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Emmanuelle Waubant

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TOP 3
Jiameng Zhang; Gary Cutter; Emmanuelle Waubant; Jerry S Wolinsky; Robert Glanzman
EDSS variability before randomization may limit treatment discovery in primary progressive MS.
Tanuja Chitnis; Angelo Ghezzi; Andrew Kornberg; Lauren B Krupp; Daniela Pohl; Kevin Rostasy; Marc Tardieu; Silvia Tenembaum; Maria Pia Amato; Brenda L Banwell; Amit Bar-Or; Emmanuelle Waubant; Evangeline Wassmer
International Pediatric MS Study Group Clinical Trials Summit: meeting report.
Sabeen Lulu; Emmanuelle Waubant
Humoral-targeted immunotherapies in multiple sclerosis.

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2013: Jiameng Zhang; Gary Cutter; Emmanuelle Waubant; Jerry S Wolinsky; Robert Glanzman
EDSS variability before randomization may limit treatment discovery in primary progressive MS.
Multiple sclerosis (Houndmills, Basingstoke, England) 2013;19(6):775-81.
2013: Tanuja Chitnis; Angelo Ghezzi; Andrew Kornberg; Lauren B Krupp; Daniela Pohl; Kevin Rostasy; Marc Tardieu; Silvia Tenembaum; Maria Pia Amato; Brenda L Banwell; Amit Bar-Or; Emmanuelle Waubant; Evangeline Wassmer
International Pediatric MS Study Group Clinical Trials Summit: meeting report.
Neurology 2013;80(12):1161-8.
2013: Sabeen Lulu; Emmanuelle Waubant
Humoral-targeted immunotherapies in multiple sclerosis.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2013;10(1):34-43.
2013: Laura Julian; Lauren B Krupp; Jayne Ness; Ellen O'Donnell; Joy Parrish; Marc Patterson; Thomas Preston; Moses Rodriguez; Dana Serafin; Emmanuelle Waubant; Bianca Weinstock-Guttman; Ann Yeh; Michael Zaccariello; Joseph Ackerson; Anita Belman; Ralph Benedict; Ellen Braaten; Tanya Brown; Leigh Charvet; Tanuja Chitnis; Mark Gorman
Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network.
Journal of child neurology 2013;28(1):102-7.
2012: Ellen M Mowry; Darin T Okuda; Mary C Owen; Don Brenneman; Monica Bucci; Alan A Evangelista; Pierre-Antoine Gourraud; Stephen L Hauser; Robin R Lincoln; Charles E McCulloch; Pamela Qualley; Emmanuelle Waubant; Daniel Pelletier
Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis.
Annals of neurology 2012;72(2):234-40.
2012: Anne H Cross; Emmanuelle Waubant
Antibodies to potassium channels in multiple sclerosis.
The New England journal of medicine 2012;367(2):172-4.
2012: Alex J Fay; Ellen M Mowry; Jonathan Strober; Emmanuelle Waubant
Relapse severity and recovery in early pediatric multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 2012;18(7):1008-12.
2012: Emmanuelle Waubant
Overview of treatment options in multiple sclerosis.
The Journal of clinical psychiatry 2012;73(6):e22.
2012: Emmanuelle Waubant; B Weinstock-Guttman; Scott S Zamvil; Amit Bar-Or; Peter A Calabresi; J A Cohen; A Cross; L Ding; A Goodman; D Iklé; N Kachuck; M Kita; H Kopetskie; Michele K Mass; A Miller; Masoud Mokhtarani; S Murphy; Daniel Pelletier; Jana Preiningerova; M Racke; E Rosenberg; S Schwid; C Spencer; Olaf Stüve; Timothy L Vollmer
Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.
Neurology 2012;78(15):1171-8.
2012: Emmanuelle Waubant
Early recognition and diagnosis of multiple sclerosis.
The Journal of clinical psychiatry 2012;73(4):e14.
2012: Emmanuelle Waubant
Improving outcomes in multiple sclerosis through early diagnosis and effective management.
The primary care companion to CNS disorders 2012;14(5):.
2011: Annette Langer-Gould; Emmanuelle Waubant; Y Yeung; J L Zhang; J Chung; J Yao
Incidence of acquired CNS demyelinating syndromes in a multiethnic cohort of children.
Neurology 2011;77(12):1143-8.
2011: Emmanuelle Waubant; B Weinstock-Guttman; E A Yeh; A Belman; Dorothee Chabas; Tanuja Chitnis; M Gorman; J A James; L Krupp; N Kuntz; J McDonald; M Milazzo; E M Mowry; J Ness; Jorge R Oksenberg; M Rodriguez; J Strober
Common viruses associated with lower pediatric multiple sclerosis risk.
Neurology 2011;76(23):1989-95.
2011: Ellen M Mowry; Judith A James; Lauren B Krupp; Emmanuelle Waubant
Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) 2011;17(6):666-71.
2011: Tanuja Chitnis; Lauren Krupp; Ann Yeh; Jennifer Rubin; Nancy Kuntz; Jonathan B Strober; Dorothee Chabas; Bianca Weinstock-Guttmann; Jayne Ness; Moses Rodriguez; Emmanuelle Waubant
Pediatric multiple sclerosis.
Neurologic clinics 2011;29(2):481-505.
2011: E Ann Yeh; Emmanuelle Waubant; Lauren B Krupp; Jayne Ness; Tanuja Chitnis; Nancy Kuntz; Murali Ramanathan; Anita Belman; Dorothee Chabas; Mark P Gorman; Moses Rodriguez; John Robert Rinker; Bianca Weinstock-Guttman
Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis.
Archives of neurology 2011;68(4):437-44.
2011: Chris H Polman; Stephen C Reingold; Brenda Banwell; Michel Clanet; Jeffrey A Cohen; Massimo Filippi; Kazuo Fujihara; Eva Havrdova; Michael Hutchinson; Ludwig Kappos; Fred D Lublin; Xavier Montalban; Paul O'Connor; Magnhild Sandberg-Wollheim; Alan J Thompson; Emmanuelle Waubant; Brian Weinshenker; Jerry S Wolinsky
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria.
Annals of neurology 2011;69(2):292-302.
2011: Anne H Cross; Emmanuelle Waubant
MS and the B cell controversy.
Biochimica et biophysica acta 2011;1812(2):231-8.
2011: Charlotte E Teunissen; Hayrettin Tumani; Vincent van Pesch; Emmanuelle Waubant; Christian Wolf; Jeffrey L Bennett; Frode S Berven; Lou Brundin; Manuel Comabella; Florian Deisenhammer; Jette L Federiksen; John O Fleming; Diego Franciotta; Roberto Furlan; Gavin Giovannoni; Rogier Q Hintzen; Steven Hughes; Connie R Jimenez; Michael H Johnson; Joep Killestein; Eva Krasulova; Jens Kuhle; Maria Chiara Magnone; Axel Petzold; Cecilia Rajda; Konrad Rejdak; Hollie K Schmidt; Bernhard Hemmer
Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies.
Multiple sclerosis international 2011;2011():246412.
2011: Tamara Castillo-Trivino; Ellen M Mowry; Alberto Gajofatto; Dorothee Chabas; Elizabeth Crabtree-Hartman; Bruce A C Cree; Douglas S Goodin; Ari J Green; Darin T Okuda; Daniel Pelletier; Scott S Zamvil; Eric Vittinghoff; Emmanuelle Waubant
Switching multiple sclerosis patients with breakthrough disease to second-line therapy.
PloS one 2011;6(2):e16664.
2010: Ellen M Mowry; Emmanuelle Waubant
Pediatric multiple sclerosis.
Continuum (Minneapolis, Minn.) 2010;16(5 Multiple Sclerosis):181-92.
2010: Ellen M Mowry; Laura Julian; Sunny Im-Wang; Dorothee Chabas; Alice J Galvin; Jonathan B Strober; Emmanuelle Waubant
Health-related quality of life is reduced in pediatric multiple sclerosis.
Pediatric neurology 2010;43(2):97-102.
2010: Ellen M Mowry; Lauren B Krupp; Maria Milazzo; Dorothee Chabas; Jonathan B Strober; Anita L Belman; Jamie C McDonald; Jorge R Oksenberg; Peter Bacchetti; Emmanuelle Waubant
Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis.
Annals of neurology 2010;67(5):618-24.
2010: Amit Bar-Or; Lama Fawaz; Boli Fan; Peter J Darlington; Aja Rieger; Christine Ghorayeb; Peter A Calabresi; Emmanuelle Waubant; Stephen L Hauser; Jiameng Zhang; Craig H Smith
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?
Annals of neurology 2010;67(4):452-61.
2010: Nancy L Kuntz; Dorothee Chabas; Bianca Weinstock-Guttman; Tanuja Chitnis; E Ann Yeh; Lauren Krupp; Jayne Ness; Moses Rodriguez; Emmanuelle Waubant
Treatment of multiple sclerosis in children and adolescents.
Expert opinion on pharmacotherapy 2010;11(4):505-20.
2010: Bruce Cree; Emmanuelle Waubant
Does race matter for multiple sclerosis?
Neurology 2010;74(7):532-3.
2009: E Ann Yeh; Tanuja Chitnis; Lauren Krupp; Jayne Ness; Dorothée Chabas; Nancy Kuntz; Emmanuelle Waubant
Pediatric multiple sclerosis.
Nature reviews. Neurology 2009;5(11):621-31.
2009: Kathleen Hawker; Paul O'Connor; Mark S Freedman; Peter A Calabresi; Jack Antel; Jack Simon; Stephen Hauser; Emmanuelle Waubant; Timothy Vollmer; Hillel Panitch; Jiameng Zhang; Peter Chin; Craig H Smith
Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial.
Annals of neurology 2009;66(4):460-71.
2009: Emmanuelle Waubant; Dorothee Chabas; Darin T Okuda; Orit Glenn; Ellen Mowry; Roland G Henry; Jonathan B Strober; Bruno Soares; Max Wintermark; Daniel Pelletier
Difference in disease burden and activity in pediatric patients on brain magnetic resonance imaging at time of multiple sclerosis onset vs adults.
Archives of neurology 2009;66(8):967-71.
2009: Ellen M Mowry; Mila Pesic; Barbara Grimes; Serina R Deen; Peter Bacchetti; Emmanuelle Waubant
Clinical predictors of early second event in patients with clinically isolated syndrome.
Journal of neurology 2009;256(7):1061-6.
2009: Craig H Smith; Emmanuelle Waubant; Annette Langer-Gould
Absence of neuromyelitis optica IgG antibody in an active relapsing-remitting multiple sclerosis population.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2009;29(2):104-6.
2009: E M Mowry; A Beheshtian; Emmanuelle Waubant; Douglas Goodin; Bruce A C Cree; P Qualley; Robin R Lincoln; M F George; R Gomez; Stephen L Hauser; D T Okuda; Daniel Pelletier
Quality of life in multiple sclerosis is associated with lesion burden and brain volume measures.
Neurology 2009;72(20):1760-5.
2009: Emmanuelle Waubant; Dorothee Chabas
Pediatric multiple sclerosis.
Current treatment options in neurology 2009;11(3):203-10.
2009: E M Mowry; S Deen; I Malikova; J Pelletier; Peter Bacchetti; Emmanuelle Waubant
The onset location of multiple sclerosis predicts the location of subsequent relapses.
Journal of neurology, neurosurgery, and psychiatry 2009;80(4):400-3.
2009: D T Okuda; E M Mowry; A Beheshtian; Emmanuelle Waubant; Sergio E Baranzini; Douglas Goodin; Stephen L Hauser; D Pelletier
Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome.
Neurology 2009;72(9):800-5.
2009: E M Mowry; M Pesic; B Grimes; S Deen; P Bacchetti; Emmanuelle Waubant
Demyelinating events in early multiple sclerosis have inherent severity and recovery.
Neurology 2009;72(7):602-8.
2009: D T Okuda; Radhika Srinivasan; Jorge R Oksenberg; Douglas Goodin; Sergio E Baranzini; A Beheshtian; Emmanuelle Waubant; Scott S Zamvil; David Leppert; P Qualley; Robin R Lincoln; R Gomez; Stacy J Caillier; M George; Juehu Wang; Sarah J Nelson; Bruce A C Cree; Stephen L Hauser; Daniel Pelletier
Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.
Brain : a journal of neurology 2009;132(Pt 1):250-9.
2008: S Deen; P Bacchetti; A High; Emmanuelle Waubant
Predictors of the location of multiple sclerosis relapse.
Journal of neurology, neurosurgery, and psychiatry 2008;79(10):1190-3.
2008: Dorothee Chabas; Jonathan Strober; Emmanuelle Waubant
Pediatric multiple sclerosis.
Current neurology and neuroscience reports 2008;8(5):434-41.
2008: Amit Bar-Or; Peter A Calabresi; Douglas Arnold; Douglas Arnlod; Clyde Markowitz; Stuart Shafer; Lloyd H Kasper; Emmanuelle Waubant; Suzanne Gazda; Robert J Fox; Michael Panzara; Neena Sarkar; Sunil Agarwal; Craig H Smith
Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial.
Annals of neurology 2008;63(3):395-400.
2008: Stephen L Hauser; Emmanuelle Waubant; Douglas L Arnold; Timothy L Vollmer; Jack Antel; Robert J Fox; Amit Bar-Or; Michael Panzara; Neena Sarkar; Sunil Agarwal; Annette Langer-Gould; Craig H Smith
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.
The New England journal of medicine 2008;358(7):676-88.
2007: Brenda L Banwell; Lauren B Krupp; Julia Kennedy; Raymond Tellier; Silvia Tenembaum; Jayne Ness; Anita L Belman; Alexei Boiko; Olga Bykova; Emmanuelle Waubant; Jean K Mah; Cristina Stoian; Marcelo Kremenchutzky; Maria Rita Bardini; Martino Ruggieri; Mary Rensel; Jin Hahn; Bianca Weinstock-Guttman; E Ann Yeh; Kevin Farrell; Mark Freedman; Matti Iivanainen; Meri Sevon; Virender Bhan; Marie-Emmanuelle Dilenge; Derek Stephens; Amit Bar-Or
Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study.
Lancet neurology 2007;6(9):773-81.
2007: Aaron B Kantor; Jun Deng; Emmanuelle Waubant; Hua Lin; Christopher H Becker; Joseph R Lacy; Andrea M Perrone; Donald Bennett; Susan E Goelz
Identification of short-term pharmacodynamic effects of interferon-beta-1a in multiple sclerosis subjects with broad- based phenotypic profiling.
Journal of neuroimmunology 2007;188(1-2):103-16.
2007: Anita L Belman; Tanuja Chitnis; Christel Renoux; Emmanuelle Waubant
Challenges in the classification of pediatric multiple sclerosis and future directions.
Neurology 2007;68(16 Suppl 2):S70-4.
2007: Daniela Pohl; Emmanuelle Waubant; Brenda L Banwell; Dorothée Chabas; Tanuja Chitnis; Bianca Weinstock-Guttman; Silvia Tenembaum
Treatment of pediatric multiple sclerosis and variants.
Neurology 2007;68(16 Suppl 2):S54-65.
2006: T West; M Wyatt; A High; A Bostrom; Emmanuelle Waubant
Are initial demyelinating event recovery and time to second event under differential control?
Neurology 2006;67(5):809-13.
2006: Dorothée Chabas; Ari J Green; Emmanuelle Waubant
Pediatric multiple sclerosis.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006;3(2):264-75.
2006: Emmanuelle Waubant
Biomarkers indicative of blood-brain barrier disruption in multiple sclerosis.
Disease markers 2006;22(4):235-44.
2005: Darin T Okuda; Abraham S C Chyung; Cynthia T Chin; Emmanuelle Waubant
Acute pathological laughter.
Movement disorders : official journal of the Movement Disorder Society 2005;20(10):1389-90.
2005: Emmanuelle Waubant; A Dessa Sadovnick
Interferon beta babies.
Neurology 2005;65(6):788-9.
2005: Bruce A C Cree; S Lamb; K Morgan; A Chen; Emmanuelle Waubant; Claude P Genain
An open label study of the effects of rituximab in neuromyelitis optica.
Neurology 2005;64(7):1270-2.
2005: Bruno Stankoff; Emmanuelle Waubant; Christian Confavreux; Gilles Edan; Marc Debouverie; Lucien Rumbach; Thibault Moreau; J Pelletier; Catherine Lubetzki; Michel Clanet
Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study.
Neurology 2005;64(7):1139-43.
2003: Emmanuelle Waubant; Sophie Tezenas du Montcel; Charles Jedynak; Michaël Obadia; Hassan Hosseini; Philippe Damier; Catherine Lubetzki; Yves Agid; Jean-Denis Degos
Multiple sclerosis tremor and the Stewart-Holmes manoeuvre.
Movement disorders : official journal of the Movement Disorder Society 2003;18(8):948-52.
2003: Emmanuelle Waubant; Sandra Vukusic; Laurence Gignoux; F Durand Dubief; Iuliana Achiti; S Blanc; Christel Renoux; Christian Confavreux
Clinical characteristics of responders to interferon therapy for relapsing MS.
Neurology 2003;61(2):184-9.
2003: Emmanuelle Waubant
Emerging disease modifying therapies for multiple sclerosis.
Expert opinion on emerging drugs 2003;8(1):145-61.
2003: Emmanuelle Waubant; Donald Goodkin; A Bostrom; P Bacchetti; J Hietpas; Raija L P Lindberg; David Leppert
IFNbeta lowers MMP-9/TIMP-1 ratio, which predicts new enhancing lesions in patients with SPMS.
Neurology 2003;60(1):52-7.
2002: David Brassat; Christian Recher; Emmanuelle Waubant; Emmanuelle Le Page; Françoise Rigal-Huguet; Guy Laurent; Gilles Edan; Michel Clanet
Therapy-related acute myeloblastic leukemia after mitoxantrone treatment in a patient with MS.
Neurology 2002;59(6):954-5.
2001: Emmanuelle Waubant; J Hietpas; T Stewart; Z Dyme; J Herbert; J Lacy; C Miller; Mary Rensel; S Schwid; Donald Goodkin
Interferon beta-1a in children with multiple sclerosis is well tolerated.
Neuropediatrics 2001;32(4):211-3.
2001: Emmanuelle Waubant; L Gee; K Miller; G Stabler; Donald Goodkin
IFN-beta1a may increase serum levels of TIMP-1 in patients with relapsing-remitting multiple sclerosis.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(3):181-5.
2001: Emmanuelle Waubant; L Gee; P Bacchetti; R Sloan; anne cotleur; R Rudick; Donald Goodkin
Relationship between serum levels of IL-10, MRI activity and interferon beta-1a therapy in patients with relapsing remitting MS.
Journal of neuroimmunology 2001;112(1-2):139-45.
2000: Joyce Suhy; WD Rooney; Donald Goodkin; Arístides A Capizzano; Brian J Soher; Andrew A Maudsley; Emmanuelle Waubant; PB Andersson; Michael Weiner
1H MRSI comparison of white matter and lesions in primary progressive and relapsing-remitting MS.
Multiple sclerosis (Houndmills, Basingstoke, England) 2000;6(3):148-55.
2000: M Kita; D E Goodkin; P Bacchetti; Emmanuelle Waubant; Sarah J Nelson; Sharmila Majumdar
Magnetization transfer ratio in new MS lesions before and during therapy with IFNbeta-1a.
Neurology 2000;54(9):1741-5.
2000: D E Goodkin; M Shulman; J Winkelhake; Emmanuelle Waubant; P Andersson; T Stewart; S Nelson; N Fischbein; P K Coyle; E Frohman; L Jacobs; J Holcenberg; M Lee; S Mocci
A phase I trial of solubilized DR2:MBP84-102 (AG284) in multiple sclerosis.
Neurology 2000;54(7):1414-20.
2000: Emmanuelle Waubant; D Goodkin
Methodological problems in evaluating efficacy of a treatment in multiple sclerosis.
Pathologie-biologie 2000;48(2):104-13.
1999: Emmanuelle Waubant; Donald Goodkin; L Gee; P Bacchetti; R Sloan; T Stewart; PB Andersson; G Stabler; K Miller
Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis.
Neurology 1999;53(7):1397-401.
1999: Emmanuelle Waubant; Donald Goodkin; R Sloan; PB Andersson
A pilot study of MRI activity before and during interferon beta-1a therapy.
Neurology 1999;53(4):874-6.
1999: PB Andersson; Emmanuelle Waubant; L Gee; Donald Goodkin
Multiple sclerosis that is progressive from the time of onset: clinical characteristics and progression of disability.
Archives of neurology 1999;56(9):1138-42.
1999: Emmanuelle Waubant; R Sloan; PB Andersson; Donald Goodkin
[Effect of weekly intramuscular interferon beta-1a on MRI lesions in patients with relapsing multiple sclerosis].
Revue neurologique 1999;155 Suppl 2():S20-3.
1999: Emmanuelle Waubant; Donald Goodkin
[How phase III therapeutic trials in multiple sclerosis should be evaluated: advances and challenges].
Revue neurologique 1999;155 Suppl 2():S7-12.
1998: Donald Goodkin; WD Rooney; R Sloan; P Bacchetti; L Gee; M Vermathen; Emmanuelle Waubant; M Abundo; Sharmila Majumdar; Sarah J Nelson; Michael Weiner
A serial study of new MS lesions and the white matter from which they arise.
Neurology 1998;51(6):1689-97.
1998: Emmanuelle Waubant; M B Delisle; A Bonafé; F Gray; Michel Clanet
Cervical cord glioma in an HIV-positive patient.
European neurology 1998;39(1):58-60.
1997: Emmanuelle Waubant; Marion Simonetta-Moreau; Michel Clanet; Isabelle Berry; A Bonafé
Left arm monoballism as a relapse in multiple sclerosis.
Movement disorders : official journal of the Movement Disorder Society 1997;12(6):1091-2.
1997: Emmanuelle Waubant; Claude Manelfe; A Bonafé; Isabelle Berry; Michel Clanet
MRI of intramedullary sarcoidosis: follow-up of a case.
Neuroradiology 1997;39(5):357-60.
1997: PB Andersson; Emmanuelle Waubant; D E Goodkin
How should we proceed with disease-modifying treatments for multiple sclerosis?
Lancet 1997;349(9052):586-7.
1996: David Leppert; Emmanuelle Waubant; M R Bürk; J R Oksenberg; Stephen L Hauser
Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: a possible mechanism for treatment efficacy in multiple sclerosis.
Annals of neurology 1996;40(6):846-52.
1996: Jean-François Albucher; Pierre Carles; J Giron; Emmanuelle Waubant; Bernard Guiraud-Chaumeil; François Chollet; Michel Clanet
[Ischemic cerebrovascular complications in Rendu-Osler disease: a case].
Revue neurologique 1996;152(4):283-7.
1995: David Leppert; Emmanuelle Waubant; R Galardy; N W Bunnett; Stephen L Hauser
T cell gelatinases mediate basement membrane transmigration in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(9):4379-89.