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Christian Brander

Research Profile

Living Beings

HIV-1

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HIV Infections

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Lorenzo Micco; Arianna Martello Panno; Dimitra Peppa; Anna Schurich; Pietro Andreone; Mauro Bernardi; Florian Bihl; Christian Brander; Carmela Cursaro; Lucy Jefferson; Elisabetta Loggi; Mala K Maini
Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B.
Anuska Llano; Silvia Marfil; Beatriz Mothe; Lidia Ruiz; Víctor Sánchez; Eloísa Yuste; Julià Blanco; Jorge Carrillo; Bonaventura Clotet; Elisabet García; Christian Brander
Expansion of antibody secreting cells and modulation of neutralizing antibody activity in HIV infected individuals undergoing structured treatment interruptions.
Anuska Llano; Christian Brander
Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome.

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All Publications

2013: Lorenzo Micco; Arianna Martello Panno; Dimitra Peppa; Anna Schurich; Pietro Andreone; Mauro Bernardi; Florian Bihl; Christian Brander; Carmela Cursaro; Lucy Jefferson; Elisabetta Loggi; Mala K Maini
Differential boosting of innate and adaptive antiviral responses during pegylated-interferon-alpha therapy of chronic hepatitis B.
Journal of hepatology 2013;58(2):225-33.
2013: Anuska Llano; Silvia Marfil; Beatriz Mothe; Lidia Ruiz; Víctor Sánchez; Eloísa Yuste; Julià Blanco; Jorge Carrillo; Bonaventura Clotet; Elisabet García; Christian Brander
Expansion of antibody secreting cells and modulation of neutralizing antibody activity in HIV infected individuals undergoing structured treatment interruptions.
Journal of translational medicine 2013;11():48.
2012: Anuska Llano; Christian Brander
Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome.
Cell research 2012;22(12):1637-9.
2012: Carmina R Fumaz; Marian Gonzalez-Garcia; Anuska Llano; Beatriz Mothe; Jose Munoz-Moreno; Nuria Perez-Alvarez; Jordi Puig; Xavier Borras; Christian Brander; Jordi Fernandez-Castro; Maria José Ferrer; Bonaventura Clotet
Psychological stress is associated with high levels of IL-6 in HIV-1 infected individuals on effective combined antiretroviral treatment.
Brain, behavior, and immunity 2012;26(4):568-72.
2012: Elisabetta Loggi; Lorenzo Micco; Antonio Daniele Pinna; Alessandro Nanni Costa; Mauro Bernardi; Florian Bihl; Andrea Bontadini; Christian Brander; Alessandro Cucchetti; Giorgio Ercolani; Stefano Gitto; Gian Luca Grazi; Paolo Grossi; Pietro Andreone
Liver transplantation from hepatitis B surface antigen positive donors: a safe way to expand the donor pool.
Journal of hepatology 2012;56(3):579-85.
2012: María Pernas; Lidia Ruiz; Jorge Sánchez; Víctor Sánchez-Merino; Amalio Telenti; José L Vicario; Eloísa Yuste; Carolina Arcones; Christian Brander; Concepcion Casado; Eulalia Grau; Anuska Llano; Beatriz Mothe; Cecilio López- Galíndez
Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller.
PloS one 2012;7(2):e31928.
2011: Christoph T Berger; Jason M Brenchley; Daniel C Douek; Nicole Frahm; Musie Ghebremichael; Kari L Hartman; Leah M Henry; Daniel E Kaufmann; Beatriz Mothe; Florencia Pereyra; David A Price; Laura E Ruff; Alessandro Sette; John Sidney; Vanessa Venturi; Bruce D Walker; Christian Brander
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Journal of virology 2011;85(18):9334-45.
2011: Philomena Kamya; Colin Kovacs; Stephen A Migueles; Jean-Pierre Routy; Todd J Suscovich; Réjean Thomas; Cecile L Tremblay; Christos M Tsoukas; Jean-Guy Baril; Nicole Bernard; Mohamed-Rachid Boulassel; Salix Boulet; Christian Brander; Mark Connors; Pierre Côté
Receptor-ligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57.
Journal of virology 2011;85(12):5949-60.
2011: Morgane Rolland; Nicole Frahm; David C Nickle; Nebojsa Jojic; Wenjie Deng; Todd M Allen; Christian Brander; David E Heckerman; James I Mullins
Increased breadth and depth of cytotoxic T lymphocytes responses against HIV-1-B Nef by inclusion of epitope variant sequences.
PloS one 2011;6(3):e17969.
2010: Alasdair Leslie; Philippa C Matthews; Jennifer Listgarten; Jonathan M Carlson; Carl Kadie; Thumbi Ndung'u; Christian Brander; Hoosen Coovadia; Bruce D Walker; David Heckerman; Philip J R Goulder
Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
Journal of virology 2010;84(19):9879-88.
2010: Christoph Berger; Jonathan M Carlson; Chanson J Brumme; Kari L Hartman; Zabrina L Brumme; Leah M Henry; Pamela C Rosato; Alicja Piechocka-Trocha; Mark Alan Brockman; P Richard Harrigan; David Heckerman; Daniel E Kaufmann; Christian Brander
Viral adaptation to immune selection pressure by HLA class I-restricted CTL responses targeting epitopes in HIV frameshift sequences.
The Journal of experimental medicine 2010;207(1):61-75.
2010: Morgane Rolland; Jonathan M Carlson; Siriphan Manocheewa; J Victor Swain; Erinn Lanxon-Cookson; Wenjie Deng; Christine M Rousseau; Dana N Raugi; Gerald Learn; Brandon S Maust; Hoosen Coovadia; Thumbi Ndung'u; Philip J R Goulder; Bruce D Walker; Christian Brander; David E Heckerman; James I Mullins
Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
PloS one 2010;5(9):.
2009: Zabrina Brumme; Bingxia Wang; Kriebashne Nair; Chanson Brumme; Chantal de Pierres; Shabashini Reddy; Boris Julg; Eshia Stephany Moodley-Govender; Christina Thobakgale; Zhigang Lu; Mary van der Stok; Karen Bishop; Zenele Mncube; Fundisiwe Chonco; Yuko Yuki; Nicole Frahm; Christian Brander; Mary Carrington; Kenneth Freedberg; Photini Kiepiela; Philip Goulder; Bruce Walker; Thumbi Ndung'u; Elena Losina
Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;49(6):956-64.
2009: Florian Bihl; Christoph Berger; John V Chisholm; Leah M Henry; Barbara Bertisch; Andreas Trojan; David Nadal; Roberto F Speck; Markus Flepp; Christian Brander; Nicolas Mueller
Cellular immune responses and disease control in acute AIDS-associated Kaposi's sarcoma.
AIDS (London, England) 2009;23(14):1918-22.
2009: Lisa M Butler; Grant Dorsey; Wolfgang Hladik; Philip J Rosenthal; Christian Brander; Torsten B Neilands; Georgina Mbisa; Denise Whitby; Photini Kiepiela; Anisa Mosam; Similo Mzolo; Sheila C Dollard; Jeffrey N Martin
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
The Journal of infectious diseases 2009;200(3):430-8.
2009: Diana M Brainard; Edward Seung; Nicole Frahm; Annaiah Cariappa; Charles C Bailey; William K Hart; Hae-Sook Shin; Sarah F Brooks; Heather L Knight; Quentin Eichbaum; Yong-Guang Yang; Megan Sykes; Bruce D Walker; Gordon J Freeman; Shiv Pillai; Susan V Westmoreland; Christian Brander; Andrew D Luster; Andrew M Tager
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
Journal of virology 2009;83(14):7305-21.
2009: O Gasser; Florian Bihl; S Sanghavi; Charles Rinaldo; D Rowe; C Hess; D Stablein; M Roland; P Stock; Christian Brander
Treatment-dependent loss of polyfunctional CD8+ T-cell responses in HIV-infected kidney transplant recipients is associated with herpesvirus reactivation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(4):794-803.
2009: Christine M Rousseau; David W Lockhart; Jennifer Listgarten; Stephen N Maley; Carl Kadie; Gerald Learn; David C Nickle; David E Heckerman; Wenjie Deng; Christian Brander; Thumbi Ndung'u; Hoosen Coovadia; Philip J R Goulder; Bette T Korber; Bruce D Walker; James I Mullins
Rare HLA drive additional HIV evolution compared to more frequent alleles.
AIDS research and human retroviruses 2009;25(3):297-303.
2009: Elisabetta Loggi; Florian Bihl; John V Chisholm; Maurizio Biselli; Andrea Bontadini; Giovanni Vitale; Giorgio Ercolani; Gian Luca Grazi; Antonio Daniele Pinna; Mauro Bernardi; Christian Brander; Pietro Andreone
Anti-HBs re-seroconversion after liver transplantation in a patient with past HBV infection receiving a HBsAg positive graft.
Journal of hepatology 2009;50(3):625-30.
2009: Toshiyuki Miura; Mark Alan Brockman; Arne Schneidewind; Michael Lobritz; Florencia Pereyra; Almas Rathod; Brian L Block; Zabrina L Brumme; Chanson J Brumme; Brett Baker; Alissa C Rothchild; Bin Li; Alicja Trocha; Emily Cutrell; Nicole Frahm; Christian Brander; Ildiko Toth; Eric J Arts; Todd M Allen; Bruce D Walker
HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognition.
Journal of virology 2009;83(6):2743-55.
2009: Yaoyu E Wang; Bin Li; Jonathan M Carlson; Hendrik Streeck; Adrianne D Gladden; Robert Goodman; Arne Schneidewind; Karen A Power; Ildiko Toth; Nicole Frahm; Galit Alter; Christian Brander; Mary Carrington; Bruce D Walker; Marcus Altfeld; David Heckerman; Todd M Allen
Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Journal of virology 2009;83(4):1845-55.
2009: Beatriz Mothe; Javier Ibarrondo; Anuska Llano; Christian Brander
Virological, immune and host genetics markers in the control of HIV infection.
Disease markers 2009;27(3):105-20.
2009: Zabrina L Brumme; Mina John; Jonathan M Carlson; Chanson J Brumme; Dennison Chan; Mark Alan Brockman; Luke C Swenson; Iris Tao; Sharon Szeto; Pamela Rosato; Jennifer Sela; Carl M Kadie; Nicole Frahm; Christian Brander; David W Haas; Sharon A Riddler; Richard Haubrich; Bruce D Walker; P Richard Harrigan; David Heckerman; Simon Mallal
HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.
PloS one 2009;4(8):e6687.
2008: Daniel Yerly; David Heckerman; Todd Allen; Todd J Suscovich; Nebojsa Jojic; Carl Kadie; Werner J Pichler; Andreas Cerny; Christian Brander
Design, expression, and processing of epitomized hepatitis C virus-encoded CTL epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6361-70.
2008: Anthony Tan; Elisabetta Loggi; Carolina Boni; Adeline Chia; Adam J Gehring; Konduru S R Sastry; Vera Goh; Paola Fisicaro; Pietro Andreone; Christian Brander; Seng Gee Lim; Carlo Ferrari; Florian Bihl; Antonio Bertoletti
Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire.
Journal of virology 2008;82(22):10986-97.
2008: Philippa C Matthews; Andrew Prendergast; Alasdair Leslie; Hayley Crawford; Rebecca Payne; Christine M Rousseau; Morgane Rolland; Isobella Honeyborne; Jonathan Carlson; Carl Kadie; Christian Brander; Karen Bishop; Nonkululeko Mlotshwa; James I Mullins; Hoosen Coovadia; Thumbi Ndung'u; Bruce D Walker; David Heckerman; Philip J R Goulder
Central role of reverting mutations in HLA associations with human immunodeficiency virus set point.
Journal of virology 2008;82(17):8548-59.
2008: Hendrik Streeck; Bin Li; Art F Y Poon; Arne Schneidewind; Adrianne D Gladden; Karen A Power; Demetre Daskalakis; Suzane Bazner; Rosario Zuniga; Christian Brander; Eric S Rosenberg; Simon D W Frost; Marcus Altfeld; Todd M Allen
Immune-driven recombination and loss of control after HIV superinfection.
The Journal of experimental medicine 2008;205(8):1789-96.
2008: Zabrina L Brumme; Iris Tao; Sharon Szeto; Chanson J Brumme; Jonathan M Carlson; Dennison Chan; Carl Kadie; Nicole Frahm; Christian Brander; Bruce Walker; David Heckerman; P Richard Harrigan
Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection.
AIDS (London, England) 2008;22(11):1277-86.
2008: Christine M Rousseau; Marcus G Daniels; Jonathan M Carlson; Carl Kadie; Hayley Crawford; Andrew Prendergast; Philippa Matthews; Rebecca Payne; Morgane Rolland; Dana N Raugi; Brandon S Maust; Gerald Learn; David C Nickle; Hoosen Coovadia; Thumbi Ndung'u; Nicole Frahm; Christian Brander; Bruce D Walker; Philip J R Goulder; Tanmoy Bhattacharya; David E Heckerman; Bette T Korber; James I Mullins
HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load.
Journal of virology 2008;82(13):6434-46.
2008: Arne Schneidewind; Mark Alan Brockman; John Sidney; Yaoyu E Wang; Huabiao Chen; Todd J Suscovich; Bin Li; Rahma I Adam; Rachel L Allgaier; Bianca R Mothé; Thomas Kuntzen; Cesar Oniangue-Ndza; Alicja Trocha; Xu G Yu; Christian Brander; Alessandro Sette; Bruce D Walker; Todd M Allen
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Journal of virology 2008;82(11):5594-605.
2008: Florian Bihl; Elisabetta Loggi; John V Chisholm; Maurizio Biselli; Maria C Morelli; Carmela Cursaro; Norah A Terrault; Mauro Bernardi; Antonio Bertoletti; Pietro Andreone; Christian Brander
Sustained and focused hepatitis B virus nucleocapsid-specific T-cell immunity in liver transplant recipients compared to individuals with chronic and self-limited hepatitis B virus infection.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2008;14(4):478-85.
2008: Aviva Joseph; Jian Hua Zheng; Antonia Follenzi; Teresa P DiLorenzo; Kaori Sango; Jaime Hyman; Ken Chen; Alicja Piechocka-Trocha; Christian Brander; Erik Hooijberg; Dario A Vignali; Bruce D Walker; Harris Goldstein
Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity.
Journal of virology 2008;82(6):3078-89.
2008: Daniel Yerly; David Heckerman; Todd M Allen; John V Chisholm; Kellie Faircloth; Caitlyn H Linde; Nicole Frahm; Joerg Timm; Werner J Pichler; Andreas Cerny; Christian Brander
Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance.
Journal of virology 2008;82(6):3147-53.
2008: Nicole Frahm; David C Nickle; Caitlyn H Linde; Daniel E Cohen; Rosario Zuñiga; Aldo Lucchetti; Timothy Roach; Bruce D Walker; Todd M Allen; Bette T Korber; James I Mullins; Christian Brander
Increased detection of HIV-specific T cell responses by combination of central sequences with comparable immunogenicity.
AIDS (London, England) 2008;22(4):447-56.
2008: Morgane Rolland; David Heckerman; Wenjie Deng; Christine M Rousseau; Hoosen Coovadia; Karen Bishop; Philip J R Goulder; Bruce D Walker; Christian Brander; James I Mullins
Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads.
PloS one 2008;3(1):e1424.
2007: Galit Alter; Maureen P Martin; Nickolas Teigen; William H Carr; Todd J Suscovich; Arne Schneidewind; Hendrik Streeck; Michael T Waring; Angela Meier; Christian Brander; Jeffrey D Lifson; Todd M Allen; Mary Carrington; Marcus Altfeld
Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.
The Journal of experimental medicine 2007;204(12):3027-36.
2007: Nicole Frahm; Daniel E Kaufmann; Karina Yusim; Mark Muldoon; Can Kesmir; Caitlyn H Linde; Will Fischer; Todd M Allen; Bin Li; Ben H McMahon; Kellie L Faircloth; Hannah S Hewitt; Elizabeth W Mackey; Toshiyuki Miura; Ashok Khatri; Steven Wolinsky; Andrew McMichael; Robert Funkhouser; Bruce D Walker; Christian Brander; Bette T Korber
Increased sequence diversity coverage improves detection of HIV-specific T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6638-50.
2007: Arne Schneidewind; Mark Alan Brockman; Ruifeng Yang; Rahma I Adam; Bin Li; Sylvie Le Gall; Charles Rinaldo; Sharon L Craggs; Rachel L Allgaier; Karen A Power; Thomas Kuntzen; Chang-Shung Tung; Montiago X LaBute; Sandra M Mueller; Thomas Harrer; Andrew J McMichael; Philip J R Goulder; Christopher Aiken; Christian Brander; Anthony D Kelleher; Todd M Allen
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.
Journal of virology 2007;81(22):12382-93.
2007: Jennifer Listgarten; Nicole Frahm; Carl Kadie; Christian Brander; David Heckerman
A statistical framework for modeling HLA-dependent T cell response data.
PLoS computational biology 2007;3(10):1879-86.
2007: Nicole Frahm; Karina Yusim; Todd J Suscovich; Sharon Adams; John Sidney; Peter T Hraber; Hannah S Hewitt; Caitlyn H Linde; Daniel G Kavanagh; Tonia Woodberry; Leah M Henry; Kellie Faircloth; Jennifer Listgarten; Carl Kadie; Nebojsa Jojic; Kaori Sango; Nancy V Brown; Eunice Pae; M Tauheed Zaman; Florian Bihl; Ashok Khatri; Mina John; Simon Mallal; Francesco M Marincola; Bruce D Walker; Alessandro Sette; David Heckerman; Bette T Korber; Christian Brander
Extensive HLA class I allele promiscuity among viral CTL epitopes.
European journal of immunology 2007;37(9):2419-33.
2007: Morgane Rolland; Christian Brander; David C Nickle; Joshua T Herbeck; Geoffrey S Gottlieb; Mary S Campbell; Brandon S Maust; James I Mullins
HIV-1 over time: fitness loss or robustness gain?
Nature reviews. Microbiology 2007;5(9):C1.
2007: Joerg Timm; Bin Li; Marcus G Daniels; Tanmoy Bhattacharya; Laura L Reyor; Rachel L Allgaier; Thomas Kuntzen; Will Fischer; Brian E Nolan; Jared Duncan; julian schulze zur wiesch; Arthur Y Kim; Nicole Frahm; Christian Brander; Raymond T Chung; Georg M Lauer; Bette T Korber; Todd M Allen
Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution.
Hepatology (Baltimore, Md.) 2007;46(2):339-49.
2007: Diana M Brainard; Andrew M Tager; Joseph Misdraji; Nicole Frahm; Mathias Lichterfeld; Rika Draenert; Christian Brander; Bruce D Walker; Andrew D Luster
Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.
Journal of virology 2007;81(16):8439-50.
2007: Hayley Crawford; Julia G Prado; Alasdair Leslie; Stéphane Hué; Isobella Honeyborne; Sharon Reddy; Mary van der Stok; Zenele Mncube; Christian Brander; Christine M Rousseau; James I Mullins; Richard A Kaslow; Paul A Goepfert; Susan Allen; Eric Hunter; Joseph Mulenga; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2007;81(15):8346-51.
2007: Zabrina L Brumme; Chanson J Brumme; David Heckerman; Bette T Korber; Marcus Daniels; Jonathan Carlson; Carl Kadie; Tanmoy Bhattacharya; Celia Chui; James Szinger; Theresa Mo; Hogg Robert; Julio S G Montaner; Nicole Frahm; Christian Brander; Bruce D Walker; P Richard Harrigan
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.
PLoS pathogens 2007;3(7):e94.
2007: Florian Bihl; Anisa Mosam; Leah N Henry; John V Chisholm; Sheila Dollard; Pamela Gumbi; Edana Cassol; Taryn Page; Nicolas Mueller; Photini Kiepiela; Jeffrey N Martin; Hoosen M Coovadia; David T Scadden; Christian Brander
Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma.
AIDS (London, England) 2007;21(10):1245-52.
2007: Keri L Schaubert; David A Price; Nicole Frahm; Jinzhu Li; Hwee Ng; Aviva Joseph; Elyse Paul; Biswanath Majumder; Velpandi Ayyavoo; Emma Gostick; Sharon Adams; Francesco M Marincola; Andrew K Sewell; Marcus Altfeld; Jason M Brenchley; Daniel C Douek; Otto O Yang; Christian Brander; Harris Goldstein; June Kan-Mitchell
Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7756-66.
2007: Galit Alter; Todd J Suscovich; Nickolas Teigen; Angela Meier; Hendrik Streeck; Christian Brander; Marcus Altfeld
Single-stranded RNA derived from HIV-1 serves as a potent activator of NK cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7658-66.
2007: John Frater; Helen Brown; Annette Oxenius; Huldrych Günthard; Bernard Hirschel; N Robinson; Alasdair Leslie; Rebecca Payne; Hayley Crawford; Andrew Prendergast; Christian Brander; Photini Kiepiela; Bruce D Walker; Philip J R Goulder; A McLean; Rodney E Phillips
Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.
Journal of virology 2007;81(12):6742-51.
2007: Joerg Timm; M Neukamm; Thomas Kuntzen; Arthur Y Kim; Raymond T Chung; Christian Brander; Georg M Lauer; Bruce D Walker; Todd M Allen
Characterization of full-length hepatitis C virus genotype 4 sequences.
Journal of viral hepatitis 2007;14(5):330-7.
2007: Florian Bihl; Murli Narayan; John V Chisholm; Leah M Henry; Todd J Suscovich; Elizabeth E Brown; Tania M Welzel; Daniel E Kaufmann; Tauheed M Zaman; Sheila Dollard; Jeffrey N Martin; Fred Wang; David T Scadden; Kenneth M Kaye; Christian Brander
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.
Journal of virology 2007;81(9):4904-8.
2007: Christine M Rousseau; Gerald Learn; Tanmoy Bhattacharya; David C Nickle; David Heckerman; Senica Chetty; Christian Brander; Philip J R Goulder; Bruce D Walker; Photini Kiepiela; Bette T Korber; James I Mullins
Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.
Journal of virology 2007;81(9):4492-500.
2007: Isobella Honeyborne; Andrew Prendergast; Florencia Pereyra; Alasdair Leslie; Hayley Crawford; Rebecca Payne; Sharon Reddy; Karen Bishop; Eshia Stephany Moodley-Govender; Kriebashnie Nair; Mary van der Stok; Noel McCarthy; Christine M Rousseau; Marylyn M Addo; James I Mullins; Christian Brander; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
Journal of virology 2007;81(7):3667-72.
2007: Tanmoy Bhattacharya; Marcus Daniels; David Heckerman; Brian Foley; Nicole Frahm; Carl Kadie; Jonathan Carlson; Karina Yusim; Ben McMahon; Brian Gaschen; Simon Mallal; James I Mullins; David C Nickle; Joshua Herbeck; Christine M Rousseau; Gerald Learn; Toshiyuki Miura; Christian Brander; Bruce Walker; Bette Korber
Founder effects in the assessment of HIV polymorphisms and HLA allele associations.
Science (New York, N.Y.) 2007;315(5818):1583-6.
2007: Xu G Yu; Mathias Lichterfeld; Senica Chetty; Katie L Williams; Stanley K Mui; Toshiyuki Miura; Nicole Frahm; Margaret E Feeney; Yanhua Tang; Florencia Pereyra; Montiago X LaBute; Katja Pfafferott; Alasdair Leslie; Hayley Crawford; Rachel L Allgaier; William H Hildebrand; Richard A Kaslow; Christian Brander; Todd M Allen; Eric S Rosenberg; Photini Kiepiela; Madhu Vajpayee; Paul A Goepfert; Marcus Altfeld; Philip J R Goulder; Bruce D Walker
Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
Journal of virology 2007;81(4):1619-31.
2007: Morgane Rolland; David C Nickle; Wenjie Deng; Nicole Frahm; Christian Brander; Gerald Learn; David Heckerman; Nebojsa Jojic; Vladimir Jojic; Bruce D Walker; James I Mullins
Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins.
PloS one 2007;2(9):e823.
2007: Florian Bihl; Damiano Castelli; Francesco M Marincola; Roger Y Dodd; Christian Brander
Transfusion-transmitted infections.
Journal of translational medicine 2007;5():25.
2007: Photini Kiepiela; Kholiswa Ngumbela; Christina Thobakgale; Danni Ramduth; Isobella Honeyborne; Eshia Stephany Moodley-Govender; Sharon Reddy; Chantal de Pierres; Zenele Mncube; Nompumelelo Mkhwanazi; Karen Bishop; Mary van der Stok; Kriebashnie Nair; Nasreen Khan; Hayley Crawford; Rebecca Payne; Alasdair Leslie; Julia G Prado; Andrew Prendergast; John Frater; Noel McCarthy; Christian Brander; Gerald Learn; David C Nickle; Christine M Rousseau; Hoosen Coovadia; James I Mullins; David Heckerman; Bruce D Walker; Philip J R Goulder
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Nature medicine 2007;13(1):46-53.
2006: Sama Adnan; Balamurugan Arumugam; Alicja Trocha; Michael S Bennett; Hwee Ng; Ayub Ali; Christian Brander; Otto O Yang
Nef interference with HIV-1-specific CTL antiviral activity is epitope specific.
Blood 2006;108(10):3414-9.
2006: Alasdair Leslie; David A Price; Pamela Mkhize; Karen Bishop; Almas Rathod; Cheryl Day; Hayley Crawford; Isobella Honeyborne; Tedi E Asher; Graz Luzzi; Anne Edwards; Christine M Rousseau; Christine M Rosseau; James I Mullins; Gareth Tudor-Williams; Vas Novelli; Christian Brander; Daniel C Douek; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4699-708.
2006: E John Wherry; Cheryl L Day; Rika Draenert; Joseph D Miller; Photini Kiepiela; Tonia Woodberry; Christian Brander; Marylyn M Addo; Paul Klenerman; Rafi Ahmed; Bruce D Walker
HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.
Virology 2006;353(2):366-73.
2006: Christine M Rousseau; Brian A Birditt; Angela R McKay; Julia N Stoddard; Tsan Chun Lee; Sherry McLaughlin; Sarah W Moore; Nice Shindo; Gerald Learn; Bette T Korber; Christian Brander; Philip J R Goulder; Photini Kiepiela; Bruce D Walker; James I Mullins
Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes.
Journal of virological methods 2006;136(1-2):118-25.
2006: Christian Brander; Nicole Frahm; Bruce D Walker
The challenges of host and viral diversity in HIV vaccine design.
Current opinion in immunology 2006;18(4):430-7.
2006: Mathias Lichterfeld; Katie L Williams; Stanley K Mui; Shivani S Shah; Bianca R Mothe; Alessandro Sette; Arthur Kim; Mary N Johnston; Nicole C Burgett; Nicole Frahm; Daniel Cohen; Christian Brander; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld; Xu G Yu
T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily.
International immunology 2006;18(7):1179-88.
2006: Isobella Honeyborne; Almas Rathod; Rico Buchli; Danni Ramduth; Eshia Stephany Moodley-Govender; Prinisha Rathnavalu; Senica Chetty; Cheryl Day; Christian Brander; William H Hildebrand; Bruce D Walker; Photini Kiepiela; Philip J R Goulder
Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(8):4699-705.
2006: Florian Bihl; Nicole Frahm; Loriana Di Giammarino; John Sidney; Mina John; Karina Yusim; Tonia Woodberry; Kaori Sango; Hannah S Hewitt; Leah Henry; Caitlyn H Linde; John V Chisholm; Tauheed M Zaman; Eunice Pae; Simon Mallal; Bruce D Walker; Alessandro Sette; Bette T Korber; David Heckerman; Christian Brander
Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4094-101.
2006: Javier Martinez-Picado; Julia G Prado; Elizabeth E Fry; Katja Pfafferott; Alasdair Leslie; Senica Chetty; Christina Thobakgale; Isobella Honeyborne; Hayley Crawford; Philippa Matthews; Tilly Pillay; Christine M Rousseau; James I Mullins; Christian Brander; Bruce D Walker; David I Stuart; Photini Kiepiela; Philip J R Goulder
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
Journal of virology 2006;80(7):3617-23.
2006: Rosario Zuñiga; Aldo Lucchetti; Patricia Galvan; Shyla Sanchez; Carmen Sanchez; Ana Hernandez; Hugo Sanchez; Nicole Frahm; Caitlyn H Linde; Hannah S Hewitt; William H Hildebrand; Marcus Altfeld; Todd M Allen; Bruce D Walker; Bette T Korber; Thomas Leitner; Jorge Sanchez; Christian Brander
Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control.
Journal of virology 2006;80(6):3122-5.
2006: Daniel G Kavanagh; Daniel E Kaufmann; Sherzana Sunderji; Nicole Frahm; Sylvie Le Gall; David Boczkowski; Eric S Rosenberg; David R Stone; Mary N Johnston; Bradford S Wagner; M Tauheed Zaman; Christian Brander; Eli Gilboa; Bruce D Walker; Nina Bhardwaj
Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef.
Blood 2006;107(5):1963-9.
2006: Nicole Frahm; Photini Kiepiela; Sharon Adams; Caitlyn H Linde; Hannah S Hewitt; Kaori Sango; Margaret E Feeney; Marylyn M Addo; Mathias Lichterfeld; Matthew P Lahaie; Eunice Pae; Alysse Wurcel; Timothy Roach; M Anne St John; Marcus Altfeld; Francesco M Marincola; Corey Moore; Simon Mallal; Mary Carrington; David Heckerman; Todd M Allen; James I Mullins; Bette T Korber; Philip J R Goulder; Bruce D Walker; Christian Brander
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Nature immunology 2006;7(2):173-8.
2006: Sabina A Islam; Seddon Y Thomas; Christoph Hess; Benjamin D Medoff; Terry K Means; Christian Brander; Craig M Lilly; Andrew M Tager; Andrew D Luster
The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.
Blood 2006;107(2):444-53.
2005: Todd M Allen; Marcus Altfeld; Shaun C Geer; Elizabeth T Kalife; Corey Moore; Kristin M O'Sullivan; Ivna Desouza; Margaret E Feeney; Robert L Eldridge; Erica L Maier; Daniel E Kaufmann; Matthew P Lahaie; Laura L Reyor; Giancarlo O Tanzi; Mary N Johnston; Christian Brander; Rika Draenert; Jürgen K Rockstroh; Heiko Jessen; Eric S Rosenberg; Simon Mallal; Bruce D Walker
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Journal of virology 2005;79(21):13239-49.
2005: Danni Ramduth; Polan Chetty; Nolwandle Cyloria Mngquandaniso; Nonhlanhla Nene; Jason Harlow; Isobella Honeyborne; Nelisiwe Ntumba; Sharika Gappoo; Chiara Henry; Prakash Jeena; Marylyn M Addo; Marcus Altfeld; Christian Brander; Cheryl Day; Hoosen Coovadia; Photini Kiepiela; Philip J R Goulder; Bruce Walker
Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
The Journal of infectious diseases 2005;192(9):1588-96.
2005: Tonia Woodberry; Todd J Suscovich; Leah M Henry; Jennifer K Davis; Nicole Frahm; Bruce D Walker; David T Scadden; Frederick Wang; Christian Brander
Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.
The Journal of infectious diseases 2005;192(9):1513-24.
2005: Todd M Allen; Xu G Yu; Elizabeth T Kalife; Laura L Reyor; Mathias Lichterfeld; Mina John; Michael Cheng; Rachel L Allgaier; Stanley K Mui; Nicole Frahm; Galit Alter; Nancy V Brown; Mary N Johnston; Eric S Rosenberg; Simon Mallal; Christian Brander; Bruce D Walker; Marcus Altfeld
De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection.
Journal of virology 2005;79(20):12952-60.
2005: Tonia Woodberry; Todd J Suscovich; Leah M Henry; Meredith August; Michael T Waring; Amitinder Kaur; Christoph Hess; Jeffery L Kutok; Jon C Aster; Frederick Wang; David T Scadden; Christian Brander
Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4355-62.
2005: Xu G Yu; Mathias Lichterfeld; Beth Perkins; Elizabeth Kalife; Stanley K Mui; Jianping Chen; Michael Cheng; Wenzhen Kang; Galit Alter; Christian Brander; Bruce D Walker; Marcus Altfeld
High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level.
AIDS (London, England) 2005;19(14):1449-56.
2005: Daniel L Levey; Christian Brander; Pramod K Srivastava
The potential of heat shock protein-peptide complexes as a therapeutic HIV vaccine.
Journal of HIV therapy 2005;10(3):56-9.
2005: Tonia Woodberry; Todd J Suscovich; Leah M Henry; Jeffrey N Martin; Sheila Dollard; Paula G O'Connor; Jennifer K Davis; Dennis H Osmond; Tzong-Hae Lee; Dean H Kedes; Ashok Khatri; Jeannette Lee; Bruce D Walker; David T Scadden; Christian Brander
Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.
The Journal of infectious diseases 2005;192(4):622-9.
2005: Nicole Frahm; Sharon Adams; Photini Kiepiela; Caitlyn H Linde; Hannah S Hewitt; Mathias Lichterfeld; Kaori Sango; Nancy V Brown; Eunice Pae; Alysse Wurcel; Marcus Altfeld; Margaret E Feeney; Todd M Allen; Timothy Roach; M Anne St John; Eric S Daar; Eric Rosenberg; Bette Korber; Francesco M Marincola; Bruce D Walker; Philip J R Goulder; Christian Brander
HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
Journal of virology 2005;79(16):10218-25.
2005: Marcus Altfeld; Todd M Allen; Elizabeth T Kalife; Nicole Frahm; Marylyn M Addo; Bianca R Mothe; Almas Rathod; Laura L Reyor; Jason Harlow; Xu G Yu; Beth Perkins; Loren K Robinson; John Sidney; Galit Alter; Mathias Lichterfeld; Alessandro Sette; Eric S Rosenberg; Philip J R Goulder; Christian Brander; Bruce D Walker
The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Journal of virology 2005;79(8):5000-5.
2005: Alasdair Leslie; Daniel Kavanagh; Isobella Honeyborne; Katja Pfafferott; Charles Edwards; Tilly Pillay; Louise Hilton; Christina Thobakgale; Danni Ramduth; Rika Draenert; Sylvie Le Gall; Graz Luzzi; Anne Edwards; Christian Brander; Andrew K Sewell; Sarah Moore; James Mullins; Corey Moore; Simon Mallal; Nina Bhardwaj; Karina Yusim; Rodney Phillips; Paul Klenerman; Bette Korber; Photini Kiepiela; Bruce Walker; Philip J R Goulder
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
The Journal of experimental medicine 2005;201(6):891-902.
2004: Photini Kiepiela; Alasdair Leslie; Isobella Honeyborne; Danni Ramduth; Christina Thobakgale; Senica Chetty; Prinisha Rathnavalu; Corey Moore; Katja Pfafferott; Louise Hilton; Peter Zimbwa; Sarah Moore; Todd Allen; Christian Brander; Marylyn M Addo; Marcus Altfeld; Ian James; Simon Mallal; Mike Bunce; Linda D Barber; James Szinger; Cheryl Day; Paul Klenerman; James Mullins; Bette Korber; Hoosen M Coovadia; Bruce D Walker; Philip J R Goulder
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Nature 2004;432(7018):769-75.
2004: Christoph Hess; Terry K Means; Patrick Autissier; Tonia Woodberry; Marcus Altfeld; Marylyn M Addo; Nicole Frahm; Christian Brander; Bruce D Walker; Andrew D Luster
IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Blood 2004;104(12):3463-71.
2004: Devi SenGupta; Philip J Norris; Todd J Suscovich; Mina Hassan-Zahraee; Howell F Moffett; Alicja Trocha; Rika Draenert; Philip J R Goulder; Robert J Binder; Daniel L Levey; Bruce D Walker; Pramod K Srivastava; Christian Brander
Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(3):1987-93.
2004: Todd M Allen; Marcus Altfeld; Xu G Yu; Kristin M O'Sullivan; Mathias Lichterfeld; Sylvie Le Gall; Mina John; Bianca R Mothe; Paul K Lee; Elizabeth T Kalife; Daniel E Cohen; Kenneth A Freedberg; Daryld Strick; Mary N Johnston; Alessandro Sette; Eric S Rosenberg; Simon Mallal; Philip J R Goulder; Christian Brander; Bruce D Walker
Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection.
Journal of virology 2004;78(13):7069-78.
2004: Todd J Suscovich; Mini Paulose-Murphy; Jason Harlow; Yidong Chen; Seddon Y Thomas; Tiffany Mellott; Bruce D Walker; David T Scadden; Steven L Zeichner; Christian Brander
Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.
Leukemia & lymphoma 2004;45(6):1223-38.
2004: Xu G Yu; Marylyn M Addo; Beth A Perkins; Feili Wej; Almas Rathod; Shaun C Geer; Mark Parta; Daniel Cohen; David R Stone; Christopher J Russell; Giancarlo O Tanzi; Shan Mei; Alysse Wurcel; Nicole Frahm; Mathias Lichterfeld; Laura Heath; James I Mullins; Francesco M Marincola; Philip J R Goulder; Christian Brander; Todd Allen; Yunzhen Cao; Bruce D Walker; Marcus Altfeld
Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians.
AIDS research and human retroviruses 2004;20(5):557-64.
2004: Daniel E Kaufmann; Paul M Bailey; John Sidney; Bradford Wagner; Philip J Norris; Mary N Johnston; Lisa A Cosimi; Marylyn M Addo; Mathias Lichterfeld; Marcus Altfeld; Nicole Frahm; Christian Brander; Alessandro Sette; Bruce D Walker; Eric S Rosenberg
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Journal of virology 2004;78(9):4463-77.
2004: Rika Draenert; Christian Brander; Xu G Yu; Marcus Altfeld; Cori L Verrill; Margaret E Feeney; Bruce D Walker; Philip J R Goulder
Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.
AIDS (London, England) 2004;18(6):871-6.
2004: Rika Draenert; Sylvie Le Gall; Katja Pfafferott; Alasdair Leslie; Polan Chetty; Christian Brander; Edward C Holmes; Shih-Chung Chang; Margaret E Feeney; Marylyn M Addo; Lidia Ruiz; Danni Ramduth; Prakash Jeena; Marcus Altfeld; Stephanie Thomas; Yanhua Tang; Cori L Verrill; Catherine Dixon; Julia G Prado; Photini Kiepiela; Javier Martinez-Picado; Bruce D Walker; Philip J R Goulder
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
The Journal of experimental medicine 2004;199(7):905-15.
2004: Philip J Norris; Howell F Moffett; Christian Brander; Todd M Allen; Kristin M O'Sullivan; Lisa A Cosimi; Daniel E Kaufmann; Bruce D Walker; Eric S Rosenberg
Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells.
AIDS research and human retroviruses 2004;20(3):315-25.
2004: Nicole Frahm; Bette T Korber; C M Adams; James Szinger; Rika Draenert; Marylyn M Addo; Margaret E Feeney; Karina Yusim; Kaori Sango; Nancy V Brown; D SenGupta; A Piechocka-Trocha; T Simonis; Francesco M Marincola; Alysse Wurcel; David R Stone; Christopher J Russell; P Adolf; Daniel Cohen; Timothy Roach; A StJohn; Ashok Khatri; K Davis; James Mullins; Philip J R Goulder; Bruce D Walker; Christian Brander
Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.
Journal of virology 2004;78(5):2187-200.
2004: Alasdair Leslie; Katja Pfafferott; Polan Chetty; Rika Draenert; Marylyn M Addo; Margaret E Feeney; Yanhua Tang; Edward C Holmes; Todd Allen; Julia G Prado; Marcus Altfeld; Christian Brander; C Dixon; Danni Ramduth; Prakash Jeena; S A Thomas; A St John; Timothy Roach; B Kupfer; Graz Luzzi; Anne Edwards; G Taylor; Hermione Lyall; Gareth Tudor-Williams; Vas Novelli; Javier Martinez-Picado; Photini Kiepiela; Bruce D Walker; Philip J R Goulder
HIV evolution: CTL escape mutation and reversion after transmission.
Nature medicine 2004;10(3):282-9.
2003: Christian Brander; Bruce D Walker
Gradual adaptation of HIV to human host populations: good or bad news?
Nature medicine 2003;9(11):1359-62.
2003: Marcus Altfeld; Marylyn M Addo; Raj Shankarappa; Paul K Lee; Todd M Allen; Xu G Yu; Almas Rathod; Jason Harlow; Kristin M O'Sullivan; Mary N Johnston; Philip J R Goulder; James I Mullins; Eric S Rosenberg; Christian Brander; Bette Korber; Bruce D Walker
Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences.
Journal of virology 2003;77(13):7330-40.
2003: Otto O Yang; Phuong Thi Nguyen Sarkis; Ayub Ali; Jason Harlow; Christian Brander; Spyros A Kalams; Bruce D Walker
Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes.
The Journal of experimental medicine 2003;197(10):1365-75.
2003: Rika Draenert; Marcus Altfeld; Christian Brander; Nesli Basgoz; Colleen Corcoran; Alysse Wurcel; David R Stone; Spyros A Kalams; Alicja Trocha; Marylyn M Addo; Philip J R Goulder; Bruce D Walker
Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses.
Journal of immunological methods 2003;275(1-2):19-29.
2003: Marylyn M Addo; Xu G Yu; Almas Rathod; Daniel Cohen; Robert L Eldridge; Daryld Strick; Mary N Johnston; Colleen Corcoran; Alysse Wurcel; C A Fitzpatrick; Margaret E Feeney; William Rodriguez; Nesli Basgoz; Rika Draenert; David R Stone; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Marcus Altfeld; Bruce D Walker
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.
Journal of virology 2003;77(3):2081-92.
2002: George B Cohen; Sabina A Islam; Miriam S Noble; Christina Lau; Christian Brander; Marcus Altfeld; Eric S Rosenberg; Joern schmitz; Thomas O Cameron; Spyros A Kalams
Clonotype tracking of TCR repertoires during chronic virus infections.
Virology 2002;304(2):474-84.
2002: Marcus Altfeld; Todd M Allen; Xu G Yu; Mary N Johnston; Deepak Agrawal; Bette T Korber; David C Montefiori; David O'Connor; Benjamin T Davis; Paul K Lee; Erica L Maier; Jason Harlow; Philip J R Goulder; Christian Brander; Eric S Rosenberg; Bruce D Walker
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus.
Nature 2002;420(6914):434-9.
2002: Christian Brander; Noopur Raje; Paula G O'Connor; Faith Davies; Jennifer Davis; Darminder Chauhan; Teru Hideshima; Jeff Martin; Dennis H Osmond; Dean H Kedes; Bruce D Walker; David T Scadden; Kenneth C Anderson
Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma.
Blood 2002;100(2):698-700.
2002: Xu G Yu; Hong Shang; Marylyn M Addo; Robert L Eldridge; Mary N Phillips; Margaret E Feeney; Daryld Strick; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker; Marcus Altfeld
Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses.
AIDS (London, England) 2002;16(3):321-8.
2002: Christian Brander; Yves Rivière
Early and late cytotoxic T lymphocyte responses in HIV infection.
AIDS (London, England) 2002;16 Suppl 4():S97-103.
2001: Philip J R Goulder; C Pasquier; Edward C Holmes; B Liang; Y Tang; J Izopet; K Saune; E S Rosenberg; S K Burchett; K McIntosh; M C N M Barnardo; M Bunce; Bruce D Walker; Christian Brander; Rodney E Phillips
Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
Immunology letters 2001;79(1-2):109-16.
2001: Philip J Norris; M Sumaroka; Christian Brander; Howell F Moffett; SL Boswell; T Nguyen; Yuri Sykulev; Bruce D Walker; Eric S Rosenberg
Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones.
Journal of virology 2001;75(20):9771-9.
2001: Marcus Altfeld; Marylyn M Addo; Robert L Eldridge; Xu G Yu; S Thomas; Ashok Khatri; Daryld Strick; Mary N Phillips; George B Cohen; Sabina A Islam; Spyros A Kalams; Christian Brander; Philip J R Goulder; Eric S Rosenberg; Bruce D Walker
Vpr is preferentially targeted by CTL during HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2743-52.
2001: Philip J R Goulder; Christian Brander; Yanhua Tang; C Tremblay; Robert A Colbert; Marylyn M Addo; Eric S Rosenberg; T Nguyen; R Allen; Alicja Trocha; Marcus Altfeld; S He; Mike Bunce; Robert Funkhouser; Stephen I Pelton; Sandra K Burchett; Kenneth McIntosh; Bette T Korber; Bruce D Walker
Evolution and transmission of stable CTL escape mutations in HIV infection.
Nature 2001;412(6844):334-8.
2001: Christian Brander; P O'Connor; Todd J Suscovich; Norman Jones; Y Lee; Dean H Kedes; Don Ganem; J Martin; Dennis H Osmond; S Southwood; Alessandro Sette; Bruce D Walker; David T Scadden
Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein.
The Journal of infectious diseases 2001;184(2):119-26.
2001: Christian Brander; Ulrike B Matter-Reissmann; Norman Jones; Bruce D Walker; David H Sachs; Jörg D Seebach
Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride.
Journal of immunological methods 2001;252(1-2):1-14.
2001: Marylyn M Addo; Marcus Altfeld; Eric S Rosenberg; Robert L Eldridge; M N Philips; K Habeeb; Ashok Khatri; Christian Brander; Gregory Robbins; G P Mazzara; Philip J R Goulder; Bruce D Walker
The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1781-6.
2001: Anthony D Kelleher; C Long; Edward C Holmes; Rachel Allen; J Wilson; Christopher Conlon; Cassy Workman; Sunil Shaunak; Kara Olson; Philip J R Goulder; Christian Brander; Graham S Ogg; John Sullivan; Wayne B Dyer; I Jones; Andrew J McMichael; Sarah Rowland-Jones; Rodney E Phillips
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.
The Journal of experimental medicine 2001;193(3):375-86.
2001: Marcus Altfeld; Brian D Livingston; N Reshamwala; Phuong Thi Nguyen; Marylyn M Addo; AK Shea; M Newman; John Fikes; John Sidney; PA Wentworth; Robert W Chesnut; Robert L Eldridge; Eric S Rosenberg; Gregory Robbins; Christian Brander; PE Sax; SL Boswell; Theresa Flynn; Susan Buchbinder; Philip J R Goulder; Bruce D Walker; Alessandro Sette; Spyros A Kalams
Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif.
Journal of virology 2001;75(3):1301-11.
2001: Philip J R Goulder; Marcus Altfeld; Eric S Rosenberg; T Nguyen; Yanhua Tang; Robert L Eldridge; Marylyn M Addo; S He; Joia S Mukherjee; Mary N Phillips; Mike Bunce; Spyros A Kalams; Rafick-Pierre Sekaly; Bruce D Walker; Christian Brander
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection.
The Journal of experimental medicine 2001;193(2):181-94.
2001: Marcus Altfeld; Eric S Rosenberg; Raj Shankarappa; Joia S Mukherjee; Frederick Hecht; Robert L Eldridge; Marylyn M Addo; S H Poon; Mary N Phillips; Gregory Robbins; PE Sax; SL Boswell; James O Kahn; Christian Brander; Philip J R Goulder; J A Levy; James I Mullins; Bruce D Walker
Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.
The Journal of experimental medicine 2001;193(2):169-80.
2000: Philip J R Goulder; Yanhua Tang; Christian Brander; M R Betts; Marcus Altfeld; K Annamalai; Alicja Trocha; S He; Eric S Rosenberg; GS Ogg; Christopher A O'Callaghan; Spyros A Kalams; R E McKinney; K Mayer; R A Koup; Stephen I Pelton; Sandra K Burchett; Kenneth McIntosh; Bruce D Walker
Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
The Journal of experimental medicine 2000;192(12):1819-32.
2000: Christian Brander; Todd J Suscovich; Y Lee; Phuong Thi Nguyen; P O'Connor; Jörg D Seebach; Norman Jones; M van Gorder; Bruce D Walker; David T Scadden
Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):2077-83.
2000: Mark C Poznansky; Richard H Evans; Russell B Foxall; Ivona T Olszak; A H Piascik; Kelly Hartman; Christian Brander; T H Meyer; Mark Pykett; Karissa T Chabner; Spyros A Kalams; Michael Rosenzweig; David T Scadden
Efficient generation of human T cells from a tissue-engineered thymic organoid.
Nature biotechnology 2000;18(7):729-34.
2000: Philip J R Goulder; Christian Brander; K Annamalai; N Mngqundaniso; UG Govender; Yanhua Tang; S He; Kelly Hartman; Christopher A O'Callaghan; GS Ogg; Marcus Altfeld; Eric S Rosenberg; H Cao; Spyros A Kalams; M Hammond; Mike Bunce; Stephen I Pelton; S A Burchett; Kenneth McIntosh; Hoosen M Coovadia; Bruce D Walker
Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children.
Journal of virology 2000;74(12):5679-90.
1999: Christian Brander; Otto O Yang; Norman Jones; Y Lee; Philip J R Goulder; R Paul Johnson; Alicja Trocha; D Colbert; C Hay; Susan Buchbinder; C C Bergmann; H J Zweerink; Steven Wolinsky; William A Blattner; Spyros A Kalams; Bruce D Walker
Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences.
Journal of virology 1999;73(12):10191-8.
1999: Christian Brander; Bruce D Walker
T lymphocyte responses in HIV-1 infection: implications for vaccine development.
Current opinion in immunology 1999;11(4):451-9.
1999: Christian Brander; Philip J R Goulder; Katherine Luzuriaga; Otto O Yang; Kelly Hartman; Norman Jones; Bruce D Walker; Spyros A Kalams
Persistent HIV-1-specific CTL clonal expansion despite high viral burden post in utero HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4796-800.
1998: Christian Brander; Kelly Hartman; Alicja Trocha; Norman Jones; R Paul Johnson; Bette Korber; PA Wentworth; SP Buchbinder; Steven Wolinsky; Bruce D Walker; Spyros A Kalams
Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.
The Journal of clinical investigation 1998;101(11):2559-66.