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Martin Watterson

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Fabeha Fazal; Jacob N Finkelstein; Antony Leonard; Mohd Minhajuddin; Matthew Murrill; Khandaker N Anwar; Kaiser M Bijli; D Martin Watterson; Arshad Rahman
Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.
Rana Al-Sadi; Karol Dokladny; Shuhong Guo; Archana Kaza; Matthew A Smith; D Martin Watterson; Dongmei Ye; Thomas Y Ma
Mechanism of interleukin-1β induced-increase in mouse intestinal permeability in vivo.
Adam D Bachstetter; Danielle Goulding; Janna H Neltner; Christopher M Norris; Pradoldej Sompol; Daret St Clair; D Martin Watterson; Donna M Wilcock; Linda J Van Eldik
Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.

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2013: Fabeha Fazal; Jacob N Finkelstein; Antony Leonard; Mohd Minhajuddin; Matthew Murrill; Khandaker N Anwar; Kaiser M Bijli; D Martin Watterson; Arshad Rahman
Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.
PloS one 2013;8(3):e59965.
2012: Rana Al-Sadi; Karol Dokladny; Shuhong Guo; Archana Kaza; Matthew A Smith; D Martin Watterson; Dongmei Ye; Thomas Y Ma
Mechanism of interleukin-1β induced-increase in mouse intestinal permeability in vivo.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2012;32(10):474-84.
2012: Adam D Bachstetter; Danielle Goulding; Janna H Neltner; Christopher M Norris; Pradoldej Sompol; Daret St Clair; D Martin Watterson; Donna M Wilcock; Linda J Van Eldik
Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(30):10201-10.
2011: Laurie K McNamara; Joseph S Brunzelle; James P Schavocky; D Martin Watterson; Valerie Grum-Tokars
Site-directed mutagenesis of the glycine-rich loop of death associated protein kinase (DAPK) identifies it as a key structure for catalytic activity.
Biochimica et biophysica acta 2011;1813(5):1068-73.
2011: Adam D Bachstetter; Lucia de Almeida; Edgardo R Dimayuga; D Martin Watterson; Bin Xing; Linda J Van Eldik
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).
Journal of neuroinflammation 2011;8():79.
2011: Tian Chen; Radhia Benmohamed; Anthony C Arvanites; Hantamalala Ralay Ranaivo; Richard I Morimoto; Robert J Ferrante; D Martin Watterson; Donald R Kirsch; Richard B Silverman
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.
Bioorganic & medicinal chemistry 2011;19(1):613-22.
2011: Brian Ross; Thao Tran; Pratip Bhattacharya; D Martin Watterson; Napapon Sailasuta
Application of NMR spectroscopy in medicinal chemistry and drug discovery.
Current topics in medicinal chemistry 2011;11(1):93-114.
2011: Tamara Mirzapoiazova; Jaideep Moitra; Liliana Moreno Vinasco; Saad Sammani; Jerry R Turner; Eddie T Chiang; Carrie Evenoski; T Wang; Patrick A Singleton; Yong Huang; Yves lussier; D Martin Watterson; Steven M Dudek; Joe G. N. Garcia
Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.
American journal of respiratory cell and molecular biology 2011;44(1):40-52.
2010: MaryAnn Chrzaszcz; Charu Venkatesan; Tina Dragisic; D Martin Watterson; Mark S Wainwright
Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures.
Journal of neurotrauma 2010;27(7):1283-95.
2010: Michael Zimmermann; Cédric Atmanene; Qingyan Xu; Laetitia Fouillen; Alain Van Dorsselaer; Dominique Bonnet; Claire Marsol; Marcel Hibert; Sarah Sanglier-Cianferani; Claire Pigault; Laurie K McNamara; D Martin Watterson; jacques haiech; Marie-Claude Kilhoffer
Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter.
PloS one 2010;5(11):e14120.
2009: Laura K Chico; Linda Van Eldik; D Martin Watterson
Targeting protein kinases in central nervous system disorders.
Nature reviews. Drug discovery 2009;8(11):892-909.
2009: Richard B Silverman; Graham R Lawton; Hantamalala Ralay Ranaivo; Laura K Chico; Jiwon Seo; D Martin Watterson
Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.
Bioorganic & medicinal chemistry 2009;17(21):7593-605.
2009: Laura K Chico; Heather A Behanna; Wenhui Hu; Guifa Zhong; Saktimayee Mitra Roy; D Martin Watterson
Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2204-11.
2009: Kathleen C Somera-Molina; Sangeetha Nair; Linda Van Eldik; D Martin Watterson; Mark S Wainwright
Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model.
Brain research 2009;1282():162-72.
2009: Graham R Lawton; Hantamalala Ralay Ranaivo; Laura K Chico; Haitao Ji; Fengtian Xue; Pavel Martásek; Linda Roman; D Martin Watterson; Richard B Silverman
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Bioorganic & medicinal chemistry 2009;17(6):2371-80.
2009: Laurie K McNamara; D Martin Watterson; Joseph S. Brunzelle
Structural insight into nucleotide recognition by human death-associated protein kinase.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 3):241-8.
2008: William J Karpus; Nathaneal Reynolds; Heather A Behanna; Linda Van Eldik; D Martin Watterson
Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug.
Journal of neuroimmunology 2008;203(1):73-8.
2008: Aaron S Borders; Lucia de Almeida; Linda Van Eldik; D Martin Watterson
The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.
BMC neuroscience 2008;9 Suppl 2():S12.
2008: Eric Lloyd; Kathleen Somera-Molina; Linda Van Eldik; D Martin Watterson; Mark S Wainwright
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury.
Journal of neuroinflammation 2008;5():28.
2007: Xiaoli Guo; Kazuaki Nakamura; Kuniko Kohyama; Chikako Harada; Heather A Behanna; D Martin Watterson; Yoh Matsumoto; Takayuki Harada
Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis.
Neuroscience research 2007;59(4):457-66.
2007: Rashell Reynoso; Rachel M Perrin; Jerome W Breslin; Dayle A Daines; Katherine D Watson; D Martin Watterson; Mack H Wu; Sarah Y Yuan
A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns.
Shock (Augusta, Ga.) 2007;28(5):589-95.
2007: Kathleen C Somera-Molina; Beverley Robin; Cherie Ann Somera; Christopher Anderson; Christy Stine; Sookyong Koh; Heather A Behanna; Linda Van Eldik; D Martin Watterson; Mark S Wainwright
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation.
Epilepsia 2007;48(9):1785-800.
2007: Janet L Rossi; Anastasia V Velentza; David Steinhorn; D Martin Watterson; Mark S Wainwright
MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice.
American journal of physiology. Lung cellular and molecular physiology 2007;292(6):L1327-34.
2007: Hantamalala Ralay Ranaivo; Nunzia Carusio; Rosemary Wangensteen; Patrick Ohlmann; Cécile Loichot; Angela Tesse; Karel Chalupsky; Irina Lobysheva; jacques haiech; D Martin Watterson; Ramaroson Andriantsitohaina
Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice.
The American journal of pathology 2007;170(2):439-46.
2007: Wenhui Hu; Hantamalala Ralay Ranaivo; Saktimayee M Roy; Heather A Behanna; Laura K Wing; Lenka Munoz; Ling Guo; Linda Van Eldik; D Martin Watterson
Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.
Bioorganic & medicinal chemistry letters 2007;17(2):414-8.
2007: Lenka Munoz; Hantamalala Ralay Ranaivo; Saktimayee M Roy; Wenhui Hu; Jeffery Craft; Laurie K McNamara; Laura Wing Chico; Linda Van Eldik; D Martin Watterson
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
Journal of neuroinflammation 2007;4():21.
2006: Andrew M Schumacher; Anastasia V Velentza; D Martin Watterson; John Dresios
Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis.
Biochemistry 2006;45(45):13614-21.
2006: Heather A Behanna; D Martin Watterson; Hantamalala Ralay Ranaivo
Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: a lead compound that attenuates vascular leak.
Biochimica et biophysica acta 2006;1763(11):1266-74.
2006: Laura K Wing; Heather A Behanna; Linda Van Eldik; D Martin Watterson; Hantamalala Ralay Ranaivo
De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders.
Current Alzheimer research 2006;3(3):205-14.
2006: Tatyana V Dudnakova; Olga V Stepanova; K V Dergilev; A V Chadin; Boris V Shekhonin; D Martin Watterson; Vladimir P Shirinsky
Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes.
Cell motility and the cytoskeleton 2006;63(7):375-83.
2006: Jeffery Craft; D Martin Watterson; Linda Van Eldik
Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration.
Glia 2006;53(5):484-90.
2006: Hantamalala Ralay Ranaivo; Jeffery Craft; Wenhui Hu; Ling Guo; Laura K Wing; Linda Van Eldik; D Martin Watterson
Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):662-70.
2005: Patrick Ohlmann; Angela Tesse; Cécile Loichot; Hantamalala Ralay Ranaivo; Gerald Roul; Claude Philippe; D Martin Watterson; jacques haiech; Ramaroson Andriantsitohaina
Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function.
American journal of physiology. Heart and circulatory physiology 2005;289(6):H2342-9.
2005: Jeffery Craft; D Martin Watterson; Linda Van Eldik
Neuroinflammation: a potential therapeutic target.
Expert opinion on therapeutic targets 2005;9(5):887-900.
2005: Daniel R Clayburgh; Terrence Anthony Barrett; Yueming Tang; Jon B Meddings; Linda Van Eldik; D Martin Watterson; Lane L Clarke; Randall J Mrsny; Jerrold R Turner
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
The Journal of clinical investigation 2005;115(10):2702-15.
2005: Jeffery Craft; D Martin Watterson; Alexander Marks; Linda Van Eldik
Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human beta-amyloid.
Glia 2005;51(3):209-16.
2005: Jeffery Craft; D Martin Watterson; Emmet Hirsch; Linda Van Eldik
Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid.
Journal of neuroinflammation 2005;2():15.
2005: Wenhui Hu; Hantamalala Ralay Ranaivo; Jeffery Craft; Linda Van Eldik; D Martin Watterson
Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model.
Current Alzheimer research 2005;2(2):197-205.
2004: Jeffery Craft; D Martin Watterson; Sally A Frautschy; Linda Van Eldik
Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo.
Neurobiology of aging 2004;25(10):1283-92.
2004: Dmitri Kudryashov; Olga V Stepanova; Elena L Vilitkevich; Tatyana A Nikonenko; Elena S Nadezhdina; Nina A Shanina; Thomas J Lukas; Linda Van Eldik; D Martin Watterson; Vladimir P Shirinsky
Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain.
Experimental cell research 2004;298(2):407-17.
2004: Andrew M Schumacher; James P Schavocky; Anastasia V Velentza; Salida Mirzoeva; D Martin Watterson
A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase.
Biochemistry 2004;43(25):8116-24.
2004: Jeffery Craft; Linda Van Eldik; Magdalena Zasadzki; Wenhui Hu; D Martin Watterson
Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation.
Journal of molecular neuroscience : MN 2004;24(1):115-22.
2003: Anastasia V Velentza; Mark S Wainwright; Magdalena Zasadzki; Salida Mirzoeva; Andrew M Schumacher; jacques haiech; Pamela J Focia; Martin Egli; D Martin Watterson
An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Bioorganic & medicinal chemistry letters 2003;13(20):3465-70.
2003: Mark S Wainwright; Janet Rossi; James Schavocky; Susan Crawford; David Steinhorn; Anastasia V Velentza; Magdalena Zasadzki; Vladimir P Shirinsky; Yuzhi Jia; jacques haiech; Linda Van Eldik; D Martin Watterson
Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(10):6233-8.
2003: D Martin Watterson; Anastasia V Velentza; Magdalena Zasadzki; Jeffery Craft; jacques haiech; Linda Van Eldik
Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's disease progression.
Journal of molecular neuroscience : MN 2003;20(3):411-23.
2002: Andrew M Schumacher; Anastasia V Velentza; D Martin Watterson; Mark S Wainwright
DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury.
Biochimica et biophysica acta 2002;1600(1-2):128-37.
2002: Andrew M Schumacher; Anastasia V Velentza; D Martin Watterson
Death-associated protein kinase as a potential therapeutic target.
Expert opinion on therapeutic targets 2002;6(4):497-506.
2002: D Martin Watterson; jacques haiech; Linda Van Eldik
Discovery of new chemical classes of synthetic ligands that suppress neuroinflammatory responses.
Journal of molecular neuroscience : MN 2002;19(1-2):89-93.
2002: Anastasia V Velentza; Andrew M Schumacher; D Martin Watterson
Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death.
Pharmacology & therapeutics 2002;93(2-3):217-24.
2002: Salida Mirzoeva; Anu Sawkar; Magdalena Zasadzki; Ling Guo; Anastasia V Velentza; Vincent Dunlap; Jean-Jacques Bourguignon; Helena Ramstrom; jacques haiech; Linda Van Eldik; D Martin Watterson
Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.
Journal of medicinal chemistry 2002;45(3):563-6.
2002: Dmitri Kudryashov; Alexander V Vorotnikov; Tatyana V Dudnakova; Olga V Stepanova; Thomas J Lukas; James R Sellers; D Martin Watterson; Vladimir P Shirinsky
Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon.
Journal of muscle research and cell motility 2002;23(4):341-51.
2002: Linda Van Eldik; Tanuja Koppal; D Martin Watterson
Barriers to Alzheimer disease drug discovery and development in academia.
Alzheimer disease and associated disorders 2002;16 Suppl 1():S18-28.
2001: L Guo; A Sawkar; Magdalena Zasadzki; D Martin Watterson; Linda Van Eldik
Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands.
Neurobiology of aging 2001;22(6):975-81.
2001: D Martin Watterson; Salida Mirzoeva; L Guo; A Whyte; Jean-Jacques Bourguignon; Marcel Hibert; jacques haiech; Linda Van Eldik
Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II.
Neurochemistry international 2001;39(5-6):459-68.
2001: Anastasia V Velentza; Andrew M Schumacher; C Weiss; Martin Egli; D Martin Watterson
A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.
The Journal of biological chemistry 2001;276(42):38956-65.
2001: Valentina Tereshko; Marianna Teplova; Joseph S. Brunzelle; D Martin Watterson; Martin Egli
Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression.
Nature structural biology 2001;8(10):899-907.
2001: A G Lam; Tanuja Koppal; KT Akama; L Guo; Jeffery Craft; B Samy; James Schavocky; D Martin Watterson; Linda Van Eldik
Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB.
Neurobiology of aging 2001;22(5):765-72.
2001: MV Medvedeva; D R Djemuchadze; D Martin Watterson; Steven B Marston; Nikolai B Gusev
Replacement of Lys-75 of calmodulin affects its interaction with smooth muscle caldesmon.
Biochimica et biophysica acta 2001;1544(1-2):143-50.
2001: Mikhail Krymskiy; Dmitri Kudryashov; Vladimir P Shirinsky; Thomas J Lukas; D Martin Watterson; Alexander V Vorotnikov
Phosphorylation of kinase-related protein (telokin) in tonic and phasic smooth muscles.
Journal of muscle research and cell motility 2001;22(5):425-37.
1999: Dmitri Kudryashov; MV Chibalina; Konstantin G Birukov; Thomas J Lukas; James R Sellers; Linda Van Eldik; D Martin Watterson; Vladimir P Shirinsky
Unique sequence of a high molecular weight myosin light chain kinase is involved in interaction with actin cytoskeleton.
FEBS letters 1999;463(1-2):67-71.
1999: D Martin Watterson; James Schavocky; L Guo; C Weiss; A Chlenski; Vladimir P Shirinsky; Linda Van Eldik; jacques haiech
Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker.
Journal of cellular biochemistry 1999;75(3):481-91.
1999: Salida Mirzoeva; Tanuja Koppal; TV Petrova; Thomas J Lukas; D Martin Watterson; Linda Van Eldik
Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets.
Brain research 1999;844(1-2):126-34.
1999: Rosa A Maldonado; Salida Mirzoeva; Lisa M Godsel; Thomas J Lukas; SAMUEL GOLDENBERG; D Martin Watterson; David M Engman
Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch protein.
Molecular and biochemical parasitology 1999;101(1-2):61-70.
1999: Donatella Tondi; U Slomczynska; M Paola Costi; D Martin Watterson; Stefano Ghelli; Brian Shoichet
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.
Chemistry & biology 1999;6(5):319-31.
1999: MV Medvedeva; Oxana V Polyakova; D Martin Watterson; Nikolai B Gusev
Mutation of Lys-75 affects calmodulin conformation.
FEBS letters 1999;450(1-2):139-43.
1999: Salida Mirzoeva; S Weigand; Thomas J Lukas; L Shuvalova; W F Anderson; D Martin Watterson
Analysis of the functional coupling between calmodulin's calcium binding and peptide recognition properties.
Biochemistry 1999;38(13):3936-47.
1999: Thomas J Lukas; Salida Mirzoeva; U Slomczynska; D Martin Watterson
Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge.
Journal of medicinal chemistry 1999;42(5):910-9.
1998: Konstantin G Birukov; James Schavocky; Vladimir P Shirinsky; MV Chibalina; Linda Van Eldik; D Martin Watterson
Organization of the genetic locus for chicken myosin light chain kinase is complex: multiple proteins are encoded and exhibit differential expression and localization.
Journal of cellular biochemistry 1998;70(3):402-13.
1997: Debra Silver; Alexander V Vorotnikov; D Martin Watterson; Vladimir P Shirinsky; James R Sellers
Sites of interaction between kinase-related protein and smooth muscle myosin.
The Journal of biological chemistry 1997;272(40):25353-9.
1996: Christophe Bosc; J D Cronk; Fabienne Pirollet; D Martin Watterson; jacques haiech; Didier Job; R L Margolis
Cloning, expression, and properties of the microtubule-stabilizing protein STOP.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):2125-30.
1995: D Martin Watterson; M Collinge; T J Lukas; Linda Van Eldik; Konstantin G Birukov; O V Stepanova; Vladimir P Shirinsky
Multiple gene products are produced from a novel protein kinase transcription region.
FEBS letters 1995;373(3):217-20.
1995: MV Medvedeva; T L Bushueva; Vladimir P Shirinsky; T J Lukas; D Martin Watterson; Nikolai B Gusev
Interaction of smooth muscle caldesmon with calmodulin mutants.
FEBS letters 1995;360(1):89-92.
1994: E Harris; D Martin Watterson; Jeremy Thorner
Functional consequences in yeast of single-residue alterations in a consensus calmodulin.
Journal of cell science 1994;107 ( Pt 11)():3235-49.
1994: T J Lukas; M Collinge; jacques haiech; D Martin Watterson
Gain of function mutations for yeast calmodulin and calcium dependent regulation of protein kinase activity.
Biochimica et biophysica acta 1994;1223(3):341-7.
1993: Vladimir P Shirinsky; Alexander V Vorotnikov; Konstantin G Birukov; A K Nanaev; M Collinge; T J Lukas; James R Sellers; D Martin Watterson
A kinase-related protein stabilizes unphosphorylated smooth muscle myosin minifilaments in the presence of ATP.
The Journal of biological chemistry 1993;268(22):16578-83.
1993: Y J Farrar; T J Lukas; T A Craig; D Martin Watterson; Gerald M Carlson
Features of calmodulin that are important in the activation of the catalytic subunit of phosphorylase kinase.
The Journal of biological chemistry 1993;268(6):4120-5.
1992: Marie-Claude Kilhoffer; T J Lukas; D Martin Watterson; jacques haiech
The heterodimer calmodulin: myosin light-chain kinase as a prototype vertebrate calcium signal transduction complex.
Biochimica et biophysica acta 1992;1160(1):8-15.
1992: A P Timerman; M M Mayrleitner; T J Lukas; C C Chadwick; A Saito; D Martin Watterson; Hansgeorg Schindler; Sidney Fleischer
Inositol polyphosphate receptor and clathrin assembly protein AP-2 are related proteins that form potassium-selective ion channels in planar lipid bilayers.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):8976-80.
1992: M Collinge; P E Matrisian; Warren Zimmer; R L Shattuck; T J Lukas; Linda Van Eldik; D Martin Watterson
Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene.
Molecular and cellular biology 1992;12(5):2359-71.
1992: Danuta Kosk-Kosicka; T Bzdega; A Wawrzynow; D Martin Watterson; T J Lukas
Site-specific amino acid alterations in Ca2+ binding domains in calmodulin impair activation of RBC Ca(2+)-ATPase.
Biophysical journal 1992;62(1):77-8.
1991: M Chabbert; T J Lukas; D Martin Watterson; Paul H Axelsen; Franklyn G Prendergast
Fluorescence analysis of calmodulin mutants containing tryptophan: conformational changes induced by calmodulin-binding peptides from myosin light chain kinase and protein kinase II.
Biochemistry 1991;30(30):7615-30.
1991: jacques haiech; Marie-Claude Kilhoffer; T J Lukas; T A Craig; D M Roberts; D Martin Watterson
Restoration of the calcium binding activity of mutant calmodulins toward normal by the presence of a calmodulin binding structure.
The Journal of biological chemistry 1991;266(6):3427-31.
1991: L R Massom; T J Lukas; A Persechini; R H Kretsinger; D Martin Watterson; Harry Jarrett
Trifluoperazine binding to mutant calmodulins.
Biochemistry 1991;30(3):663-7.
1990: R Hinrichsen; E Wilson; T Lukas; T Craig; J Schultz; D Martin Watterson
Analysis of the molecular basis of calmodulin defects that affect ion channel-mediated cellular responses: site-specific mutagenesis and microinjection.
The Journal of cell biology 1990;111(6 Pt 1):2537-42.
1990: M O Shoemaker; W Lau; R L Shattuck; A P Kwiatkowski; P E Matrisian; L Guerra-Santos; E Wilson; T J Lukas; Linda Van Eldik; D Martin Watterson
Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity.
The Journal of cell biology 1990;111(3):1107-25.
1990: K Jiang; J Zheng; S B Higgins; D Martin Watterson; T A Craig; T J Lukas; Linda Van Eldik
A knowledge-based experimental design system for nucleic acid engineering.
Computer applications in the biosciences : CABIOS 1990;6(3):205-12.
1990: jacques haiech; Marie-Claude Kilhoffer; T A Craig; T J Lukas; E Wilson; L Guerra-Santos; D Martin Watterson
Mutant analysis approaches to understanding calcium signal transduction through calmodulin and calmodulin regulated enzymes.
Advances in experimental medicine and biology 1990;269():43-56.
1990: Linda Van Eldik; Warren Zimmer; Steven W Barger; D Martin Watterson
Perturbation of the calmodulin system in transformed cells.
Advances in experimental medicine and biology 1990;269():111-20.
1990: joachim krebs; T Vorherr; P James; Ernesto Carafoli; T A Craig; D Martin Watterson
Structural details of the interaction of calmodulin with the plasma membrane Ca2(+)-ATPase.
Advances in experimental medicine and biology 1990;269():163-7.
1989: T J Lukas; M Wallen-Friedman; Ching Kung; D Martin Watterson
In vivo mutations of calmodulin: a mutant Paramecium with altered ion current regulation has an isoleucine-to-threonine change at residue 136 and an altered methylation state at lysine residue 115.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7331-5.
1989: M Chabbert; Marie-Claude Kilhoffer; D Martin Watterson; jacques haiech; H Lami
Time-resolved fluorescence study of VU-9 calmodulin, an engineered calmodulin possessing a single tryptophan residue.
Biochemistry 1989;28(14):6093-8.
1989: Marie-Claude Kilhoffer; D M Roberts; A Adibi; D Martin Watterson; jacques haiech
Fluorescence characterization of VU-9 calmodulin, an engineered calmodulin with one tryptophan in calcium binding domain III.
Biochemistry 1989;28(14):6086-92.
1989: J Asselin; S Phaneuf; D Martin Watterson; jacques haiech
Metabolically 35S-labeled recombinant calmodulin as a ligand for the detection of calmodulin-binding proteins.
Analytical biochemistry 1989;178(1):141-7.
1989: P C Weber; T J Lukas; T A Craig; E Wilson; M M King; A P Kwiatkowski; D Martin Watterson
Computational and site-specific mutagenesis analyses of the asymmetric charge distribution on calmodulin.
Proteins 1989;6(1):70-85.
1988: Warren Zimmer; J A Schloss; Carolyn D Silflow; J Youngblom; D Martin Watterson
Structural organization, DNA sequence, and expression of the calmodulin gene.
The Journal of biological chemistry 1988;263(36):19370-83.
1988: Marie-Claude Kilhoffer; D M Roberts; A O Adibi; D Martin Watterson; jacques haiech
Investigation of the mechanism of calcium binding to calmodulin. Use of an isofunctional mutant with a tryptophan introduced by site-directed mutagenesis.
The Journal of biological chemistry 1988;263(32):17023-9.
1988: B Huang; D Martin Watterson; V D Lee; M J Schibler
Purification and characterization of a basal body-associated Ca2+-binding protein.
The Journal of cell biology 1988;107(1):121-31.
1988: jacques haiech; R Predeleanu; D Martin Watterson; Daniel Ladant; J Bellalou; Agnes Ullmann; Octavian Bârzu
Affinity-based chromatography utilizing genetically engineered proteins. Interaction of Bordetella pertussis adenylate cyclase with calmodulin.
The Journal of biological chemistry 1988;263(9):4259-62.
1988: T J Lukas; jacques haiech; W Lau; T A Craig; Warren Zimmer; R L Shattuck; M O Shoemaker; D Martin Watterson
Calmodulin and calmodulin-regulated protein kinases as transducers of intracellular calcium signals.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():185-93.
1988: T J Lukas; D Martin Watterson
Purification of calmodulin and preparation of immobilized calmodulin.
Methods in enzymology 1988;157():328-39.
1988: J Zheng; K Jiang; D Martin Watterson; T A Craig; S B Higgins
A knowledge-based system for cassette mutagenesis experimental design.
Computers in biology and medicine 1988;18(6):409-18.
1988: D Martin Watterson; T J Lukas
Analysis of phosphodiesterase reaction mixtures by high-performance liquid chromatography.
Methods in enzymology 1988;159():471-7.
1987: W H Schaefer; R D Hinrichsen; A Burgess-Cassler; Ching Kung; Ian Blair; D Martin Watterson
A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: a nonlethal selective alteration in calmodulin regulation.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(11):3931-5.
1987: T A Craig; D Martin Watterson; Franklyn G Prendergast; jacques haiech; D M Roberts
Site-specific mutagenesis of the alpha-helices of calmodulin. Effects of altering a charge cluster in the helix that links the two halves of calmodulin.
The Journal of biological chemistry 1987;262(7):3278-84.
1987: W H Schaefer; T J Lukas; Ian Blair; J E Schultz; D Martin Watterson
Amino acid sequence of a novel calmodulin from Paramecium tetraurelia that contains dimethyllysine in the first domain.
The Journal of biological chemistry 1987;262(3):1025-9.
1987: D M Roberts; Warren Zimmer; D Martin Watterson
The use of synthetic oligodeoxyribonucleotides in the examination of calmodulin gene and protein structure and function.
Methods in enzymology 1987;139():290-303.
1986: T J Lukas; W H Burgess; Franklyn G Prendergast; W Lau; D Martin Watterson
Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase.
Biochemistry 1986;25(6):1458-64.
1986: D M Roberts; P M Rowe; F L Siegel; T J Lukas; D Martin Watterson
Trimethyllysine and protein function. Effect of methylation and mutagenesis of lysine 115 of calmodulin on NAD kinase activation.
The Journal of biological chemistry 1986;261(4):1491-4.
1985: D M Roberts; R Crea; M Malecha; G Alvarado-Urbina; R H Chiarello; D Martin Watterson
Chemical synthesis and expression of a calmodulin gene designed for site-specific mutagenesis.
Biochemistry 1985;24(19):5090-8.
1985: R Jensen; D R Marshak; C Anderson; T J Lukas; D Martin Watterson
Characterization of human brain S100 protein fraction: amino acid sequence of S100 beta.
Journal of neurochemistry 1985;45(3):700-5.
1985: D R Marshak; H Umekawa; D Martin Watterson; H Hidaka
Structural characterization of the calcium binding protein s100 from adipose tissue.
Archives of biochemistry and biophysics 1985;240(2):777-80.
1985: T J Lukas; M E Wiggins; D Martin Watterson
Amino Acid sequence of a novel calmodulin from the unicellular alga chlamydomonas.
Plant physiology 1985;78(3):477-83.
1985: T J Lukas; A Redelfs; W H Burgess; D Martin Watterson
Amino acid sequence of the phosphorylation site of bovine cardiac myosin light chain.
Archives of biochemistry and biophysics 1985;238(2):664-9.
1985: T J Lukas; D R Marshak; D Martin Watterson
Drug-protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin.
Biochemistry 1985;24(1):151-7.
1985: D R Marshak; T J Lukas; D Martin Watterson
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins.
Biochemistry 1985;24(1):144-50.
1984: Linda Van Eldik; D Martin Watterson; W H Burgess
Immunoreactive levels of myosin light-chain kinase in normal and virus-transformed chicken embryo fibroblasts.
Molecular and cellular biology 1984;4(10):2224-6.
1984: W H Burgess; D Martin Watterson; L J Van Eldik
Identification of calmodulin-binding proteins in chicken embryo fibroblasts.
The Journal of cell biology 1984;99(2):550-7.
1984: D M Roberts; W H Burgess; D Martin Watterson
Comparison of the NAD Kinase and Myosin Light Chain Kinase Activator Properties of Vertebrate, Higher Plant, and Algal Calmodulins.
Plant physiology 1984;75(3):796-8.
1984: T J Lukas; D B Iverson; M Schleicher; D Martin Watterson
Structural characterization of a higher plant calmodulin : spinacia oleracea.
Plant physiology 1984;75(3):788-95.
1984: D R Marshak; M Clarke; D M Roberts; D Martin Watterson
Structural and functional properties of calmodulin from the eukaryotic microorganism Dictyostelium discoideum.
Biochemistry 1984;23(13):2891-9.
1984: J G Zendegui; R E Zielinski; D Martin Watterson; L J Van Eldik
Biosynthesis of calmodulin in normal and virus-transformed chicken embryo fibroblasts.
Molecular and cellular biology 1984;4(5):883-9.
1984: M Schleicher; T J Lukas; D Martin Watterson
Isolation and characterization of calmodulin from the motile green alga Chlamydomonas reinhardtii.
Archives of biochemistry and biophysics 1984;229(1):33-42.
1984: D Martin Watterson; W H Burgess; T J Lukas; D Iverson; D R Marshak; M Schleicher; B W Erickson; K F Fok; L J Van Eldik
Towards a molecular and atomic anatomy of calmodulin and calmodulin-binding proteins.
Advances in cyclic nucleotide and protein phosphorylation research 1984;16():205-26.
1983: L J Van Eldik; D Martin Watterson; K F Fok; B W Erickson
Elucidation of a minimal immunoreactive site of vertebrate calmodulin.
Archives of biochemistry and biophysics 1983;227(2):522-33.
1983: M Schleicher; T J Lukas; D Martin Watterson
Further Characterization of Calmodulin from the Monocotyledon Barley (Hordeum vulgare).
Plant physiology 1983;73(3):666-70.
1983: D M Roberts; R E Zielinski; M Schleicher; D Martin Watterson
Analysis of suborganellar fractions from spinach and pea chloroplasts for calmodulin-binding proteins.
The Journal of cell biology 1983;97(5 Pt 1):1644-7.
1983: L J Van Eldik; K F Fok; B W Erickson; D Martin Watterson
Engineering of site-directed antisera against vertebrate calmodulin by using synthetic peptide immunogens containing an immunoreactive site.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(22):6775-9.
1983: M Schleicher; D Martin Watterson
Analysis of differences between coomassie blue stain and silver stain procedures in polyacrylamide gels: conditions for the detection of calmodulin and troponin C.
Analytical biochemistry 1983;131(2):312-7.
1982: L J Van Eldik; J G Zendegui; D R Marshak; D Martin Watterson
Calcium-binding proteins and the molecular basis of calcium action.
International review of cytology 1982;77():1-61.
1981: D R Marshak; D Martin Watterson; L J Van Eldik
Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(11):6793-7.
1981: L J Van Eldik; D Martin Watterson
Reproducible production of antiserum against vertebrate calmodulin and determination of the immunoreactive site.
The Journal of biological chemistry 1981;256(9):4205-10.
1980: D Martin Watterson; D B Iverson; L J Van Eldik
Spinach calmodulin: isolation, characterization, and comparison with vertebrate calmodulins.
Biochemistry 1980;19(25):5762-8.
1980: L J Van Eldik; G Piperno; D Martin Watterson
Similarities and dissimilarities between calmodulin and a Chlamydomonas flagellar protein.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(8):4779-83.
1980: D Martin Watterson; P A Mendel; T C Vanaman
Comparison of calcium-modulated proteins from vertebrate brains.
Biochemistry 1980;19(12):2672-6.
1980: D A Flockhart; D Martin Watterson; J D Corbin
Studies on functional domains of the regulatory subunit of bovine heart adenosine 3':5'-monophosphate-dependent protein kinase.
The Journal of biological chemistry 1980;255(10):4435-40.
1980: D Martin Watterson; D B Iverson; L J Van Eldik
Rapid separation and quantitation of 3',5'-cyclic nucleotides and 5'-nucleotides in phosphodiesterase reaction mixtures using high-performance liquid chromatography.
Journal of biochemical and biophysical methods 1980;2(3):139-46.
1980: D Martin Watterson; F Sharief; T C Vanaman
The complete amino acid sequence of the Ca2+-dependent modulator protein (calmodulin) of bovine brain.
The Journal of biological chemistry 1980;255(3):962-75.
1980: L J Van Eldik; D Martin Watterson
Reproducible production and characterization of anti-calmodulin antisera.
Annals of the New York Academy of Sciences 1980;356():437-8.
1980: D R Marshak; L J Van Eldik; D Martin Watterson
Isolation of a protein from brain using calcium-dependent affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates.
Annals of the New York Academy of Sciences 1980;356():410-1.
1980: B W Erickson; D Martin Watterson; D R Marshak
Sequence alignment of calmodulin domains by metric analysis.
Annals of the New York Academy of Sciences 1980;356():378-9.
1980: L J Van Eldik; G Piperno; D Martin Watterson
Comparative biochemistry of calmodulins and calmodulin-like proteins.
Annals of the New York Academy of Sciences 1980;356():36-42.
1979: L J Van Eldik; D Martin Watterson
Characterization of a calcium-modulated protein from transformed chicken fibroblasts.
The Journal of biological chemistry 1979;254(20):10250-5.
1976: D Martin Watterson; T C Vanaman
Affinity chromatography purification of a cyclic nucleotide phosphodiesterase using immobilized modulator protein, a troponin C-like protein from brain.
Biochemical and biophysical research communications 1976;73(1):40-6.
1976: D Martin Watterson; W G Harrelson; P M Keller; F Sharief; T C Vanaman
Structural similarities between the Ca2+-dependent regulatory proteins of 3':5'-cyclic nucleotide phosphodiesterase and actomyosin ATPase.
The Journal of biological chemistry 1976;251(15):4501-13.
1976: D Martin Watterson; L J Van Eldik; R E Smith; T C Vanaman
Calcium-dependent regulatory protein of cyclic nucleotide metabolism in normal and transformed chicken embryo fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1976;73(8):2711-5.