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Heike Weighardt

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Julia Tigges; Heike Weighardt; Sandra Wolff; Josef Abel; Irmgard Förster; Christine Götz; Thomas Haarmann-Stemmann; Ulrike Huebenthal; Zippora Kohne; Jean Krutmann; Hans F Merk; Ellen Fritsche
Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.
Petra Gais; Felicitas Altmayr; Klaus-Peter Janssen; Gabriela Jusek; Klaus Pfeffer; Daniel Reim; Tanja Rossmann-Bloeck; Heike Weighardt; Bernhard Holzmann
Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.
Theresa Köhler; Boris Reizis; Heike Weighardt; Randall S Johnson; Irmgard Förster
Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration.

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All Publications

2013: Julia Tigges; Heike Weighardt; Sandra Wolff; Josef Abel; Irmgard Förster; Christine Götz; Thomas Haarmann-Stemmann; Ulrike Huebenthal; Zippora Kohne; Jean Krutmann; Hans F Merk; Ellen Fritsche
Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.
The Journal of investigative dermatology 2013;133(1):87-96.
2012: Petra Gais; Felicitas Altmayr; Klaus-Peter Janssen; Gabriela Jusek; Klaus Pfeffer; Daniel Reim; Tanja Rossmann-Bloeck; Heike Weighardt; Bernhard Holzmann
Cutting edge: Divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):5833-7.
2012: Theresa Köhler; Boris Reizis; Heike Weighardt; Randall S Johnson; Irmgard Förster
Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration.
European journal of immunology 2012;42(5):1226-36.
2010: Stefanie Chmill; Stephanie Kadow; Meike Winter; Heike Weighardt; Charlotte Esser
2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs stable establishment of oral tolerance in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(1):98-107.
2010: Michael Hammer; Bernd Echtenachter; Heike Weighardt; Katrin Jozefowski; Stefan Rose-John; Daniela N Männel; Bernhard Holzmann; Roland Lang
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.
Immunology 2010;131(3):395-404.
2010: Petra Gais; Christopher Tiedje; Felicitas Altmayr; Matthias Gaestel; Heike Weighardt; Bernhard Holzmann
TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(10):5842-8.
2010: Volker Assfalg; Norbert Hüser; Daniel Reim; Simone Kaiser-Moore; Tanja Rossmann-Bloeck; Heike Weighardt; Alexander R Novotny; Manfred Stangl; Bernhard Holzmann; Klaus L Emmanuel
Combined immunosuppressive and antibiotic therapy improves bacterial clearance and survival of polymicrobial septic peritonitis.
Shock (Augusta, Ga.) 2010;33(2):155-61.
2009: Daniel Reim; Kay Westenfelder; Simone Kaiser-Moore; Sylvia Schlautkötter; Bernhard Holzmann; Heike Weighardt
Role of T cells for cytokine production and outcome in a model of acute septic peritonitis.
Shock (Augusta, Ga.) 2009;31(3):245-50.
2008: Matthias Lochner; Kathrin Kastenmüller; Michael Neuenhahn; Heike Weighardt; Dirk H Busch; Wolfgang Reindl; Irmgard Förster
Decreased susceptibility of mice to infection with Listeria monocytogenes in the absence of interleukin-18.
Infection and immunity 2008;76(9):3881-90.
2007: Kate Schroder; Martina Spille; Andreas Pilz; Jane Lattin; Konrad A Bode; Katharine M Irvine; Allan D Burrows; Timothy Ravasi; Heike Weighardt; Katryn J Stacey; Thomas Decker; David A Hume; Alexander H Dalpke; Matthew J Sweet
Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3495-503.
2007: Alexander R Novotny; Klaus Emmanuel; Edouard Matevossian; Monika Kriner; Kurt Ulm; Holger Bartels; Bernhard Holzmann; Heike Weighardt; Jörg Rüdiger Siewert
Use of procalcitonin for early prediction of lethal outcome of postoperative sepsis.
American journal of surgery 2007;194(1):35-9.
2007: Georg F Weber; Sylvia Schlautkötter; Simone Kaiser-Moore; Felicitas Altmayr; Bernhard Holzmann; Heike Weighardt
Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis.
Infection and immunity 2007;75(4):1690-7.
2007: Alexander R Novotny; Klaus Emmanuel; Stefan Maier; Alexandra Westerholt; Heike Weighardt; Josef Stadler; Holger Bartels; Markus Schwaiger; Jörg Rüdiger Siewert; Bernhard Holzmann; Claus-Dieter Heidecke
Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: predictive indicators of lethal outcome.
Surgery 2007;141(3):376-84.
2007: Heike Weighardt; Bernhard Holzmann
Role of Toll-like receptor responses for sepsis pathogenesis.
Immunobiology 2007;212(9-10):715-22.
2006: Georg F Weber; Florian C Gaertner; Wolfgang Erl; Klaus-Peter Janssen; Birgit Blechert; Bernhard Holzmann; Heike Weighardt; Markus Essler
IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):8266-72.
2006: Heike Weighardt; Simone Kaiser-Moore; Sylvia Schlautkötter; Tanja Rossmann-Bloeck; Ulrike Schleicher; Christian Bogdan; Bernhard Holzmann
Type I IFN modulates host defense and late hyperinflammation in septic peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5623-30.
2006: Alexander R Novotny; Klaus Emmanuel; Kurt Ulm; Holger Bartels; Jörg Rüdiger Siewert; Heike Weighardt; Bernhard Holzmann
Blood interleukin 12 as preoperative predictor of fatal postoperative sepsis after neoadjuvant radiochemotherapy.
The British journal of surgery 2006;93(10):1283-9.
2006: Heike Weighardt; Jörg Mages; Gabriela Jusek; Simone Kaiser-Moore; Roland Lang; Bernhard Holzmann
Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis.
Infection and immunity 2006;74(6):3618-32.
2006: Ferdinand von Meyenn; Martin Schaefer; Heike Weighardt; Stefan Bauer; Carsten J Kirschning; Hermann Wagner; Tim D. Sparwasser
Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells.
Immunobiology 2006;211(6-8):557-65.
2005: Carolin Feterowski; Alexander R Novotny; Simone Kaiser-Moore; Peter F Mühlradt; Tanja Rossmann-Bloeck; Martina Rump; Bernhard Holzmann; Heike Weighardt
Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation.
International immunology 2005;17(8):1035-46.
2005: Klaus Emmanuel; Heike Weighardt; Holger Bartels; Jorg-Rudiger Siewert; Bernhard Holzmann
Current and future concepts of abdominal sepsis.
World journal of surgery 2005;29(1):3-9.
2004: Carolin Feterowski; Matthias Mack; Heike Weighardt; Bernadett Bartsch; Simone Kaiser-Moore; Bernhard Holzmann
CC chemokine receptor 2 regulates leukocyte recruitment and IL-10 production during acute polymicrobial sepsis.
European journal of immunology 2004;34(12):3664-73.
2004: Klaus Ruckdeschel; Gudrun Pfaffinger; Rudolf Haase; Andreas Sing; Heike Weighardt; Georg Häcker; Bernhard Holzmann; Jürgen Heesemann
Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3320-8.
2004: Heike Weighardt; Gabriela Jusek; Jörg Mages; Roland Lang; Kasper Hoebe; Bruce Beutler; Bernhard Holzmann
Identification of a TLR4- and TRIF-dependent activation program of dendritic cells.
European journal of immunology 2004;34(2):558-64.
2003: Carolin Feterowski; Klaus Emmanuilidis; Thomas Miethke; Klaus Gerauer; Martina Rump; Kurt Ulm; Bernhard Holzmann; Heike Weighardt
Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis.
Immunology 2003;109(3):426-31.
2003: Bernhard Holzmann; Heike Weighardt; Claus-Dieter Heidecke
[Receptors and signal proteins of the innate immune system as new targets in sepsis therapy. Reprogramming of the immune response].
Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen 2003;74(1):61-4.
2002: Klaus Emmanuilidis; Heike Weighardt; Edouard Matevossian; Claus-Dieter Heidecke; Kurt Ulm; Holger Bartels; Jörg Rüdiger Siewert; Bernhard Holzmann
Differential regulation of systemic IL-18 and IL-12 release during postoperative sepsis: high serum IL-18 as an early predictive indicator of lethal outcome.
Shock (Augusta, Ga.) 2002;18(4):301-5.
2002: Heike Weighardt; Simone Kaiser-Moore; Ramunas M Vabulas; Carsten J Kirschning; Hermann Wagner; Bernhard Holzmann
Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):2823-7.
2002: Claus-Dieter Heidecke; Heike Weighardt; Marcus Feith; Ulrich Fink; Frank Zimmermann; Hubert J Stein; Jörg Rüdiger Siewert; Bernhard Holzmann
Neoadjuvant treatment of esophageal cancer: Immunosuppression following combined radiochemotherapy.
Surgery 2002;132(3):495-501.
2002: Sandra Beer; Heike Weighardt; Klaus Emmanuilidis; Marit D Harzenetter; Edouard Matevossian; Claus-Dieter Heidecke; Holger Bartels; Jörg Rüdiger Siewert; Bernhard Holzmann
Systemic neuropeptide levels as predictive indicators for lethal outcome in patients with postoperative sepsis.
Critical care medicine 2002;30(8):1794-8.
2002: Heike Weighardt; Claus-Dieter Heidecke; Alexandra Westerholt; Klaus Emmanuilidis; Stefan Maier; Martin Veit; Klaus Gerauer; Edouard Matevossian; Kurt Ulm; Jörg Rüdiger Siewert; Bernhard Holzmann
Impaired monocyte IL-12 production before surgery as a predictive factor for the lethal outcome of postoperative sepsis.
Annals of surgery 2002;235(4):560-7.
2001: Klaus Emmanuilidis; Heike Weighardt; Stefan Maier; Klaus Gerauer; T Fleischmann; X X Zheng; W W Hancock; Bernhard Holzmann; Claus-Dieter Heidecke
Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(7):3919-27.
2001: Carolin Feterowski; Heike Weighardt; Klaus Emmanuilidis; Thomas Hartung; Bernhard Holzmann
Immune protection against septic peritonitis in endotoxin-primed mice is related to reduced neutrophil apoptosis.
European journal of immunology 2001;31(4):1268-77.
2000: Heike Weighardt; Carolin Feterowski; M Veit; Martina Rump; Hermann Wagner; Bernhard Holzmann
Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4537-43.
2000: Heike Weighardt; Claus-Dieter Heidecke; Klaus Emmanuilidis; Stefan Maier; Holger Bartels; Jörg Rüdiger Siewert; Bernhard Holzmann
Sepsis after major visceral surgery is associated with sustained and interferon-gamma-resistant defects of monocyte cytokine production.
Surgery 2000;127(3):309-15.
2000: Claus-Dieter Heidecke; Heike Weighardt; T Hensler; Holger Bartels; Bernhard Holzmann
[Immune paralysis of T-lymphocytes and monocytes in postoperative abdominal sepsis. Correlation of immune function with survival].
Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen 2000;71(2):159-65.
1999: Claus-Dieter Heidecke; T Hensler; Heike Weighardt; N Zantl; Hermann Wagner; Jörg Rüdiger Siewert; Bernhard Holzmann
Selective defects of T lymphocyte function in patients with lethal intraabdominal infection.
American journal of surgery 1999;178(4):288-92.
1999: A B Simins; Heike Weighardt; K M Weidner; U H Weidle; Bernhard Holzmann
Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells.
Clinical & experimental metastasis 1999;17(8):641-8.