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Robert Weinstein

Research Profile

Anatomy

Living Beings

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Bone Density

Chemicals & Drugs

Physiology

Disorders

Osteoporosis

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Publications

TOP 3
Robert L Jilka; Brendon Noble; Robert S Weinstein
Osteocyte apoptosis.
Shoshana M Bartell; Ken L Chambliss; Li Han; Robert L Jilka; Benita S Katzenellenbogen; John A Katzenellenbogen; Ha-neui Kim; Sung Hoon Kim; Paula K Roberson; Philip W Shaul; Robert S Weinstein; Maria Almeida; Stavros C Manolagas
Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.
Robert S Weinstein
Glucocorticoid-induced osteoporosis and osteonecrosis.

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All Publications

2013: Robert L Jilka; Brendon Noble; Robert S Weinstein
Osteocyte apoptosis.
Bone 2013;54(2):264-71.
2013: Shoshana M Bartell; Ken L Chambliss; Li Han; Robert L Jilka; Benita S Katzenellenbogen; John A Katzenellenbogen; Ha-neui Kim; Sung Hoon Kim; Paula K Roberson; Philip W Shaul; Robert S Weinstein; Maria Almeida; Stavros C Manolagas
Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.
Molecular endocrinology (Baltimore, Md.) 2013;27(4):649-56.
2012: Robert S Weinstein
Glucocorticoid-induced osteoporosis and osteonecrosis.
Endocrinology and metabolism clinics of North America 2012;41(3):595-611.
2012: Robert S Weinstein
Glucocorticoid-induced osteonecrosis.
Endocrine 2012;41(2):183-90.
2012: Melda Onal; Robert S Weinstein; Jinhu Xiong; Qiang Fu; Carlo Galli; Stavros C Manolagas; Charles A O'Brien
The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice.
Molecular endocrinology (Baltimore, Md.) 2012;26(2):341-8.
2011: Jinhu Xiong; Robert L Jilka; Stavros C Manolagas; Melda Onal; Robert S Weinstein; Charles A O'Brien
Matrix-embedded cells control osteoclast formation.
Nature medicine 2011;17(10):1235-41.
2011: Robert S Weinstein; Haibo Zhao; Maria Almeida; Robert L Jilka; Charles A O'Brien; Paula K Roberson; Stavros C Manolagas
Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice.
Endocrinology 2011;152(9):3323-31.
2011: Robert S Weinstein
Clinical practice. Glucocorticoid-induced bone disease.
The New England journal of medicine 2011;365(1):62-70.
2010: Robert L Jilka; Charles A O'Brien; Shoshana M Bartell; Robert S Weinstein; Stavros C Manolagas
Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(11):2427-37.
2010: Robert L Jilka; Maria Almeida; Elena Ambrogini; Li Han; Paula K Roberson; Robert S Weinstein; Starros C Manolagas
Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration.
Aging cell 2010;9(5):851-67.
2010: Robert S Weinstein; Robert L Jilka; Maria Almeida; Paula K Roberson; Stavros C Manolagas
Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.
Endocrinology 2010;151(6):2641-9.
2010: Maria Almeida; Marta Martin-Millan; Elena Ambrogini; Robert Bradsher; Li Han; Xiao-Dong Chen; Paula K Roberson; Robert S Weinstein; Charles A O'Brien; Robert L Jilka; Stavros C Manolagas
Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2010;25(4):769-81.
2010: Robert S Weinstein
Glucocorticoids, osteocytes, and skeletal fragility: the role of bone vascularity.
Bone 2010;46(3):564-70.
2010: Elena Ambrogini; Maria Almeida; Marta Martin-Millan; Ji-Hye Paik; Ronald A DePinho; Li Han; Joseph Goellner; Robert S Weinstein; Robert L Jilka; Charles A O'Brien; Stavros C Manolagas
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Cell metabolism 2010;11(2):136-46.
2010: Marta Martin-Millan; Maria Almeida; Elena Ambrogini; Li Han; Haibo Zhao; Robert S Weinstein; Robert L Jilka; Charles A O'Brien; Stavros C Manolagas
The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.
Molecular endocrinology (Baltimore, Md.) 2010;24(2):323-34.
2009: Robert L Jilka; Charles A O'Brien; A Afshan Ali; Paula K Roberson; Robert S Weinstein; Stavros C Manolagas
Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts.
Bone 2009;44(2):275-86.
2009: Robert S Weinstein; Paula K Roberson; Stavros C Manolagas
Giant osteoclast formation and long-term oral bisphosphonate therapy.
The New England journal of medicine 2009;360(1):53-62.
2008: Charles A O'Brien; Lilian Plotkin; Carlo Galli; Joseph J Goellner; Arancha R Gortazar; Matthew R Allen; Alexander G Robling; Mary L Bouxsein; Ernestina Schipani; Charles H Turner; Robert L Jilka; Robert S Weinstein; Stavros C Manolagas; Teresita Bellido
Control of bone mass and remodeling by PTH receptor signaling in osteocytes.
PloS one 2008;3(8):e2942.
2008: Carlo Galli; Lee A Zella; Jackie A Fretz; Qiang Fu; J Wesley Pike; Robert S Weinstein; Stavros C Manolagas; Charles A O'Brien
Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass.
Endocrinology 2008;149(1):146-53.
2007: Robert L Jilka; Robert S Weinstein; A Michael Parfitt; Stavros C Manolagas
Quantifying osteoblast and osteocyte apoptosis: challenges and rewards.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(10):1492-501.
2007: Maria Almeida; Li Han; Marta Martin-Millan; Lilian Plotkin; Scott A Stewart; Paula K Roberson; Stavroula Kousteni; Charles A O'Brien; Teresita Bellido; A Michael Parfitt; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.
The Journal of biological chemistry 2007;282(37):27285-97.
2007: Dorota Szumska; Helen Benes; Ping Kang; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas; Robert J Shmookler Reis
A novel locus on the X chromosome regulates post-maturity bone density changes in mice.
Bone 2007;40(3):758-66.
2007: Robert S Weinstein
Is long-term glucocorticoid therapy associated with a high prevalence of asymptomatic vertebral fractures?
Nature clinical practice. Endocrinology & metabolism 2007;3(2):86-7.
2006: Dan Jia; Charles A O'Brien; Scott A Stewart; Stavros C Manolagas; Robert S Weinstein
Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density.
Endocrinology 2006;147(12):5592-9.
2006: Stavros C Manolagas; Robert L Jilka; Stavroula Kousteni; Teresita Bellido; Robert S Weinstein; Charles A O'Brien; Lilian Plotkin; Li Han
Response to Windahl et al.
The Journal of clinical investigation 2006;116(11):2834.
2006: J Ignacio Aguirre; Lilian Plotkin; Scott A Stewart; Robert S Weinstein; A Michael Parfitt; Stavros C Manolagas; Teresita Bellido
Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(4):605-15.
2005: Charles A O'Brien; Robert L Jilka; Qiang Fu; Scott Stewart; Robert S Weinstein; Stavros C Manolagas
IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.
American journal of physiology. Endocrinology and metabolism 2005;289(5):E784-93.
2005: A Afshan Ali; Robert S Weinstein; Scott A Stewart; A Michael Parfitt; Stavros C Manolagas; Robert L Jilka
Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation.
Endocrinology 2005;146(3):1226-35.
2004: Robert S Weinstein; Dan Jia; Cara Powers; Scott A Stewart; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
The skeletal effects of glucocorticoid excess override those of orchidectomy in mice.
Endocrinology 2004;145(4):1980-7.
2004: Charles A O'Brien; Dan Jia; Lilian Plotkin; Teresita Bellido; Cara Powers; Scott A Stewart; Stavros C Manolagas; Robert S Weinstein
Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.
Endocrinology 2004;145(4):1835-41.
2003: Teresita Bellido; A Afshan Ali; Lilian Plotkin; Qiang Fu; Igor Gubrij; Paula K Roberson; Robert S Weinstein; Charles A O'Brien; Stavros C Manolagas; Robert L Jilka
Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.
The Journal of biological chemistry 2003;278(50):50259-72.
2003: Robert S Weinstein; A Michael Parfitt; Robert Marcus; Maria Greenwald; Gerald Crans; Douglas B Muchmore
Effects of raloxifene, hormone replacement therapy, and placebo on bone turnover in postmenopausal women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2003;14(10):814-22.
2002: Stavroula Kousteni; Jin-Ran Chen; Teresita Bellido; Li Han; A Afshan Ali; Charles A O'Brien; Lilian Plotkin; Qiang Fu; Anne Mancino; Yeshao Wen; Anthony M Vertino; Cara Powers; Scott A Stewart; R Ebert; A Michael Parfitt; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas
Reversal of bone loss in mice by nongenotropic signaling of sex steroids.
Science (New York, N.Y.) 2002;298(5594):843-6.
2002: Robert S Weinstein; Jin-Ran Chen; Cara Powers; Scott A Stewart; Reid D Landes; Teresita Bellido; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids.
The Journal of clinical investigation 2002;109(8):1041-8.
2001: Stavroula Kousteni; Teresita Bellido; Lilian Plotkin; Charles A O'Brien; Donald L Bodenner; L Han; K Han; G B DiGregorio; J A Katzenellenbogen; Benita S Katzenellenbogen; Paula K Roberson; Robert S Weinstein; Robert L Jilka; Stavros C Manolagas
Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity.
Cell 2001;104(5):719-30.
2000: Robert S Weinstein; Richard W Nicholas; Stavros C Manolagas
Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip.
The Journal of clinical endocrinology and metabolism 2000;85(8):2907-12.
2000: Helen Benes; Robert S Weinstein; W Zheng; John J Thaden; Robert L Jilka; Stavros C Manolagas; Robert J Shmookler Reis
Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(4):626-33.
1999: Lilian Plotkin; Robert S Weinstein; A Michael Parfitt; Paula K Roberson; Stavros C Manolagas; Teresita Bellido
Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin.
The Journal of clinical investigation 1999;104(10):1363-74.
1999: Robert L Jilka; Robert S Weinstein; Teresita Bellido; Paula K Roberson; A Michael Parfitt; Stavros C Manolagas
Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone.
The Journal of clinical investigation 1999;104(4):439-46.
1999: Stavros C Manolagas; Robert S Weinstein
New developments in the pathogenesis and treatment of steroid-induced osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999;14(7):1061-6.
1998: Robert S Weinstein; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.
The Journal of clinical investigation 1998;102(2):274-82.
1998: Robert L Jilka; Robert S Weinstein; Teresita Bellido; A Michael Parfitt; Stavros C Manolagas
Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(5):793-802.
1997: Robert S Weinstein; Robert L Jilka; A Michael Parfitt; Stavros C Manolagas
The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage.
Endocrinology 1997;138(9):4013-21.
1997: Robert S Weinstein
Long-term aminobisphosphonate treatment of fibrous dysplasia: spectacular increase in bone density.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(8):1314-5.
1997: H Mocharla; Anthony W Butch; AA Pappas; JT Flick; Robert S Weinstein; P De Togni; Robert L Jilka; Paula K Roberson; A Michael Parfitt; Stavros C Manolagas
Quantification of vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC: lack of correspondence with common allelic variants.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(5):726-33.
1996: Robert L Jilka; Robert S Weinstein; K Takahashi; A Michael Parfitt; Stavros C Manolagas
Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.
The Journal of clinical investigation 1996;97(7):1732-40.
1994: Robert S Weinstein; Sharmila Majumdar
Fractal geometry and vertebral compression fractures.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(11):1797-802.