I Khatri; Christian Alexander; Klaus Brandenburg; Karin Fournier; Lydia Lee; Jean-Pierre Mach; Ernst Th Rietschel; Artur J Ulmer; Th Waelli; Reginald M Gorczynski
A role for altered TLR gene expression in association with increased expression of CD200R in the induction of mucosal tissue CD4(+) Treg in aged mice following gavage with a liver extract along with intramuscular monophosphoryl lipid A (MPLA) injection.
Experimental gerontology 2008;43(8):771-81.
2008: Lauren Mashburn-Warren; Jörg Howe; Patrick Garidel; Walter Richter; Frank Steiniger; Manfred Roessle; Klaus Brandenburg; Marvin Whiteley
Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation.
Molecular microbiology 2008;69(2):491-502.
2008: Jörg Howe; Patrick Garidel; Manfred Roessle; Walter Richter; Christian Alexander; Karin Fournier; Jean-Pierre Mach; Th Waelli; Reginald M Gorczynski; Artur J Ulmer; Ulrich Zähringer; Alfred Hartmann; Ernst Th Rietschel; Klaus Brandenburg
Structural investigations into the interaction of hemoglobin and part structures with bacterial endotoxins.
Innate immunity 2008;14(1):39-49.
2008: Susana Sánchez-Gómez; Marta Lamata; José Leiva; Sylvie E Blondelle; Roman Jerala; Jörg Andrä; Klaus Brandenburg; Karl Lohner; Ignacio Moriyón; Guillermo Martínez de Tejada
Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides.
BMC microbiology 2008;8():196.
2008: Patrick Garidel; Jörg Howe; Götz Milkereit; Manfred Rössle; Sebastian Linser; Regine Willumeit; Thomas Gutsmann; Volkmar Vill; Klaus Brandenburg
Structural polymorphism of hydrated ether-linked dimyristyl maltoside and melibioside.
Chemistry and physics of lipids 2008;151(1):18-29.
2007: Xi Chen; Jörg Howe; Jörg Andrä; Manfred Rössle; Walter Richter; Ana Paula Galvão da Silva; Alan Krensky; Carol Clayberger; Klaus Brandenburg
Biophysical analysis of the interaction of granulysin-derived peptides with enterobacterial endotoxins.
Biochimica et biophysica acta 2007;1768(10):2421-31.
2007: Jörg Howe; Markus von Minden; Thomas Gutsmann; Michel H J Koch; Matthias Wulf; Sven Gerber; Götz Milkereit; Volkmar Vill; Klaus Brandenburg
Structural preferences of dioleoyl glycolipids with mono- and disaccharide head groups.
Chemistry and physics of lipids 2007;149(1-2):52-8.
2007: Jörg Andrä; Jörg Howe; Patrick Garidel; Manfred Rössle; Walter Richter; José Leiva-León; Ignacio Moriyon; Rainer Bartels; Thomas Gutsmann; Klaus Brandenburg
Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis.
The Biochemical journal 2007;406(2):297-307.
2007: Thomas Gutsmann; Andra B Schromm; Klaus Brandenburg
The physicochemistry of endotoxins in relation to bioactivity.
International journal of medical microbiology : IJMM 2007;297(5):341-52.
2007: Jörg Andrä; Daniel Monreal; Guillermo Martinez de Tejada; Claudia Olak; Gerald Brezesinski; Susana Sanchez Gomez; Torsten Goldmann; Rainer Bartels; Klaus Brandenburg; Ignacio Moriyon
Rationale for the design of shortened derivatives of the NK-lysin-derived antimicrobial peptide NK-2 with improved activity against Gram-negative pathogens.
The Journal of biological chemistry 2007;282(20):14719-28.
2007: Jörg Howe; Jörg Andrä; Raquel Conde; Maite Iriarte; Patrick Garidel; Michel H J Koch; Thomas Gutsmann; Ignacio Moriyón; Klaus Brandenburg
Thermodynamic analysis of the lipopolysaccharide-dependent resistance of gram-negative bacteria against polymyxin B.
Biophysical journal 2007;92(8):2796-805.
2007: Andra B Schromm; Jörg Howe; Artur J Ulmer; Karl-Heinz Wiesmüller; Tobias Seyberth; Günther Jung; Manfred Rössle; Michel H J Koch; Thomas Gutsmann; Klaus Brandenburg
Physicochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation.
The Journal of biological chemistry 2007;282(15):11030-7.
2007: Bostjan Japelj; Mateja Zorko; Andreja Majerle; Primoz Pristovsek; Susana Sanchez-Gomez; Guillermo Martinez de Tejada; Ignacio Moriyon; Sylvie E Blondelle; Klaus Brandenburg; Jörg Andrä; Karl Lohner; Roman Jerala
The acyl group as the central element of the structural organization of antimicrobial lipopeptide.
Journal of the American Chemical Society 2007;129(5):1022-3.
2007: Susu M Zughaier; Buko Lindner; Jörg Howe; Patrick Garidel; Michel H J Koch; Klaus Brandenburg; David S Stephens
Physicochemical characterization and biological activity of lipooligosaccharides and lipid A from Neisseria meningitidis.
Journal of endotoxin research 2007;13(6):343-57.
2007: Jörg Howe; Malte Hammer; Christian Alexander; Manfred Rössle; Karin Fournier; Jean-Pierre Mach; Th Waelli; Reginald M Gorczynski; Artur J Ulmer; Ulrich Zähringer; Ernst Th Rietschel; Klaus Brandenburg
Biophysical characterization of the interaction of endotoxins with hemoglobins.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(1):13-20.
2006: Jörg Howe; Jörg Bauer; Jörg Andrä; Andra B Schromm; Martin Ernst; Manfred Rössle; Ulrich Zähringer; Jörg Rademann; Klaus Brandenburg
Biophysical characterization of synthetic rhamnolipids.
The FEBS journal 2006;273(22):5101-12.
2006: Jörg Bauer; Klaus Brandenburg; Ulrich Zähringer; Jörg Rademann
Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural specificity of immunostimulation by rhamnolipids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(27):7116-24.
2006: Jörg Andrä; Jörg Rademann; Jörg Howe; Michel H J Koch; Holger Heine; Ulrich Zähringer; Klaus Brandenburg
Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization.
Biological chemistry 2006;387(3):301-10.
2006: Jörg Andrä; Thomas Gutsmann; Patrick Garidel; Klaus Brandenburg
Mechanisms of endotoxin neutralization by synthetic cationic compounds.
Journal of endotoxin research 2006;12(5):261-77.
2005: Jörg Andrä; Hans de Cock; Patrick Garidel; Jörg Howe; Klaus Brandenburg
Investigation into the interaction of the phosphoporin PhoE with outer membrane lipids: physicochemical characterization and biological activity.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2005;1(6):537-46.
2005: Patrick Garidel; Michael Rappolt; Andra B Schromm; Jörg Howe; Karl Lohner; Jörg Andrä; Michel H J Koch; Klaus Brandenburg
Divalent cations affect chain mobility and aggregate structure of lipopolysaccharide from Salmonella minnesota reflected in a decrease of its biological activity.
Biochimica et biophysica acta 2005;1715(2):122-31.
2005: Lorea Manterola; Ignacio Moriyón; Edgardo Moreno; Alberto Sola-Landa; David S Weiss; Michel H J Koch; Jörg Howe; Klaus Brandenburg; Ignacio Lopez-Goñi
The lipopolysaccharide of Brucella abortus BvrS/BvrR mutants contains lipid A modifications and has higher affinity for bactericidal cationic peptides.
Journal of bacteriology 2005;187(16):5631-9.
2005: Regine Willumeit; Mont Kumpugdee; Sérgio S Funari; Karl Lohner; Beatriz Pozo Navas; Klaus Brandenburg; Sebastian Linser; Jörg Andrä
Structural rearrangement of model membranes by the peptide antibiotic NK-2.
Biochimica et biophysica acta 2005;1669(2):125-34.
2005: Götz Milkereit; Klaus Brandenburg; Sven Gerber; Michel H J Koch; Michael Morr; Jörg Andrä; Ulrich Seydel; Volkmar Vill
Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part II. Mesomorphic properties.
Chemistry and physics of lipids 2005;135(1):15-26.
2005: Götz Milkereit; Sven Gerber; Klaus Brandenburg; Michael Morr; Volkmar Vill
Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part I. Synthesis.
Chemistry and physics of lipids 2005;135(1):1-14.
2005: Klaus Brandenburg; Alexander David; Jörg Howe; Michel H J Koch; Jörg Andrä; Patrick Garidel
Temperature dependence of the binding of endotoxins to the polycationic peptides polymyxin B and its nonapeptide.
Biophysical journal 2005;88(3):1845-58.
2005: Klaus Brandenburg; Patrick Garidel; Andra B Schromm; Jörg Andrä; Arjen Kramer; Maarten R Egmond; Andre Wiese
Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes.
European biophysics journal : EBJ 2005;34(1):28-41.
2005: Mareike Mueller; Klaus Brandenburg; Russ Dedrick; Andra B Schromm; Ulrich Seydel
Phospholipids inhibit lipopolysaccharide (LPS)-induced cell activation: a role for LPS-binding protein.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(2):1091-6.
2005: Ulrich Seydel; Andra B Schromm; Lore Brade; Sabine Gronow; Jörg Andrä; Mareike Müller; Michel H J Koch; Koichi Fukase; Mikayo Kataoka; Masaya Hashimoto; Shoichi Kusumoto; Klaus Brandenburg
Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity.
The FEBS journal 2005;272(2):327-40.
2005: Jörg Andrä; Karl Lohner; Sylvie E Blondelle; Roman Jerala; Ignacio Moriyon; Michel H J Koch; Patrick Garidel; Klaus Brandenburg
Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide.
The Biochemical journal 2005;385(Pt 1):135-43.
2004: Jörg Andrä; Marta Lamata; Guillermo Martinez de Tejada; Rainer Bartels; Michel H J Koch; Klaus Brandenburg
Cyclic antimicrobial peptides based on Limulus anti-lipopolysaccharide factor for neutralization of lipopolysaccharide.
Biochemical pharmacology 2004;68(7):1297-307.
2004: Jörg Andrä; Patrick Garidel; Andreja Majerle; Roman Jerala; Richard Ridge; Erik Paus; Tom Novitsky; Michel H J Koch; Klaus Brandenburg
Biophysical characterization of the interaction of Limulus polyphemus endotoxin neutralizing protein with lipopolysaccharide.
European journal of biochemistry / FEBS 2004;271(10):2037-46.
2004: Jörg Andrä; Michel H J Koch; Rainer Bartels; Klaus Brandenburg
Biophysical characterization of endotoxin inactivation by NK-2, an antimicrobial peptide derived from mammalian NK-lysin.
Antimicrobial agents and chemotherapy 2004;48(5):1593-9.
2004: Klaus Brandenburg; L Hawkins; Patrick Garidel; Jörg Andrä; Mareike Müller; Holger Heine; Michel H J Koch; Ulrich Seydel
Structural polymorphism and endotoxic activity of synthetic phospholipid-like amphiphiles.
Biochemistry 2004;43(13):4039-46.
2004: Klaus Brandenburg; Andre Wiese
Endotoxins: relationships between structure, function, and activity.
Current topics in medicinal chemistry 2004;4(11):1127-46.
2003: Klaus Brandenburg; Patrick Garidel; Jörg Andra; Gudrun Jürgens; Mareike Müller; Alfred Blume; Michel H J Koch; Jack Levin
Cross-linked hemoglobin converts endotoxically inactive pentaacyl endotoxins into a physiologically active conformation.
The Journal of biological chemistry 2003;278(48):47660-9.
2003: Klaus Brandenburg; Jörg Andrä; Mareike Müller; Michel H J Koch; Patrick Garidel
Physicochemical properties of bacterial glycopolymers in relation to bioactivity.
Carbohydrate research 2003;338(23):2477-89.
2003: Klaus Brandenburg; Frauke Wagner; Mareike Müller; Holger Heine; Jörg Andrä; Michel H J Koch; Ulrich Zähringer; Ulrich Seydel
Physicochemical characterization and biological activity of a glycoglycerolipid from Mycoplasma fermentans.
European journal of biochemistry / FEBS 2003;270(15):3271-9.
2003: Hannah Schröder-Borm; Regine Willumeit; Klaus Brandenburg; Jörg Andrä
Molecular basis for membrane selectivity of NK-2, a potent peptide antibiotic derived from NK-lysin.
Biochimica et biophysica acta 2003;1612(2):164-71.
2003: Ulrich Seydel; Lynn Hawkins; Andra B Schromm; Holger Heine; Olaf Scheel; Michel H J Koch; Klaus Brandenburg
The generalized endotoxic principle.
European journal of immunology 2003;33(6):1586-92.
2003: José Antonio Bengoechea; Klaus Brandenburg; M D Arraiza; U Seydel; Mikael Skurnik; Ignacio Moriyón
Pathogenic Yersinia enterocolitica strains increase the outer membrane permeability in response to environmental stimuli by modulating lipopolysaccharide fluidity and lipid A structure.
Infection and immunity 2003;71(4):2014-21.
2002: Klaus Brandenburg; Gudrun Jürgens; Jörg Andrä; Buko Lindner; Michel H J Koch; Alfred Blume; Patrick Garidel
Biophysical characterization of the interaction of high-density lipoprotein (HDL) with endotoxins.
European journal of biochemistry / FEBS 2002;269(23):5972-81.
2002: Klaus Brandenburg; Motohiro Matsuura; Holger Heine; Mareike Müller; Makato Kiso; Hideharu Ishida; Michel H J Koch; Ulrich Seydel
Biophysical characterization of triacyl monosaccharide lipid a partial structures in relation to bioactivity.
Biophysical journal 2002;83(1):322-33.
2002: Buko Lindner; Andre Wiese; Klaus Brandenburg; Ulrich Seydel; A Dalhoff
Lack of interaction of fluoroquinolones with lipopolysaccharides.
Antimicrobial agents and chemotherapy 2002;46(5):1568-70.
2002: R Arjen Kramer; Klaus Brandenburg; Lucy Vandeputte-Rutten; Marjolein Werkhoven; Piet Gros; Nick Dekker; Maarten R Egmond
Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT.
European journal of biochemistry / FEBS 2002;269(6):1746-52.
2002: Gudrun Jürgens; Mareike Müller; Patrick Garidel; Michel H J Koch; Hiroshi Nakakubo; Alfred Blume; Klaus Brandenburg
Investigation into the interaction of recombinant human serum albumin with Re-lipopolysaccharide and lipid A.
Journal of endotoxin research 2002;8(2):115-26.
2001: Klaus Brandenburg; Gudrun Jürgens; Mareike Müller; S Fukuoka; Michel H J Koch
Biophysical characterization of lipopolysaccharide and lipid A inactivation by lactoferrin.
Biological chemistry 2001;382(8):1215-25.
2001: Gudrun Jürgens; Mareike Müller; Michel H J Koch; Klaus Brandenburg
Interaction of hemoglobin with enterobacterial lipopolysaccharide and lipid A. Physicochemical characterization and biological activity.
European journal of biochemistry / FEBS 2001;268(15):4233-42.
2001: Rikard Blunck; Olaf Scheel; Mareike Müller; Klaus Brandenburg; Ulrike Seitzer; Ulrich Seydel
New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1009-15.
2001: Ulrich Seydel; Olaf Scheel; Mareike Müller; Klaus Brandenburg; Rikard Blunck
A K+ channel is involved in LPS signaling.
Journal of endotoxin research 2001;7(3):243-7.
2000: HM von Minden; Klaus Brandenburg; Ulrich Seydel; Michel H J Koch; Vasil M Garamus; Regine Willumeit; Volkmar Vill
Thermotropic and lyotropic properties of long chain alkyl glycopyranosides. Part II. Disaccharide headgroups.
Chemistry and physics of lipids 2000;106(2):157-79.
2000: Klaus Brandenburg; Buko Lindner; Andra B Schromm; Michel H J Koch; J Bauer; A Merkli; C Zbaeren; J G Davies; Ulrich Seydel
Physicochemical characteristics of triacyl lipid A partial structure OM-174 in relation to biological activity.
European journal of biochemistry / FEBS 2000;267(11):3370-7.
2000: J Velasco; José Antonio Bengoechea; Klaus Brandenburg; B Lindner; U Seydel; David González; Ulrich Zähringer; Edgardo Moreno; Ignacio Moriyón
Brucella abortus and its closest phylogenetic relative, Ochrobactrum spp., differ in outer membrane permeability and cationic peptide resistance.
Infection and immunity 2000;68(6):3210-8.
2000: Ulrich Seydel; M Oikawa; Koichi Fukase; Shoichi Kusumoto; Klaus Brandenburg
Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity.
European journal of biochemistry / FEBS 2000;267(10):3032-9.
2000: Andra B Schromm; Klaus Brandenburg; Harald Loppnow; A P Moran; Michel H J Koch; Ernst Th Rietschel; Ulrich Seydel
Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion.
European journal of biochemistry / FEBS 2000;267(7):2008-13.
2000: Volkmar Vill; HM von Minden; Michel H J Koch; Ulrich Seydel; Klaus Brandenburg
Thermotropic and lyotropic properties of long chain alkyl glycopyranosides. Part I: monosaccharide headgroups.
Chemistry and physics of lipids 2000;104(1):75-91.
2000: Ulrich Seydel; Andra B Schromm; Rikard Blunck; Klaus Brandenburg
Chemical structure, molecular conformation, and bioactivity of endotoxins.
Chemical immunology 2000;74():5-24.
1999: Klaus Brandenburg; S S Funari; Michel H J Koch; Ulrich Seydel
Investigation into the acyl chain packing of endotoxins and phospholipids under near physiological conditions by WAXS and FTIR spectroscopy.
Journal of structural biology 1999;128(2):175-86.
1999: Andre Wiese; Klaus Brandenburg; Artur J Ulmer; Ulrich Seydel; Sven Müller-Loennies
The dual role of lipopolysaccharide as effector and target molecule.
Biological chemistry 1999;380(7-8):767-84.
1999: Hans de Cock; Klaus Brandenburg; Andre Wiese; Otto Holst; Ulrich Seydel
Non-lamellar structure and negative charges of lipopolysaccharides required for efficient folding of outer membrane protein PhoE of Escherichia coli.
The Journal of biological chemistry 1999;274(8):5114-9.
1999: M Münstermann; Andre Wiese; Klaus Brandenburg; Ulrich Zähringer; Lore Brade; K Kawahara; Ulrich Seydel
Complement activation by bacterial surface glycolipids: a study with planar bilayer membranes.
The Journal of membrane biology 1999;167(3):223-32.
1998: Klaus Brandenburg; Michel H J Koch; Ulrich Seydel
Biophysical characterisation of lysozyme binding to LPS Re and lipid A.
European journal of biochemistry / FEBS 1998;258(2):686-95.
1998: Andra B Schromm; Klaus Brandenburg; Harald Loppnow; Ulrich Zähringer; Ernst Th Rietschel; SF Carroll; Michel H J Koch; Shoichi Kusumoto; Ulrich Seydel
The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5464-71.
1998: Klaus Brandenburg; Ulrich Seydel
Infrared spectroscopy of glycolipids.
Chemistry and physics of lipids 1998;96(1-2):23-40.
1998: Jürgen Luhm; Andra B Schromm; Ulrich Seydel; Klaus Brandenburg; Nele Wellinghausen; E Riedel; R R Schumann; Lothar Rink
Hypothermia enhances the biological activity of lipopolysaccharide by altering its fluidity state.
European journal of biochemistry / FEBS 1998;256(2):325-33.
1998: José Antonio Bengoechea; Klaus Brandenburg; U Seydel; R Díaz; Ignacio Moriyón
Yersinia pseudotuberculosis and Yersinia pestis show increased outer membrane permeability to hydrophobic agents which correlates with lipopolysaccharide acyl-chain fluidity.
Microbiology (Reading, England) 1998;144 ( Pt 6)():1517-26.
1998: Klaus Brandenburg; W Richter; Michel H J Koch; H W Meyer; Ulrich Seydel
Characterization of the nonlamellar cubic and HII structures of lipid A from Salmonella enterica serovar Minnesota by X-ray diffraction and freeze-fracture electron microscopy.
Chemistry and physics of lipids 1998;91(1):53-69.
1997: Klaus Brandenburg; Shoichi Kusumoto; Ulrich Seydel
Conformational studies of synthetic lipid A analogues and partial structures by infrared spectroscopy.
Biochimica et biophysica acta 1997;1329(1):183-201.
1997: Andre Wiese; Klaus Brandenburg; SF Carroll; Ernst Th Rietschel; Ulrich Seydel
Mechanisms of action of bactericidal/permeability-increasing protein BPI on reconstituted outer membranes of gram-negative bacteria.
Biochemistry 1997;36(33):10311-9.
1997: Andre Wiese; Klaus Brandenburg; Buko Lindner; Andra B Schromm; SF Carroll; Ernst Th Rietschel; Ulrich Seydel
Mechanisms of action of the bactericidal/permeability-increasing protein BPI on endotoxin and phospholipid monolayers and aggregates.
Biochemistry 1997;36(33):10301-10.
1996: Andra B Schromm; Klaus Brandenburg; Ernst Th Rietschel; Hans-Dieter Flad; SF Carroll; Ulrich Seydel
Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes.
FEBS letters 1996;399(3):267-71.
1996: Nele Wellinghausen; Andra B Schromm; Ulrich Seydel; Klaus Brandenburg; Jürgen Luhm; Holger Kirchner; Lothar Rink
Zinc enhances lipopolysaccharide-induced monokine secretion by alteration of fluidity state of lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(7):3139-45.
1996: Ernst Th Rietschel; Helmut Brade; Otto Holst; Lore Brade; Sven Müller-Loennies; Uwe Mamat; Ulrich Zähringer; F Beckmann; Ulrich Seydel; Klaus Brandenburg; Artur J Ulmer; T Mattern; Holger Heine; J Schletter; Harald Loppnow; Uwe Schönbeck; Hans-Dieter Flad; Sunna Hauschildt; U F Schade; F Di Padova; S Kusumoto; Ralf R Schumann
Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification.
Current topics in microbiology and immunology 1996;216():39-81.
1996: Andre Wiese; J O Reiners; Klaus Brandenburg; K Kawahara; Ulrich Zähringer; Ulrich Seydel
Planar asymmetric lipid bilayers of glycosphingolipid or lipopolysaccharide on one side and phospholipids on the other: membrane potential, porin function, and complement activation.
Biophysical journal 1996;70(1):321-9.
1995: Klaus Brandenburg; Andra B Schromm; Michel H J Koch; Ulrich Seydel
Conformation and fluidity of endotoxins as determinants of biological activity.
Progress in clinical and biological research 1995;392():167-82.
1994: Andre Wiese; G Schröder; Klaus Brandenburg; A Hirsch; W Welte; Ulrich Seydel
Influence of the lipid matrix on incorporation and function of LPS-free porin from Paracoccus denitrificans.
Biochimica et biophysica acta 1994;1190(2):231-42.
1994: Ulrich Seydel; Klaus Brandenburg; Ernst Th Rietschel
A case for an endotoxic conformation.
Progress in clinical and biological research 1994;388():17-30.
1993: Klaus Brandenburg; H Mayer; Michel H J Koch; J Weckesser; Ernst Th Rietschel; Ulrich Seydel
Influence of the supramolecular structure of free lipid A on its biological activity.
European journal of biochemistry / FEBS 1993;218(2):555-63.
1993: Ulrich Seydel; Michel H J Koch; Klaus Brandenburg
Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota.
Journal of structural biology 1993;110(3):232-43.
1993: Klaus Brandenburg
Fourier transform infrared spectroscopy characterization of the lamellar and nonlamellar structures of free lipid A and Re lipopolysaccharides from Salmonella minnesota and Escherichia coli.
Biophysical journal 1993;64(4):1215-31.
1993: Ulrich Seydel; Harald Labischinski; M Kastowsky; Klaus Brandenburg
Phase behavior, supramolecular structure, and molecular conformation of lipopolysaccharide.
Immunobiology 1993;187(3-5):191-211.
1992: Ulrich Seydel; W Eberstein; G Schröder; Klaus Brandenburg
Electrostatic potential barrier in asymmetric planar lipopolysaccharide/phospholipid bilayers probed with the valinomycin-K+ complex.
Zeitschrift für Naturforschung. C, Journal of biosciences 1992;47(9-10):757-61.
1992: Klaus Brandenburg; Michel H J Koch; Ulrich Seydel
Phase diagram of deep rough mutant lipopolysaccharide from Salmonella minnesota R595.
Journal of structural biology 1992;108(2):93-106.
1992: G Schröder; Klaus Brandenburg; Ulrich Seydel
Polymyxin B induces transient permeability fluctuations in asymmetric planar lipopolysaccharide/phospholipid bilayers.
Biochemistry 1992;31(3):631-8.
1990: G Schröder; Klaus Brandenburg; Lore Brade; Ulrich Seydel
Pore formation by complement in the outer membrane of gram-negative bacteria studied with asymmetric planar lipopolysaccharide/phospholipid bilayers.
The Journal of membrane biology 1990;118(2):161-70.
1990: Klaus Brandenburg; M H Koch; Ulrich Seydel
Phase diagram of lipid A from Salmonella minnesota and Escherichia coli rough mutant lipopolysaccharide.
Journal of structural biology 1990;105(1-3):11-21.
1990: Klaus Brandenburg; Ulrich Seydel
Investigation into the fluidity of lipopolysaccharide and free lipid A membrane systems by Fourier-transform infrared spectroscopy and differential scanning calorimetry.
European journal of biochemistry / FEBS 1990;191(1):229-36.
1990: Ernst Th Rietschel; Lore Brade; U Schade; Ulrich Seydel; Ulrich Zähringer; Klaus Brandenburg; I Helander; Otto Holst; S Kondo; H M Kuhn
Bacterial lipopolysaccharides: relationship of structure and conformation to endotoxic activity, serological specificity and biological function.
Advances in experimental medicine and biology 1990;256():81-99.
1989: Ulrich Seydel; Klaus Brandenburg; M H Koch; Ernst Th Rietschel
Supramolecular structure of lipopolysaccharide and free lipid A under physiological conditions as determined by synchrotron small-angle X-ray diffraction.
European journal of biochemistry / FEBS 1989;186(1-2):325-32.
1989: Ulrich Seydel; G Schröder; Klaus Brandenburg
Reconstitution of the lipid matrix of the outer membrane of gram-negative bacteria as asymmetric planar bilayer.
The Journal of membrane biology 1989;109(2):95-103.
1989: T Lüderitz; Klaus Brandenburg; Ulrich Seydel; A Roth; C Galanos; Ernst Th Rietschel
Structural and physicochemical requirements of endotoxins for the activation of arachidonic acid metabolism in mouse peritoneal macrophages in vitro.
European journal of biochemistry / FEBS 1989;179(1):11-6.
1988: Klaus Brandenburg; Ulrich Seydel
Orientation measurements on membrane systems made from lipopolysaccharides and free lipid A by FT-IR spectroscopy.
European biophysics journal : EBJ 1988;16(2):83-94.
1987: Lore Brade; Klaus Brandenburg; H M Kuhn; S Kusumoto; I Macher; Ernst Th Rietschel; Helmut Brade
The immunogenicity and antigenicity of lipid A are influenced by its physicochemical state and environment.
Infection and immunity 1987;55(11):2636-44.
1987: Ernst Th Rietschel; Lore Brade; Klaus Brandenburg; H D Flad; J de Jong-Leuveninck; K Kawahara; Buko Lindner; Harald Loppnow; T Lüderitz; U Schade
Chemical structure and biologic activity of bacterial and synthetic lipid A.
Reviews of infectious diseases 1987;9 Suppl 5():S527-36.
1987: Dieter Naumann; C Schultz; J Born; Harald Labischinski; Klaus Brandenburg; G von Busse; H Brade; Ulrich Seydel
Investigations into the polymorphism of lipid A from lipopolysaccharides of Escherichia coli and Salmonella minnesota by Fourier-transform infrared spectroscopy.
European journal of biochemistry / FEBS 1987;164(1):159-69.
1987: Ernst Th Rietschel; Helmut Brade; Lore Brade; Klaus Brandenburg; U Schade; Ulrich Seydel; U Zähringer; C Galanos; O Lüderitz; O Westphal
Lipid A, the endotoxic center of bacterial lipopolysaccharides: relation of chemical structure to biological activity.
Progress in clinical and biological research 1987;231():25-53.