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Sascha Weggen

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Andreas Rennhack; Sascha Weggen; Sandra Baches; Thorsten Jumpertz; Julia Ness; Claus U Pietrzik; Bruno Bulic
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells.
Jessica Bien; Tamara Jefferson; Thorsten Jumpertz; Gerd Multhaup; Lisa Munter; Sascha Weggen; Mirsada Causevic; Christoph Becker-Pauly; Claus U Pietrzik
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.
Heiko Zettl; Karlheinz Baumann; Dirk Beher; Bruno Bulic; Volker Hähnke; Thorsten Jumpertz; Julia Ness; Claus U Pietrzik; Arman Saric; Gisbert Schneider; Sascha Weggen
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.

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All Publications

2012: Andreas Rennhack; Sascha Weggen; Sandra Baches; Thorsten Jumpertz; Julia Ness; Claus U Pietrzik; Bruno Bulic
Synthesis of a potent photoreactive acidic γ-secretase modulator for target identification in cells.
Bioorganic & medicinal chemistry 2012;20(21):6523-32.
2012: Jessica Bien; Tamara Jefferson; Thorsten Jumpertz; Gerd Multhaup; Lisa Munter; Sascha Weggen; Mirsada Causevic; Christoph Becker-Pauly; Claus U Pietrzik
The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.
The Journal of biological chemistry 2012;287(40):33304-13.
2012: Heiko Zettl; Karlheinz Baumann; Dirk Beher; Bruno Bulic; Volker Hähnke; Thorsten Jumpertz; Julia Ness; Claus U Pietrzik; Arman Saric; Gisbert Schneider; Sascha Weggen
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
ACS chemical biology 2012;7(9):1488-95.
2012: Thorsten Pflanzner; Lothar Stitz; Sabrina Tschickardt; Sascha Weggen; Bettina André-Dohmen; Carsten Korth; Andreas Müller-Schiffmann; Benjamin Petsch; Claus U Pietrzik
Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(4):628-32.
2012: Simone Isbert; Stefan Kins; Gerd Multhaup; Andrea Schweitzer; Katja Wagner; Sascha Weggen; Simone Eggert; Claus U Pietrzik
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.
Cellular and molecular life sciences : CMLS 2012;69(8):1353-75.
2012: Antje Hillmann; Torsten Hoffmann; Stephan Schilling; Thomas Schneider-Axmann; Sascha Weggen; Thomas A Bayer; Bruno Bulic; Hans-Ulrich Demuth; Stefanie Hahn; Oliver Wirths
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.
Neurobiology of aging 2012;33(4):833.e39-50.
2012: Juan Deng; Frank Fernandez; Brian Giunta; Huayan Hou; Takashi Mori; Demian Obregon; Yan-Jiang Wang; Sascha Weggen; Wataru Araki; Jun Tan
Autoreactive-Aβ antibodies promote APP β-secretase processing.
Journal of neurochemistry 2012;120(5):732-40.
2012: Sascha Weggen; Dirk Beher
Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease.
Alzheimer's research & therapy 2012;4(2):9.
2012: Markus Hartenfeller; Ewgenij Proschak; Felix Reisen; Matthias Rupp; Holger Stark; Miriam Walter; Sascha Weggen; Heiko Zettl; Gisbert Schneider
DOGS: reaction-driven de novo design of bioactive compounds.
PLoS computational biology 2012;8(2):e1002380.
2011: Bruno Bulic; Stefanie Hahn; Thorsten Jumpertz; Julia Ness; Andreas Rennhack; Sascha Weggen
Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease.
Current neuropharmacology 2011;9(4):598-622.
2011: Thorsten Pflanzner; Bettina André-Dohmen; Maren C Janko; Christoph Rüdiger Wolfram Kuhlmann; Stefan Reuss; Anton J M Roebroek; Sascha Weggen; Claus U Pietrzik
LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier.
Neurobiology of aging 2011;32(12):2323.e1-11.
2011: Sarah A Sagi; Sascha Weggen; Kellen D Winden; todd golde; Jeremy C Koo; Thomas L Kukar; Christian B Lessard; Hiroko Maruyama; Edward H Koo
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
The Journal of biological chemistry 2011;286(46):39794-803.
2011: Martina Hieke; Julia Ness; Manfred Schubert-Zsilavecz; Ramona Steri; Sascha Weggen; Oliver Werz; Christine Greiner; Heiko Zettl
SAR studies of acidic dual γ-secretase/PPARγ modulators.
Bioorganic & medicinal chemistry 2011;19(18):5372-82.
2011: Michael T Heneka; Markus P Kummer; Sascha Weggen; B Bulic; Gerd Multhaup; L Münter; M Hüll; T Pflanzner; Claus U Pietrzik
Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease.
Current Alzheimer research 2011;8(2):115-31.
2011: Stefanie Hahn; Tanja Brüning; Julia Ness; Eva Czirr; Sandra Baches; Harrie Gijsen; Carsten Korth; Claus U Pietrzik; Bruno Bulic; Sascha Weggen
Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
Journal of neurochemistry 2011;116(3):385-95.
2010: Heiko Zettl; Sascha Weggen; Petra Schneider; Gisbert Schneider
Exploring the chemical space of gamma-secretase modulators.
Trends in pharmacological sciences 2010;31(9):402-10.
2010: Luise Richter; Lisa-Marie Munter; Julia Ness; Peter W Hildebrand; Muralidhar Dasari; Stephanie Unterreitmeier; Bruno Bulic; Michael Beyermann; Ronald Gust; Bernd Reif; Sascha Weggen; Dieter Langosch; Gerd Multhaup
Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(33):14597-602.
2010: Martina Hieke; Julia Ness; Ramona Steri; Michaela Dittrich; Christine Greiner; Oliver Werz; Karlheinz Baumann; Manfred Schubert-Zsilavecz; Sascha Weggen; Heiko Zettl
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Journal of medicinal chemistry 2010;53(12):4691-700.
2010: Sara M Reekmans; Thorsten Pflanzner; Philip L S M Gordts; Simone Isbert; Pascale Zimmermann; Wim Annaert; Sascha Weggen; Anton J M Roebroek; Claus U Pietrzik
Inactivation of the proximal NPXY motif impairs early steps in LRP1 biosynthesis.
Cellular and molecular life sciences : CMLS 2010;67(1):135-45.
2009: Sebastian Jäger; Stefanie Leuchtenberger; Anne Martin; Eva Czirr; Johanna Wesselowski; Marco Dieckmann; Elaine Waldron; Carsten Korth; Edward H Koo; Michael Heneka; Sascha Weggen; Claus U Pietrzik
alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
Journal of neurochemistry 2009;111(6):1369-82.
2009: Markus P Kummer; Hiroko Maruyama; Claudia Huelsmann; Sandra Baches; Sascha Weggen; Edward H Koo
Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase.
The Journal of biological chemistry 2009;284(4):2296-306.
2008: Elaine Waldron; Catherine Heilig; Andrea Schweitzer; Nirupa Nadella; Sebastian Jaeger; Anne M Martin; Sascha Weggen; Klaudia Brix; Claus U Pietrzik
LRP1 modulates APP trafficking along early compartments of the secretory pathway.
Neurobiology of disease 2008;31(2):188-97.
2008: Elaine Waldron; Simone Isbert; Andreas Kern; Sebastian Jaeger; Anne M Martin; Sébastien S Hébert; Christian Behl; Sascha Weggen; Bart De Strooper; Claus U Pietrzik
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
Experimental cell research 2008;314(13):2419-33.
2008: Eva Czirr; Barbara A Cottrell; Stefanie Leuchtenberger; Thomas Kukar; Thomas B Ladd; Hermann Esselmann; Sabine Paul; Robert Schubenel; Justin W Torpey; Claus U Pietrzik; todd golde; Jens Wiltfang; Karlheinz Baumann; Edward H Koo; Sascha Weggen
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
The Journal of biological chemistry 2008;283(25):17049-54.
2008: Anne M Martin; Christoph Kuhlmann; Svenja Trossbach; Sebastian Jaeger; Elaine Waldron; Anton J M Roebroek; Heiko J Luhmann; Alexander Laatsch; Sascha Weggen; Volkmar Lessmann; Claus U Pietrzik
The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.
The Journal of biological chemistry 2008;283(18):12004-13.
2008: Rajeshwar Narlawar; Marcus Pickhardt; Stefanie Leuchtenberger; Karlheinz Baumann; Sabine Krause; Thomas Dyrks; Sascha Weggen; Eckhard Mandelkow; Boris Schmidt
Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?
ChemMedChem 2008;3(1):165-72.
2007: Sascha Weggen; Mark Rogers; Jason Eriksen
NSAIDs: small molecules for prevention of Alzheimer's disease or precursors for future drug development?
Trends in pharmacological sciences 2007;28(10):536-43.
2007: Eva Czirr; Stefanie Leuchtenberger; Cornelia Dorner-Ciossek; Anna Schneider; Mathias Jucker; Edward H Koo; Claus U Pietrzik; Karlheinz Baumann; Sascha Weggen
Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
The Journal of biological chemistry 2007;282(34):24504-13.
2006: Stefanie Leuchtenberger; Dirk Beher; Sascha Weggen
Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond.
Current pharmaceutical design 2006;12(33):4337-55.
2006: Eva Czirr; Sascha Weggen
Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds.
Neuro-degenerative diseases 2006;3(4-5):298-304.
2006: Stefanie Leuchtenberger; Markus P Kummer; Thomas Kukar; Eva Czirr; Nicole Teusch; Sarah A Sagi; Rebecca Berdeaux; Claus U Pietrzik; Thomas B Ladd; todd golde; Edward H Koo; Sascha Weggen
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
Journal of neurochemistry 2006;96(2):355-65.
2005: Thomas Kukar; Michael Murphy; Jason Eriksen; Sarah A Sagi; Sascha Weggen; Tawnya E Smith; Thomas B Ladd; Murad A Khan; Rajashaker Kache; Jenny Beard; Mark Dodson; Sami Merit; Victor V Ozols; PZ Anastasiadis; Pritam Das; Abdul Fauq; Edward H Koo; todd golde
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.
Nature medicine 2005;11(5):545-50.
2004: Claus U Pietrzik; Il-Sang Yoon; Sebastian Jaeger; Tracy Busse; Sascha Weggen; Edward H Koo
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(17):4259-65.
2003: Andreas Waha; Andreas Waha; Arend Koch; Birgit Meyer-Puttlitz; Sascha Weggen; Niels Sörensen; Jörg-Christian Tonn; Steffen Albrecht; Cynthia G Goodyer; Frank Berthold; Otmar D Wiestler; Torsten Pietsch
Epigenetic silencing of the HIC-1 gene in human medulloblastomas.
Journal of neuropathology and experimental neurology 2003;62(11):1192-201.
2003: Sascha Weggen; Jason Eriksen; Sarah A Sagi; Claus U Pietrzik; Victor V Ozols; Abdul Fauq; todd golde; Edward H Koo
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.
The Journal of biological chemistry 2003;278(34):31831-7.
2003: Sarah A Sagi; Sascha Weggen; Jason Eriksen; todd golde; Edward H Koo
The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production.
The Journal of biological chemistry 2003;278(34):31825-30.
2003: Sascha Weggen; Jason Eriksen; Sarah A Sagi; Claus U Pietrzik; todd golde; Edward H Koo
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.
The Journal of biological chemistry 2003;278(33):30748-54.
2003: Michele Carbone; Maurizio Bocchetta; Alfonso Cristaudo; Salih Emri; Adi F Gazdar; Bharat Jasani; John A Lednicky; Lucio Miele; Luciano Mutti; Harvey I Pass; Marc Ramael; Paola Rizzo; Joseph R Testa; Sascha Weggen; Anthony Yeung
SV40 and human brain tumors.
International journal of cancer. Journal international du cancer 2003;106(1):140-2; author reply 143-5.
2003: Jason Eriksen; Sarah A Sagi; Tawnya E Smith; Sascha Weggen; Pritam Das; D C McLendon; Victor V Ozols; Kevin W Jessing; Kenton H Zavitz; Edward H Koo; todd golde
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.
The Journal of clinical investigation 2003;112(3):440-9.
2003: Oliver Wirths; Andreas Waha; Sascha Weggen; Peter Schirmacher; Thomas Kühne; Cynthia G Goodyer; Steffen Albrecht; Dietrich von Schweinitz; Torsten Pietsch
Overexpression of human Dickkopf-1, an antagonist of wingless/WNT signaling, in human hepatoblastomas and Wilms' tumors.
Laboratory investigation; a journal of technical methods and pathology 2003;83(3):429-34.
2002: Claus U Pietrzik; Tracy Busse; David E Merriam; Sascha Weggen; Edward H Koo
The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing.
The EMBO journal 2002;21(21):5691-700.
2001: Sascha Weggen; Jason Eriksen; Pritam Das; Sarah A Sagi; Rong Wang; Claus U Pietrzik; Kirk Findlay; Tawnya E Smith; Michael Murphy; T Bulter; David E Kang; NR Marquez-Sterling; todd golde; Edward H Koo
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
Nature 2001;414(6860):212-6.
2001: Sascha Weggen; Ute Preuss; Torsten Pietsch; N Hilger; Ingrid Klawitz; Karl-Heinz Scheidtmann; Otmar D Wiestler; Thomas A Bayer
Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping.
Oncogene 2001;20(16):2023-31.
2000: Sascha Weggen; Thomas A Bayer; Andreas von Deimling; Guido Reifenberger; Dietrich von Schweinitz; Otmar D Wiestler; Torsten Pietsch
Low frequency of SV40, JC and BK polyomavirus sequences in human medulloblastomas, meningiomas and ependymomas.
Brain pathology (Zurich, Switzerland) 2000;10(1):85-92.
1999: Thomas A Bayer; M Thier; Elke Roeb; B Breuer; Sascha Weggen; Otmar D Wiestler; J Weis
Migratory potential of transplantable neural tumor cell lines.
Acta neuropathologica 1999;97(6):607-12.
1999: A Diehlmann; N Ida; Sascha Weggen; J Grünberg; Christian Haass; Colin L Masters; Thomas A Bayer; Konrad Beyreuther
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
Journal of neuroscience research 1999;56(4):405-19.
1999: H Salewski; Thomas A Bayer; U Eidhoff; Ute Preuss; Sascha Weggen; Karl-Heinz Scheidtmann
Increased oncogenicity of subclones of SV40 large T-induced neuroectodermal tumor cell lines after loss of large T expression and concomitant mutation in p53.
Cancer research 1999;59(8):1980-6.
1999: R Egensperger; Sascha Weggen; N Ida; Gerd Multhaup; R Schnabel; Konrad Beyreuther; Thomas A Bayer
Reverse relationship between beta-amyloid precursor protein and beta-amyloid peptide plaques in Down's syndrome versus sporadic/familial Alzheimer's disease.
Acta neuropathologica 1999;97(2):113-8.
1998: Sascha Weggen; A Diehlmann; R Buslei; Konrad Beyreuther; Thomas A Bayer
Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer's disease brain.
Neuroreport 1998;9(14):3279-83.
1997: Thomas A Bayer; Krzysztof Paliga; Sascha Weggen; Otmar D Wiestler; Konrad Beyreuther; Gerd Multhaup
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease.
Acta neuropathologica 1997;94(6):519-24.
1997: Sascha Weggen; Thomas A Bayer; Arend Koch; H Salewski; Karl-Heinz Scheidtmann; Torsten Pietsch; Otmar D Wiestler
Characterization of neural cell lines derived from SV40 large T-induced primitive neuroectodermal tumors.
Brain pathology (Zurich, Switzerland) 1997;7(2):731-9.