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Ann Weber

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Liping Wang; James A Hubert; Susan J Lee; Jie Pan; Su Qian; Marc L Reitman; Alison M Strack; Drew T Weingarth; Douglas J MacNeil; Ann E Weber; Scott D Edmondson
Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
Ping Chen; Charles G Caldwell; Wallace T Ashton; Joseph K Wu; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.
Stephen D Goble; Liping Wang; K Lulu Howell; Alka Bansal; Richard Berger; Linda L Brockunier; Jerry DiSalvo; Scott Feighner; Bart Harper; Jiafang He; Amanda Hurley; Donna L Hreniuk; Emma Parmee; Michael Robbins; Gino M Salituro; Anthony Sanfiz; Eric Streckfuss; Eloisa Watkins; Ann E Weber; Mary Struthers; Scott D Edmondson
Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.

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2011: Liping Wang; James A Hubert; Susan J Lee; Jie Pan; Su Qian; Marc L Reitman; Alison M Strack; Drew T Weingarth; Douglas J MacNeil; Ann E Weber; Scott D Edmondson
Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
Bioorganic & medicinal chemistry letters 2011;21(10):2911-5.
2011: Ping Chen; Charles G Caldwell; Wallace T Ashton; Joseph K Wu; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(6):1880-6.
2010: Stephen D Goble; Liping Wang; K Lulu Howell; Alka Bansal; Richard Berger; Linda L Brockunier; Jerry DiSalvo; Scott Feighner; Bart Harper; Jiafang He; Amanda Hurley; Donna L Hreniuk; Emma Parmee; Michael Robbins; Gino M Salituro; Anthony Sanfiz; Eric Streckfuss; Eloisa Watkins; Ann E Weber; Mary Struthers; Scott D Edmondson
Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.
Bioorganic & medicinal chemistry letters 2010;20(6):1895-9.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2009;19(18):5334-8.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorganic & medicinal chemistry letters 2009;19(18):5329-33.
2009: Scott D Edmondson; Anthony Mastracchio; Jason M. Cox; George J Eiermann; Huaibing He; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ranabir Sinha Roy; Ann E Weber
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4097-101.
2008: Richard Berger; Cheng Zhu; Alexa R Hansen; Bart Harper; Zhesheng Chen; Tom Holt; James Hubert; Susan J Lee; Jie Pan; Su Qian; Marc L Reitman; Alison M Strack; Drew T Weingarth; Michael Wolff; Douglas J Macneil; Ann E Weber; Scott D Edmondson
2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.
Bioorganic & medicinal chemistry letters 2008;18(17):4833-7.
2008: Cheng Zhu; Alexa R Hansen; Thomas Bateman; Zhesheng Chen; Tom Holt; James A Hubert; Bindhu V Karanam; Susan J Lee; Jie Pan; Su Qian; Vijay B G Reddy; Marc L Reitman; Alison M Strack; Vincent Tong; Drew T Weingarth; Michael S Wolff; Douglas J MacNeil; Ann E Weber; Joseph L Duffy; Scott D Edmondson
Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
Bioorganic & medicinal chemistry letters 2008;18(15):4393-6.
2008: Gui-Bai Liang; Xiaoxia Qian; Szalkowski Deborah; Suresh Singh; Ying-Duo Gao; Giovanna Scapin; Sangita Patel; Barbara Leiting; Reshma Patel; Joseph Wu; Xiaoping Zhang; Nancy A Thornberry; Ann E Weber
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Bioorganic & medicinal chemistry letters 2008;18(13):3706-10.
2008: Scott D Edmondson; Lan Wei; Jinyou Xu; Jackie Shang; Shiyao Xu; Jianmei Pang; Ashok Chaudhary; Dennis C Dean; Huaibing He; Barbara Leiting; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Giovanna Scapin; Joseph K Wu; Maria G Beconi; Nancy A Thornberry; Ann E Weber
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(7):2409-13.
2008: Dooseop Kim; Jennifer E Kowalchick; Linda L Brockunier; Emma R Parmee; George J Eiermann; Michael H Fisher; Huaibing He; Barbara Leiting; Kathryn Lyons; Giovanna Scapin; Sangita B Patel; Aleksandr Petrov; KellyAnn D Pryor; Ranabir Sinha Roy; Joseph K Wu; Xiaoping Zhang; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
Journal of medicinal chemistry 2008;51(3):589-602.
2007: Ping Chen; Charles G Caldwell; Robert J Mathvink; Barbara Leiting; Frank Marsilio; Reshma A Patel; Joseph K Wu; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.
Bioorganic & medicinal chemistry letters 2007;17(21):5853-7.
2007: David E Kaelin; Abigail L Smenton; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Nancy A Thornberry; Ann E Weber; Joseph L Duffy
4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
Bioorganic & medicinal chemistry letters 2007;17(21):5806-11.
2007: Jennifer E Kowalchick; Barbara Leiting; KellyAnn D Pryor; Frank Marsilio; Joseph K Wu; Huaibing He; Kathryn A Lyons; George J Eiermann; Aleksandr Petrov; Giovanna Scapin; Reshma A Patel; Nancy A Thornberry; Ann E Weber; Dooseop Kim
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(21):5934-9.
2007: Jason M. Cox; Bart Harper; Anthony Mastracchio; Barbara Leiting; Ranabir Sinha Roy; Reshma A Patel; Joseph K Wu; Kathryn A Lyons; Huaibing He; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ann E Weber; Scott D Edmondson
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(16):4579-83.
2007: Ying-Duo Gao; Dennis Feng; Robert P Sheridan; Giovanna Scapin; Sangita B Patel; Joseph K Wu; Xiaoping Zhang; Ranabir Sinha Roy; Nancy A Thornberry; Ann E Weber; Szalkowski Deborah
Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(14):3877-9.
2007: Dooseop Kim; Jennifer E Kowalchick; Scott D Edmondson; Anthony Mastracchio; Jinyou Xu; George J Eiermann; Barbara Leiting; Joseph K Wu; KellyAnn D Pryor; Reshma A Patel; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).
Bioorganic & medicinal chemistry letters 2007;17(12):3373-7.
2007: Szalkowski Deborah; Giovanna Scapin; Suresh Singh; Dennis Feng; Joseph W Becker; George J Eiermann; Huaibing He; Kathryn Lyons; Sangita Patel; Aleksandr Petrov; Ranabir Sinha Roy; Bei Zhang; Joseph Wu; Xiaoping Zhang; George A Doss; Nancy A Thornberry; Ann E Weber
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.
Bioorganic & medicinal chemistry letters 2007;17(12):3384-7.
2007: Joseph L Duffy; Brian A Kirk; Liping Wang; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Nancy A Thornberry; Ann E Weber
4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.
Bioorganic & medicinal chemistry letters 2007;17(10):2879-85.
2007: Gui-Bai Liang; Xiaoxia Qian; Dennis Feng; Szalkowski Deborah; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn Lyons; Aleksandr Petrov; Ranabir Sinha Roy; Bei Zhang; Joseph Wu; Xiaoping Zhang; Nancy A Thornberry; Ann E Weber
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.
Bioorganic & medicinal chemistry letters 2007;17(7):1903-7.
2007: Szalkowski Deborah; Dennis Feng; Xiaoxia Qian; Gui-Bai Liang; Gerard Kieczykowski; George J Eiermann; Huaibing He; Barbara Leiting; Kathryn Lyons; Aleksandr Petrov; Ranabir Sinha Roy; Bei Zhang; Giovanna Scapin; Sangita Patel; Ying-Duo Gao; Suresh Singh; Joseph Wu; Xiaoping Zhang; Nancy A Thornberry; Ann E Weber
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorganic & medicinal chemistry letters 2007;17(1):49-52.
2006: Jinyou Xu; Lan Wei; Robert J Mathvink; Scott D Edmondson; George J Eiermann; Huaibing He; Joseph F Leone; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(20):5373-7.
2006: Scott D Edmondson; Anthony Mastracchio; Robert J Mathvink; Jiafang He; Bart Harper; You-Jung Park; Maria G Beconi; Jerry Di Salvo; George J Eiermann; Huaibing He; Barbara Leiting; Joseph F Leone; Dorothy A Levorse; Kathryn Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Jackie Shang; Ranabir Sinha Roy; Aaron Smith; Joseph K Wu; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ann E Weber
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2006;49(12):3614-27.
2006: Jinyou Xu; Lan Wei; Robert J Mathvink; Scott D Edmondson; Anthony Mastracchio; George J Eiermann; Huaibing He; Joseph F Leone; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Aleksandr Petrov; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(5):1346-9.
2005: George R Lankas; Barbara Leiting; Ranabir Sinha Roy; George J Eiermann; Maria G Beconi; Szalkowski Deborah; Chi-Chung Chan; Scott D Edmondson; William P Feeney; Huaibing He; Dawn E Ippolito; Dooseop Kim; Kathryn A Lyons; Hyun O Ok; Reshma A Patel; Aleksandr N Petrov; Kelly Ann Pryor; Xiaoxia Qian; Leah Reigle; Andrea Woods; Joseph K Wu; Dennis Zaller; Xiaoping Zhang; Lan Zhu; Ann E Weber; Nancy A Thornberry
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Diabetes 2005;54(10):2988-94.
2005: Scott D Edmondson; Anthony Mastracchio; Joseph L Duffy; George J Eiermann; Huaibing He; Ida Ita; Barbara Leiting; Joseph F Leone; Kathryn A Lyons; Amanda M Makarewicz; Reshma A Patel; Aleksandr Petrov; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(12):3048-52.
2005: Jinyou Xu; Lan Wei; Robert J Mathvink; Jiafang He; You-Jung Park; Huaibing He; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Joseph K Wu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(10):2533-6.
2005: Wallace T Ashton; Rosemary M Sisco; Hong Dong; Kathryn A Lyons; Huaibing He; George A Doss; Barbara Leiting; Reshma A Patel; Joseph K Wu; Frank Marsilio; Nancy A Thornberry; Ann E Weber
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Bioorganic & medicinal chemistry letters 2005;15(9):2253-8.
2005: Dooseop Kim; Liping Wang; Maria G Beconi; George J Eiermann; Michael H Fisher; Huaibing He; Gerard J Hickey; Jennifer E Kowalchick; Barbara Leiting; Kathryn Lyons; Frank Marsilio; Margaret E McCann; Reshma A Patel; Aleksandr Petrov; Giovanna Scapin; Sangita B Patel; Ranabir Sinha Roy; Joseph K Wu; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2005;48(1):141-51.
2004: Scott D Edmondson; Anthony Mastracchio; Maria G Beconi; Lawrence F Colwell; Bahanu Habulihaz; Huaibing He; Sanjeev Kumar; Barbara Leiting; Kathryn A Lyons; Ann Mao; Frank Marsilio; Reshma A Patel; Joseph K Wu; Lan Zhu; Nancy A Thornberry; Ann E Weber; Emma R Parmee
Potent and selective proline derived dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(20):5151-5.
2004: Linda L Brockunier; Jiafang He; Lawrence F Colwell; Bahanu Habulihaz; Huaibing He; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Yohannes Teffera; Joseph K Wu; Nancy A Thornberry; Ann E Weber; Emma R Parmee
Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(18):4763-6.
2004: Jinyou Xu; Hyun O Ok; Edward J Gonzalez; Lawrence F Colwell; Bahanu Habulihaz; Huaibing He; Barbara Leiting; Kathryn A Lyons; Frank Marsilio; Reshma A Patel; Joseph K Wu; Nancy A Thornberry; Ann E Weber; Emma R Parmee
Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(18):4759-62.
2004: Charles G Caldwell; Ping Chen; Jiafang He; Emma R Parmee; Barbara Leiting; Frank Marsilio; Reshma A Patel; Joseph K Wu; George J Eiermann; Aleksandr Petrov; Huaibing He; Kathryn A Lyons; Nancy A Thornberry; Ann E Weber
Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(5):1265-8.
2004: Wallace T Ashton; Hong Dong; Rosemary M Sisco; George A Doss; Barbara Leiting; Reshma A Patel; Joseph K Wu; Frank Marsilio; Nancy A Thornberry; Ann E Weber
Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(4):859-63.
2004: Emma R Parmee; Jiafang He; Anthony Mastracchio; Scott D Edmondson; Lawrence F Colwell; George J Eiermann; William P Feeney; Bahanu Habulihaz; Huaibing He; Ruth Kilburn; Barbara Leiting; Kathryn Lyons; Frank Marsilio; Reshma A Patel; Aleksandr Petrov; Jerry Di Salvo; Joseph K Wu; Nancy A Thornberry; Ann E Weber
4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(1):43-6.
2003: Scott D Edmondson; Anthony Mastracchio; Jiafang He; Christine C Chung; Michael J Forrest; Scott Hofsess; Euan MacIntyre; Joseph Metzger; Naphtali O'Connor; Kajal Patel; Xinchun Tong; Michael R Tota; Lex H T Van Der Ploeg; Jeffrey P Varnerin; Michael H Fisher; Matthew J Wyvratt; Ann E Weber; Emma R Parmee
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(22):3983-7.
2002: Wei Tang; Ralph A Stearns; Randall R Miller; Jason S Ngui; Robert J Mathvink; Ann E Weber; Gloria Y Kwei; John R Strauss; Carol Ann Keohane; George A Doss; Shuet-Hing Lee Chiu; Thomas A Baillie
Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(7):778-87.
2002: Ralph A Stearns; Randall R Miller; Wei Tang; Gloria Y Kwei; Frank S Tang; Robert J Mathvink; Elizabeth M Naylor; Dawn Chitty; Vincent J Colandrea; Ann E Weber; Adria Colletti; John R Strauss; Carol Ann Keohane; William P Feeney; Susan A Iliff; Shuet-Hing Lee Chiu
The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(7):771-7.
2001: Gary J Hom; Michael J Forrest; TJ Bach; Edward J Brady; Mari Rios Candelore; Margaret A Cascieri; D J Fletcher; Michael H Fisher; Susan A Iliff; Robert J Mathvink; J Metzger; V Pecore; Richard Saperstein; T Shih; Ann E Weber; Matthew J Wyvratt; P Zafian; D Euan MacIntyre
Beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, facial flushing, and reflex tachycardia in anesthetized rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2001;297(1):299-307.
2001: L Chu; JE Hutchins; Ann E Weber; Jane-L Lo; Yi Tien Yang; Kang Cheng; Roy G Smith; Michael H Fisher; Matthew J Wyvratt; Mark T Goulet
Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles.
Bioorganic & medicinal chemistry letters 2001;11(4):509-13.
2001: Linda L Brockunier; Mari Rios Candelore; Margaret A Cascieri; Y Liu; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber; Emma R Parmee
Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.
Bioorganic & medicinal chemistry letters 2001;11(3):379-82.
2000: Michael J Forrest; Gary J Hom; TJ Bach; Mari Rios Candelore; Margaret A Cascieri; Catherine D Strader; Laurie M Tota; Michael H Fisher; J Szumiloski; Hyun O Ok; Ann E Weber; Matthew J Wyvratt; Pasquale P Vicario; O Marko; L Deng; C Cioffe; B Hegarty-Friscino; E MacIntyre
L-750355, a human beta3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey.
European journal of pharmacology 2000;407(1-2):175-81.
2000: Robert J Mathvink; J S Tolman; Dawn Chitty; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide.
Journal of medicinal chemistry 2000;43(21):3832-6.
2000: Emma R Parmee; Linda L Brockunier; Jiafang He; Sheo B Singh; Mari Rios Candelore; Margaret A Cascieri; L Deng; Y Liu; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 2000;10(20):2283-6.
2000: Linda L Brockunier; Emma R Parmee; Hyun O Ok; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides.
Bioorganic & medicinal chemistry letters 2000;10(18):2111-4.
2000: Robert J Mathvink; J S Tolman; Dawn Chitty; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.
Bioorganic & medicinal chemistry letters 2000;10(17):1971-3.
2000: Hyun O Ok; L B Reigle; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Catherine D Strader; Laurie M Tota; P Wang; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 2000;10(14):1531-4.
2000: Szalkowski Deborah; D D Feng; Gui-Bai Liang; H Kuo; Xiaoxia Qian; Elizabeth M Naylor; Vincent J Colandrea; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Ralph A Stearns; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents.
Bioorganic & medicinal chemistry letters 2000;10(13):1431-4.
2000: D D Feng; Szalkowski Deborah; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Catherine D Strader; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist.
Bioorganic & medicinal chemistry letters 2000;10(13):1427-9.
1999: Mari Rios Candelore; L Deng; Laurie M Tota; Xiao-Ming Guan; A Amend; Y Liu; R Newbold; Margaret A Cascieri; Ann E Weber
Potent and selective human beta(3)-adrenergic receptor antagonists.
The Journal of pharmacology and experimental therapeutics 1999;290(2):649-55.
1999: Robert J Mathvink; A M Barritta; Mari Rios Candelore; Margaret A Cascieri; L Deng; Laurie M Tota; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Potent, elective human beta3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore.
Bioorganic & medicinal chemistry letters 1999;9(13):1869-74.
1999: Thomas L Shih; Mari Rios Candelore; Margaret A Cascieri; Shuet-Hing Lee Chiu; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Catherine D Strader; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability.
Bioorganic & medicinal chemistry letters 1999;9(9):1251-4.
1999: Elizabeth M Naylor; Emma R Parmee; Vincent J Colandrea; L Perkins; Linda L Brockunier; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Catherine D Strader; Laurie M Tota; Pei-ran Wang; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides.
Bioorganic & medicinal chemistry letters 1999;9(5):755-8.
1999: Emma R Parmee; Elizabeth M Naylor; L Perkins; Vincent J Colandrea; Hyun O Ok; Mari Rios Candelore; Margaret A Cascieri; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Randall R Miller; Ralph A Stearns; Catherine D Strader; Laurie M Tota; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides.
Bioorganic & medicinal chemistry letters 1999;9(5):749-54.
1998: Elizabeth M Naylor; Vincent J Colandrea; Mari Rios Candelore; Margaret A Cascieri; Lawrence F Colwell; L Deng; William P Feeney; Michael J Forrest; Gary J Hom; D Euan MacIntyre; Catherine D Strader; Laurie M Tota; Pei-ran Wang; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.
Bioorganic & medicinal chemistry letters 1998;8(21):3087-92.
1998: Ann E Weber; Hyun O Ok; Raul Alvaro; Mari Rios Candelore; Margaret A Cascieri; Shuet-Hing Lee Chiu; L Deng; Michael J Forrest; Gary J Hom; JE Hutchins; J Kao; D Euan MacIntyre; Robert J Mathvink; Debra McLoughlin; Randall R Miller; R C Newbold; Timothy V Olah; Emma R Parmee; L Perkins; Ralph A Stearns; Catherine D Strader; J Szumiloski; Yui S Tang; Laurie M Tota; Michael H Fisher
3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 1998;8(16):2111-6.
1998: Emma R Parmee; Hyun O Ok; Mari Rios Candelore; Laurie M Tota; L Deng; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher; Ann E Weber
Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist.
Bioorganic & medicinal chemistry letters 1998;8(9):1107-12.
1998: Ann E Weber; Robert J Mathvink; L Perkins; JE Hutchins; Mari Rios Candelore; Laurie M Tota; Catherine D Strader; Matthew J Wyvratt; Michael H Fisher
Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.
Bioorganic & medicinal chemistry letters 1998;8(9):1101-6.
1992: Ann E Weber; M G Steiner; P A Krieter; Adria Colletti; J R Tata; T A Halgren; R G Ball; J J Doyle; TW Schorn; Ralph A Stearns
Highly potent, orally active diester macrocyclic human renin inhibitors.
Journal of medicinal chemistry 1992;35(21):3755-73.
1991: Ann E Weber; T A Halgren; J J Doyle; R J Lynch; Peter K S Siegl; W H Parsons; W J Greenlee; Arthur A Patchett
Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.
Journal of medicinal chemistry 1991;34(9):2692-701.