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Xander Wehrens

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Sameer Ather; Na Li; Qiongling Wang; Wei Wang; Mark E Anderson; Xander H T Wehrens
Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.
Laëtitia Pereira; Ralph J van Oort; Xander H T Wehrens; Joan Heller Brown; Ju Chen; Hongqiang Cheng; Dieu-Hung Lao; Li Na; Donald M Bers
Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.
Sayali S Dixit; Jeongkyung Lee; Eiffel John Q Manzano; Jonathan L Respress; Nicole Ryan; Tiannan Wang; Vijay K Yechoor; Shin Yoo; David Y Chiang; Xander H T Wehrens
Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.

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2013: Sameer Ather; Na Li; Qiongling Wang; Wei Wang; Mark E Anderson; Xander H T Wehrens
Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.
Heart rhythm : the official journal of the Heart Rhythm Society 2013;10(4):592-9.
2013: Laëtitia Pereira; Ralph J van Oort; Xander H T Wehrens; Joan Heller Brown; Ju Chen; Hongqiang Cheng; Dieu-Hung Lao; Li Na; Donald M Bers
Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.
Circulation 2013;127(8):913-22.
2013: Sayali S Dixit; Jeongkyung Lee; Eiffel John Q Manzano; Jonathan L Respress; Nicole Ryan; Tiannan Wang; Vijay K Yechoor; Shin Yoo; David Y Chiang; Xander H T Wehrens
Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.
PloS one 2013;8(3):e58655.
2013: Na Li; Xander H T Wehrens
Extinguishing intracellular calcium leak: a promising antiarrhythmic approach.
Heart rhythm : the official journal of the Heart Rhythm Society 2013;10(1):108-9.
2012: Sean DeGrande; Thomas J Hund; Farshid Kashef; Olha Koval; Na Li; Derek Nixon; Qiongling Wang; Xander H T Wehrens; Patrick Wright; Mark E Anderson; David Chiang; Jerald W Curran; Peter J Mohler
CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(12):2034-41.
2012: Priyatansh Gurha; Robert J Kelm; Brendan Lee; Maricela O Ramirez; Anilkumar K Reddy; Cei Abreu-Goodger; Nenad Bartonicek; Allan Bradley; Yuqing Chen; Ana L Drumond; Anton J Enright; Mark L Entman; George E Taffet; Stijn van Dongen; Tiannan Wang; Xander H T Wehrens; Antony Rodriguez
Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.
Circulation 2012;125(22):2751-61.
2012: Jonathan L Respress; Natale Rolim; Darlene G Skapura; Kristine Skårdal; Ralph J van Oort; Niels Voigt; Xun Ai; Angela deAlmeida; Sayali S Dixit; Dobromir Dobrev; William S Lawrence; Na Li; Steven M Pogwizd; Thomas Wieland; Ulrik Wisløff; Xander H T Wehrens
Role of RyR2 phosphorylation at S2814 during heart failure progression.
Circulation research 2012;110(11):1474-83.
2012: Niels Voigt; Qiongling Wang; Wei Wang; Xander H T Wehrens; Thomas Wieland; Na Li; Stanley Nattel; Ursula Ravens; Qiang Sun; Andrew W Trafford; Issam Abu-Taha; Dobromir Dobrev
Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.
Circulation 2012;125(17):2059-70.
2012: Tiannan Wang; Xander H T Wehrens
Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform.
Heart rhythm : the official journal of the Heart Rhythm Society 2012;9(4):598-9.
2012: Sameer Ather; Biykem Bozkurt; Wenyaw Chan; Kumudha Ramasubbu; Xander H T Wehrens; Amit A Zachariah; David Aguilar; Anita Deswal
Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction.
Journal of the American College of Cardiology 2012;59(11):998-1005.
2012: I Jayasinghe; Cherrie H T Kong; David Baddeley; Mark Cannell; Xander H T Wehrens; Christian Soeller
Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes.
Biophysical journal 2012;102(5):L19-21.
2012: Darwin Jeyaraj; Roman V Kondratov; Yuan Lu; Mark D McCauley; Jürgen A Ripperger; Jeffrey Robbins; David S Rosenbaum; Atsushi Sanbe; Nikunj Sharma; Steven A Shea; Xiaoping Wan; Xander H T Wehrens; Urs Albrecht; Michael J Cutler; Sophie Demolombe; Betty L Eapen; Eckhard Ficker; James Gulick; Saptarsi M Haldar; Kun Hu; Mukesh K Jain
Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Nature 2012;483(7387):96-9.
2012: Na Li; David S Rosenbaum; Niels Voigt; Qiongling Wang; Tiannan Wang; Wei Wang; Michael J Cutler; Dobromir Dobrev; Xander H T Wehrens
Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.
Circulation research 2012;110(3):465-70.
2012: Dajun Liu; Wei Wang; Yanlin Wang; Xander H T Wehrens; Maen Abdelrahim; Tatiana Belousova; Gabriel DiMattia; Luping Huang; David Sheikh-Hamad
Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway.
PloS one 2012;7(5):e36994.
2011: Shane R Cunha; Dobromir Dobrev; Hjalti Gudmundsson; Richard J Gumina; Seyed Hashemi; Thomas J Hund; Matthias Karck; Olha Koval; Herve Le Marec; Jingdong Li; Na Li; Vincent Probst; Jean-Jacques Schott; Niels Voigt; Xander H T Wehrens; Patrick Wright; Mark E Anderson; Peter J Mohler
Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation.
Circulation 2011;124(11):1212-22.
2011: Sameer Ather; Alvin Blaustein; Anita Deswal; Vijay G Divakaran; Irakli Giorgberidze; Douglas L Mann; Leif E Peterson; Kumudha Ramasubbu; Xander H T Wehrens; Biykem Bozkurt
Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data.
International journal of cardiology 2011;150(3):264-9.
2011: Mark D McCauley; Xander H T Wehrens
Targeting ryanodine receptors for anti-arrhythmic therapy.
Acta pharmacologica Sinica 2011;32(6):749-57.
2011: Ralph J van Oort; Alejandro Garbino; Wei Wang; Sayali S Dixit; Andrew P Landstrom; Namit Gaur; Angela C De Almeida; Darlene G Skapura; Yoram Rudy; Alan R Burns; Michael J Ackerman; Xander H T Wehrens
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
Circulation 2011;123(9):979-88.
2011: Sameer Ather; Wenyaw Chan; Annirudha Chillar; David Aguilar; Allison M Pritchett; Kumudha Ramasubbu; Xander H T Wehrens; Anita Deswal; Biykem Bozkurt
Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship.
American heart journal 2011;161(3):567-73.
2011: Andrew P Landstrom; Cherisse A Kellen; Sayali S Dixit; Ralph J van Oort; Alejandro Garbino; Noah Weisleder; Jianjie Ma; Xander H T Wehrens; Michael J Ackerman
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Circulation. Heart failure 2011;4(2):214-23.
2011: Dobromir Dobrev; Niels Voigt; Xander H T Wehrens
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications.
Cardiovascular research 2011;89(4):734-43.
2011: Mark D McCauley; Xander H T Wehrens
Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias.
Trends in cardiovascular medicine 2011;21(2):48-51.
2011: Xander H T Wehrens
CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(2):323-5.
2010: Ralph J van Oort; Mark D McCauley; Sayali S Dixit; Laetitia Pereira; Yi Yang; Jonathan L Respress; Qiongling Wang; Angela C De Almeida; Darlene G Skapura; Mark E Anderson; Donald M Bers; Xander H T Wehrens
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Circulation 2010;122(25):2669-79.
2010: Alejandro Garbino; Xander H T Wehrens
Emerging role of junctophilin-2 as a regulator of calcium handling in the heart.
Acta pharmacologica Sinica 2010;31(9):1019-21.
2010: Satyam Sarma; Na Li; Ralph J van Oort; Corey Reynolds; Darlene G Skapura; Xander H T Wehrens
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(29):13165-70.
2010: Jun Wang; Elzbieta Klysik; Subeena Sood; Randy L Johnson; Xander H T Wehrens; James F Martin
Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9753-8.
2010: Ralph J van Oort; Jonathan L Respress; Na Li; Corey Reynolds; Angela C De Almeida; Darlene G Skapura; Leon J De Windt; Xander H T Wehrens
Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.
Hypertension 2010;55(4):932-8.
2010: Misha Koshelev; Satyam Sarma; Roger E Price; Xander H T Wehrens; Thomas A Cooper
Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.
Human molecular genetics 2010;19(6):1066-75.
2010: Wei Wang; Xander H T Wehrens
Stress synchronizes calcium release and promotes SR calcium leak.
The Journal of physiology 2010;588(Pt 3):391-2.
2010: Dobromir Dobrev; Xander H T Wehrens
Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation.
Trends in cardiovascular medicine 2010;20(1):30-4.
2010: Mark D McCauley; Xander H T Wehrens
Ambulatory ECG recording in mice.
Journal of visualized experiments : JoVE 2010;(39):.
2010: Jonathan L Respress; Xander H T Wehrens
Transthoracic echocardiography in mice.
Journal of visualized experiments : JoVE 2010;(39):.
2010: Na Li; Xander H T Wehrens
Programmed electrical stimulation in mice.
Journal of visualized experiments : JoVE 2010;(39):.
2009: Nitin Mathur; Subeena Sood; Sufen Wang; Ralph J van Oort; Satyam Sarma; Na Li; Darlene G Skapura; J Henri Bayle; Miguel Valderrábano; Xander H T Wehrens
Sudden infant death syndrome in mice with an inherited mutation in RyR2.
Circulation. Arrhythmia and electrophysiology 2009;2(6):677-85.
2009: Guey-Shin Wang; Muge N Kuyumcu-Martinez; Satyam Sarma; Nitin Mathur; Xander H T Wehrens; Thomas A Cooper
PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.
The Journal of clinical investigation 2009;119(12):3797-806.
2009: Mark D McCauley; Xander H T Wehrens
Animal models of arrhythmogenic cardiomyopathy.
Disease models & mechanisms 2009;2(11-12):563-70.
2009: Mihail G Chelu; Satyam Sarma; Subeena Sood; Sufen Wang; Ralph J van Oort; Darlene G Skapura; Na Li; Marco Santonastasi; Frank Ulrich Müller; Wilhelm Schmitz; Ulrich Schotten; Mark E Anderson; Miguel Valderrábano; Dobromir Dobrev; Xander H T Wehrens
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
The Journal of clinical investigation 2009;119(7):1940-51.
2009: Alejandro Garbino; Ralph J van Oort; Sayali S Dixit; Andrew P Landstrom; Michael J Ackerman; Xander H T Wehrens
Molecular evolution of the junctophilin gene family.
Physiological genomics 2009;37(3):175-86.
2009: Yuejin Wu; Zhan Gao; Biyi Chen; Olha M Koval; Madhu Singh; Xiaoqun Guan; Thomas J Hund; William Kutschke; Satyam Sarma; Isabella M Grumbach; Xander H T Wehrens; Peter J Mohler; Long-Sheng Song; Mark E Anderson
Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5972-7.
2009: Chun-Hong Shao; Xander H T Wehrens; Todd A Wyatt; Sheeva Parbhu; George J Rozanski; Kaushik P Patel; Keshore R Bidasee
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(4):1280-92.
2008: Ralph J van Oort; Julio Altamirano; William Lederer; Xander H T Wehrens
Alternative splicing: a key mechanism for ankyrin-B functional diversity?
Journal of molecular and cellular cardiology 2008;45(6):709-11.
2008: Subeena Sood; Mihail G Chelu; Ralph J van Oort; Darlene Skapura; Marco Santonastasi; Dobromir Dobrev; Xander H T Wehrens
Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.
Heart rhythm : the official journal of the Heart Rhythm Society 2008;5(7):1047-54.
2007: Mihail G Chelu; Xander H T Wehrens
Sarcoplasmic reticulum calcium leak and cardiac arrhythmias.
Biochemical Society transactions 2007;35(Pt 5):952-6.
2007: colleen clancy; Xander H T Wehrens
Mutation-specific effects of lidocaine in Brugada syndrome.
International journal of cardiology 2007;121(3):249-52.
2007: Peter J Mohler; Xander H T Wehrens
Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions.
Physiology (Bethesda, Md.) 2007;22():342-50.
2007: Ye Chen-Izu; Christopher Ward; Wayne Stark; Tamas Banyasz; Marius P Sumandea; C William Balke; Leighton Izu; Xander H T Wehrens
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2409-17.
2007: Marco Santonastasi; Xander H T Wehrens
Ryanodine receptors as pharmacological targets for heart disease.
Acta pharmacologica Sinica 2007;28(7):937-44.
2007: Ralph J van Oort; Xander H T Wehrens
Subcellular targeting of phosphatases: a novel function of ankyrins.
American journal of physiology. Heart and circulatory physiology 2007;293(1):H15-6.
2007: Xander H T Wehrens
The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms?
Heart rhythm : the official journal of the Heart Rhythm Society 2007;4(6):794-7.
2007: Andrew P Landstrom; Noah Weisleder; Karin B Batalden; J Martijn Bos; David J Tester; Steve R Ommen; Xander H T Wehrens; William C Claycomb; Jae-Kyun Ko; Moonsun Hwang; Zui Pan; Jianjie Ma; Michael J Ackerman
Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.
Journal of molecular and cellular cardiology 2007;42(6):1026-35.
2007: Xander H T Wehrens
Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias.
European heart journal 2007;28(9):1054-6.
2007: William J Durham; Xander H T Wehrens; S Sood; Susan Hamilton
Diseases associated with altered ryanodine receptor activity.
Sub-cellular biochemistry 2007;45():273-321.
2006: Prince J Kannankeril; Brett M Mitchell; Sanjeewa A Goonasekera; Mihail G Chelu; Wei Zhang; Subeena Sood; Debra L Kearney; Cristina I Danila; Mariella De Biasi; Xander H T Wehrens; Robia Pautler; Dan Mark Roden; George E Taffet; Robert T Dirksen; Mark E Anderson; Susan Hamilton
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):12179-84.
2006: Stephan Lehnart; Cecile Terrenoire; Steven Reiken; Xander H T Wehrens; Long-Sheng Song; Erik J Tillman; Salvatore Mancarella; James Coromilas; William Lederer; Robert Kass; Andrew R Marks
Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7906-10.
2006: Fannie Huang; Jian Shan; Steven Reiken; Xander H T Wehrens; Andrew R Marks
Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3456-61.
2006: Xander H T Wehrens; Stephan Lehnart; Steven Reiken; John A Vest; Anetta Wronska; Andrew R Marks
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(3):511-8.
2006: Xander H T Wehrens
Structural determinants of potassium channel blockade and drug-induced arrhythmias.
Handbook of experimental pharmacology 2006;(171):123-57.
2005: Stephan Lehnart; Xander H T Wehrens; Steven Reiken; Sunita Warrier; Andriy Belevych; Robert Harvey; Wito Richter; S-L Catherine Jin; Marco Conti; Andrew R Marks
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
Cell 2005;123(1):25-35.
2005: Xander H T Wehrens; Stephan Lehnart; Steven Reiken; Roel van der Nagel; Raymond Morales; Jie Sun; Zhenzhuang Cheng; Shi-Xian Deng; Leon J De Windt; Donald W Landry; Andrew R Marks
Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9607-12.
2005: Stephan Lehnart; Xander H T Wehrens; Andrew R Marks
Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure.
Circulation 2005;111(25):3342-6.
2005: Xander H T Wehrens; Stephan Lehnart; Andrew R Marks
Ryanodine receptor-targeted anti-arrhythmic therapy.
Annals of the New York Academy of Sciences 2005;1047():366-75.
2005: John A Vest; Xander H T Wehrens; Steven Reiken; Stephan Lehnart; Dobromir Dobrev; Parag Chandra; Peter Danilo; Ursula Ravens; Michael R Rosen; Andrew R Marks
Defective cardiac ryanodine receptor regulation during atrial fibrillation.
Circulation 2005;111(16):2025-32.
2005: Xander H T Wehrens; Stephan Lehnart; Andrew R Marks
Intracellular calcium release and cardiac disease.
Annual review of physiology 2005;67():69-98.
2004: Xander H T Wehrens; Andrew R Marks
Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations.
Mayo Clinic proceedings. Mayo Clinic 2004;79(11):1367-71.
2004: Stephan Lehnart; Xander H T Wehrens; Andrew R Marks
Calstabin deficiency, ryanodine receptors, and sudden cardiac death.
Biochemical and biophysical research communications 2004;322(4):1267-79.
2004: Xander H T Wehrens; Andrew R Marks
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
Nature reviews. Drug discovery 2004;3(7):565-73.
2004: Stephan Lehnart; Xander H T Wehrens; Päivi J Laitinen; Steven Reiken; Shi-Xian Deng; Zhenzhuang Cheng; Donald W Landry; Kimmo Kontula; Heikki Swan; Andrew R Marks
Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak.
Circulation 2004;109(25):3208-14.
2004: Xander H T Wehrens; Pieter A Doevendans
Cardiac rupture complicating myocardial infarction.
International journal of cardiology 2004;95(2-3):285-92.
2004: Stephan Lehnart; Xander H T Wehrens; Alexander Kushnir; Andrew R Marks
Cardiac ryanodine receptor function and regulation in heart disease.
Annals of the New York Academy of Sciences 2004;1015():144-59.
2004: Xander H T Wehrens; Stephan Lehnart; Steven Reiken; Shi-Xian Deng; John A Vest; Daniel Cervantes; James Coromilas; Donald W Landry; Andrew R Marks
Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2.
Science (New York, N.Y.) 2004;304(5668):292-6.
2004: Xander H T Wehrens; Stephan Lehnart; Steven Reiken; Andrew R Marks
Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor.
Circulation research 2004;94(6):e61-70.
2004: Xander H T Wehrens; Andrew R Marks
Molecular determinants of altered contractility in heart failure.
Annals of medicine 2004;36 Suppl 1():70-80.
2004: Xander H T Wehrens; Jos P M Offermans; Mark Snijders; Louis L H Peeters
Fetal cardiovascular response to large placental chorioangiomas.
Journal of perinatal medicine 2004;32(2):107-12.
2003: Xander H T Wehrens; Andrew R Marks
Altered function and regulation of cardiac ryanodine receptors in cardiac disease.
Trends in biochemical sciences 2003;28(12):671-8.
2003: Xander H T Wehrens; Stephan Lehnart; Fannie Huang; John A Vest; Steven Reiken; Peter J Mohler; Jie Sun; Silvia Guatimosim; Long-Sheng Song; Nora Rosemblit; Jeanine D'Armiento; Carlo Napolitano; Mirella Memmi; silvia priori; William Lederer; Andrew R Marks
FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.
Cell 2003;113(7):829-40.
2003: Steven Reiken; Xander H T Wehrens; John A Vest; Alessandro Barbone; Stefan Klotz; Donna Mancini; Daniel Burkhoff; Andrew R Marks
Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure.
Circulation 2003;107(19):2459-66.
2003: colleen clancy; Michihiro Tateyama; Huajun Liu; Xander H T Wehrens; Robert Kass
Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia.
Circulation 2003;107(17):2233-7.
2003: Xander H T Wehrens; Tom Rossenbacker; Roselie J Jongbloed; Marc Gewillig; Hein Heidbüchel; Pieter A Doevendans; Marc A Vos; Hein J J Wellens; Robert Kass
A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating.
Human mutation 2003;21(5):552.
2003: colleen clancy; Junko Kurokawa; Michihiro Tateyama; Xander H T Wehrens; Robert Kass
K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation.
Annual review of pharmacology and toxicology 2003;43():441-61.
2002: Xander H T Wehrens; Marc A Vos; Pieter A Doevendans; Hein J J Wellens
Novel insights in the congenital long QT syndrome.
Annals of internal medicine 2002;137(12):981-92.
2002: Alexandra Buehler; Alessandra Martire; Claudia Strohm; Swen Wolfram; Borja Fernandez; Meindert Palmen; Xander H T Wehrens; Pieter A Doevendans; Wolfgang M Franz; Wolfgang Schaper; René Zimmermann
Angiogenesis-independent cardioprotection in FGF-1 transgenic mice.
Cardiovascular research 2002;55(4):768-77.
2002: Xander H T Wehrens; Ellen V Rouwet; mirjam oude egbrink; Dick W Slaaf; Graham Ramsay
Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation.
The British journal of surgery 2002;89(2):185-91.
2002: mirjam oude egbrink; Gijsbertus H G W Janssen; Keiko Ookawa; Dick W Slaaf; Robert S Reneman; Xander H T Wehrens; Kristel Maaijwee; Norio Ohshima; Harry A J Struijker Boudier; Geert Jan Tangelder
Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin.
The Journal of investigative dermatology 2002;118(2):323-6.
2002: Xander H T Wehrens; Andrew R Marks
Myocardial disease in failing hearts: defective excitation-contraction coupling.
Cold Spring Harbor symposia on quantitative biology 2002;67():533-41.
2001: Ruben Dammers; Xander H T Wehrens; mirjam oude egbrink; Dick W Slaaf; H A J M Kurvers; Graham Ramsay
Microcirculatory effects of experimental acute limb ischaemia-reperfusion.
The British journal of surgery 2001;88(6):816-24.
2001: Hugues Abriel; Candido Cabo; Xander H T Wehrens; Ilaria Rivolta; Howard K Motoike; Mirella Memmi; Carlo Napolitano; silvia priori; Robert Kass
Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.
Circulation research 2001;88(7):740-5.
2000: Xander H T Wehrens; Eric van Breda; J S van Velzen; mirjam oude egbrink; Dick W Slaaf
Use of an intact mouse skeletal muscle preparation for endocrine vascular studies: evaluation of the model.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(9):378-80.
2000: Hugues Abriel; Xander H T Wehrens; Jesaia Benhorin; Batsheva Kerem; Robert Kass
Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome.
Circulation 2000;102(8):921-5.
2000: Xander H T Wehrens; Hugues Abriel; Candido Cabo; Jesaia Benhorin; Robert Kass
Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis.
Circulation 2000;102(5):584-90.