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Paul Webb
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Research Profile (preview)
Chemicals & Drugs
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Concepts & Ideas
Phenomena
Physiology
Procedures
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Network (preview)
34
Baxter, John
22
Kushner, Peter
14
Fletterick, Robert
13
Nguyen, Phuong
11
Scanlan, Thomas
10
Togashi, Marie
10
Apriletti, James
8
Ribeiro, Ralff
7
Uht, Rosalie
7
Polikarpov, Igor
7
Neves, Francisco
7
Lopez, Gabriela
6
West, Brian
5
Cunha Lima, Suzana
5
Dias, Sandra
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Geonetwork of Paul Webb (preview)
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All Publications
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2009: Cunha Lima Suzana T; Nguyen Ngoc-Ha; Togashi Marie; Apriletti James W; Nguyen Phuong; Polikarpov Igor; Scanlan Thomas S; Baxter John D; Webb Paul
Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways.
The Journal of steroid biochemistry and molecular biology 2009;117(4-5):125-31.
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2009: Jouravel Natalia; Sablin Elena; Togashi Marie; Baxter John D; Webb Paul; Fletterick Robert J
Molecular basis for dimer formation of TRbeta variant D355R.
Proteins 2009;75(1):111-7.
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2008: Shah Vanya; Nguyen Phuong; Nguyen Ngoc-Ha; Togashi Marie; Scanlan Thomas S; Baxter John D; Webb Paul
Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines.
Molecular and cellular endocrinology 2008;296(1-2):69-77.
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2008: Sonoda Milton T; Martínez Leandro; Webb Paul; Skaf Munir S; Polikarpov Igor
Ligand dissociation from estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations.
Molecular endocrinology (Baltimore, Md.) 2008;22(7):1565-78.
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2008: Bleicher Lucas; Aparicio Ricardo; Nunes Fabio M; Martinez Leandro; Gomes Dias Sandra M; Figueira Ana Carolina Migliorini; Santos Maria Auxiliadora Morim; Venturelli Walter H; da Silva Rosangela; Donate Paulo Marcos; Neves Francisco Ar; Simeoni Luiz A; Baxter John D; Webb Paul; Skaf Munir S; Polikarpov Igor
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms.
BMC structural biology 2008;8():8.
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2007: Estébanez-Perpiñá Eva; Arnold Leggy A; Jouravel Natalia; Togashi Marie; Blethrow Justin; Mar Ellena; Nguyen Phuong; Phillips Kevin J; Baxter John D; Webb Paul; Guy R Kiplin; Fletterick Robert J
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(12):2919-28.
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2007: Estébanez-Perpiñá Eva; Arnold Leggy A; Nguyen Phuong; Rodrigues Edson Delgado; Mar Ellena; Bateman Raynard; Pallai Peter; Shokat Kevan M; Baxter John D; Guy R Kiplin; Webb Paul; Fletterick Robert J
A surface on the androgen receptor that allosterically regulates coactivator binding.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16074-9.
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2007: Velasco Lara F R; Togashi Marie; Walfish Paul G; Pessanha Rutinéia P; Moura Fanny N; Barra Gustavo B; Nguyen Phuong; Rebong Rachelle; Yuan Chaoshen; Simeoni Luiz A; Ribeiro Ralff C J; Baxter John D; Webb Paul; Neves Francisco A R
Thyroid hormone response element organization dictates the composition of active receptor.
The Journal of biological chemistry 2007;282(17):12458-66.
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2007: Figueira Ana Carolina Migliorini; Neto Mario de Oliveira; Bernardes Amanda; Dias Sandra Martha Gomes; Craievich Aldo F; Baxter John D; Webb Paul; Polikarpov Igor
Low-resolution structures of thyroid hormone receptor dimers and tetramers in solution.
Biochemistry 2007;46(5):1273-83.
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2006: Santos Guilherme M; Afonso Valéry; Barra Gustavo B; Togashi Marie; Webb Paul; Neves Francisco A R; Lomri Noureddine; Lomri Abderrahim
Negative regulation of superoxide dismutase-1 promoter by thyroid hormone.
Molecular pharmacology 2006;70(3):793-800.
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2006: Nascimento Alessandro S; Dias Sandra Martha Gomes; Nunes Fábio M; Aparício Ricardo; Ambrosio Andre L B; Bleicher Lucas; Figueira Ana Carolina M; Santos Maria Auxiliadora M; de Oliveira Neto Mário; Fischer Hannes; Togashi Marie; Craievich Aldo F; Garratt Richard C; Baxter John D; Webb Paul; Polikarpov Igor
Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function.
Journal of molecular biology 2006;360(3):586-98.
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2006: Arnold Leggy A; Estébanez-Perpiñá Eva; Togashi Marie; Shelat Anang; Ocasio Cory A; McReynolds Andrea C; Nguyen Phuong; Baxter John D; Fletterick Robert J; Webb Paul; Guy R Kiplin
A high-throughput screening method to identify small molecule inhibitors of thyroid hormone receptor coactivator binding.
Science's STKE : signal transduction knowledge environment 2006;2006(341):pl3.
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2006: Figueira Ana C M; Dias Sandra M G; Santos Maria A M; Apriletti James W; Baxter John D; Webb Paul; Neves Francisco A R; Simeoni Luiz A; Ribeiro Ralff C J; Polikarpov Igor
Human thyroid receptor forms tetramers in solution, which dissociate into dimers upon ligand binding.
Cell biochemistry and biophysics 2006;44(3):453-62.
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2005: Arnold Leggy A; Estébanez-Perpiñá Eva; Togashi Marie; Jouravel Natalia; Shelat Anang; McReynolds Andrea C; Mar Ellena; Nguyen Phuong; Baxter John D; Fletterick Robert J; Webb Paul; Guy R Kiplin
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators.
The Journal of biological chemistry 2005;280(52):43048-55.
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2005: Togashi Marie; Nguyen Phuong; Fletterick Robert; Baxter John D; Webb Paul
Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation.
The Journal of biological chemistry 2005;280(27):25665-73.
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2005: Estébanez-Perpiñá Eva; Moore Jamie M R; Mar Ellena; Delgado-Rodrigues Edson; Nguyen Phuong; Baxter John D; Buehrer Benjamin M; Webb Paul; Fletterick Robert J; Guy R Kiplin
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.
The Journal of biological chemistry 2005;280(9):8060-8.
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2005: Togashi Marie; Borngraeber Sabine; Sandler Ben; Fletterick Robert J; Webb Paul; Baxter John D
Conformational adaptation of nuclear receptor ligand binding domains to agonists: potential for novel approaches to ligand design.
The Journal of steroid biochemistry and molecular biology 2005;93(2-5):127-37.
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2004: Sandler Ben; Webb Paul; Apriletti James W; Huber B Russell; Togashi Marie; Cunha Lima Suzana T; Juric Sanja; Nilsson Stefan; Wagner Richard; Fletterick Robert J; Baxter John D
Thyroxine-thyroid hormone receptor interactions.
The Journal of biological chemistry 2004;279(53):55801-8.
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2004: Nunes F M; Aparicio R; Santos M A M; Portugal R V; Dias S M G; Neves F A R; Simeoni L A; Baxter J D; Webb P; Polikarpov I
Crystallization and preliminary X-ray diffraction studies of isoform alpha1 of the human thyroid hormone receptor ligand-binding domain.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1867-70.
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2004: Rodrigues Maria C S; Santos Guilherme M; da Silva C Aluízio; Baxter John D; Webb Paul; Lomri Noureddine; Neves Francisco A R; Ribeiro Ralff C J; Simeoni Luiz A
Thyroid hormone transport is disturbed in erythrocytes from patients with chronic renal failure on hemodialysis.
Renal failure 2004;26(4):461-6.
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2004: Baxter John D; Funder John W; Apriletti James W; Webb Paul
Towards selectively modulating mineralocorticoid receptor function: lessons from other systems.
Molecular and cellular endocrinology 2004;217(1-2):151-65.
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2003: Borngraeber Sabine; Budny Mary-Jane; Chiellini Grazia; Cunha-Lima Suzana T; Togashi Marie; Webb Paul; Baxter John D; Scanlan Thomas S; Fletterick Robert J
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15358-63.
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2003: Baxter John D; Young William F; Webb Paul
Cardiovascular endocrinology: introduction.
Endocrine reviews 2003;24(3):253-60.
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2003: Fischer Hannes; Dias Sandra M G; Santos Maria A M; Alves Adriana C; Zanchin Nilson; Craievich Aldo F; Apriletti James W; Baxter John D; Webb Paul; Neves Francisco A R; Ribeiro Ralff C J; Polikarpov Igor
Low resolution structures of the retinoid X receptor DNA-binding and ligand-binding domains revealed by synchrotron X-ray solution scattering.
The Journal of biological chemistry 2003;278(18):16030-8.
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2003: Liang Faquan; Webb Paul; Marimuthu Adhirai; Zhang Sumei; Gardner David G
Triiodothyronine increases brain natriuretic peptide (BNP) gene transcription and amplifies endothelin-dependent BNP gene transcription and hypertrophy in neonatal rat ventricular myocytes.
The Journal of biological chemistry 2003;278(17):15073-83.
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2003: Webb Paul; Nguyen Phuong; Kushner Peter J
Differential SERM effects on corepressor binding dictate ERalpha activity in vivo.
The Journal of biological chemistry 2003;278(9):6912-20.
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2002: Webb Paul; Nguyen Ngoc-Ha; Chiellini Grazia; Yoshihara Hikari A I; Cunha Lima Suzana T; Apriletti James W; Ribeiro Ralff C J; Marimuthu Adhirai; West Brian L; Goede Patrick; Mellstrom Karin; Nilsson Stefan; Kushner Peter J; Fletterick Robert J; Scanlan Thomas S; Baxter John D
Design of thyroid hormone receptor antagonists from first principles.
The Journal of steroid biochemistry and molecular biology 2002;83(1-5):59-73.
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2002: Nguyen Ngoc-Ha; Apriletti James W; Cunha Lima Suzana T; Webb Paul; Baxter John D; Scanlan Thomas S
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.
Journal of medicinal chemistry 2002;45(15):3310-20.
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2002: Liu Meng-Min; Albanese Chris; Anderson Carol M; Hilty Kristin; Webb Paul; Uht Rosalie M; Price Richard H; Pestell Richard G; Kushner Peter J
Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression.
The Journal of biological chemistry 2002;277(27):24353-60.
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2002: Baxter John D; Goede Patrick; Apriletti James W; West Brian L; Feng Weijun; Mellstrom Karin; Fletterick Robert J; Wagner Richard L; Kushner Peter J; Ribeiro Ralff C J; Webb Paul; Scanlan Thomas S; Nilsson Stefan
Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.
Endocrinology 2002;143(2):517-24.
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2001: Price R H; Butler C A; Webb P; Uht R; Kushner P; Handa R J
A splice variant of estrogen receptor beta missing exon 3 displays altered subnuclear localization and capacity for transcriptional activation.
Endocrinology 2001;142(5):2039-49.
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2001: Baxter J D; Dillmann W H; West B L; Huber R; Furlow J D; Fletterick R J; Webb P; Apriletti J W; Scanlan T S
Selective modulation of thyroid hormone receptor action.
The Journal of steroid biochemistry and molecular biology 2001;76(1-5):31-42.
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2001: Feng W; Webb P; Nguyen P; Liu X; Li J; Karin M; Kushner P J
Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway.
Molecular endocrinology (Baltimore, Md.) 2001;15(1):32-45.
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2000: Webb P; Anderson C M; Valentine C; Nguyen P; Marimuthu A; West B L; Baxter J D; Kushner P J
The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).
Molecular endocrinology (Baltimore, Md.) 2000;14(12):1976-85.
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2000: Webb P; Nguyen P; Valentine C; Weatherman R V; Scanlan T S; Kushner P J
An antiestrogen-responsive estrogen receptor-alpha mutant (D351Y) shows weak AF-2 activity in the presence of tamoxifen.
The Journal of biological chemistry 2000;275(48):37552-8.
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2000: Kushner P J; Agard D A; Greene G L; Scanlan T S; Shiau A K; Uht R M; Webb P
Estrogen receptor pathways to AP-1.
The Journal of steroid biochemistry and molecular biology 2000;74(5):311-7.
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2000: Kushner P J; Agard D; Feng W J; Lopez G; Schiau A; Uht R; Webb P; Greene G
Oestrogen receptor function at classical and alternative response elements.
Novartis Foundation symposium 2000;230():20-6; discussion 27-40.
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1999: An J; Ribeiro R C; Webb P; Gustafsson J A; Kushner P J; Baxter J D; Leitman D C
Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15161-6.
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1999: Webb P; Nguyen P; Valentine C; Lopez G N; Kwok G R; McInerney E; Katzenellenbogen B S; Enmark E; Gustafsson J A; Nilsson S; Kushner P J
The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions.
Molecular endocrinology (Baltimore, Md.) 1999;13(10):1672-85.
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1999: Lopez G N; Webb P; Shinsako J H; Baxter J D; Greene G L; Kushner P J
Titration by estrogen receptor activation function-2 of targets that are downstream from coactivators.
Molecular endocrinology (Baltimore, Md.) 1999;13(6):897-909.
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1998: Apriletti J W; Ribeiro R C; Wagner R L; Feng W; Webb P; Kushner P J; West B L; Nilsson S; Scanlan T S; Fletterick R J; Baxter J D
Molecular and structural biology of thyroid hormone receptors.
Clinical and experimental pharmacology & physiology. Supplement 1998;25():S2-11.
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1998: Webb P; Nguyen P; Shinsako J; Anderson C; Feng W; Nguyen M P; Chen D; Huang S M; Subramanian S; McKinerney E; Katzenellenbogen B S; Stallcup M R; Kushner P J
Estrogen receptor activation function 1 works by binding p160 coactivator proteins.
Molecular endocrinology (Baltimore, Md.) 1998;12(10):1605-18.
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1997: Paech K; Webb P; Kuiper G G; Nilsson S; Gustafsson J; Kushner P J; Scanlan T S
Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites.
Science (New York, N.Y.) 1997;277(5331):1508-10.
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1997: Uht R M; Anderson C M; Webb P; Kushner P J
Transcriptional activities of estrogen and glucocorticoid receptors are functionally integrated at the AP-1 response element.
Endocrinology 1997;138(7):2900-8.
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1995: Webb P; Lopez G N; Uht R M; Kushner P J
Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.
Molecular endocrinology (Baltimore, Md.) 1995;9(4):443-56.
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1995: Sadovsky Y; Webb P; Lopez G; Baxter J D; Fitzpatrick P M; Gizang-Ginsberg E; Cavailles V; Parker M G; Kushner P J
Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein.
Molecular and cellular biology 1995;15(3):1554-63.
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1994: Kushner P J; Baxter J D; Duncan K G; Lopez G N; Schaufele F; Uht R M; Webb P; West B L
Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein-1 site in pUC.
Molecular endocrinology (Baltimore, Md.) 1994;8(4):405-7.
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1993: Lopez G; Schaufele F; Webb P; Holloway J M; Baxter J D; Kushner P J
Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site.
Molecular and cellular biology 1993;13(5):3042-9.
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1992: Webb P; Lopez G N; Greene G L; Baxter J D; Kushner P J
The limits of the cellular capacity to mediate an estrogen response.
Molecular endocrinology (Baltimore, Md.) 1992;6(2):157-67.
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