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Dirk Wedekind

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Matthias Elsner; Hans-Jürgen Hedrich; Anne Jörns; Ortwin Naujok; Taivankhuu Terbish; Dirk Wedekind; Sigurd Lenzen
Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction.
Hassina Baraki; André Bleich; Silke Glage; Hans-Juergen Hedrich; Ingo Kutschka; Martin Meier; Dirk Wedekind; Norman Zinne; Axel Haverich
Magnetic resonance imaging of soft tissue infection with iron oxide labeled granulocytes in a rat model.
Nils-Holger Zschemisch; Dirk Wedekind; Edward J Weinstein; Xiaoxia Cui; Martina Dorsch; Silke Glage; Hans-Jürgen Hedrich
Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat.

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All Publications

2012: Matthias Elsner; Hans-Jürgen Hedrich; Anne Jörns; Ortwin Naujok; Taivankhuu Terbish; Dirk Wedekind; Sigurd Lenzen
Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):918-26.
2012: Hassina Baraki; André Bleich; Silke Glage; Hans-Juergen Hedrich; Ingo Kutschka; Martin Meier; Dirk Wedekind; Norman Zinne; Axel Haverich
Magnetic resonance imaging of soft tissue infection with iron oxide labeled granulocytes in a rat model.
PloS one 2012;7(12):e51770.
2012: Nils-Holger Zschemisch; Dirk Wedekind; Edward J Weinstein; Xiaoxia Cui; Martina Dorsch; Silke Glage; Hans-Jürgen Hedrich
Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat.
BMC immunology 2012;13():60.
2012: Emily Northrup; Dirk Wedekind; Nils-Holger Zschemisch; Edwin Cuppen; Martina Dorsch; Regina Eisenblätter; Silke Glage; Hans-Jürgen Hedrich
The ter mutation in the rat Dnd1 gene initiates gonadal teratomas and infertility in both genders.
PloS one 2012;7(5):e38001.
2011: Gustavo Salguero; Bala Sai Sundarasetty; Sarvari Velaga; Gregor Warnecke; Dirk Wedekind; Georg Behrens; Rainer Blasczyk; Sylvia Borchers; Britta Eiz-Vesper; Arnold Ganser; Adan C Jirmo; Ann-Kathrin Knöfel; Eva Mischak-Weissinger; Renata Stripecke
Preconditioning therapy with lentiviral vector-programmed dendritic cells accelerates the homeostatic expansion of antigen-reactive human T cells in NOD.Rag1-/-.IL-2rγc-/- mice.
Human gene therapy 2011;22(10):1209-24.
2011: Nadine Held; Bart M G Smits; Roland Gockeln; Stephanie Schubert; Heike Nave; Emily Northrup; Edwin Cuppen; Hans J Hedrich; Dirk Wedekind
A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats.
PloS one 2011;6(3):e15669.
2010: Andreas Schmiedl; J Krainski; F Schwichtenhövel; J Schade; C Klemann; K A Raber; Katja Zscheppang; T Beekmann; C Acevedo; Thomas Glaab; Dirk Wedekind; Reinhard Pabst; Stephan von Hörsten; Michael Stephan
Reduced airway inflammation in CD26/DPP4-deficient F344 rats is associated with altered recruitment patterns of regulatory T cells and expression of pulmonary surfactant proteins.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010;40(12):1794-808.
2010: Anne Jörns; Klaus Jan Rath; Taivankhuu Terbish; Tanja Arndt; Andreas Meyer zu Vilsendorf; Dirk Wedekind; Hans-Jürgen Hedrich; Sigurd Lenzen
Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation.
Endocrinology 2010;151(8):3555-65.
2010: Martina Dorsch; Dirk Wedekind
Cryopreservation and orthotopic transplantation of rat ovaries.
Methods in molecular biology (Clifton, N.J.) 2010;597():301-10.
2009: T Arndt; Dirk Wedekind; Heike Weiss; Markus Tiedge; Sigurd Lenzen; Hans J Hedrich; Anne Jörns
Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes.
Diabetologia 2009;52(7):1381-90.
2009: Nadine Frerker; Kerstin Raber; Felix Bode; Thomas Skripuletz; Heike Nave; Christian Klemann; Reinhard Pabst; Michael Stephan; Jutta Schade; Georg Brabant; Dirk Wedekind; Roland Jacobs; Anne Jörns; Ulf Forssmann; Rainer H Straub; Sigrid Johannes; Torsten Hoffmann; Leona Wagner; Hans-Ulrich Demuth; Stephan von Hörsten
Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):275-87.
2008: Heike Weiss; Tanja Arndt; Anne Jörns; Sigurd Lenzen; Edwin Cuppen; Hans J Hedrich; Markus Tiedge; Dirk Wedekind
The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(4):292-7.
2008: Balázs Tóth; Martina Wilke; Frauke Stanke; Martina Dorsch; Silke Jansen; Dirk Wedekind; Nikoletta Charizopoulou; Alice Bot; Marion Burmester; Sabine Leonhard-Marek; Hugo R de Jonge; Hans J Hedrich; Gerhard Breves; Burkhard Tümmler
Very mild disease phenotype of congenic CftrTgH(neoim)Hgu cystic fibrosis mice.
BMC genetics 2008;9():28.
2007: Martina Dorsch; Dirk Wedekind; Kenji Kamino; Hans J Hedrich
Cryopreservation and orthotopic transplantation of rat ovaries as a means of gamete banking.
Laboratory animals 2007;41(2):247-54.
2006: Xiaojiang Quan; Jean-Francois Laes; Daniel Stieber; Michèle Rivière; Jose Russo; Dirk Wedekind; Wouter Coppieters; Frédéric Farnir; Michel Georges; Josiane Szpirer; Claude Szpirer
Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat.
Mammalian genome : official journal of the International Mammalian Genome Society 2006;17(4):310-21.
2005: Takashi Kuramoto; Hiroshi Gohma; Kunio Kimura; Dirk Wedekind; Hans J Hedrich; Tadao Serikawa
The rat pink-eyed dilution (p) mutation: an identical intragenic deletion in pink-eye dilute-coat strains and several Wistar-derived albino strains.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(9):712-9.
2005: Anne Jörns; Armin Günther; Hans J Hedrich; Dirk Wedekind; Markus Tiedge; Sigurd Lenzen
Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.
Diabetes 2005;54(7):2041-52.
2005: Dirk Wedekind; Heike Weiss; Anne Jörns; Sigurd Lenzen; Markus Tiedge; Hans J Hedrich
Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the Lew.1AR1-iddm rat and in its coisogenic LEW.1AR1 background strain.
Autoimmunity 2005;38(4):265-75.
2005: Heike Weiss; Andre Bleich; Hans J Hedrich; Bernd Kölsch; Matthias Elsner; Anne Jörns; Sigurd Lenzen; Markus Tiedge; Dirk Wedekind
Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(6):432-41.
2005: Leyla Roshani; P Mallon; E Sjostrand; Dirk Wedekind; Josiane Szpirer; Claude Szpirer; Hans J Hedrich; Karin Klinga-Levan
Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model.
Cancer genetics and cytogenetics 2005;158(2):137-41.
2005: Bart M G Smits; Victor Guryev; Dimphy Zeegers; Dirk Wedekind; Hans J Hedrich; Edwin Cuppen
Efficient single nucleotide polymorphism discovery in laboratory rat strains using wild rat-derived SNP candidates.
BMC genomics 2005;6():170.
2004: B Länger; Martina Dorsch; K Gärtner; Dirk Wedekind; Kenji Kamino; Hans J Hedrich
WKY/Ztm-ter: a new rat inbred strain on the WKY/Ztm genetic background with congenital teratomas.
Laboratory animals 2004;38(4):425-31.
2004: Martina Dorsch; Dirk Wedekind; Kenji Kamino; Hans J Hedrich
Orthotopic transplantation of rat ovaries as a tool for strain rescue.
Laboratory animals 2004;38(3):307-12.
2004: Peter Olofsson; Asa Johansson; Dirk Wedekind; Ingrid Klöting; Karin Klinga-Levan; Shemin Lu; Rikard Holmdahl
Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.
Genomics 2004;83(5):765-71.
2004: Anne Jörns; Birgit Kubat; Markus Tiedge; Dirk Wedekind; Hans J Hedrich; Günter Klöppel; Sigurd Lenzen
Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm- iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus.
Virchows Archiv : an international journal of pathology 2004;444(2):183-9.
2003: Tim Karl; Wojciech T Chwalisz; Dirk Wedekind; Hans J Hedrich; Torsten Hoffmann; Roland Jacobs; Reinhard Pabst; Stephan von Hörsten
Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (Dipeptidyl-peptidase IV; CD26) gene in rats.
Regulatory peptides 2003;115(2):81-90.
2003: Wojciech T Chwalisz; Bernd U Koelsch; Andrea Kindler-Röhrborn; Hans J Hedrich; Dirk Wedekind
The circling behavior of the deafblind LEW-ci2 rat is linked to a segment of RNO10 containing Myo15 and Kcnj12.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(9):620-7.
2003: Andrea L González-Muñoz; Anne-France Le Rolle; Hélène Brun; Hans J Hedrich; Dirk Wedekind; Simon J Powis; Etienne Joly; Geoffrey W Butcher
A novel instance of class I modification (cim) affecting two of three rat class I RT1-A molecules within one MHC haplotype.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):274-84.
2001: Leyla Roshani; Dirk Wedekind; Josiane Szpirer; Z Taib; Claude Szpirer; B Beckmann; Michèle Rivière; Hans J Hedrich; Karin Klinga-Levan
Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model.
International journal of cancer. Journal international du cancer 2001;94(6):795-9.
2001: Alexander Kaiser; Maren Fedrowitz; Ulrich Ebert; E Zimmermann; Hans J Hedrich; Dirk Wedekind; Wolfgang Löscher
Auditory and vestibular defects in the circling (ci2) rat mutant.
The European journal of neuroscience 2001;14(7):1129-42.
2001: Sigurd Lenzen; Markus Tiedge; Matthias Elsner; Stephan Lortz; Heike Weiss; Anne Jörns; Günter Klöppel; Dirk Wedekind; CM Prokop; Hans J Hedrich
The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus.
Diabetologia 2001;44(9):1189-96.
2001: Alina Lessenich; Sven Lindemann; Angelika Richter; Hans J Hedrich; Dirk Wedekind; Alexander Kaiser; Wolfgang Löscher
A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions.
Neuroscience 2001;107(4):615-28.
1999: Dirk Wedekind; Hans J Hedrich
Characterization of RT1.B alleles from serologically identical and different RT1.B/D haplotypes.
Transplantation proceedings 1999;31(3):1522.
1999: Andreas S Beutler; Michaela S Banck; Dirk Wedekind; Hans J Hedrich
Tumor gene therapy made easy: allogeneic major histocompatibility complex in the C6 rat glioma model.
Human gene therapy 1999;10(1):95-101.
1998: Mikael Vestberg; U Brunsberg; K Bergsteinsdottir; M Karlsson; Kenth Gustafsson; Dirk Wedekind; Hans J Hedrich; Rikard Holmdahl
Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule.
Immunogenetics 1998;48(5):344-9.
1997: Dirk Wedekind; CM Prokop; U Brunsberg; Rikard Holmdahl; Hans J Hedrich
Identification and differentiation of transcribed major histocompatibility complex class II RT1B alpha and RT1B beta alleles from laboratory rats.
Transplantation proceedings 1997;29(3):1668-9.