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Jan Wehkamp

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Svetlana Becker; Tobias A Oelschlaeger; Manolis Pasparakis; Eduard F Stange; Jan Wehkamp; Andy Wullaert; Michael Gersemann
Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo.
Simon Jäger; Eduard F Stange; Jan Wehkamp
Inflammatory bowel disease: an impaired barrier disease.
Jeanette Wagener; Jan Wehkamp; Lydia Schild; Josef J Schneider; Susann Baxmann; Claudia Borelli; Christina Braunsdorf; Wolf-Georg Forssmann; Bernhard Hube; Matthias D Kaeser; Hubert Kalbacher; Hans-Christian Korting; Robert Küchler; Cornelia Liepke; Daniela Mailänder-Sanchez; Sabine Nuding; Martin Schaller
A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation.

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All Publications

2013: Svetlana Becker; Tobias A Oelschlaeger; Manolis Pasparakis; Eduard F Stange; Jan Wehkamp; Andy Wullaert; Michael Gersemann
Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo.
PloS one 2013;8(2):e55620.
2013: Simon Jäger; Eduard F Stange; Jan Wehkamp
Inflammatory bowel disease: an impaired barrier disease.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2013;398(1):1-12.
2013: Jeanette Wagener; Jan Wehkamp; Lydia Schild; Josef J Schneider; Susann Baxmann; Claudia Borelli; Christina Braunsdorf; Wolf-Georg Forssmann; Bernhard Hube; Matthias D Kaeser; Hubert Kalbacher; Hans-Christian Korting; Robert Küchler; Cornelia Liepke; Daniela Mailänder-Sanchez; Sabine Nuding; Martin Schaller
A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation.
The Journal of investigative dermatology 2013;133(1):144-53.
2012: Anja Troge; Jan Wehkamp; Klaus Heuner; Stefan A Rund; Wolfgang Scheppach; Bjoern O Schroeder; Eduard F Stange; Tobias A Oelschlaeger
More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus.
International journal of medical microbiology : IJMM 2012;302(7-8):304-14.
2012: Wolfgang Hueber; Jacek Karczewski; Marek Karczewski; Steve Lewitzky; Marco Londei; Bjoern Mellgard; Nicole Pezous; Walter Reinisch; Bruce E Sands; Gervais Tougas; Simon P L Travis; Marc Vandemeulebroecke; Jan Wehkamp; Michael D Yao; Stephan Bek; Claudia Berger; Arthur P Bertolino; Gerard Bruin; Brian G Feagan; Peter Higgins
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial.
Gut 2012;61(12):1693-700.
2012: B O Schroeder; E F Stange; Jan Wehkamp
[Human beta-defensin 1: from defence to offence].
Zeitschrift für Gastroenterologie 2012;50(11):1171-5.
2012: Ean-jeong Seo; Jan Wehkamp; Stephanie Weibel; Tobias A Oelschlaeger
Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins.
International journal of medical microbiology : IJMM 2012;302(6):276-87.
2012: Hiutung Chu; Maarten F de Jong; Grace Jung; Robert I Lehrer; Wuyuan Lu; Sean-Paul Nuccio; Marzena Pazgier; Nita H Salzman; Bo Shen; Renée M Tsolis; Mark A Underwood; Jan Wehkamp; Maria G Winter; Sebastian E Winter; Glenn M Young; Andreas J Baumler; Patricia A Castillo; Charles L Bevins
Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets.
Science (New York, N.Y.) 2012;337(6093):477-81.
2012: Michael Gersemann; Sabine Nuding; German Ott; Naohide Oue; Lena Antoni; Svetlana Becker; Peter Fritz; Jan Wehkamp; Wataru Yasui; Eduard F Stange
Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD.
Journal of Crohn's & colitis 2012;6(4):425-34.
2012: M Gersemann; Jan Wehkamp; Eduard F Stange
Innate immune dysfunction in inflammatory bowel disease.
Journal of internal medicine 2012;271(5):421-8.
2012: Mark A Underwood; Jan Wehkamp; Camille K Adkins-Reick; Stephen H Bennett; Patricia A Castillo; Hiutung Chu; Christine F Coursodon; Bohuslav Dvorak; Anchasa Kananurak; Brian C Leonard; Michael P Sherman; Daniel J Tancredi; Charles L Bevins
Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses.
Pediatric research 2012;71(5):546-51.
2012: F Rieder; Gerhard Rogler; Shomron Ben-Horin; Colin de Haar; Robert Ehehalt; Peter Higgins; Thomas Karrasch; Giovanni Latella; Franco Scaldaferri; Anja Schirbel; Dominique Velin; Jan Wehkamp; Miquel Sans
Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing.
Journal of Crohn's & colitis 2012;6(3):373-85.
2012: Zora Teltschik; Reiner Wiest; Julia Beisner; Charles L Bevins; Claudia Hofmann; Sabine Nuding; Juergen Schoelmerich; Eduard F Stange; Jan Wehkamp
Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.
Hepatology (Baltimore, Md.) 2012;55(4):1154-63.
2012: Maureen J Koslowski; Irmgard Kübler; Walter Reinisch; Paul Rutgeerts; Elke Schaeffeler; Matthias Schwab; Eduard F Stange; Zora Teltschik; Séverine Vermeire; Guoxing Wang; Julia Beisner; Rachel Cooney; Michael Gersemann; Derek Jewell; Jan Wehkamp
Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease.
PLoS genetics 2012;8(2):e1002523.
2011: Michael Gersemann; Eduard Friedrich Stange; Jan Wehkamp
From intestinal stem cells to inflammatory bowel diseases.
World journal of gastroenterology : WJG 2011;17(27):3198-203.
2011: Bjoern O Schroeder; Eduard F Stange; Jan Wehkamp
Waking the wimp: redox-modulation activates human beta-defensin 1.
Gut microbes 2011;2(4):262-6.
2011: Bjoern O Schroeder; Zhihong Wu; Sabine Nuding; Sandra Groscurth; Moritz Marcinowski; Julia Beisner; Johannes Buchner; Martin Schaller; Eduard F Stange; Jan Wehkamp
Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1.
Nature 2011;469(7330):419-23.
2011: Julia Beisner; Eduard F Stange; Jan Wehkamp
Paneth cell function--implications in pediatric Crohn disease.
Gut microbes 2011;2(1):47-51.
2010: Jan Wehkamp; Eduard F Stange
Paneth's disease.
Journal of Crohn's & colitis 2010;4(5):523-31.
2010: Julia Beisner; Eduard F Stange; Jan Wehkamp
Innate antimicrobial immunity in inflammatory bowel diseases.
Expert review of clinical immunology 2010;6(5):809-18.
2010: Laurent Peyrin-Biroulet; Julia Beisner; Guoxing Wang; Sabine Nuding; Sajit Thottathil Oommen; Denise Kelly; Erika Parmentier-Decrucq; Rodrigue Dessein; Emilie Merour; Philipe Chavatte; Teddy Grandjean; Aude Bressenot; Pierre Desreumaux; Jean-Frédéric Colombel; Béatrice Desvergne; Eduard F Stange; Jan Wehkamp; Mathias Chamaillard
Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(19):8772-7.
2010: Gøri Perminow; Julia Beisner; Maureen Koslowski; Lars Gustav Lyckander; Eduard Stange; Morten Vatn; Jan Wehkamp
Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease.
The American journal of gastroenterology 2010;105(2):452-9.
2010: Simon Jäger; Eduard F Stange; Jan Wehkamp
Antimicrobial peptides in gastrointestinal inflammation.
International journal of inflammation 2010;2010():910283.
2010: Maureen J Koslowski; Julia Beisner; Eduard F Stange; Jan Wehkamp
Innate antimicrobial host defense in small intestinal Crohn's disease.
International journal of medical microbiology : IJMM 2010;300(1):34-40.
2009: I Kübler; M J Koslowski; M Gersemann; Klaus Fellermann; J Beisner; S Becker; K Rothfuss; Klaus R Herrlinger; Eduard F Stange; Jan Wehkamp
Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease.
Alimentary pharmacology & therapeutics 2009;30(6):621-33.
2009: Charles L Bevins; Eduard F Stange; Jan Wehkamp
Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype.
Gut 2009;58(6):882-3; discussion 883-4.
2009: Sabine Nuding; Lutz T Zabel; Corinne Enders; Edith Porter; Klaus Fellermann; Jan Wehkamp; Holger A G Mueller; Eduard F Stange
Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3.
Microbes and infection / Institut Pasteur 2009;11(3):384-93.
2009: M Möndel; B O Schroeder; K Zimmermann; H Huber; Sabine Nuding; J Beisner; Klaus Fellermann; Eduard F Stange; Jan Wehkamp
Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans.
Mucosal immunology 2009;2(2):166-72.
2009: Jost Langhorst; Angela Junge; Andreas Rueffer; Jan Wehkamp; Dirk Foell; Andreas Michalsen; Frauke Musial; Gustav J Dobos
Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome.
The American journal of gastroenterology 2009;104(2):404-10.
2009: Bo Shen; Feza H Remzi; Jeffrey P Hammel; Bret A Lashner; Charles L Bevins; Ian C Lavery; Jan Wehkamp; Victor W Fazio
Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch.
Inflammatory bowel diseases 2009;15(2):163-70.
2009: Michael Gersemann; Svetlana Becker; Irmgard Kübler; Maureen Koslowski; Guoxing Wang; Klaus Robert Herrlinger; Joscha Griger; Peter Fritz; Klaus Fellermann; Matthias Schwab; Jan Wehkamp; Eduard Friedrich Stange
Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis.
Differentiation; research in biological diversity 2009;77(1):84-94.
2009: Maureen J Koslowski; Irmgard Kübler; Mathias Chamaillard; Elke Schaeffeler; Walter Reinisch; Guoxing Wang; Julia Beisner; Alexander Teml; Laurent Peyrin-Biroulet; Stefan Winter; Klaus R Herrlinger; Paul Rutgeerts; Séverine Vermeire; Rachel Cooney; Klaus Fellermann; Derek Jewell; Charles L Bevins; Matthias Schwab; Eduard F Stange; Jan Wehkamp
Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease.
PloS one 2009;4(2):e4496.
2008: Yoshio Hosaka; Maureen Koslowski; Sabine Nuding; Guoxing Wang; Miriam Schlee; Christian Schäfer; Katunori Saigenji; Eduard F Stange; Jan Wehkamp
Antimicrobial host defense in the upper gastrointestinal tract.
European journal of gastroenterology & hepatology 2008;20(12):1151-8.
2008: Jan Wehkamp; Eduard F Stange
Is there a role for defensins in IBD?
Inflammatory bowel diseases 2008;14 Suppl 2():S85-7.
2008: Michael Gersemann; Jan Wehkamp; Klaus Fellermann; Eduard Friedrich Stange
Crohn's disease--defect in innate defence.
World journal of gastroenterology : WJG 2008;14(36):5499-503.
2008: Sieglinde Angelberger; Walter Reinisch; Clemens Dejaco; Wolfgang Miehsler; Thomas Waldhoer; Jan Wehkamp; Cornelia Lichtenberger; Elke Schaeffeler; Harald Vogelsang; Matthias Schwab; Alexander Teml
NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease.
The American journal of gastroenterology 2008;103(5):1197-202.
2008: Miriam Schlee; J Harder; B Köten; Eduard F Stange; Jan Wehkamp; Klaus Fellermann
Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2.
Clinical and experimental immunology 2008;151(3):528-35.
2008: Arthur Holzer; Simone Harsch; Olga Renner; André Strohmeyer; Silke Schimmel; Jan Wehkamp; Peter Fritz; Eduard F Stange
Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation.
Digestion 2008;78(1):52-9.
2008: Michael D George; Jan Wehkamp; Robert J Kays; Christian M Leutenegger; Sadiah Sabir; Irina Grishina; Satya Dandekar; Charles L Bevins
In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues.
BMC genomics 2008;9():209.
2007: Guoxing Wang; Eduard F Stange; Jan Wehkamp
Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.
Expert review of anti-infective therapy 2007;5(6):1049-57.
2007: Jan Wehkamp; Guoxing Wang; Irmgard Kübler; Sabine Nuding; Alex Gregorieff; Anke Schnabel; Robert J Kays; Klaus Fellermann; Oliver Burk; Matthias Schwab; Hans Clevers; Charles L Bevins; Eduard F Stange
The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3109-18.
2007: Sabine Nuding; Klaus Fellermann; Jan Wehkamp; Eduard F Stange
Reduced mucosal antimicrobial activity in Crohn's disease of the colon.
Gut 2007;56(9):1240-7.
2007: Jan Wehkamp; Michael Schmid; Eduard F Stange
Defensins and other antimicrobial peptides in inflammatory bowel disease.
Current opinion in gastroenterology 2007;23(4):370-8.
2007: Miriam Schlee; Jan Wehkamp; Artur Altenhoefer; Tobias A Oelschlaeger; Eduard F Stange; Klaus Fellermann
Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin.
Infection and immunity 2007;75(5):2399-407.
2007: Michael Schmid; Klaus Fellermann; Peter Fritz; Oliver Wiedow; Eduard F Stange; Jan Wehkamp
Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease.
Journal of leukocyte biology 2007;81(4):907-15.
2007: Jan Wehkamp; Jürgen Schauber; Eduard F Stange
Defensins and cathelicidins in gastrointestinal infections.
Current opinion in gastroenterology 2007;23(1):32-8.
2006: Jan Wehkamp; Eduard F Stange
Paneth cells and the innate immune response.
Current opinion in gastroenterology 2006;22(6):644-50.
2006: Jan Wehkamp; Hiutung Chu; Bo Shen; Ryan W Feathers; Robert J Kays; Sarah K Lee; Charles L Bevins
Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues.
FEBS letters 2006;580(22):5344-50.
2006: I Kübler; E F Stange; Klaus Fellermann; Jan Wehkamp
[Defensins: endogenous antibiotics as a central part of innate immunity].
Deutsche medizinische Wochenschrift (1946) 2006;131(36):1960-4.
2006: Klaus Fellermann; Daniel E Stange; Elke Schaeffeler; Hartmut Schmalzl; Jan Wehkamp; Charles L Bevins; Walter Reinisch; Alexander Teml; Matthias Schwab; Peter Lichter; Bernhard Radlwimmer; Eduard F Stange
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.
American journal of human genetics 2006;79(3):439-48.
2006: Jan Wehkamp; Eduard F Stange
A new look at Crohn's disease: breakdown of the mucosal antibacterial defense.
Annals of the New York Academy of Sciences 2006;1072():321-31.
2006: Jürgen Schauber; Daniel Rieger; Frank Weiler; Jan Wehkamp; Matthias Eck; Klaus Fellermann; Wolfgang Scheppach; Richard L Gallo; Eduard F Stange
Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases.
European journal of gastroenterology & hepatology 2006;18(6):615-21.
2006: Sabine Nuding; Klaus Fellermann; Jan Wehkamp; Holger A G Mueller; Eduard F Stange
A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts.
Journal of microbiological methods 2006;65(2):335-45.
2006: Eske Voss; Jan Wehkamp; Kai Wehkamp; Eduard F Stange; Jens Schröder; Jürgen Harder
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.
The Journal of biological chemistry 2006;281(4):2005-11.
2005: Jan Wehkamp; Nita H Salzman; Edith Porter; Sabine Nuding; Michael Weichenthal; Robert E Petras; Bo Shen; Elke Schaeffeler; Matthias Schwab; Rose Linzmeier; Ryan W Feathers; Hiutung Chu; Heriberto Lima; Klaus Fellermann; Tomas Ganz; Eduard F Stange; Charles L Bevins
Reduced Paneth cell alpha-defensins in ileal Crohn's disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18129-34.
2005: E F Stange; M Schmid; Klaus Fellermann; Jan Wehkamp
[Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance].
Praxis 2005;94(37):1429-32.
2005: Jan Wehkamp; Klaus Fellermann; Klaus R Herrlinger; Charles L Bevins; Eduard F Stange
Mechanisms of disease: defensins in gastrointestinal diseases.
Nature clinical practice. Gastroenterology & hepatology 2005;2(9):406-15.
2005: Jan Wehkamp; Eduard F Stange
NOD2 mutation and mice: no Crohn's disease but many lessons to learn.
Trends in molecular medicine 2005;11(7):307-9.
2005: Jan Wehkamp; Michael Schmid; Klaus Fellermann; Eduard F Stange
Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease.
Journal of leukocyte biology 2005;77(4):460-5.
2005: Jan Wehkamp; Klaus Fellermann; Eduard F Stange
Human defensins in Crohn's disease.
Chemical immunology and allergy 2005;86():42-54.
2004: Jan Wehkamp; Jürgen Harder; Michael Weichenthal; M Schwab; E Schäffeler; Miriam Schlee; Klaus R Herrlinger; A Stallmach; F Noack; P Fritz; Jens Schröder; Charles L Bevins; Klaus Fellermann; Eduard F Stange
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression.
Gut 2004;53(11):1658-64.
2004: Jan Wehkamp; Jürgen Harder; Kai Wehkamp; Birte Wehkamp-von Meissner; Miriam Schlee; Corinne Enders; Ulrich Sonnenborn; Sabine Nuding; Stig Bengmark; Klaus Fellermann; Jens Schröder; Eduard F Stange
NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium.
Infection and immunity 2004;72(10):5750-8.
2004: Klaus R Herrlinger; Rike Dittmann; Gunther Weitz; Jan Wehkamp; Diether Ludwig; Matthias Schwab; Eduard F Stange; Klaus Fellermann
Serum procalcitonin differentiates inflammatory bowel disease and self-limited colitis.
Inflammatory bowel diseases 2004;10(3):229-33.
2004: M Schmid; Klaus Fellermann; Jan Wehkamp; Klaus R Herrlinger; E F Stange
[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease].
Zeitschrift für Gastroenterologie 2004;42(4):333-8.
2003: Jan Wehkamp; Jürgen Harder; Michael Weichenthal; Oliver Mueller; Klaus R Herrlinger; Klaus Fellermann; Jens M Schroeder; Eduard F Stange
Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis.
Inflammatory bowel diseases 2003;9(4):215-23.
2003: Klaus Fellermann; Jan Wehkamp; Klaus R Herrlinger; Eduard F Stange
Crohn's disease: a defensin deficiency syndrome?
European journal of gastroenterology & hepatology 2003;15(6):627-34.
2003: Jan Wehkamp; Klaus Schmidt; Klaus R Herrlinger; Steffi Baxmann; S Behling; Charlotte Wohlschläger; Alfred C Feller; Eduard F Stange; Klaus Fellermann
Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.
Journal of clinical pathology 2003;56(5):352-7.
2003: Klaus Fellermann; Jan Wehkamp; Eduard F Stange
Antimicrobial peptides in the skin.
The New England journal of medicine 2003;348(4):361-3; author reply 361-3.
2002: Jan Wehkamp; Klaus Fellermann; Klaus R Herrlinger; Steffi Baxmann; Klaus Schmidt; Bettina Schwind; Michael Duchrow; Charlotte Wohlschläger; Alfred C Feller; Eduard F Stange
Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease.
European journal of gastroenterology & hepatology 2002;14(7):745-52.
2002: Jan Wehkamp; B Schwind; Klaus R Herrlinger; Steffi Baxmann; Klaus Schmidt; Michael Duchrow; Charlotte Wohlschläger; Alfred C Feller; Eduard F Stange; Klaus Fellermann
Innate immunity and colonic inflammation: enhanced expression of epithelial alpha-defensins.
Digestive diseases and sciences 2002;47(6):1349-55.