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Yongkun Wei

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Dahu Chen; Sumeet Gupta; Mien-Chie Hung; Han Liang; Hui-Kuan Lin; Abdol Hossein Rezaeian; Yutong Sun; Julie Teruya-Feldstein; Yongkun Wei; Peijing Zhang; Li Ma
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.
Mo Liu; Yongkun Wei; Weiya Xia; Chia-Jui Yen; Michael Karin; Hsu-Ping Kuo; Dung-Fang Lee; Hong-Jen Lee; Long-Yuan Li; Chun-Ju Chang; Wei-Chao Chang; Chung-Hsuan Chen; Chun-Te Chen; Pei-Chun Chiu; Chao-Kai Chou; Debanjan Dhar; Yi Du; Jung-Mao Hsu; Mien-Chie Hung
IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression.
Yongkun Wei; Ya-Huey Chen; Long-Yuan Li; Jingyu Lang; Su-Peng Yeh; Bin Shi; Cheng-Chieh Yang; Jer-Yen Yang; Chun-Yi Lin; Chien-Chen Lai; Mien-Chie Hung
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.

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All Publications

2012: Dahu Chen; Sumeet Gupta; Mien-Chie Hung; Han Liang; Hui-Kuan Lin; Abdol Hossein Rezaeian; Yutong Sun; Julie Teruya-Feldstein; Yongkun Wei; Peijing Zhang; Li Ma
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker.
Nature medicine 2012;18(10):1511-7.
2012: Mo Liu; Yongkun Wei; Weiya Xia; Chia-Jui Yen; Michael Karin; Hsu-Ping Kuo; Dung-Fang Lee; Hong-Jen Lee; Long-Yuan Li; Chun-Ju Chang; Wei-Chao Chang; Chung-Hsuan Chen; Chun-Te Chen; Pei-Chun Chiu; Chao-Kai Chou; Debanjan Dhar; Yi Du; Jung-Mao Hsu; Mien-Chie Hung
IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression.
Molecular cell 2012;45(2):171-84.
2011: Yongkun Wei; Ya-Huey Chen; Long-Yuan Li; Jingyu Lang; Su-Peng Yeh; Bin Shi; Cheng-Chieh Yang; Jer-Yen Yang; Chun-Yi Lin; Chien-Chen Lai; Mien-Chie Hung
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.
Nature cell biology 2011;13(1):87-94.
2010: Hsu-Ping Kuo; Dung-Fang Lee; Chun-Te Chen; Mo Liu; Chao-Kai Chou; Hong-Jen Lee; Yi Du; Xiaoming Xie; Yongkun Wei; Weiya Xia; Zhang Weihua; Jer-Yen Yang; Chia-Jui Yen; Tzu-Hsuan Huang; Minjia Tan; Gang Xing; Yingming Zhao; Chien-Hsing Lin; Shih-Feng Tsai; Isaiah J Fidler; Mien-Chie Hung
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Science signaling 2010;3(108):ra9.
2009: Hsu-Ping Kuo; Dung-Fang Lee; Weiya Xia; Yongkun Wei; Mien-Chie Hung
TNFalpha induces HIF-1alpha expression through activation of IKKbeta.
Biochemical and biophysical research communications 2009;389(4):640-4.
2009: Yong Liao; Yongkun Wei; X Zhou; Jer-Yen Yang; C Dai; Y-J Chen; N K Agarwal; Dos D. Sarbassov; D Shi; Dihua Yu; Mien-Chie Hung
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.
Oncogene 2009;28(26):2436-45.
2009: Weiya Xia; Yongkun Wei; Yi Du; Jinsong Liu; Bin Chang; Yung-Luen Yu; Long-Fei Huo; Stephanie Miller; Mien-Chie Hung
Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer.
Molecular carcinogenesis 2009;48(7):610-7.
2008: Dung-Fang Lee; Hsu-Ping Kuo; Chun-Te Chen; Yongkun Wei; Chao-Kai Chou; Jen-Yu Hung; Chia-Jui Yen; Mien-Chie Hung
IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance.
International journal of molecular medicine 2008;22(5):633-8.
2008: Yongkun Wei; Weiya Xia; Zhihong Zhang; Jinsong Liu; Huamin Wang; Nazmi V Adsay; Constance Albarracin; Dihua Yu; James L Abbruzzese; Gordon B Mills; Robert C Bast; Gabriel N Hortobagyi; Mien-Chie Hung
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Molecular carcinogenesis 2008;47(9):701-6.
2008: Qingqing Ding; Longfei Huo; Jer-Yen Yang; Weiya Xia; Yongkun Wei; Yong Liao; Chun-Ju Chang; Y Yang; Chien-Chen Lai; Dung-Fang Lee; Chia-Jui Yen; Yun-Ju Rita Chen; Jung-Mao Hsu; Hsu-Ping Kuo; Chun-Yi Lin; Fuu-Jen Tsai; Long-Yuan Li; Chang-Hai Tsai; Mien-Chie Hung
Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer.
Cancer research 2008;68(15):6109-17.
2008: S-Q Kuang; W-G Tong; Huiling Yang; W Lin; M K Lee; Z H Fang; Yongkun Wei; Jaroslav Jelinek; Jean-Pierre J Issa; Guillermo Garcia-Manero
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.
Leukemia 2008;22(8):1529-38.
2008: Chia-Jui Yen; Julie G Izzo; Dung-Fang Lee; Sushovan Guha; Yongkun Wei; Tsung-Teh Wu; Chun-Te Chen; Hsu-Ping Kuo; Jung-Mao Hsu; Hui-Lung Sun; Chao-Kai Chou; Navtej S Buttar; Kenneth K Wang; Peng Huang; Jaffer Ajani; Mien-Chie Hung
Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma.
Cancer research 2008;68(8):2632-40.
2008: Tiebang Kang; Yongkun Wei; Yuchi Honaker; Hiroshi Yamaguchi; Ettore Appella; Mien-Chie Hung; Helen Piwnica-Worms
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
Cancer cell 2008;13(1):36-47.
2007: Hui Wen Lo; Sheng-Chieh Hsu; Weiya Xia; Xinyu Cao; Jin-Yuan Shih; Yongkun Wei; James L Abbruzzese; Gabriel N Hortobagyi; Mien-Chie Hung
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression.
Cancer research 2007;67(19):9066-76.
2007: Dung-Fang Lee; Hsu-Ping Kuo; Chun-Te Chen; Jung-Mao Hsu; Chao-Kai Chou; Yongkun Wei; Hui-Lung Sun; Long-Yuan Li; Bo Ping; Huang Wei-Chien; Xianghuo He; Jen-Yu Hung; Chien-Chen Lai; Qingqing Ding; Jen-Liang Su; Jer-Yen Yang; Aysegul A Sahin; Gabriel N Hortobagyi; Fuu-Jen Tsai; Chang-Hai Tsai; Mien-Chie Hung
IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway.
Cell 2007;130(3):440-55.
2007: Xiaoming Xie; Weiya Xia; Zhongkui Li; Hsu-Ping Kuo; Yuanfang Liu; Zheng Li; Qingqing Ding; Su Zhang; Bill Spohn; Yan Yang; Yongkun Wei; Jing-Yu Lang; Douglas B Evans; Paul J Chiao; James L Abbruzzese; Mien-Chie Hung
Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models.
Cancer cell 2007;12(1):52-65.
2006: Bo Ping; Xianghuo He; Weiya Xia; Dung-Fang Lee; Yongkun Wei; Dihua Yu; Gordon Mills; Daren Shi; Mien-Chie Hung
Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers.
International journal of oncology 2006;29(5):1103-10.
2006: Jer-Yen Yang; Cong S Zong; Weiya Xia; Yongkun Wei; Mohamed Ali-Seyed; Zheng Li; Kristine Broglio; Donald A Berry; Mien-Chie Hung
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation.
Molecular and cellular biology 2006;26(19):7269-82.
2006: Fu Ou-Yang; Keng-Li Lan; Chun-Te Chen; Jaw-Ching Liu; Chu-Li Weng; Chao-Kai Chou; Xiaoming Xie; Jen-Yu Hung; Yongkun Wei; Gabriel N Hortobagyi; Mien-Chie Hung
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells.
Cancer research 2006;66(1):378-84.
2005: Hui Wen Lo; Sheng-Chieh Hsu; Mohamed Ali-Seyed; Mehmet Gunduz; Weiya Xia; Yongkun Wei; Geoffrey Bartholomeusz; Jin-Yuan Shih; Mien-Chie Hung
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
Cancer cell 2005;7(6):575-89.
2005: Hui Wen Lo; Weiya Xia; Yongkun Wei; Mohamed Ali-Seyed; Shiu-Feng Huang; Mien-Chie Hung
Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.
Cancer research 2005;65(1):338-48.
2004: Yan M Li; Yong Pan; Yongkun Wei; Xiaoyun Cheng; Binhua P Zhou; Ming Tan; Xiaoyan Zhou; Weiya Xia; Gabriel N Hortobagyi; Dihua Yu; Mien-Chie Hung
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.
Cancer cell 2004;6(5):459-69.
2003: Yongkun Wei; Menghong Sun; Gunnar Nilsson; Trisha Dwight; Yuntao Xie; Jian Wang; Yingyong Hou; Olle Larsson; Catharina Larsson; Xiongzeng Zhu
Characteristic sequence motifs located at the genomic breakpoints of the translocation t(X;18) in synovial sarcomas.
Oncogene 2003;22(14):2215-22.
2002: Yongkun Wei; Jian Wang; Xiongzeng Zhu
[Advances in mechanism of chromosomal translocations in soft tissue sarcoma].
Zhonghua bing li xue za zhi Chinese journal of pathology 2002;31(6):553-5.
2002: Yongkun Wei; Menghong Sun; Jian Wang; Yingyong Hou; Xiongzeng Zhu
[Sequence analysis of translocation t (X; 18) genomic breakpoints characterized in synovial sarcoma].
Zhonghua bing li xue za zhi Chinese journal of pathology 2002;31(5):411-5.
2002: Yongkun Wei; Jian Wang; Xiongzeng Zhu; Daren Shi; Masanori Hisaoka; Hiroshi Hashimoto
Detection of SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction.
Chinese medical journal 2002;115(7):1043-7.
2001: Yongkun Wei; Menghong Sun; H Zhu; Z Xu; Jian Wang; Xiongzeng Zhu
[Detection of SYT-SSX fusion gene in paraffin-embedded tissues and its clinicopathologic significance for synovial sarcoma].
Zhonghua bing li xue za zhi Chinese journal of pathology 2001;30(6):426-30.