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Gerald Weeks

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Dictyostelium

Chemicals & Drugs

Physiology

Genes & Molecular Sequences

Concepts & Ideas

Molecular Sequence Data

Phenomena

Phosphorylation

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Network (preview)

Co-Publications
Name
36
Spiegelman, George
11
Khosla, Meenal
5
Insall, Robert
5
Lim, Chinten James
5
Cardelli, James
5
Kae, Helmut
4
Secko, David
3
Bush, Jason
3
Pears, Catherine
3
Rebstein, PJ
2
van haastert, peter
2
Louis, Sharon
2
Kortholt, Arjan
2
Buczynski, G
2
Huang, Hao-Jen

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Publications

TOP 3
Bolourani Parvin; Spiegelman George B; Weeks Gerald
Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation.
Kae Helmut; Kortholt Arjan; Rehmann Holger; Insall Robert H; Van Haastert Peter J M; Spiegelman George B; Weeks Gerald
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs.
Bolourani Parvin; Spiegelman George B; Weeks Gerald
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum.

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All Publications

2008: Bolourani Parvin; Spiegelman George B; Weeks Gerald
Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation.
The Journal of biological chemistry 2008;283(16):10232-40.
2007: Kae Helmut; Kortholt Arjan; Rehmann Holger; Insall Robert H; Van Haastert Peter J M; Spiegelman George B; Weeks Gerald
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs.
EMBO reports 2007;8(5):477-82.
2006: Bolourani Parvin; Spiegelman George B; Weeks Gerald
Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum.
Molecular biology of the cell 2006;17(10):4543-50.
2006: Kortholt Arjan; Rehmann Holger; Kae Helmut; Bosgraaf Leonard; Keizer-Gunnink Ineke; Weeks Gerald; Wittinghofer Alfred; Van Haastert Peter J M
Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum.
The Journal of biological chemistry 2006;281(33):23367-76.
2006: Secko David M; Siu Chi-Hung; Spiegelman George B; Weeks Gerald
An activated Ras protein alters cell adhesion by dephosphorylating Dictyostelium DdCAD-1.
Microbiology (Reading, England) 2006;152(Pt 5):1497-505.
2006: Khosla Meenal; Kriebel Paul; Parent Carole A; Spiegelman George B; Weeks Gerald
A secondary disruption of the dmpA gene encoding a large membrane protein allows aggregation defective Dictyostelium rasC- cells to form multicellular structures.
Developmental biology 2006;292(1):68-78.
2005: Khosla Meenal; Spiegelman George B; Weeks Gerald
The effect of the disruption of a gene encoding a PI4 kinase on the developmental defect exhibited by Dictyostelium rasC(-) cells.
Developmental biology 2005;284(2):412-20.
2005: Lim Chinten James; Zawadzki Karl A; Khosla Meenal; Secko David M; Spiegelman George B; Weeks Gerald
Loss of the Dictyostelium RasC protein alters vegetative cell size, motility and endocytosis.
Experimental cell research 2005;306(1):47-55.
2005: Arigoni Maddalena; Bracco Enrico; Lusche Daniel F; Kae Helmut; Weeks Gerald; Bozzaro Salvatore
A novel Dictyostelium RasGEF required for chemotaxis and development.
BMC cell biology 2005;6():43.
2004: Secko David M; Insall Robert H; Spiegelman George B; Weeks Gerry
The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG.
Proteomics 2004;4(9):2629-39.
2004: Lin Hsiu-Hsu Sophia; Khosla Meenal; Huang Hao-Jen; Hsu Duen-Wei; Michaelis Christine; Weeks Gerald; Pears Catherine
A homologue of Cdk8 is required for spore cell differentiation in Dictyostelium.
Developmental biology 2004;271(1):49-58.
2004: Wessels Deborah; Brincks Rebecca; Kuhl Spencer; Stepanovic Vesna; Daniels Karla J; Weeks Gerald; Lim Chinten J; Spiegelman George; Fuller Danny; Iranfar Negin; Loomis William F; Soll David R
RasC plays a role in transduction of temporal gradient information in the cyclic-AMP wave of Dictyostelium discoideum.
Eukaryotic cell 2004;3(3):646-62.
2004: Kae Helmut; Lim Chinten James; Spiegelman George B; Weeks Gerald
Chemoattractant-induced Ras activation during Dictyostelium aggregation.
EMBO reports 2004;5(6):602-6.
2003: Weeks Gerald; Spiegelman George B
Roles played by Ras subfamily proteins in the cell and developmental biology of microorganisms.
Cellular signalling 2003;15(10):901-9.
2002: Kang Rujun; Kae Helmut; Ip Hermia; Spiegelman George B; Weeks Gerald
Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress.
Journal of cell science 2002;115(Pt 18):3675-82.
2002: Sharma Shiv K; Brock Debra A; Ammann Robin R; DeShazo Tiffany; Khosla Meenal; Gomer Richard H; Weeks Gerald
The cdk5 homologue, crp, regulates endocytosis and secretion in dictyostelium and is necessary for optimum growth and differentiation.
Developmental biology 2002;247(1):1-10.
2002: Lim Chinten James; Spiegelman George B; Weeks Gerald
Cytoskeletal regulation by Dictyostelium Ras subfamily proteins.
Journal of muscle research and cell motility 2002;23(7-8):729-36.
2001: Sutherland B W; Spiegelman G B; Weeks G
A Ras subfamily GTPase shows cell cycle-dependent nuclear localization.
EMBO reports 2001;2(11):1024-8.
2001: Lim C J; Spiegelman G B; Weeks G
RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation.
The EMBO journal 2001;20(16):4490-9.
2001: Secko D M; Khosla M; Gaudet P; Tsang A; Spiegelman G B; Weeks G
RasG regulates discoidin gene expression during Dictyostelium growth.
Experimental cell research 2001;266(1):135-41.
2001: Jaffer Z M; Khosla M; Spiegelman G B; Weeks G
Expression of activated Ras during Dictyostelium development alters cell localization and changes cell fate.
Development (Cambridge, England) 2001;128(6):907-16.
2000: Weeks G
Signalling molecules involved in cellular differentiation during Dictyostelium morphogenesis.
Current opinion in microbiology 2000;3(6):625-30.
2000: Wilkins A; Khosla M; Fraser D J; Spiegelman G B; Fisher P R; Weeks G; Insall R H
Dictyostelium RasD is required for normal phototaxis, but not differentiation.
Genes & development 2000;14(11):1407-13.
2000: Khosla M; Spiegelman G B; Insall R; Weeks G
Functional overlap of the dictyostelium RasG, RasD and RasB proteins.
Journal of cell science 2000;113 ( Pt 8)():1427-34.
1999: Sharma S K; Michaelis C; Lee K Y; Wang J H; Weeks G
Binding and catalytic properties of the Cdc2 and Crp proteins of Dictyostelium.
European journal of biochemistry / FEBS 1999;260(3):603-8.
1999: Zhang T; Rebstein P J; Khosla M; Cardelli J; Buczynski G; Bush J; Spiegelman G B; Weeks G
A mutation that separates the RasG signals that regulate development and cytoskeletal function in Dictyostelium.
Experimental cell research 1999;247(2):356-66.
1999: Seastone D J; Zhang L; Buczynski G; Rebstein P; Weeks G; Spiegelman G; Cardelli J
The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum.
Molecular biology of the cell 1999;10(2):393-406.
1998: Kosaka C; Khosla M; Weeks G; Pears C
Negative influence of RasG on chemoattractant-induced ERK2 phosphorylation in Dictyostelium.
Biochimica et biophysica acta 1998;1402(1):1-5.
1997: Huang H J; Takagawa D; Weeks G; Pears C
Cells at the center of Dictyostelium aggregates become spores.
Developmental biology 1997;192(2):564-71.
1997: Louis S A; Weeks G; Spiegelman G B
Rap1 overexpression reveals that activated RasD induces separable defects during Dictyostelium development.
Developmental biology 1997;190(2):273-83.
1997: Tuxworth R I; Cheetham J L; Machesky L M; Spiegelmann G B; Weeks G; Insall R H
Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.
The Journal of cell biology 1997;138(3):605-14.
1997: Rebstein P J; Cardelli J; Weeks G; Spiegelman G B
Mutational analysis of the role of Rap1 in regulating cytoskeletal function in Dictyostelium.
Experimental cell research 1997;231(2):276-83.
1997: Louis S A; Spiegelman G B; Weeks G
Expression of an activated rasD gene changes cell fate decisions during Dictyostelium development.
Molecular biology of the cell 1997;8(2):303-12.
1996: Khosla M; Spiegelman G B; Weeks G
Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development.
Molecular and cellular biology 1996;16(8):4156-62.
1995: Luo Q; Michaelis C; Weeks G
Cyclin B and Cdc2 expression and Cd2 kinase activity during Dictyostelium differentiation.
DNA and cell biology 1995;14(11):901-8.
1995: Michaelis C; Luo Q; Weeks G
A Dictyostelium discoideum gene, which is highly related to mo15 from Xenopus, is expressed during growth but not during development.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(1-2):51-8.
1994: Weeks G; Weijer C J
The Dictyostelium cell cycle and its relationship to differentiation.
FEMS microbiology letters 1994;124(2):123-30.
1994: Luo Q; Michaelis C; Weeks G
Overexpression of a truncated cyclin B gene arrests Dictyostelium cell division during mitosis.
Journal of cell science 1994;107 ( Pt 11)():3105-14.
1994: So J S; Weeks G
The effect of extracellular cyclic AMP on differentiation inducing factor (DIF)-dependent prestalk cell gene expression in monolayers of Dictyostelium is complex.
Differentiation; research in biological diversity 1994;56(3):131-5.
1994: Khosla M; Spiegelman G B; Weeks G; Sands T W; Virdy K J; Cotter D A
RasG protein accumulation occurs just prior to amoebae emergence during spore germination in Dictyostelium discoideum.
FEMS microbiology letters 1994;117(3):293-8.
1994: Daniel J; Bush J; Cardelli J; Spiegelman G B; Weeks G
Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily.
Oncogene 1994;9(2):501-8.
1993: Bush J; Franek K; Daniel J; Spiegelman G B; Weeks G; Cardelli J
Cloning and characterization of five novel Dictyostelium discoideum rab-related genes.
Gene 1993;136(1-2):55-60.
1993: Michaelis C; Weeks G
The isolation from a unicellular organism, Dictyostelium discoideum, of a highly-related cdc2 gene with characteristics of the PCTAIRE subfamily.
Biochimica et biophysica acta 1993;1179(2):117-24.
1993: Daniel J; Spiegelman G B; Weeks G
Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum.
Oncogene 1993;8(4):1041-7.
1993: Rebstein P J; Weeks G; Spiegelman G B
Altered morphology of vegetative amoebae induced by increased expression of the Dictyostelium discoideum ras-related gene rap1.
Developmental genetics 1993;14(5):347-55.
1992: Thiery R; Robbins S; Khosla M; Spiegelman G B; Weeks G
The effects of expression of an activated rasG mutation on the differentiation of Dictyostelium.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1992;70(10-11):1193-9.
1992: Michaelis C; Weeks G
Isolation and characterization of a cdc 2 cDNA from Dictyostelium discoideum.
Biochimica et biophysica acta 1992;1132(1):35-42.
1992: Robbins S M; Williams J G; Spiegelman G B; Weeks G
Cloning and characterization of the Dictyostelium discoideum rasG genomic sequences.
Biochimica et biophysica acta 1992;1130(1):85-9.
1991: Weeks G; Gross J D
Potential morphogens involved in pattern formation during Dictyostelium differentiation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1991;69(9):608-17.
1991: Xie Y J; Kwong L; Weeks G
A possible role for DIF-2 in the formation of stalk cells during Dictyostelium development.
Developmental biology 1991;145(1):195-200.
1991: Robbins S M; Khosla M; Thiery R; Weeks G; Spiegelman G B
Ras-related genes in Dictyostelium discoideum.
Developmental genetics 1991;12(1-2):147-53.
1990: Robbins S M; Suttorp V V; Weeks G; Spiegelman G B
A ras-related gene from the lower eukaryote Dictyostelium that is highly conserved relative to the human rap genes.
Nucleic acids research 1990;18(17):5265-9.
1990: Kwong L; Xie Y J; Daniel J; Robbins S M; Weeks G
A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of prestalk cells.
Development (Cambridge, England) 1990;110(1):303-10.
1990: Khosla M; Robbins S M; Spiegelman G B; Weeks G
Regulation of DdrasG gene expression during Dictyostelium development.
Molecular and cellular biology 1990;10(3):918-22.
1989: Bhanot P; Weeks G
Studies on the mechanism of action of the alkaline phosphatase from Dictyostelium discoideum.
Biochimica et biophysica acta 1989;995(3):291-4.
1989: Kwong L; Weeks G
Studies on the accumulation of the differentiation-inducing factor (DIF) in high-cell-density monolayers of Dictyostelium discoideum.
Developmental biology 1989;132(2):554-8.
1989: Robbins S M; Williams J G; Jermyn K A; Spiegelman G B; Weeks G
Growing and developing Dictyostelium cells express different ras genes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):938-42.
1988: MacDonald J I; Weeks G
Purification and characterization of a Ca2+- or Mg2+-stimulated ATPase from plasma membrane enriched fractions of Dictyostelium discoideum.
Biochimica et biophysica acta 1988;945(2):211-20.
1988: Kwong L; Sobolewski A; Atkinson L; Weeks G
Stalk cell formation in monolayers from isolated prestalk and prespore cells of Dictyostelium discoideum: evidence for two populations of prestalk cells.
Development (Cambridge, England) 1988;104(1):121-7.
1988: MacDonald J I; Weeks G
Evidence for a membrane-bound pyrophosphatase in Dictyostelium discoideum.
FEBS letters 1988;238(1):9-12.
1988: Sobolewski A; Weeks G
The requirement for DIF for prestalk and stalk cell formation in Dictyostelium discoideum: a comparison of in vivo and in vitro differentiation conditions.
Developmental biology 1988;127(2):296-303.
1988: Sobolewski A; Kwong L; Weeks G
Stalk cell formation in monolayers of Dictyostelium discoideum V12-M2.
Developmental genetics 1988;9(4-5):597-605.
1987: Weeks G; Lima A F; Pawson T
A ras-encoded protein in Dictyostelium discoideum is acylated and membrane-associated.
Molecular microbiology 1987;1(3):347-54.
1985: MacDonald J I; Weeks G
The biosynthesis and turnover of lipid during the differentiation of Dictyostelium discoideum.
Biochimica et biophysica acta 1985;834(3):301-7.
1985: Bhanot P; Weeks G
The membrane-bound alkaline phosphatase and 5'-nucleotidase activities of vegetative cells of Dictyostelium discoideum.
Archives of biochemistry and biophysics 1985;236(2):497-505.
1985: Pawson T; Amiel T; Hinze E; Auersperg N; Neave N; Sobolewski A; Weeks G
Regulation of a ras-related protein during development of Dictyostelium discoideum.
Molecular and cellular biology 1985;5(1):33-9.
1984: Macdonald J I; Weeks G
A plasma membrane Mg2+-ATPase in the cellular slime mold Dictyostelium discoideum.
Archives of biochemistry and biophysics 1984;235(1):1-7.

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