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Alan Weiner

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Lucas T Gray; T Pavelitz; Kimberly K Fong; Alan M Weiner
Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.
Arnold D Bailey; Lucas T Gray; Katsuyoshi Horibata; John C Newman; T Pavelitz; Kiyoji Tanaka; Alan M Weiner
The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
Lucas T Gray; Alan M Weiner
Ubiquitin recognition by the Cockayne syndrome group B protein: binding will set you free.

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All Publications

2012: Lucas T Gray; T Pavelitz; Kimberly K Fong; Alan M Weiner
Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.
PLoS genetics 2012;8(9):e1002972.
2012: Arnold D Bailey; Lucas T Gray; Katsuyoshi Horibata; John C Newman; T Pavelitz; Kiyoji Tanaka; Alan M Weiner
The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
DNA repair 2012;11(5):488-501.
2010: Lucas T Gray; Alan M Weiner
Ubiquitin recognition by the Cockayne syndrome group B protein: binding will set you free.
Molecular cell 2010;38(5):621-2.
2008: Hyundae D Cho; Vanita D Sood; David Baker; Alan M Weiner
On the role of a conserved, potentially helix-breaking residue in the tRNA-binding alpha-helix of archaeal CCA-adding enzymes.
RNA (New York, N.Y.) 2008;14(7):1284-9.
2008: Thomas Pavelitz; Arnold D Bailey; Christopher P Elco; Alan M Weiner
Human U2 snRNA genes exhibit a persistently open transcriptional state and promoter disassembly at metaphase.
Molecular and cellular biology 2008;28(11):3573-88.
2008: John C Newman; Arnold D Bailey; Hua-Ying Fan; Thomas Pavelitz; Alan M Weiner
An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.
PLoS genetics 2008;4(3):e1000031.
2007: Hyundae D Cho; Christophe Verlinde; Alan M Weiner
Reengineering CCA-adding enzymes to function as (U,G)- or dCdCdA-adding enzymes or poly(C,A) and poly(U,G) polymerases.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):54-9.
2006: John C Newman; Arnold D Bailey; Alan M Weiner
Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9613-8.
2006: Hyundae D Cho; Yu Chen; Gabriele Varani; Alan M Weiner
A model for C74 addition by CCA-adding enzymes: C74 addition, like C75 and A76 addition, does not involve tRNA translocation.
The Journal of biological chemistry 2006;281(14):9801-11.
2005: Alan M Weiner
E Pluribus Unum: 3' end formation of polyadenylated mRNAs, histone mRNAs, and U snRNAs.
Molecular cell 2005;20(2):168-70.
2005: Hyundae D Cho; Christophe Verlinde; Alan M Weiner
Archaeal CCA-adding enzymes: central role of a highly conserved beta-turn motif in RNA polymerization without translocation.
The Journal of biological chemistry 2005;280(10):9555-66.
2005: John C Newman; Alan M Weiner
L2L: a simple tool for discovering the hidden significance in microarray expression data.
Genome biology 2005;6(9):R81.
2004: Alan M Weiner
tRNA maturation: RNA polymerization without a nucleic acid template.
Current biology : CB 2004;14(20):R883-5.
2004: Hyundae D Cho; Alan M Weiner
A single catalytically active subunit in the multimeric Sulfolobus shibatae CCA-adding enzyme can carry out all three steps of CCA addition.
The Journal of biological chemistry 2004;279(38):40130-6.
2004: Erica Y Jacobs; Ikuo Ogiwara; Alan M Weiner
Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3' processing.
Molecular and cellular biology 2004;24(2):846-55.
2003: Yong Xiong; Fang Li; Jimin Wang; Alan M Weiner; Thomas A Steitz
Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes.
Molecular cell 2003;12(5):1165-72.
2003: Alan M Weiner
Soaking up RNAi.
Molecular cell 2003;12(3):535-6.
2003: Hyundae D Cho; Adegboyega K Oyelere; Scott A Strobel; Alan M Weiner
Use of nucleotide analogs by class I and class II CCA-adding enzymes (tRNA nucleotidyltransferase): deciphering the basis for nucleotide selection.
RNA (New York, N.Y.) 2003;9(8):970-81.
2002: Fang Li; Yong Xiong; Jimin Wang; Hyundae D Cho; Kozo Tomita; Alan M Weiner; Thomas A Steitz
Crystal structures of the Bacillus stearothermophilus CCA-adding enzyme and its complexes with ATP or CTP.
Cell 2002;111(6):815-24.
2002: Kozo Tomita; Alan M Weiner
Closely related CC- and A-adding enzymes collaborate to construct and repair the 3'-terminal CCA of tRNA in Synechocystis sp. and Deinococcus radiodurans.
The Journal of biological chemistry 2002;277(50):48192-8.
2002: John C Newman; Alan M Weiner
Measuring the immeasurable.
Molecular cell 2002;10(3):437-9.
2002: Alan M Weiner
SINEs and LINEs: the art of biting the hand that feeds you.
Current opinion in cell biology 2002;14(3):343-50.
2002: Hyundae D Cho; Kozo Tomita; Tsutomu Suzuki; Alan M Weiner
U2 small nuclear RNA is a substrate for the CCA-adding enzyme (tRNA nucleotidyltransferase).
The Journal of biological chemistry 2002;277(5):3447-55.
2001: Kozo Tomita; Alan M Weiner
Collaboration between CC- and A-adding enzymes to build and repair the 3'-terminal CCA of tRNA in Aquifex aeolicus.
Science (New York, N.Y.) 2001;294(5545):1334-6.
2001: Gil Ast; T Pavelitz; Alan M Weiner
Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.
Nucleic acids research 2001;29(8):1741-9.
2000: A Yu; H Y Fan; Daiqing Liao; Arnold D Bailey; Alan M Weiner
Activation of p53 or loss of the Cockayne syndrome group B repair protein causes metaphase fragility of human U1, U2, and 5S genes.
Molecular cell 2000;5(5):801-10.
2000: Alan M Weiner
Do all SINEs lead to LINEs?
Nature genetics 2000;24(4):332-3.
1999: Alan M Weiner
Molecular evolution: aminoacyl-tRNA synthetases on the loose.
Current biology : CB 1999;9(22):R842-4.
1999: T Pavelitz; Daiqing Liao; Alan M Weiner
Concerted evolution of the tandem array encoding primate U2 snRNA (the RNU2 locus) is accompanied by dramatic remodeling of the junctions with flanking chromosomal sequences.
The EMBO journal 1999;18(13):3783-92.
1999: Nancy Maizels; Alan M Weiner; Dongxian Yue; PY Shi
New evidence for the genomic tag hypothesis: archaeal CCA-adding enzymes and tDNA substrates.
The Biological bulletin 1999;196(3):331-3; discussion 333-4.
1999: Alan M Weiner; Nancy Maizels
The genomic tag hypothesis: modern viruses as molecular fossils of ancient strategies for genomic replication, and clues regarding the origin of protein synthesis.
The Biological bulletin 1999;196(3):327-8; discussion 329-30.
1999: Alan M Weiner; N Maizels
A deadly double life.
Science (New York, N.Y.) 1999;284(5411):63-4.
1999: Mark R Frey; Arnold D Bailey; Alan M Weiner; A Gregory Matera
Association of snRNA genes with coiled bodies is mediated by nascent snRNA transcripts.
Current biology : CB 1999;9(3):126-35.
1999: Daiqing Liao; A Yu; Alan M Weiner
Coexpression of the adenovirus 12 E1B 55 kDa oncoprotein and cellular tumor suppressor p53 is sufficient to induce metaphase fragility of the human RNU2 locus.
Virology 1999;254(1):11-23.
1998: Dongxian Yue; Alan M Weiner; Nancy Maizels
The CCA-adding enzyme has a single active site.
The Journal of biological chemistry 1998;273(45):29693-700.
1998: Daiqing Liao; T Pavelitz; Alan M Weiner
Characterization of a novel class of interspersed LTR elements in primate genomes: structure, genomic distribution, and evolution.
Journal of molecular evolution 1998;46(6):649-60.
1998: PY Shi; Nancy Maizels; Alan M Weiner
CCA addition by tRNA nucleotidyltransferase: polymerization without translocation?
The EMBO journal 1998;17(11):3197-206.
1998: Z Li; Arnold D Bailey; J Buchowski; Alan M Weiner
A tandem array of minimal U1 small nuclear RNA genes is sufficient to generate a new adenovirus type 12-inducible chromosome fragile site.
Journal of virology 1998;72(5):4205-11.
1998: Z Li; A Yu; Alan M Weiner
Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
Journal of virology 1998;72(5):4183-91.
1998: Arnold D Bailey; T Pavelitz; Alan M Weiner
The microsatellite sequence (CT)n x (GA)n promotes stable chromosomal integration of large tandem arrays of functional human U2 small nuclear RNA genes.
Molecular and cellular biology 1998;18(4):2262-71.
1998: A Yu; Arnold D Bailey; Alan M Weiner
Metaphase fragility of the human RNU1 and RNU2 loci is induced by actinomycin D through a p53-dependent pathway.
Human molecular genetics 1998;7(4):609-17.
1998: PY Shi; Alan M Weiner; Nancy Maizels
A top-half tDNA minihelix is a good substrate for the eubacterial CCA-adding enzyme.
RNA (New York, N.Y.) 1998;4(3):276-84.
1997: PY Shi; Nancy Maizels; Alan M Weiner
Recovery of soluble, active recombinant protein from inclusion bodies.
BioTechniques 1997;23(6):1036-8.
1997: Gil Ast; Alan M Weiner
Antisense oligonucleotide binding to U5 snRNP induces a conformational change that exposes the conserved loop of U5 snRNA.
Nucleic acids research 1997;25(17):3508-13.
1997: Marlene Belfort; Alan M Weiner
Another bridge between kingdoms: tRNA splicing in archaea and eukaryotes.
Cell 1997;89(7):1003-6.
1997: Gil Ast; Alan M Weiner
A novel U1/U5 interaction indicates proximity between U1 and U5 snRNAs during an early step of mRNA splicing.
RNA (New York, N.Y.) 1997;3(4):371-81.
1997: Daiqing Liao; T Pavelitz; Judith R Kidd; Kenneth K Kidd; Alan M Weiner
Concerted evolution of the tandemly repeated genes encoding human U2 snRNA (the RNU2 locus) involves rapid intrachromosomal homogenization and rare interchromosomal gene conversion.
The EMBO journal 1997;16(3):588-98.
1996: Dongxian Yue; Nancy Maizels; Alan M Weiner
CCA-adding enzymes and poly(A) polymerases are all members of the same nucleotidyltransferase superfamily: characterization of the CCA-adding enzyme from the archaeal hyperthermophile Sulfolobus shibatae.
RNA (New York, N.Y.) 1996;2(9):895-908.
1996: Gil Ast; Alan M Weiner
A U1/U4/U5 snRNP complex induced by a 2'-O-methyl-oligoribonucleotide complementary to U5 snRNA.
Science (New York, N.Y.) 1996;272(5263):881-4.
1995: Daiqing Liao; Alan M Weiner
Concerted evolution of the tandemly repeated genes encoding primate U2 small nuclear RNA (the RNU2 locus) does not prevent rapid diversification of the (CT)n.(GA)n microsatellite embedded within the U2 repeat unit.
Genomics 1995;30(3):583-93.
1995: Arnold D Bailey; Z Li; T Pavelitz; Alan M Weiner
Adenovirus type 12-induced fragility of the human RNU2 locus requires U2 small nuclear RNA transcriptional regulatory elements.
Molecular and cellular biology 1995;15(11):6246-55.
1995: T Pavelitz; L Rusché; A Gregory Matera; J M Scharf; Alan M Weiner
Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.
The EMBO journal 1995;14(1):169-77.
1994: Nancy Maizels; Alan M Weiner
Phylogeny from function: evidence from the molecular fossil record that tRNA originated in replication, not translation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(15):6729-34.
1994: Alan M Weiner; Nancy Maizels
Molecular evolution. Unlocking the secrets of retroviral evolution.
Current biology : CB 1994;4(6):560-3.
1993: B Datta; Alan M Weiner
The phylogenetically invariant ACAGAGA and AGC sequences of U6 small nuclear RNA are more tolerant of mutation in human cells than in Saccharomyces cerevisiae.
Molecular and cellular biology 1993;13(9):5377-82.
1993: M Mirfakhrai; Alan M Weiner
Chemical Cleveland mapping: a rapid technique for characterization of crosslinked nucleic acid-protein complexes.
Nucleic acids research 1993;21(15):3591-2.
1993: Alan M Weiner
mRNA splicing and autocatalytic introns: distant cousins or the products of chemical determinism?
Cell 1993;72(2):161-4.
1992: M Williams; April Brys; Alan M Weiner; Nancy Maizels
A rapid method for determining the molecular weight of a protein bound to nucleic acid in a mobility shift assay.
Nucleic acids research 1992;20(18):4935-6.
1992: B Datta; Alan M Weiner
Cross-linking of U2 snRNA using nitrogen mustard. Evidence for higher order structure.
The Journal of biological chemistry 1992;267(7):4497-502.
1992: B Datta; Alan M Weiner
Cross-linking of U1 snRNA using nitrogen mustard. Evidence for higher order structure.
The Journal of biological chemistry 1992;267(7):4503-7.
1991: B Datta; Alan M Weiner
Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing.
Nature 1991;352(6338):821-4.
1991: R A Ach; Alan M Weiner
Cooperation between CCAAT and octamer motifs in the distal sequence element of the rat U3 small nucleolar RNA promoter.
Nucleic acids research 1991;19(15):4209-18.
1990: T P Hausner; L M Giglio; Alan M Weiner
Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles.
Genes & development 1990;4(12A):2146-56.
1990: A G Matera; Alan M Weiner; Carl W Schmid
Structure and evolution of the U2 small nuclear RNA multigene family in primates: gene amplification under natural selection?
Molecular and cellular biology 1990;10(11):5876-82.
1990: Y Zhuang; Alan M Weiner
The conserved dinucleotide AG of the 3' splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors.
Gene 1990;90(2):263-9.
1990: Alan M Weiner; Nancy Maizels
RNA editing: guided but not templated?
Cell 1990;61(6):917-20.
1989: I L Stroke; Alan M Weiner
The 5' end of U3 snRNA can be crosslinked in vivo to the external transcribed spacer of rat ribosomal RNA precursors.
Journal of molecular biology 1989;210(3):497-512.
1989: Y Zhuang; Alan M Weiner
A compensatory base change in human U2 snRNA can suppress a branch site mutation.
Genes & development 1989;3(10):1545-52.
1989: C Y Yuo; Alan M Weiner
A U1 small nuclear ribonucleoprotein particle with altered specificity induces alternative splicing of an adenovirus E1A mRNA precursor.
Molecular and cellular biology 1989;9(8):3429-37.
1989: C Y Yuo; Alan M Weiner
Genetic analysis of the role of human U1 snRNA in mRNA splicing: I. Effect of mutations in the highly conserved stem-loop I of U1.
Genes & development 1989;3(5):697-707.
1989: Y A Zhuang; A M Goldstein; Alan M Weiner
UACUAAC is the preferred branch site for mammalian mRNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2752-6.
1988: N Maizels; Alan M Weiner
RNA editing. In search of a template.
Nature 1988;334(6182):469-70.
1988: Alan M Weiner
Eukaryotic nuclear telomeres: molecular fossils of the RNP world?
Cell 1988;52(2):155-8.
1987: N Maizels; Alan M Weiner
The 'last ribo-organism' was no breakthrough.
Nature 1987;330(6149):616.
1987: Alan M Weiner; Nancy Maizels
tRNA-like structures tag the 3' ends of genomic RNA molecules for replication: implications for the origin of protein synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7383-7.
1987: Manuel Ares; JS Chung; L Giglio; Alan M Weiner
Distinct factors with Sp1 and NF-A specificities bind to adjacent functional elements of the human U2 snRNA gene enhancer.
Genes & development 1987;1(8):808-17.
1987: Y Zhuang; Helios T Leung; Alan M Weiner
The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA.
Molecular and cellular biology 1987;7(8):3018-20.
1987: R A Ach; Alan M Weiner
The highly conserved U small nuclear RNA 3'-end formation signal is quite tolerant to mutation.
Molecular and cellular biology 1987;7(6):2070-9.
1987: Nancy Maizels; Alan M Weiner
Peptide-specific ribosomes, genomic tags, and the origin of the genetic code.
Cold Spring Harbor symposia on quantitative biology 1987;52():743-9.
1986: N Hernandez; Alan M Weiner
Formation of the 3' end of U1 snRNA requires compatible snRNA promoter elements.
Cell 1986;47(2):249-58.
1986: Y Zhuang; Alan M Weiner
A compensatory base change in U1 snRNA suppresses a 5' splice site mutation.
Cell 1986;46(6):827-35.
1986: M Mangin; Manuel Ares; Alan M Weiner
Human U2 small nuclear RNA genes contain an upstream enhancer.
The EMBO journal 1986;5(5):987-95.
1986: Alan M Weiner; P L Deininger; A Efstratiadis
Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information.
Annual review of biochemistry 1986;55():631-61.
1985: E Ullu; Alan M Weiner
Upstream sequences modulate the internal promoter of the human 7SL RNA gene.
Nature 1985;318(6044):371-4.
1985: Valerie Lindgren; L B Bernstein; Alan M Weiner; U Francke
Human U1 small nuclear RNA pseudogenes do not map to the site of the U1 genes in 1p36 but are clustered in 1q12-q22.
Molecular and cellular biology 1985;5(9):2172-80.
1985: L B Bernstein; T Manser; Alan M Weiner
Human U1 small nuclear RNA genes: extensive conservation of flanking sequences suggests cycles of gene amplification and transposition.
Molecular and cellular biology 1985;5(9):2159-71.
1985: C Y Yuo; Manuel Ares; Alan M Weiner
Sequences required for 3' end formation of human U2 small nuclear RNA.
Cell 1985;42(1):193-202.
1985: I L Stroke; Alan M Weiner
Genes and pseudogenes for rat U3A and U3B small nuclear RNA.
Journal of molecular biology 1985;184(2):183-93.
1985: M Mangin; Manuel Ares; Alan M Weiner
U1 small nuclear RNA genes are subject to dosage compensation in mouse cells.
Science (New York, N.Y.) 1985;229(4710):272-5.
1985: Manuel Ares; M Mangin; Alan M Weiner
Orientation-dependent transcriptional activator upstream of a human U2 snRNA gene.
Molecular and cellular biology 1985;5(7):1560-70.
1985: Valerie Lindgren; Manuel Ares; Alan M Weiner; U Francke
Human genes for U2 small nuclear RNA map to a major adenovirus 12 modification site on chromosome 17.
Nature 1985;314(6006):115-6.
1984: E Ullu; Alan M Weiner
Human genes and pseudogenes for the 7SL RNA component of signal recognition particle.
The EMBO journal 1984;3(13):3303-10.
1984: S W Van Arsdell; Alan M Weiner
Human genes for U2 small nuclear RNA are tandemly repeated.
Molecular and cellular biology 1984;4(3):492-9.
1984: S W Van Arsdell; Alan M Weiner
Pseudogenes for human U2 small nuclear RNA do not have a fixed site of 3' truncation.
Nucleic acids research 1984;12(3):1463-71.
1983: L B Bernstein; Steve Mount; Alan M Weiner
Pseudogenes for human small nuclear RNA U3 appear to arise by integration of self-primed reverse transcripts of the RNA into new chromosomal sites.
Cell 1983;32(2):461-72.
1983: Alan M Weiner; R A Denison
Either gene amplification or gene conversion may maintain the homogeneity of the multigene family encoding human U1 small nuclear RNA.
Cold Spring Harbor symposia on quantitative biology 1983;47 Pt 2():1141-9.
1982: R A Denison; Alan M Weiner
Human U1 RNA pseudogenes may be generated by both DNA- and RNA-mediated mechanisms.
Molecular and cellular biology 1982;2(7):815-28.
1981: H S Emery; Alan M Weiner
An irregular satellite sequence is found at the termini of the linear extrachromosomal rDNA in Dictyostelium discoideum.
Cell 1981;26(3 Pt 1):411-9.
1981: S W Van Arsdell; R A Denison; L B Bernstein; Alan M Weiner; T Manser; R F Gesteland
Direct repeats flank three small nuclear RNA pseudogenes in the human genome.
Cell 1981;26(1 Pt 1):11-7.
1981: R A Denison; S W Van Arsdell; L B Bernstein; Alan M Weiner
Abundant pseudogenes for small nuclear RNAs are dispersed in the human genome.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(2):810-4.
1981: J A Wise; Alan M Weiner
The small nuclear RNAs of the cellular slime mold Dictyostelium discoideum. Isolation and characterization.
The Journal of biological chemistry 1981;256(2):956-63.
1980: Alan M Weiner
An abundant cytoplasmic 7S RNA is complementary to the dominant interspersed middle repetitive DNA sequence family in the human genome.
Cell 1980;22(1 Pt 1):209-18.
1980: J A Wise; Alan M Weiner
Dictyostelium small nuclear RNA D2 is homologous to rat nucleolar RNA U3 and is encoded by a dispersed multigene family.
Cell 1980;22(1 Pt 1):109-18.
1975: R Schekman; Joel Weiner; Alan M Weiner; A Kornberg
Ten proteins required for conversion of phiX174 single-stranded DNA to duplex form in vitro. Resolution and reconstitution.
The Journal of biological chemistry 1975;250(15):5859-65.
1974: R Schekman; Alan M Weiner; A Kornberg
Multienzyme systems of DNA replication.
Science (New York, N.Y.) 1974;186(4168):987-93.
1973: Alan M Weiner; K Weber
A single UGA codon functions as a natural termination signal in the coliphage q beta coat protein cistron.
Journal of molecular biology 1973;80(4):837-55.
1972: Alan M Weiner; T Platt; K Weber
Amino-terminal sequence analysis of proteins purified on a nanomole scale by gel electrophoresis.
The Journal of biological chemistry 1972;247(10):3242-51.
1971: Alan M Weiner; K Weber
Natural read-through at the UGA termination signal of Q-beta coat protein cistron.
Nature: New biology 1971;234(50):206-9.
1970: M Osborn; Alan M Weiner; K Weber
Large scale purification of A-protein from bacterior17.
European journal of biochemistry / FEBS 1970;17(1):63-7.