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David Webb

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Wei Leng Teoh; Liesbeth A F Van Look; David J Webb; Ian B Wilkinson; Rachel M Williamson; Brian M Frier; Rupert A Payne; Jackie F Price; Rebecca M Reynolds; Mark W J Strachan
Metabolic parameters associated with arterial stiffness in older adults with Type 2 diabetes: the Edinburgh Type 2 diabetes study.
Emma J Turtle; Louise E Bath; Martin Denvir; Ailsa Gebbie; Saeed Mirsadraee; Ashish A Sule; David J Webb
Assessing and addressing cardiovascular risk in adults with Turner syndrome.
Teresa M Attinà; Iain D Drummond; Lorenzo S Malatino; Simon R J Maxwell; David J Webb
Phosphodiesterase type 5 inhibition improves arterial stiffness after exercise but not exercise capacity in hypertensive men.

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2013: Wei Leng Teoh; Liesbeth A F Van Look; David J Webb; Ian B Wilkinson; Rachel M Williamson; Brian M Frier; Rupert A Payne; Jackie F Price; Rebecca M Reynolds; Mark W J Strachan
Metabolic parameters associated with arterial stiffness in older adults with Type 2 diabetes: the Edinburgh Type 2 diabetes study.
Journal of hypertension 2013;31(5):1010-7.
2013: Emma J Turtle; Louise E Bath; Martin Denvir; Ailsa Gebbie; Saeed Mirsadraee; Ashish A Sule; David J Webb
Assessing and addressing cardiovascular risk in adults with Turner syndrome.
Clinical endocrinology 2013;78(5):639-45.
2013: Teresa M Attinà; Iain D Drummond; Lorenzo S Malatino; Simon R J Maxwell; David J Webb
Phosphodiesterase type 5 inhibition improves arterial stiffness after exercise but not exercise capacity in hypertensive men.
American journal of hypertension 2013;26(3):342-50.
2013: H K Ruben Thanacoody; Simon Hl Thomas; David J Webb; Judy Coyle; James W Dear; Michael Eddleston; Alasdair Gray; Steff Lewis; Euan A Sandilands; D Nicholas Bateman
Scottish and Newcastle Antiemetic Pre-treatment for paracetamol poisoning study (SNAP).
BMC pharmacology & toxicology 2013;14():20.
2013: Neeraj Dhaun; Jane Goddard; Neil R Johnston; Vanessa Melville; Dinesh K Talwar; Scott Blackwell; David J Webb
Endothelin-A receptor antagonism modifies cardiovascular risk factors in CKD.
Journal of the American Society of Nephrology : JASN 2013;24(1):31-6.
2012: Jonathan D Towler; Neeraj Dhaun; Jane Goddard; Margaret MacDougall; Vanessa Melville; David J Webb
What is the best method of proteinuria measurement in clinical trials of endothelin receptor antagonists?
Life sciences 2012;91(13-14):733-8.
2012: Lowell Ling; Janet J Maguire; David J Webb; Graeme J M Alexander; Neil J Davie; Paul Gibbs; Rhoda E Kuc; Anthony P Davenport
Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice.
Life sciences 2012;91(13-14):716-22.
2012: Nicholas S Kirkby; Yuri Kotelevtsev; Eileen Miller; David J Webb; Alan Bagnall; Karolina M Duthie; Patrick W F Hadoke
Non-endothelial cell endothelin-B receptors limit neointima formation following vascular injury.
Cardiovascular research 2012;95(1):19-28.
2012: David J Webb
UK medicines policy: the role of clinical pharmacologists.
British journal of clinical pharmacology 2012;73(6):948-52.
2012: Stelios Kokkoris; Peter Andrews; David J Webb
Role of calcitonin gene-related peptide in cerebral vasospasm, and as a therapeutic approach to subarachnoid hemorrhage.
Frontiers in endocrinology 2012;3():135.
2012: Euan A Sandilands; Adrian Thompson; Neal Uren; David J Webb; Nicholas Bateman; Lesley Briody; Sharon Cameron; Jane Crowe; Sam Donaldson; Julie Donnelly; Jane Goddard; Neil R Johnston; Ivor Mackenzie; Ian L Megson; Frances Paterson; Michael Eddleston
Mechanisms for an effect of acetylcysteine on renal function after exposure to radio-graphic contrast material: study protocol.
BMC clinical pharmacology 2012;12():3.
2012: Jonathan M Street; Tim S Walsh; David J Webb; Stefan Weidt; Craig Balmforth; Perdita E Barran; Rod T A Chalmers; C Logan Mackay; James W Dear
Identification and proteomic profiling of exosomes in human cerebrospinal fluid.
Journal of translational medicine 2012;10():5.
2011: James W Dear; Kevin Dhaliwal; Tineke Huizinga; Melianthe P J Nicolai; Kenneth J Simpson; Jonathan Street; D Nicholas Bateman; James H Catterson; Darren G Craig; Sheila Webb; David J Webb
Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(6):3347-52.
2011: David J Webb
Value-based medicine pricing: NICE work?
Lancet 2011;377(9777):1552-3.
2011: Pajaree Lilitkarntakul; Neeraj Dhaun; Vanessa Melville; Scott Blackwell; Dinesh K Talwar; Barbara Liebman; Takae Asai; Jennifer Pollock; Jane Goddard; David J Webb
Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity.
Atherosclerosis 2011;216(1):217-25.
2011: Neeraj Dhaun; Iain M MacIntyre; Debbie Kerr; Vanessa Melville; Neil R Johnston; Scott Haughie; Jane Goddard; David J Webb
Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney disease.
Hypertension 2011;57(4):772-9.
2011: Neeraj Dhaun; David J Webb
Dual endothelin-converting enzyme/neutral endopeptidase inhibition: a novel treatment for renovascular hypertension beyond blood pressure lowering?
Hypertension 2011;57(4):667-9.
2011: Matthew G D Bates; Nikhil Hirani; John B Irving; Andrew I Sutherland; A A Roger Thompson; J Kenneth Baillie; David J Webb
Sildenafil citrate for the prevention of high altitude hypoxic pulmonary hypertension: double blind, randomized, placebo-controlled trial.
High altitude medicine & biology 2011;12(3):207-14.
2011: Neeraj Dhaun; Jane Goddard; David J Webb
Endothelin antagonism in patients with nondiabetic chronic kidney disease.
Contributions to nephrology 2011;172():243-54.
2011: Nicholas S Kirkby; Lucinda Low; Jonathan R Seckl; Brian R Walker; David J Webb; Patrick W F Hadoke
Quantitative 3-dimensional imaging of murine neointimal and atherosclerotic lesions by optical projection tomography.
PloS one 2011;6(2):e16906.
2011: Euan A Sandilands; Karen Reid; Laura Shaw; D Nicholas Bateman; David J Webb; Neeraj Dhaun; David C Kluth
Impact of a focussed teaching programme on practical prescribing skills among final year medical students.
British journal of clinical pharmacology 2011;71(1):29-33.
2011: Graeme A Deuchar; Danielle McLean; Patrick W F Hadoke; David G Brownstein; David J Webb; John J Mullins; Karen Chapman; Jonathan R Seckl; Yuri V Kotelevtsev
11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice.
Endocrinology 2011;152(1):236-46.
2010: Rupert A Payne; Pajaree Lilitkarntakul; Neeraj Dhaun; Vanessa Melville; Takae Asai; Jane Goddard; David J Webb
Renal dysfunction does not affect the peripheral-to-central arterial pressure transfer function.
Hypertension 2010;56(6):1083-8.
2010: David J Webb
DORADO: opportunity postponed: lessons from studies of endothelin receptor antagonists in treatment-resistant hypertension.
Hypertension 2010;56(5):806-7.
2010: James J Oliver; James W Dear; Victoria E C Hughes; David J Webb
Clinical potential of combined organic nitrate and phosphodiesterase type 5 inhibitor in treatment-resistant hypertension.
Hypertension 2010;56(1):62-7.
2010: N F Kelland; R E Kuc; D L McLean; A Azfer; Alan Bagnall; Gillian A Gray; F H Gulliver-Sloan; J J Maguire; A P Davenport; Yuri Kotelevtsev; David J Webb
Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1.
Canadian journal of physiology and pharmacology 2010;88(6):644-51.
2010: Iain M MacIntyre; Neeraj Dhaun; Pajaree Lilitkarntakul; Vanessa Melville; Jane Goddard; David J Webb
Greater functional ETB receptor antagonism with bosentan than sitaxsentan in healthy men.
Hypertension 2010;55(6):1406-11.
2010: Neeraj Dhaun; Jane Goddard; David J Webb
An endothelin antagonist for resistant hypertension.
Lancet 2010;375(9715):635; author reply 636-7.
2010: Rupert A Payne; Ian B Wilkinson; David J Webb
Arterial stiffness and hypertension: emerging concepts.
Hypertension 2010;55(1):9-14.
2010: N F Kelland; Alan Bagnall; I Morecroft; F H Gulliver-Sloan; Y Dempsie; M Nilsen; M Yanagisawa; M R Maclean; Yuri Kotelevtsev; David J Webb
Endothelial ET(B) limits vascular remodelling and development of pulmonary hypertension during hypoxia.
Journal of vascular research 2010;47(1):16-22.
2009: Jeremy P Langrish; Magnus Lundbäck; Nicholas L Mills; Neil R Johnston; David J Webb; Thomas Sandström; Anders Blomberg; David E Newby
Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans.
Hypertension 2009;54(4):910-5.
2009: Neeraj Dhaun; Iain M Macintyre; Vanessa Melville; Pajaree Lilitkarntakul; Neil R Johnston; Jane Goddard; David J Webb
Effects of endothelin receptor antagonism relate to the degree of renin-angiotensin system blockade in chronic proteinuric kidney disease.
Hypertension 2009;54(3):e19-20.
2009: Neeraj Dhaun; Iain M Macintyre; Vanessa Melville; Pajaree Lilitkarntakul; Neil R Johnston; Jane Goddard; David J Webb
Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease.
Hypertension 2009;54(1):113-9.
2009: Rebecca M Reynolds; B Ilyas; J F Price; F G R Fowkes; David E Newby; David J Webb; Brian R Walker
Circulating plasma cortisol concentrations are not associated with coronary artery disease or peripheral vascular disease.
QJM : monthly journal of the Association of Physicians 2009;102(7):469-75.
2009: Neeraj Dhaun; Pajaree Lilitkarntakul; Iain M Macintyre; Eline Muilwijk; Neil R Johnston; David C Kluth; David J Webb; Jane Goddard
Urinary endothelin-1 in chronic kidney disease and as a marker of disease activity in lupus nephritis.
American journal of physiology. Renal physiology 2009;296(6):F1477-83.
2009: Jeremy P Langrish; Nicholas L Mills; Louise E Bath; Pamela Warner; David J Webb; C J H Kelnar; Hilary Critchley; David E Newby; W Hamish B Wallace
Cardiovascular effects of physiological and standard sex steroid replacement regimens in premature ovarian failure.
Hypertension 2009;53(5):805-11.
2009: J Kenneth Baillie; A A R Thompson; J B Irving; M G D Bates; A I Sutherland; William MacNee; Simon R J Maxwell; David J Webb
Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial.
QJM : monthly journal of the Association of Physicians 2009;102(5):341-8.
2009: B Ilyas; Neeraj Dhaun; D Markie; P Stansell; Jane Goddard; David E Newby; David J Webb
Renal function is associated with arterial stiffness and predicts outcome in patients with coronary artery disease.
QJM : monthly journal of the Association of Physicians 2009;102(3):183-91.
2009: Connie Raine; David J Webb; Simon R J Maxwell
The availability of prescription-only analgesics purchased from the internet in the UK.
British journal of clinical pharmacology 2009;67(2):250-4.
2009: Catherine A Shaw; David J Webb; Adriano G Rossi; Ian L Megson
Cyclic GMP protects human macrophages against peroxynitrite-induced apoptosis.
Journal of inflammation (London, England) 2009;6():14.
2008: Iain M Macintyre; Neeraj Dhaun; Jane Goddard; David J Webb
Ambrisentan and its role in the management of pulmonary arterial hypertension.
Drugs of today (Barcelona, Spain : 1998) 2008;44(12):875-85.
2008: Alan G Japp; Nicholas L M Cruden; David A B Amer; Vivienne K Y Li; Ewan B Goudie; Neil R Johnston; Sushma Sharma; Ilene Neilson; David J Webb; Ian L Megson; Andrew D Flapan; David E Newby
Vascular effects of apelin in vivo in man.
Journal of the American College of Cardiology 2008;52(11):908-13.
2008: Neeraj Dhaun; Jane Goddard; Donald E Kohan; David M Pollock; Ernesto L Schiffrin; David J Webb
Role of endothelin-1 in clinical hypertension: 20 years on.
Hypertension 2008;52(3):452-9.
2008: Iain M MacIntyre; Neeraj Dhaun; Jane Goddard; David J Webb
Sitaxsentan sodium for pulmonary hypertension.
Drugs of today (Barcelona, Spain : 1998) 2008;44(8):585-600.
2008: Simon R J Maxwell; David J Webb
Internet pharmacy: a web of mistrust?
British journal of clinical pharmacology 2008;66(2):196-8.
2008: Teresa M Attinà; James J Oliver; Lorenzo S Malatino; David J Webb
Contribution of the M3 muscarinic receptors to the vasodilator response to acetylcholine in the human forearm vascular bed.
British journal of clinical pharmacology 2008;66(2):300-3.
2008: Amy Heaton; David J Webb; Simon R J Maxwell
Undergraduate preparation for prescribing: the views of 2413 UK medical students and recent graduates.
British journal of clinical pharmacology 2008;66(1):128-34.
2008: Neeraj Dhaun; David J Webb
Endothelin-receptor antagonism: the future is bright.
Lancet 2008;371(9630):2061-2.
2008: Ingibjörg J Gudmundsdóttir; Ninian N Lang; Nicholas A Boon; Christopher A Ludlam; David J Webb; Keith A A Fox; David E Newby
Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans.
Journal of the American College of Cardiology 2008;51(18):1749-56.
2008: Teresa M Attinà; Lorenzo S Malatino; Simon R J Maxwell; Paul L Padfield; David J Webb
Phosphodiesterase type 5 inhibition reverses impaired forearm exercise-induced vasodilatation in hypertensive patients.
Journal of hypertension 2008;26(3):501-7.
2008: Nicholas S Kirkby; Patrick W F Hadoke; Alan Bagnall; David J Webb
The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?
British journal of pharmacology 2008;153(6):1105-19.
2008: D Ross Camidge; James J Oliver; Carolyn Skinner; Ben Attwood; Fiona Nussey; Duncan Jodrell; David J Webb
The impact of prognosis without treatment on doctors' and patients' resource allocation decisions and its relevance to new drug recommendation processes.
British journal of clinical pharmacology 2008;65(2):224-9.
2008: Rupert A Payne; David J Webb
Peripheral augmentation index: shouldering the central pressure load.
Hypertension 2008;51(1):37-8.
2008: James W Ferguson; Ahmed Helmy; Christopher A Ludlam; David J Webb; Peter C Hayes; David C Newby
Hyperfibrinolysis in alcoholic cirrhosis: relative plasminogen activator inhibitor type 1 deficiency.
Thrombosis research 2008;121(5):675-80.
2007: James W Dear; Paul L Padfield; David J Webb
New guidelines for drive-by renal arteriography may lead to an unjustifiable increase in percutaneous intervention.
Heart (British Cardiac Society) 2007;93(12):1528-32.
2007: W Stephen Waring; John A McKnight; David J Webb; Simon R J Maxwell
Lowering serum urate does not improve endothelial function in patients with type 2 diabetes.
Diabetologia 2007;50(12):2572-9.
2007: Simon R J Maxwell; Ingolf Cascorbi; Michael Orme; David J Webb
Educating European (junior) doctors for safe prescribing.
Basic & clinical pharmacology & toxicology 2007;101(6):395-400.
2007: Neeraj Dhaun; Vanessa Melville; William Kramer; Fiona Stavros; Terrance Coyne; Suzanne Swan; Jane Goddard; David J Webb
The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment.
British journal of clinical pharmacology 2007;64(6):733-7.
2007: Neeraj Dhaun; David M Pollock; Jane Goddard; David J Webb
Selective and mixed endothelin receptor antagonism in cardiovascular disease.
Trends in pharmacological sciences 2007;28(11):573-9.
2007: Rupert A Payne; Chun Huat Teh; David J Webb; Simon R J Maxwell
A generalized arterial transfer function derived at rest underestimates augmentation of central pressure after exercise.
Journal of hypertension 2007;25(11):2266-72.
2007: Rupert A Payne; D Isnardi; Peter J D Andrews; Simon R J Maxwell; David J Webb
Similarity between the suprasystolic wideband external pulse wave and the first derivative of the intra-arterial pulse wave.
British journal of anaesthesia 2007;99(5):653-61.
2007: Jane Goddard; Neil R Johnston; Allan D Cumming; David J Webb
Fractional urinary excretion of endothelin-1 is reduced by acute ETB receptor blockade.
American journal of physiology. Renal physiology 2007;293(5):F1433-8.
2007: Neeraj Dhaun; Charles J Ferro; Anthony P Davenport; William G Haynes; Jane Goddard; David J Webb
Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007;22(11):3228-34.
2007: Robert V Carlson; Nadja H van Ginneken; Luisa M Pettigrew; Alan Davies; Kenneth M Boyd; David J Webb
The three official language versions of the Declaration of Helsinki: what's lost in translation?
Journal of medical ethics 2007;33(9):545-8.
2007: James W Dear; C O'Dowd; A Timoney; K R Paterson; A Walker; David J Webb
Scottish Medicines Consortium: an overview of rapid new drug assessment in Scotland.
Scottish medical journal 2007;52(3):20-6.
2007: James W Dear; David J Webb
Disease mongering -- a challenge for everyone involved in healthcare.
British journal of clinical pharmacology 2007;64(2):122-4.
2007: J Kenneth Baillie; Matthew G D Bates; A A Roger Thompson; W Stephen Waring; Roland W Partridge; Martin F Schnopp; Alistair Simpson; Fiona Gulliver-Sloan; Simon R J Maxwell; David J Webb
Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude.
Chest 2007;131(5):1473-8.
2007: Rupert A Payne; Roland C Hilling-Smith; David J Webb; Simon R J Maxwell; Martin A Denvir
Augmentation index assessed by applanation tonometry is elevated in Marfan Syndrome.
Journal of cardiothoracic surgery 2007;2():43.
2006: Yuqiang Ge; Alan Bagnall; Peter K Stricklett; Kevin A Strait; David J Webb; Yuri Kotelevtsev; Donald E Kohan
Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention.
American journal of physiology. Renal physiology 2006;291(6):F1274-80.
2006: Brian McKinstry; Janet Hanley; David Heaney; Lucy McCloughan; Rob Elton; David J Webb
Impact on hypertension control of a patient-held guideline: a randomised controlled trial.
The British journal of general practice : the journal of the Royal College of General Practitioners 2006;56(532):842-7.
2006: W Stephen Waring; John A McKnight; David J Webb; Simon R J Maxwell
Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers.
Diabetes 2006;55(11):3127-32.
2006: W Stephen Waring; Hannah M Sinclair; David J Webb
Effects of salbutamol and glyceryl trinitrate on large arterial stiffness are similar between patients with hypertension and adults with normal blood pressure.
British journal of clinical pharmacology 2006;62(5):621-6.
2006: Ingibjörg J Gudmundsdóttir; Ian L Megson; Jillian S Kell; Christopher A Ludlam; Keith A A Fox; David J Webb; David E Newby
Direct vascular effects of protease-activated receptor type 1 agonism in vivo in humans.
Circulation 2006;114(15):1625-32.
2006: James J Oliver; Vanessa P Melville; David J Webb
Effect of regular phosphodiesterase type 5 inhibition in hypertension.
Hypertension 2006;48(4):622-7.
2006: James W Dear; Pajaree Lilitkarntakul; David J Webb
Are rare diseases still orphans or happily adopted? The challenges of developing and using orphan medicinal products.
British journal of clinical pharmacology 2006;62(3):264-71.
2006: Rupert A Payne; David J Webb
Arterial blood pressure and stiffness in hypertension: is arterial structure important?
Hypertension 2006;48(3):366-7.
2006: Simon R J Maxwell; Rupert A Payne; Gordon D Murray; David J Webb
Selectivity of NSAIDs for COX-2 and cardiovascular outcome.
British journal of clinical pharmacology 2006;62(2):243-5.
2006: Alan Bagnall; Nicholas F Kelland; Fiona Gulliver-Sloan; Anthony P Davenport; Gillian A Gray; Masashi Yanagisawa; David J Webb; Yuri Kotelevtsev
Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt.
Hypertension 2006;48(2):286-93.
2006: Nicholas F Kelland; David J Webb
Clinical trials of endothelin antagonists in heart failure: a question of dose?
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):696-9.
2006: Ahmed Helmy; James W Ferguson; Peter C Hayes; David E Newby; David J Webb
Bradykinin does not contribute to peripheral vascular tone in patients with cirrhosis and ascites.
Journal of cardiovascular pharmacology 2006;47(4):556-60.
2006: Neeraj Dhaun; Jane Goddard; David J Webb
The endothelin system and its antagonism in chronic kidney disease.
Journal of the American Society of Nephrology : JASN 2006;17(4):943-55.
2006: A A Roger Thompson; J Kenneth Baillie; M Toshner; Simon R J Maxwell; David J Webb; J B Irving
Pericardial effusions in healthy lowlanders after acute ascent to high altitude.
Heart (British Cardiac Society) 2006;92(4):539-40.
2006: Simon R J Maxwell; David J Webb
Clinical pharmacology--too young to die?
Lancet 2006;367(9513):799-800.
2006: Eve M D Smith; J Kenneth Baillie; A A Roger Thompson; John B Irving; David Porteous; David J Webb
Endothelial nitric oxide synthase polymorphisms do not influence pulmonary artery systolic pressure at altitude.
High altitude medicine & biology 2006;7(3):221-7.
2006: Rupert A Payne; C N Symeonides; David J Webb; Simon R J Maxwell
Pulse transit time measured from the ECG: an unreliable marker of beat-to-beat blood pressure.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(1):136-41.
2005: Neeraj Dhaun; Fiona E Strachan; David E Newby; Neil R Johnston; Neville F Ford; Janis L Hammett; Maria Palmisano; David J Webb
Vasodilator effects of the endothelin ET receptor selective antagonist BMS-193884 in healthy men.
British journal of clinical pharmacology 2005;60(6):611-22.
2005: James J Oliver; David J Webb; David E Newby
Stimulated tissue plasminogen activator release as a marker of endothelial function in humans.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2470-9.
2005: Stephen J Leslie; J C S Spratt; Sinéad P McKee; Fiona E Strachan; David E Newby; David B Northridge; Martin A Denvir; David J Webb
Direct comparison of selective endothelin A and non-selective endothelin A/B receptor blockade in chronic heart failure.
Heart (British Cardiac Society) 2005;91(7):914-9.
2005: Ross Camidge; Andrew Walker; James J Oliver; Fiona Nussey; Simon Maxwell; Duncan I Jodrell; David J Webb
Prognosis without treatment as a modifier in health economic assessments.
BMJ (Clinical research ed.) 2005;330(7504):1382-4.
2005: T Attinà; R Camidge; David E Newby; David J Webb
Endothelin antagonism in pulmonary hypertension, heart failure, and beyond.
Heart (British Cardiac Society) 2005;91(6):825-31.
2005: Lynn D Greig; Stephen J Leslie; Fraser W Gibb; Sherilyn Tan; David E Newby; David J Webb
Comparative effects of glyceryl trinitrate and amyl nitrite on pulse wave reflection and augmentation index.
British journal of clinical pharmacology 2005;59(3):265-70.
2005: Simon R J Maxwell; David J Webb
COX-2 selective inhibitors--important lessons learned.
Lancet 2005;365(9458):449-51.
2005: Martin A Denvir; Isam Sharif; Tom Anderson; David J Webb; Gillian A Gray; W Norman McDicken
Influence of scanning frequency and ultrasonic contrast agent on reproducibility of left ventricular measurements in the mouse.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2005;18(2):155-62.
2004: Stephen J Leslie; Neil Johnston; Fiona E Strachan; Alan Bagnall; Gillian A Gray; David E Newby; Martin A Denvir; David J Webb
Endothelin-1[1-31] is not elevated in men with chronic heart failure.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S96-9.
2004: Stephen J Leslie; James C Spratt; Lynn Grieg; Teresa Attina; Martin A Denvir; David J Webb
The effect of cerivastatin therapy on vascular responses to endothelin antagonists in humans.
Journal of cardiovascular pharmacology 2004;44 Suppl 1():S410-2.
2004: Stephen J Leslie; Sinéad McKee; David E Newby; David J Webb; Martin A Denvir
Non-invasive measurement of cardiac output in patients with chronic heart failure.
Blood pressure monitoring 2004;9(5):277-80.
2004: Stephen J Leslie; Graham Atkins; James J Oliver; David J Webb
No adverse hemodynamic interaction between sildenafil and red wine.
Clinical pharmacology and therapeutics 2004;76(4):365-70.
2004: Jane Goddard; Corine Eckhart; Neil R Johnston; Allan D Cumming; Andrew Rankin; David J Webb
Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism.
Journal of the American Society of Nephrology : JASN 2004;15(10):2601-10.
2004: Carmel M McEniery; Matthias Schmitt; Ahmad Qasem; David J Webb; Alberto P Avolio; Ian B Wilkinson; John R Cockcroft
Nebivolol increases arterial distensibility in vivo.
Hypertension 2004;44(3):305-10.
2004: Maria Paola Pellegrini; David E Newby; Neil R Johnston; Simon Maxwell; David J Webb
Vitamin C has no effect on endothelium-dependent vasomotion and acute endogenous fibrinolysis in healthy smokers.
Journal of cardiovascular pharmacology 2004;44(1):117-24.
2004: Stephen J Leslie; Mamun Q Rahman; Martin A Denvir; David E Newby; David J Webb
Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide.
British journal of clinical pharmacology 2004;57(6):720-5.
2004: Robert V Carlson; Kenneth M Boyd; David J Webb
The revision of the Declaration of Helsinki: past, present and future.
British journal of clinical pharmacology 2004;57(6):695-713.
2004: Nicholas L M Cruden; Fraser N Witherow; David J Webb; Keith A A Fox; David E Newby
Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(6):1043-8.
2004: Stephen J Leslie; Teresa Attinà; Ellen Hultsch; Luc Bolscher; Matthias Grossman; Martin A Denvir; David J Webb
Comparison of two plethysmography systems in assessment of forearm blood flow.
Journal of applied physiology (Bethesda, Md. : 1985) 2004;96(5):1794-9.
2004: Peter A Henriksen; Mary Hitt; Zhou Xing; Jun Wang; Christopher Haslett; Rudolph A Riemersma; David J Webb; Yuri Kotelevtsev; Jean-Michel Sallenave
Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-kappa B-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4535-44.
2004: Jane Goddard; Neil R Johnston; Malcolm F Hand; Allan D Cumming; ton rabelink; Andrew Rankin; David J Webb
Endothelin-A receptor antagonism reduces blood pressure and increases renal blood flow in hypertensive patients with chronic renal failure: a comparison of selective and combined endothelin receptor blockade.
Circulation 2004;109(9):1186-93.
2004: Mark R Miller; K Okubo; MJ Roseberry; David J Webb; Ian L Megson
Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries.
Journal of cardiovascular pharmacology 2004;43(3):440-51.
2004: Andrew L McLeod; Neal G Uren; Ian B Wilkinson; David J Webb; Simon R J Maxwell; David B Northridge; David E Newby
Non-invasive measures of pulse wave velocity correlate with coronary arterial plaque load in humans.
Journal of hypertension 2004;22(2):363-8.
2004: Sinéad P McKee; Stephen J Leslie; John P LeMaitre; David J Webb; Martin A Denvir
Physician opinions on the implementation of the SIGN guideline for heart failure.
Scottish medical journal 2004;49(1):10-3.
2004: W Stephen Waring; S H Adwani; O Breukels; David J Webb; Simon R J Maxwell
Hyperuricaemia does not impair cardiovascular function in healthy adults.
Heart (British Cardiac Society) 2004;90(2):155-9.
2003: W Stephen Waring; Judith Goudsmit; John Marwick; David J Webb; Simon R J Maxwell
Acute caffeine intake influences central more than peripheral blood pressure in young adults.
American journal of hypertension 2003;16(11 Pt 1):919-24.
2003: W Stephen Waring; A Convery; V Mishra; A Shenkin; David J Webb; Simon R J Maxwell
Uric acid reduces exercise-induced oxidative stress in healthy adults.
Clinical science (London, England : 1979) 2003;105(4):425-30.
2003: Fraser N Witherow; Pamela Dawson; Christopher A Ludlam; David J Webb; Keith A A Fox; David E Newby
Bradykinin receptor antagonism and endothelial tissue plasminogen activator release in humans.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(9):1667-70.
2003: Sinéad P McKee; Stephen J Leslie; John P LeMaitre; David J Webb; Martin A Denvir
Management of chronic heart failure due to systolic left ventricular dysfunction by cardiologist and non-cardiologist physicians.
European journal of heart failure 2003;5(4):549-55.
2003: W Stephen Waring; Alastair J Thomson; Sunil H Adwani; Arendi J Rosseel; John Potter; David J Webb; Simon R J Maxwell
Cardiovascular effects of acute oxygen administration in healthy adults.
Journal of cardiovascular pharmacology 2003;42(2):245-50.
2003: Jonathan T Affolter; Sinéad P McKee; Ahmed Helmy; Richard jones; David E Newby; David J Webb
Intra-arterial vasopressin in the human forearm: pharmacodynamics and the role of nitric oxide.
Clinical pharmacology and therapeutics 2003;74(1):9-16.
2003: Stephen J Leslie; Jonathan Affolter; Martin A Denvir; David J Webb
Validation of laser Doppler flowmetry coupled with intra-dermal injection for investigating effects of vasoactive agents on the skin microcirculation in man.
European journal of clinical pharmacology 2003;59(2):99-102.
2003: James J Oliver; David J Webb
Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):554-66.
2003: Mark R Miller; Inderraj S Hanspal; Patrick W F Hadoke; David E Newby; Adriano G Rossi; David J Webb; Ian L Megson
A novel S-nitrosothiol causes prolonged and selective inhibition of platelet adhesion at sites of vascular injury.
Cardiovascular research 2003;57(3):853-60.
2002: Jonathan T Affolter; David E Newby; Ian B Wilkinson; matthew winter; Richard J Balment; David J Webb
No effect on central or peripheral blood pressure of systemic urotensin II infusion in humans.
British journal of clinical pharmacology 2002;54(6):617-21.
2002: Nicholas L M Cruden; David E Newby; David J Webb
Salmeterol for the prevention of high-altitude pulmonary edema.
The New England journal of medicine 2002;347(16):1282-5; author reply 1282-5.
2002: W Stephen Waring; David J Webb; Simon R J Maxwell
Lithium carbonate as a potential pharmacological vehicle: intravenous kinetics of single-dose administration in healthy subjects.
European journal of clinical pharmacology 2002;58(6):431-4.
2002: Charles J Ferro; William G Haynes; Malcolm F Hand; David J Webb
Forearm vasoconstriction to endothelin-1 is impaired, but constriction to sarafotoxin 6c and vasodilatation to BQ-123 unaltered, in patients with essential hypertension.
Clinical science (London, England : 1979) 2002;103 Suppl 48():53S-58S.
2002: Carmel M McEniery; Ian B Wilkinson; David G Jenkins; David J Webb
Endogenous endothelin-1 limits exercise-induced vasodilation in hypertensive humans.
Hypertension 2002;40(2):202-6.
2002: Inderraj S Hanspal; Kesson S Magid; David J Webb; Ian L Megson
The effect of oxidative stress on endothelium-dependent and nitric oxide donor-induced relaxation: implications for nitrate tolerance.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;6(3):263-70.
2002: Ian L Megson; David J Webb
Nitric oxide donor drugs: current status and future trends.
Expert opinion on investigational drugs 2002;11(5):587-601.
2002: Ian B Wilkinson; Krishna Prasad; Ian R Hall; Anne Thomas; Helen MacCallum; David J Webb; Michael P Frenneaux; John R Cockcroft
Increased central pulse pressure and augmentation index in subjects with hypercholesterolemia.
Journal of the American College of Cardiology 2002;39(6):1005-11.
2002: David E Newby; Fiona E Strachan; David J Webb
Abnormal endothelin B receptor vasomotor responses in patients with Hirschsprung's disease.
QJM : monthly journal of the Association of Physicians 2002;95(3):159-63.
2002: Sanne L de Haas; Ian B Wilkinson; J L Boyd; David J Webb
Local nitric oxide release does not affect tachyphylaxis to angiotensin II in dorsal hand veins in man in the presence of prostaglandin synthesis inhibition.
British journal of clinical pharmacology 2002;53(2):193-5.
2002: Ian B Wilkinson; Helen MacCallum; John R Cockcroft; David J Webb
Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo.
British journal of clinical pharmacology 2002;53(2):189-92.
2002: Ian B Wilkinson; Jonathan T Affolter; Sanne L de Haas; Maria Paola Pellegrini; Judith Boyd; matthew winter; Richard J Balment; David J Webb
High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man.
Cardiovascular research 2002;53(2):341-7.
2002: Ian B Wilkinson; Ahmad Qasem; Carmel M McEniery; David J Webb; Alberto P Avolio; John R Cockcroft
Nitric oxide regulates local arterial distensibility in vivo.
Circulation 2002;105(2):213-7.
2002: Ian B Wilkinson; Nadia Haj Mohammad; Sian Tyrrell; Ian R Hall; David J Webb; Vince E Paul; Terry Levy; John R Cockcroft
Heart rate dependency of pulse pressure amplification and arterial stiffness.
American journal of hypertension 2002;15(1 Pt 1):24-30.
2002: Ian B Wilkinson; Ian R Hall; Helen MacCallum; Isla S Mackenzie; Carmel M McEniery; Bart J van der Arend; Yae-Eun Shu; Laura S MacKay; David J Webb; John R Cockcroft
Pulse-wave analysis: clinical evaluation of a noninvasive, widely applicable method for assessing endothelial function.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):147-52.
2002: David E Newby; Fraser N Witherow; R A Wright; Peter Bloomfield; Christopher A Ludlam; Nicholas A Boon; Keith A A Fox; David J Webb
Hypercholesterolaemia and lipid lowering treatment do not affect the acute endogenous fibrinolytic capacity in vivo.
Heart (British Cardiac Society) 2002;87(1):48-53.
2001: J C Spratt; David J Webb; A Shiels; B Williams
Effects of candesartan on cardiac and arterial structure and function in hypertensive subjects.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2001;2(4):227-32.
2001: Ian B Wilkinson; David J Webb
Venous occlusion plethysmography in cardiovascular research: methodology and clinical applications.
British journal of clinical pharmacology 2001;52(6):631-46.
2001: C Labinjoh; David E Newby; Maria Paola Pellegrini; Neil R Johnston; Nicholas A Boon; David J Webb
Potentiation of bradykinin-induced tissue plasminogen activator release by angiotensin-converting enzyme inhibition.
Journal of the American College of Cardiology 2001;38(5):1402-8.
2001: Maria Paola Pellegrini; David E Newby; S Maxwell; David J Webb
Short-term effects of transdermal nicotine on acute tissue plasminogen activator release in vivo in man.
Cardiovascular research 2001;52(2):321-7.
2001: Fraser N Witherow; Ahmed Helmy; David J Webb; Keith A A Fox; David E Newby
Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure.
Circulation 2001;104(18):2177-81.
2001: J C Spratt; J Goddard; N Patel; Fiona E Strachan; Andrew Rankin; David J Webb
Systemic ETA receptor antagonism with BQ-123 blocks ET-1 induced forearm vasoconstriction and decreases peripheral vascular resistance in healthy men.
British journal of pharmacology 2001;134(3):648-54.
2001: J Affolter; David J Webb
Urotensin II: a new mediator in cardiopulmonary regulation?
Lancet 2001;358(9284):774-5.
2001: W Stephen Waring; David J Webb; Simon R J Maxwell
Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers.
Journal of cardiovascular pharmacology 2001;38(3):365-71.
2001: Yuri Kotelevtsev; David J Webb
Endothelin as a natriuretic hormone: the case for a paracrine action mediated by nitric oxide.
Cardiovascular research 2001;51(3):481-8.
2001: Ian B Wilkinson; Carmel M McEniery; K H Bongaerts; Helen MacCallum; David J Webb; John R Cockcroft
Adrenomedullin (ADM) in the human forearm vascular bed: effect of neutral endopeptidase inhibition and comparison with proadrenomedullin NH2-terminal 20 peptide (PAMP).
British journal of clinical pharmacology 2001;52(2):159-64.
2001: David E Newby; Andrew L McLeod; Neal G Uren; L Flint; Christopher A Ludlam; David J Webb; Keith A A Fox; Nicholas A Boon
Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis.
Circulation 2001;103(15):1936-41.
2001: Gillian A Gray; Isam Sharif; David J Webb; Jonathan R Seckl
Oestrogen and the cardiovascular system: the good, the bad and the puzzling.
Trends in pharmacological sciences 2001;22(3):152-6.
2001: C Labinjoh; David E Newby; Ian B Wilkinson; Ian L Megson; Helen MacCallum; V Melville; Nicholas A Boon; David J Webb
Effects of acute methionine loading and vitamin C on endogenous fibrinolysis, endothelium-dependent vasomotion and platelet aggregation.
Clinical science (London, England : 1979) 2001;100(2):127-35.
2001: Malcolm F Hand; William G Haynes; David J Webb
Reduced venous responsiveness to endothelin-1 but not noradrenaline in hypertensive chronic renal failure.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2001;16(2):295-301.
2001: Ian B Wilkinson; Helen MacCallum; P C Hupperetz; C J van Thoor ; John R Cockcroft; David J Webb
Changes in the derived central pressure waveform and pulse pressure in response to angiotensin II and noradrenaline in man.
The Journal of physiology 2001;530(Pt 3):541-50.
2001: I B Wilkinson; I L Megson; T MacCallum; D F Rooijmans; S M Johnson; J L Boyd; J R Cockcroft; David J Webb
Acute methionine loading does not alter arterial stiffness in humans.
Journal of cardiovascular pharmacology 2001;37(1):1-5.
2000: N Sogo; Kesson S Magid; Catherine A Shaw; David J Webb; Ian L Megson
Inhibition of human platelet aggregation by nitric oxide donor drugs: relative contribution of cGMP-independent mechanisms.
Biochemical and biophysical research communications 2000;279(2):412-9.
2000: Ian L Megson; N Sogo; FA Mazzei; Anthony R Butler; J C Walton; David J Webb
Inhibition of human platelet aggregation by a novel S-nitrosothiol is abolished by haemoglobin and red blood cells in vitro: implications for anti-thrombotic therapy.
British journal of pharmacology 2000;131(7):1391-8.
2000: Mark R Miller; MJ Roseberry; FA Mazzei; Anthony R Butler; David J Webb; Ian L Megson
Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries.
European journal of pharmacology 2000;408(3):335-43.
2000: N Sogo; C Campanella; David J Webb; Ian L Megson
S-nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery.
British journal of pharmacology 2000;131(6):1236-44.
2000: PE McEwan; Lorcan Sherry; Christopher J Kenyon; David J Webb; Gillian A Gray
Regulation of the myocardial endothelin system by angiotensin-II and losartan.
Journal of cardiovascular pharmacology 2000;36(5 Suppl 1):S144-7.
2000: W Stephen Waring; David J Webb; Simon R J Maxwell
Uric acid as a risk factor for cardiovascular disease.
QJM : monthly journal of the Association of Physicians 2000;93(11):707-13.
2000: C Labinjoh; David E Newby; Pamela Dawson; Neil R Johnston; Christopher A Ludlam; Nicholas A Boon; David J Webb
Fibrinolytic actions of intra-arterial angiotensin II and bradykinin in vivo in man.
Cardiovascular research 2000;47(4):707-14.
2000: Mark R Miller; Ian L Megson; MJ Roseberry; FA Mazzei; Anthony R Butler; David J Webb
Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryl trinitrate-tolerant rat femoral arteries.
European journal of pharmacology 2000;403(1-2):111-9.
2000: David E Newby; A Stewart; Fraser N Witherow; S Grieve; Pamela Dawson; Keith A A Fox; David J Webb; Christopher A Ludlam
Local and systemic effects of intra-arterial desmopressin in healthy volunteers and patients with type 3 von Willebrand disease. Role of interleukin-6.
Thrombosis and haemostasis 2000;84(2):195-203.
2000: Gillian A Gray; EJ Mickley; David J Webb; PE McEwan
Localization and function of ET-1 and ET receptors in small arteries post-myocardial infarction: upregulation of smooth muscle ET(B) receptors that modulate contraction.
British journal of pharmacology 2000;130(8):1735-44.
2000: N Sogo; Ian B Wilkinson; Helen MacCallum; S Q Khan; Fiona E Strachan; David E Newby; Ian L Megson; David J Webb
A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium.
Clinical pharmacology and therapeutics 2000;68(1):75-81.
2000: C J Ferro; Fiona E Strachan; E Shepherd; William G Haynes; David J Webb
Big endothelin-3 constricts forearm resistance vessels but not hand veins in humans.
Clinical pharmacology and therapeutics 2000;68(1):67-74.
2000: Fiona E Strachan; Thomas R Crockett; N L Mills; Gillian A Gray; David J Webb
Constriction to ETB receptor agonists, BQ-3020 and sarafotoxin s6c, in human resistance and capacitance vessels in vivo.
British journal of clinical pharmacology 2000;50(1):27-30.
2000: Ian B Wilkinson; Helen MacCallum; D F Rooijmans; Gordon D Murray; John R Cockcroft; J A McKnight; David J Webb
Increased augmentation index and systolic stress in type 1 diabetes mellitus.
QJM : monthly journal of the Association of Physicians 2000;93(7):441-8.
2000: Ian B Wilkinson; Helen MacCallum; L Flint; John R Cockcroft; David E Newby; David J Webb
The influence of heart rate on augmentation index and central arterial pressure in humans.
The Journal of physiology 2000;525 Pt 1():263-70.
2000: Gillian A Gray; B Battistini; David J Webb
Endothelins are potent vasoconstrictors, and much more besides.
Trends in pharmacological sciences 2000;21(2):38-40.
2000: J Goddard; David J Webb
Plasma endothelin concentrations in hypertension.
Journal of cardiovascular pharmacology 2000;35(4 Suppl 2):S25-31.
2000: M P Love; W G Haynes; David J Webb; john mcmurray
Venous endothelin receptor function in patients with chronic heart failure.
Clinical science (London, England : 1979) 2000;98(1):65-70.
1999: I B Wilkinson; Ian L Megson; Helen MacCallum; N Sogo; J R Cockcroft; David J Webb
Oral vitamin C reduces arterial stiffness and platelet aggregation in humans.
Journal of cardiovascular pharmacology 1999;34(5):690-3.
1999: Nicholas L M Cruden; David E Newby; J A Ross; Neil R Johnston; David J Webb
Effect of cold exposure, exercise and high altitude on plasma endothelin-1 and endothelial cell markers in man.
Scottish medical journal 1999;44(5):143-6.
1999: David E Newby; David G Sciberras; C J Ferro; Barry J Gertz; D Sommerville; A Majumdar; R C Lowry; David J Webb
Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man.
British journal of clinical pharmacology 1999;48(3):336-44.
1999: Jane Goddard; David J Webb
Endothelin receptor antagonists. Promising new agents in the management of cardiovascular disorders.
Drugs in R&D 1999;2(1):1-12.
1999: P J Smith; C J Ferro; D S McQueen; David J Webb
Impaired cholinergic dilator response of resistance arteries isolated from patients with Raynaud's disease.
British journal of clinical pharmacology 1999;47(5):507-13.
1999: David E Newby; R A Wright; C Labinjoh; Christopher A Ludlam; Keith A A Fox; Nicholas A Boon; David J Webb
Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction.
Circulation 1999;99(11):1411-5.
1999: David J Webb; Sarah H Freestone; M J Allen; G J Muirhead
Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist.
The American journal of cardiology 1999;83(5A):21C-28C.
1999: Ian L Megson; S Morton; IR Greig; FA Mazzei; R A Field; Anthony R Butler; Giulia Caron; Alberto Gasco; Roberta Fruttero; David J Webb
N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries.
British journal of pharmacology 1999;126(3):639-48.
1999: Malcolm F Hand; William G Haynes; David J Webb
Reduced endogenous endothelin-1-mediated vascular tone in chronic renal failure.
Kidney international 1999;55(2):613-20.
1999: Fiona E Strachan; J C Spratt; Ian B Wilkinson; Neil R Johnston; Gillian A Gray; David J Webb
Systemic blockade of the endothelin-B receptor increases peripheral vascular resistance in healthy men.
Hypertension 1999;33(1 Pt 2):581-5.
1998: PE McEwan; Gillian A Gray; Lorcan Sherry; David J Webb; Christopher J Kenyon
Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo.
Circulation 1998;98(24):2765-73.
1998: Ian B Wilkinson; S A Fuchs; I M Jansen; J C Spratt; Gordon D Murray; John R Cockcroft; David J Webb
Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis.
Journal of hypertension 1998;16(12 Pt 2):2079-84.
1998: David E Newby; NE Goodfield; Andrew D Flapan; Nicholas A Boon; K A Fox; David J Webb
Regulation of peripheral vascular tone in patients with heart failure: contribution of angiotensin II.
Heart (British Cardiac Society) 1998;80(2):134-40.
1998: C J Ferro; J C Spratt; William G Haynes; David J Webb
Inhibition of neutral endopeptidase causes vasoconstriction of human resistance vessels in vivo.
Circulation 1998;97(23):2323-30.
1998: David E Newby; L L Flint; Keith A A Fox; Nicholas A Boon; David J Webb
Reduced responsiveness to endothelin-1 in peripheral resistance vessels of patients with syndrome X.
Journal of the American College of Cardiology 1998;31(7):1585-90.
1998: David E Newby; R A Wright; Pamela Dawson; Christopher A Ludlam; Nicholas A Boon; Keith A A Fox; David J Webb
The L-arginine/nitric oxide pathway contributes to the acute release of tissue plasminogen activator in vivo in man.
Cardiovascular research 1998;38(2):485-92.
1998: Widjaja Luman; J E Ardill; E Armstrong; G D Smith; L Brett; Alistair Lessells; W G Haynes; Gillian A Gray; EJ Mickley; David J Webb; Kelvin R Palmer
Nitric oxide and gall-bladder motor function.
Alimentary pharmacology & therapeutics 1998;12(5):425-32.
1998: David E Newby; R Jalan; S Masumori; P C Hayes; Nicholas A Boon; David J Webb
Peripheral vascular tone in patients with cirrhosis: role of the renin-angiotensin and sympathetic nervous systems.
Cardiovascular research 1998;38(1):221-8.
1998: David J Webb; Fiona E Strachan
Clinical experience with endothelin antagonists.
American journal of hypertension 1998;11(4 Pt 3):71S-79S.
1998: M F Hand; W G Haynes; David J Webb
Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction.
Kidney international 1998;53(4):1068-77.
1998: P J Smith; C J Ferro; D S McQueen; David J Webb
Functional studies in small arteries do not support a primary role for endothelin in the pathogenesis of Raynaud's disease.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S473-6.
1998: PE McEwan; O Valdenaire; L Sutherland; David J Webb; Gillian A Gray
A nonradioactive method for localization of endothelin receptor mRNA in situ.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S443-6.
1997: Ian L Megson; IR Greig; Gillian A Gray; David J Webb; Anthony R Butler
Prolonged effect of a novel S-nitrosated glyco-amino acid in endothelium-denuded rat femoral arteries: potential as a slow release nitric oxide donor drug.
British journal of pharmacology 1997;122(8):1617-24.
1997: David E Newby; S Masumori; Neil R Johnston; Nicholas A Boon; David J Webb
Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man.
Cardiovascular research 1997;36(2):268-75.
1997: David E Newby; R A Wright; Christopher A Ludlam; Keith A A Fox; Nicholas A Boon; David J Webb
An in vivo model for the assessment of acute fibrinolytic capacity of the endothelium.
Thrombosis and haemostasis 1997;78(4):1242-8.
1997: C J Ferro; W G Haynes; Neil R Johnston; C C Lomax; David E Newby; David J Webb
The peptide endothelin receptor antagonist, TAK-044, produces sustained inhibition of endothelin-1 mediated arteriolar vasoconstriction.
British journal of clinical pharmacology 1997;44(4):377-83.
1997: S Masumori; David E Newby; F E Strachan; Nicholas A Boon; David J Webb
Endogenous angiotensin II does not contribute to sympathetic venoconstriction in dorsal hand veins of healthy humans.
Clinical pharmacology and therapeutics 1997;62(3):327-33.
1997: David J Webb
Endothelin: from molecule to man.
British journal of clinical pharmacology 1997;44(1):9-20.
1997: Ian L Megson; IR Greig; Anthony R Butler; Gillian A Gray; David J Webb
Therapeutic potential of S-nitrosothiols as nitric oxide donor drugs.
Scottish medical journal 1997;42(3):88-9.
1997: David E Newby; David G Sciberras; C M Mendel; Barry J Gertz; Nicholas A Boon; David J Webb
Intra-arterial substance P mediated vasodilatation in the human forearm: pharmacology, reproducibility and tolerability.
British journal of clinical pharmacology 1997;43(5):493-9.
1997: EJ Mickley; Gillian A Gray; David J Webb
Activation of endothelin ETA receptors masks the constrictor role of endothelin ETB receptors in rat isolated small mesenteric arteries.
British journal of pharmacology 1997;120(7):1376-82.
1997: William G Haynes; Malcolm F Hand; Mark Dockrell; D W Eadington; M R Lee; Z Hussein; N Benjamin; David J Webb
Physiological role of nitric oxide in regulation of renal function in humans.
The American journal of physiology 1997;272(3 Pt 2):F364-71.
1997: R J Parris; David J Webb
The endothelin system in cardiovascular physiology and pathophysiology.
Vascular medicine (London, England) 1997;2(1):31-43.
1997: C J Ferro; David J Webb
Endothelial dysfunction and hypertension.
Drugs 1997;53 Suppl 1():30-41.