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Gordon Weir

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Cristina Aguayo-Mazzucato; Ilham El Khattabi; Jennifer Hollister-Lock; P. Reed larsen; Alejandra Marinelarena; Alessandro Marsili; Arun Sharma; Gordon C Weir; Ann Marie Zavacki; Susan Bonner-Weir
Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA.
Gordon C Weir; Susan Bonner-Weir
Islet β cell mass in diabetes and how it relates to function, birth, and death.
Gordon C Weir
Cellular transplantation into lymph nodes may not be such a crazy idea.

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2013: Cristina Aguayo-Mazzucato; Ilham El Khattabi; Jennifer Hollister-Lock; P. Reed larsen; Alejandra Marinelarena; Alessandro Marsili; Arun Sharma; Gordon C Weir; Ann Marie Zavacki; Susan Bonner-Weir
Thyroid Hormone Promotes Postnatal Rat Pancreatic β-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA.
Diabetes 2013;62(5):1569-80.
2013: Gordon C Weir; Susan Bonner-Weir
Islet β cell mass in diabetes and how it relates to function, birth, and death.
Annals of the New York Academy of Sciences 2013;1281():92-105.
2012: Gordon C Weir
Cellular transplantation into lymph nodes may not be such a crazy idea.
Cell stem cell 2012;11(5):587-8.
2012: Hitoshi Katsuta; Rimiko Katsuta; Arun J Sharma; Cristina Aguayo-Mazzucato; Tomoyuki Akashi; Susan Bonner-Weir; Jennifer Hollister-Lock; Gordon C Weir
Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion.
Endocrinology 2012;153(11):5180-7.
2012: Philippe Lysy; Gordon C Weir; Susan Bonner-Weir
Concise review: pancreas regeneration: recent advances and perspectives.
Stem cells translational medicine 2012;1(2):150-9.
2011: Amy S Johnson; Esther O'Sullivan; Laura N D'Aoust; Abdulkadir Omer; Susan Bonner-Weir; Robert J Fisher; Gordon C Weir; Clark K Colton
Quantitative assessment of islets of Langerhans encapsulated in alginate.
Tissue engineering. Part C, Methods 2011;17(4):435-49.
2011: A Jermendy; Elena Toschi; T Aye; A Koh; C Aguayo-Mazzucato; Arun Sharma; Gordon C Weir; Dennis C Sgroi; Susan Bonner-Weir
Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.
Diabetologia 2011;54(3):594-604.
2011: C Aguayo-Mazzucato; A Koh; I El Khattabi; W-C Li; Elena Toschi; A Jermendy; K Juhl; K Mao; Gordon C Weir; Arun Sharma; Susan Bonner-Weir
Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.
Diabetologia 2011;54(3):583-93.
2011: Gordon C Weir; Claudia Cavelti-Weder; Susan Bonner-Weir
Stem cell approaches for diabetes: towards beta cell replacement.
Genome medicine 2011;3(9):61.
2010: Ying Mei; Jennifer Hollister-Lock; Said R Bogatyrev; Seung-Woo Cho; Gordon C Weir; Robert Langer; Daniel G Anderson
A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells.
Biomaterials 2010;31(34):8989-95.
2010: Anna Pisania; Gordon C Weir; John J O'Neil; Abdulkadir Omer; Vaja Tchipashvili; Ji Lei; Clark K Colton; Susan Bonner-Weir
Quantitative analysis of cell composition and purity of human pancreatic islet preparations.
Laboratory investigation; a journal of technical methods and pathology 2010;90(11):1661-75.
2010: Anna Pisania; Klearchos K Papas; Daryl E Powers; Michael J Rappel; Abdulkadir Omer; Susan Bonner-Weir; Gordon C Weir; Clark K Colton
Enumeration of islets by nuclei counting and light microscopic analysis.
Laboratory investigation; a journal of technical methods and pathology 2010;90(11):1676-86.
2010: E S O'Sullivan; A S Johnson; Abdulkadir Omer; Jennifer Hollister-Lock; Susan Bonner-Weir; CK Colton; Gordon C Weir
Rat islet cell aggregates are superior to islets for transplantation in microcapsules.
Diabetologia 2010;53(5):937-45.
2010: Klearchos K Papas; Clark K Colton; Andi Qipo; Haiyan Wu; Rebecca A Nelson; Bernhard J Hering; Gordon C Weir; Maria Koulmanda
Prediction of marginal mass required for successful islet transplantation.
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2010;23(1):28-34.
2010: Yoshiyuki Hamamoto; Tomoyuki Akashi; Akari Inada; Susan Bonner-Weir; Gordon C Weir
Lack of evidence for recipient precursor cells replenishing β-cells in transplanted islets.
Cell transplantation 2010;19(12):1563-72.
2010: Lorella Marselli; Jeffrey Thorne; Sonika Dahiya; Dennis C Sgroi; Arun Sharma; Susan Bonner-Weir; Piero Marchetti; Gordon C Weir
Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.
PloS one 2010;5(7):e11499.
2010: Jeffrey Kennedy; Hitoshi Katsuta; Min-Ho Jung; Lorella Marselli; Allison B Goldfine; Ulysses J Balis; Dennis C Sgroi; Susan Bonner-Weir; Gordon C Weir
Protective unfolded protein response in human pancreatic beta cells transplanted into mice.
PloS one 2010;5(6):e11211.
2010: H Katsuta; T Akashi; R Katsuta; M Nagaya; D Kim; Y Arinobu; M Hara; Susan Bonner-Weir; A J Sharma; Koichi Akashi; Gordon C Weir
Single pancreatic beta cells co-express multiple islet hormone genes in mice.
Diabetologia 2010;53(1):128-38.
2009: Gordon C Weir; Lorella Marselli; P Marchetti; H Katsuta; M H Jung; Susan Bonner-Weir
Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes.
Diabetes, obesity & metabolism 2009;11 Suppl 4():82-90.
2009: Gordon C Weir; Maria Koulamnda
Control of inflammation with alpha1-antitrypsin: a potential treatment for islet transplantation and new-onset type 1 diabetes.
Current diabetes reports 2009;9(2):100-2.
2009: R Kikugawa; H Katsuta; T Akashi; S Yatoh; Gordon C Weir; Arun Sharma; Susan Bonner-Weir
Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse.
Diabetologia 2009;52(4):645-52.
2009: Lorella Marselli; Dennis C Sgroi; Susan Bonner-Weir; Gordon C Weir
Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.
Methods in molecular biology (Clifton, N.J.) 2009;560():87-98.
2008: Keiji Isshiki; Zhiheng He; Yasuhiro Maeno; Ronald Ma; Yutaka Yasuda; Tatsuya Kuroki; Gregory S White; Mary E Patti; Gordon C Weir; George L King
Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells.
Kidney international 2008;74(11):1434-43.
2008: Tomoyuki Akashi; Hirokazu Shigematsu; Yoshiyuki Hamamoto; Hiromi Iwasaki; Shigeru Yatoh; Susan Bonner-Weir; Koichi Akashi; Gordon C Weir
Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice.
Diabetes/metabolism research and reviews 2008;24(7):585-90.
2008: Akari Inada; Hiroshi Kanamori; Hidenori Arai; Tomoyuki Akashi; Makoto Araki; Gordon C Weir; Atsushi Fukatsu
A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse.
Journal of cellular physiology 2008;215(2):383-91.
2008: Noriko Tonomura; Akira Shimizu; Shumei Wang; Kazuhiko Yamada; Vaja Tchipashvili; Gordon C Weir; Yong-Guang Yang
Pig islet xenograft rejection in a mouse model with an established human immune system.
Xenotransplantation 2008;15(2):129-35.
2008: Lorella Marselli; Jeffrey Thorne; Yu-Bae Ahn; Abdulkadir Omer; Dennis C Sgroi; Towia Libermann; Hasan H Otu; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.
The Journal of clinical endocrinology and metabolism 2008;93(3):1046-53.
2007: D Ross Laybutt; Y C Hawkins; J Lock; J Lebet; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.
Diabetologia 2007;50(10):2117-25.
2007: Aileen J F King; Justin R Fernandes; Jennifer Hollister-Lock; Cameron E Nienaber; Susan Bonner-Weir; Gordon C Weir
Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation.
Diabetes 2007;56(9):2312-8.
2007: Shigeru Yatoh; Rikke Dodge; Tomoyuki Akashi; Abdulkadir Omer; Arun Sharma; Gordon C Weir; Susan Bonner-Weir
Differentiation of affinity-purified human pancreatic duct cells to beta-cells.
Diabetes 2007;56(7):1802-9.
2007: Gang Xu; Hideaki Kaneto; D Ross Laybutt; Valérie F Duvivier-Kali; Nitin Trivedi; Kiyoshi Suzuma; George L King; Gordon C Weir; Susan Bonner-Weir
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.
Diabetes 2007;56(6):1551-8.
2007: Emi Arikawa; Ronald Ma; Keiji Isshiki; Ivan Luptak; Zhiheng He; Yutaka Yasuda; Yasuhiro Maeno; Mary-Elizabeth Patti; Gordon C Weir; Robert Harris; Victor A Zammit; Rong Tian; George L King
Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats.
Diabetes 2007;56(5):1410-20.
2007: Shigeru Yatoh; Tomoyuki Akashi; Phillip P Chan; Hideaki Kaneto; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes.
Diabetes/metabolism research and reviews 2007;23(3):239-49.
2007: Yu-Bae Ahn; G Xu; Lorella Marselli; Elena Toschi; Arun Sharma; Susan Bonner-Weir; Dennis C Sgroi; Gordon C Weir
Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection.
Diabetologia 2007;50(2):334-42.
2007: Gordon C Weir; Susan Bonner-Weir
A dominant role for glucose in beta cell compensation of insulin resistance.
The Journal of clinical investigation 2007;117(1):81-3.
2006: Gang Xu; Hideaki Kaneto; Maria D Lopez-Avalos; Gordon C Weir; Susan Bonner-Weir
GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts.
Diabetes research and clinical practice 2006;73(1):107-10.
2006: María D López-Avalos; Valérie F Duvivier-Kali; Gang Xu; Susan Bonner-Weir; Arun Sharma; Gordon C Weir
Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.
Diabetes 2006;55(5):1223-31.
2006: Maria Koulmanda; Rex Smith; Andi Qipo; Gordon C Weir; Hugh Auchincloss; Terry B Strom
Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(4):687-96.
2005: A King; J Lock; G Xu; Susan Bonner-Weir; Gordon C Weir
Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment.
Diabetologia 2005;48(10):2074-9.
2005: Akari Inada; Kojiro Nagai; Hidenori Arai; Jun-ichi Miyazaki; Keiko Nomura; Hiroshi Kanamori; Shinya Toyokuni; Yuichiro Yamada; Susan Bonner-Weir; Gordon C Weir; Atsushi Fukatsu; Yutaka Seino
Establishment of a diabetic mouse model with progressive diabetic nephropathy.
The American journal of pathology 2005;167(2):327-36.
2005: Susan Bonner-Weir; Gordon C Weir
New sources of pancreatic beta-cells.
Nature biotechnology 2005;23(7):857-61.
2005: Jason L Gaglia; A M James Shapiro; Gordon C Weir
Islet transplantation: progress and challenge.
Archives of medical research 2005;36(3):273-80.
2005: Akari Inada; Gordon C Weir; Susan Bonner-Weir
Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells.
Biochemical and biophysical research communications 2005;329(3):925-9.
2005: Abdulkadir Omer; Valérie F Duvivier-Kali; Justin Fernandes; Vaja Tchipashvili; Clark K Colton; Gordon C Weir
Long-term normoglycemia in rats receiving transplants with encapsulated islets.
Transplantation 2005;79(1):52-8.
2004: Valérie F Duvivier-Kali; Abdulkadir Omer; Maria D Lopez-Avalos; John J O'Neil; Gordon C Weir
Survival of microencapsulated adult pig islets in mice in spite of an antibody response.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(12):1991-2000.
2004: Gordon C Weir; Susan Bonner-Weir
Five stages of evolving beta-cell dysfunction during progression to diabetes.
Diabetes 2004;53 Suppl 3():S16-21.
2004: Justin R Fernandes; Valérie F Duvivier-Kali; Mitchell Keegan; Jennifer Hollister-Lock; Abdulkadir Omer; Stacey Su; Susan Bonner-Weir; Sandy Feng; Jeng-Shin Lee; Richard C Mulligan; Gordon C Weir
Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors.
Transplant immunology 2004;13(3):191-200.
2004: Gordon C Weir
Can we make surrogate beta-cells better than the original?
Seminars in cell & developmental biology 2004;15(3):347-57.
2004: Seung Hyun Ko; Sun-Hee Suh; B J Kim; Yu-Bae Ahn; Ki-Ho Song; Soon-Jib Yoo; Hyun-Shik Son; Bong-Yun Cha; Kwang Woo Lee; Ho-Young Son; Sung Koo Kang; Susan Bonner-Weir; Gordon C Weir; Kun-Ho Yoon; Chung-Gyu Park
Expression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells.
Pancreas 2004;28(2):121-8.
2004: Abdulkadir Omer; Valérie F Duvivier-Kali; william aschenbach; Vaja Tchipashvili; Laurie J Goodyear; Gordon C Weir
Exercise induces hypoglycemia in rats with islet transplantation.
Diabetes 2004;53(2):360-5.
2003: Leila Makhlouf; Valérie F Duvivier-Kali; Susan Bonner-Weir; Hans Dieperink; Gordon C Weir; Mohamed H Sayegh
Importance of hyperglycemia on the primary function of allogeneic islet transplants.
Transplantation 2003;76(4):657-64.
2003: Hirofumi Noguchi; Hideaki Kaneto; Gordon C Weir; Susan Bonner-Weir
PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.
Diabetes 2003;52(7):1732-7.
2003: Abdulkadir Omer; Mitchell Keegan; Eva Czismadia; Paul De Vos; Nico van Rooijen; Susan Bonner-Weir; Gordon C Weir
Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats.
Xenotransplantation 2003;10(3):240-51.
2003: Giovanni Patané; Hideaki Kaneto; Elena Toschi; Arun Sharma; Sanjeev Gupta; Gordon C Weir
Induction of Mad expression leads to augmentation of insulin gene transcription.
Biochemical and biophysical research communications 2003;303(4):1199-208.
2003: Krystyna Tatarkiewicz; Maria D López-Avalos; Kun-Ho Yoon; Nitin Trivedi; Robert R Quickel; Susan Bonner-Weir; Gordon C Weir
Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture.
Development, growth & differentiation 2003;45(1):39-50.
2003: D Ross Laybutt; Mariela Glandt; Gang Xu; Yu-Bae Ahn; Nitin Trivedi; Susan Bonner-Weir; Gordon C Weir
Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.
The Journal of biological chemistry 2003;278(5):2997-3005.
2003: Abdulkadir Omer; Valérie F Duvivier-Kali; Nitin Trivedi; Karen Wilmot; Susan Bonner-Weir; Gordon C Weir
Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice.
Diabetes 2003;52(1):69-75.
2002: Hideaki Kaneto; Gang Xu; Nobuharu Fujii; Shokei Kim; Susan Bonner-Weir; Gordon C Weir
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression.
The Journal of biological chemistry 2002;277(33):30010-8.
2002: D Ross Laybutt; Gordon C Weir; Hideaki Kaneto; Judith Lebet; Richard D Palmiter; Arun Sharma; Susan Bonner-Weir
Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.
Diabetes 2002;51(6):1793-804.
2002: Hideaki Kaneto; Arun Sharma; Kiyoshi Suzuma; D Ross Laybutt; Gang Xu; Susan Bonner-Weir; Gordon C Weir
Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.
The Journal of biological chemistry 2002;277(15):12998-3006.
2002: D Ross Laybutt; Arun Sharma; Dennis C Sgroi; Justin Gaudet; Susan Bonner-Weir; Gordon C Weir
Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.
The Journal of biological chemistry 2002;277(13):10912-21.
2002: D Ross Laybutt; Hideaki Kaneto; Wendy Hasenkamp; Shane T Grey; Jean-Christophe Jonas; Dennis C Sgroi; Adam Groff; Christiane Ferran; Susan Bonner-Weir; Arun Sharma; Gordon C Weir
Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.
Diabetes 2002;51(2):413-23.
2002: Hideaki Kaneto; Kiyoshi Suzuma; Arun Sharma; Susan Bonner-Weir; George L King; Gordon C Weir
Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells.
The Journal of biological chemistry 2002;277(5):3680-5.
2002: Leo H Bühler; S Deng; J O'Neil; Hiroshi Kitamura; Maria Koulmanda; A Baldi; J Rahier; Ian P J Alwayn; James Z Appel; Michel Awwad; David H Sachs; Gordon C Weir; J P Squifflet; David K C Cooper; Ph Morel
Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade.
Xenotransplantation 2002;9(1):3-13.
2001: Jean-Christophe Jonas; D Ross Laybutt; Garry Steil; Nitin Trivedi; J G Pertusa; Mark Van de Casteele; Gordon C Weir; Jean-Claude Henquin
High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells.
The Journal of biological chemistry 2001;276(38):35375-81.
2001: Hideaki Kaneto; Gang Xu; K H Song; Kiyoshi Suzuma; Susan Bonner-Weir; Arun Sharma; Gordon C Weir
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress.
The Journal of biological chemistry 2001;276(33):31099-104.
2001: Valérie F Duvivier-Kali; Abdulkadir Omer; R J Parent; John J O'Neil; Gordon C Weir
Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane.
Diabetes 2001;50(8):1698-705.
2001: Krystyna Tatarkiewicz; M Garcia; Maria D Lopez-Avalos; Susan Bonner-Weir; Gordon C Weir
Porcine neonatal pancreatic cell clusters in tissue culture: benefits of serum and immobilization in alginate hydrogel.
Transplantation 2001;71(11):1518-26.
2001: Krystyna Tatarkiewicz; M Garcia; Abdulkadir Omer; R Van Schilfgaarde; Gordon C Weir; P De Vos
C-peptide responses after meal challenge in mice transplanted with microencapsulated rat islets.
Diabetologia 2001;44(5):646-53.
2001: Nitin Trivedi; Jennifer Hollister-Lock; Maria D Lopez-Avalos; John J O'Neil; Mitchell Keegan; Susan Bonner-Weir; Gordon C Weir
Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells.
Endocrinology 2001;142(5):2115-22.
2001: Garry Steil; Nitin Trivedi; Jean-Christophe Jonas; Wendy Hasenkamp; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression.
American journal of physiology. Endocrinology and metabolism 2001;280(5):E788-96.
2001: Maria D Lopez-Avalos; Krystyna Tatarkiewicz; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
Enhanced maturation of porcine neonatal pancreatic cell clusters with growth factors fails to improve transplantation outcome.
Transplantation 2001;71(8):1154-62.
2001: B Vasir; Jean-Christophe Jonas; Garry Steil; Jennifer Hollister-Lock; Wendy Hasenkamp; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets.
Transplantation 2001;71(7):924-35.
2001: R Laybutt; Wendy Hasenkamp; A Groff; Shane T Grey; Jean-Christophe Jonas; Hideaki Kaneto; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
beta-cell adaptation to hyperglycemia.
Diabetes 2001;50 Suppl 1():S180-1.
2001: Gordon C Weir; D Ross Laybutt; Hideaki Kaneto; Susan Bonner-Weir; Arun Sharma
Beta-cell adaptation and decompensation during the progression of diabetes.
Diabetes 2001;50 Suppl 1():S154-9.
2001: Jean-Christophe Jonas; R Laybutt; Garry Steil; Nitin Trivedi; Gordon C Weir; Jean-Claude Henquin
Potential role of the early response gene c-myc in beta-cell adaptation to changes in glucose concentration.
Diabetes 2001;50 Suppl 1():S137.
2001: Nitin Trivedi; Mitchell Keegan; Garry Steil; Jennifer Hollister-Lock; Wendy Hasenkamp; CK Colton; Susan Bonner-Weir; Gordon C Weir
Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses.
Transplantation 2001;71(2):203-11.
2000: Susan Bonner-Weir; M Taneja; Gordon C Weir; Krystyna Tatarkiewicz; K H Song; Arun Sharma; John J O'Neil
In vitro cultivation of human islets from expanded ductal tissue.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7999-8004.
2000: B Vasir; Petra Reitz; G Xu; Arun Sharma; Susan Bonner-Weir; Gordon C Weir
Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-alpha, TGF-beta, bFGF and Vimentin) in cultured and transplanted rat islets.
Diabetologia 2000;43(6):763-72.
2000: Nitin Trivedi; Garry Steil; CK Colton; Susan Bonner-Weir; Gordon C Weir
Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor.
Cell transplantation 2000;9(1):115-24.
1999: Kun-Ho Yoon; Robert R Quickel; Krystyna Tatarkiewicz; Thomas Ulrich; Jennifer Hollister-Lock; Nitin Trivedi; Susan Bonner-Weir; Gordon C Weir
Differentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice.
Cell transplantation 1999;8(6):673-89.
1999: Sandy Feng; Robert R Quickel; Jennifer Hollister-Lock; M McLeod; Susan Bonner-Weir; Richard C Mulligan; Gordon C Weir
Prolonged xenograft survival of islets infected with small doses of adenovirus expressing CTLA4Ig.
Transplantation 1999;67(12):1607-13.
1999: Jean-Christophe Jonas; Arun Sharma; Wendy Hasenkamp; H Ilkova; G Patanè; R Laybutt; Susan Bonner-Weir; Gordon C Weir
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes.
The Journal of biological chemistry 1999;274(20):14112-21.
1999: D T Finegood; Gordon C Weir; Susan Bonner-Weir
Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats.
The American journal of physiology 1999;276(5 Pt 1):E822-7.
1999: Krystyna Tatarkiewicz; Jennifer Hollister-Lock; Robert R Quickel; CK Colton; Susan Bonner-Weir; Gordon C Weir
Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets.
Transplantation 1999;67(5):665-71.
1999: Arun Sharma; DH Zangen; Petra Reitz; M Taneja; Matthew E Lissauer; Christopher P Miller; Gordon C Weir; Joel F Habener; Susan Bonner-Weir
The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.
Diabetes 1999;48(3):507-13.
1999: R Weitgasser; Alberto M Davalli; Gordon C Weir
Measurement of glucose concentrations in rats: differences between glucose meter and plasma laboratory results.
Diabetologia 1999;42(2):256.
1998: B Vasir; Lloyd Paul Aiello; Kun-Ho Yoon; Robert R Quickel; Susan Bonner-Weir; Gordon C Weir
Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells.
Diabetes 1998;47(12):1894-903.
1998: Gordon C Weir; Susan Bonner-Weir
Islet transplantation as a treatment for diabetes.
Journal of the American Optometric Association 1998;69(11):727-32.
1998: K Suzuki; Susan Bonner-Weir; Nitin Trivedi; Kun-Ho Yoon; Jennifer Hollister-Lock; CK Colton; Gordon C Weir
Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice.
Transplantation 1998;66(1):21-8.
1998: Jochen Seufert; Gordon C Weir; Joel F Habener
Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.
The Journal of clinical investigation 1998;101(11):2528-39.
1998: Kun-Ho Yoon; Robert R Quickel; Krystyna Tatarkiewicz; Gordon C Weir; Susan Bonner-Weir
Growth and differentiation of transplanted porcine neonatal pancreatic cell clusters in normal nude mice.
Transplantation proceedings 1998;30(2):601.
1998: Krystyna Tatarkiewicz; Jennifer Hollister-Lock; Robert R Quickel; C K Cotton; Susan Bonner-Weir; Gordon C Weir
Subcutaneous transplantation of rat islets into diabetic nude.
Transplantation proceedings 1998;30(2):479-80.
1998: K Suzuki; Susan Bonner-Weir; Jennifer Hollister-Lock; CK Colton; Gordon C Weir
Number and volume of islets transplanted in immunobarrier devices.
Cell transplantation 1998;7(1):47-52.
1997: Gordon C Weir; Arun Sharma; DH Zangen; Susan Bonner-Weir
Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis.
Acta diabetologica 1997;34(3):177-84.
1997: Gordon C Weir; Susan Bonner-Weir
Scientific and political impediments to successful islet transplantation.
Diabetes 1997;46(8):1247-56.
1997: Nitin Trivedi; K Suzuki; Susan Bonner-Weir; Jennifer Hollister-Lock; Gordon C Weir
Islet number in an immunobarrier device required to treat diabetes in mice.
Transplantation proceedings 1997;29(4):2142-3.
1997: DH Zangen; Susan Bonner-Weir; C H Lee; J B Latimer; Christopher P Miller; Joel F Habener; Gordon C Weir
Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy.
Diabetes 1997;46(2):258-64.
1997: Gordon C Weir; Robert R Quickel; Kun-Ho Yoon; Krystyna Tatarkiewicz; Thomas Ulrich; Jennifer Hollister-Lock; Susan Bonner-Weir
Porcine neonatal pancreatic cell clusters (NPCCs): a potential source of tissue for islet transplantation.
Annals of transplantation : quarterly of the Polish Transplantation Society 1997;2(3):63-8.
1996: K Suzuki; Susan Bonner-Weir; J Hollister; Gordon C Weir
A method for estimating number and mass of islets transplanted within a membrane device.
Cell transplantation 1996;5(6):613-25.
1996: Timothy J Kieffer; R Scott Heller; C G Unson; Gordon C Weir; Joel F Habener
Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets.
Endocrinology 1996;137(11):5119-25.
1996: Alberto M Davalli; L Scaglia; D H Zangen; J Hollister; Susan Bonner-Weir; Gordon C Weir
Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function.
Diabetes 1996;45(9):1161-7.
1996: M A Lipes; E M Cooper; R Skelly; C J Rhodes; E Boschetti; Gordon C Weir; Alberto M Davalli
Insulin-secreting non-islet cells are resistant to autoimmune destruction.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(16):8595-600.
1996: Alberto M Davalli; Raffaele Napoli; R Weitgasser; J V Capotorto; Michael F Hirshman; D T Finegood; Susan Bonner-Weir; Edward S Horton; Gordon C Weir
Long-term normalization of GLUT-4 protein content in skeletal muscle of diabetic rats following islet transplantation.
The Journal of endocrinology 1996;150(2):255-63.
1996: J H Juang; Susan Bonner-Weir; Y Ogawa; J P Vacanti; Gordon C Weir
Outcome of subcutaneous islet transplantation improved by polymer device.
Transplantation 1996;61(11):1557-61.
1996: Raffaele Napoli; Alberto M Davalli; Michael F Hirshman; R Weitgasser; Gordon C Weir; Edward S Horton
Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozocin diabetic rats.
The Journal of clinical investigation 1996;97(6):1389-97.
1996: R Weitgasser; Alberto M Davalli; J V Capotorto; D T Finegood; Susan Bonner-Weir; Gordon C Weir
Islet transplantation in diabetic Lewis rats--a comparison of the transplantation sites kidney and spleen capsule.
Acta medica Austriaca 1996;23(5):156-9.
1995: Alberto M Davalli; L Scaglia; D H Zangen; J Hollister; Susan Bonner-Weir; Gordon C Weir
Early changes in syngeneic islet grafts: effect of recipient's metabolic control on graft outcome.
Transplantation proceedings 1995;27(6):3238-9.
1995: J H Juang; Susan Bonner-Weir; J P Vacanti; Gordon C Weir
Outcome of subcutaneous islet transplantation improved by a polymer device.
Transplantation proceedings 1995;27(6):3215-6.
1995: R Weitgasser; Alberto M Davalli; Raffaele Napoli; J V Capotorto; D T Finegood; Susan Bonner-Weir; Gordon C Weir
Long-term normalization of GLUT 4 protein content in skeletal muscle of streptozotocin-diabetic Lewis rats after islet transplantation.
Transplantation proceedings 1995;27(6):3184-5.
1995: Alberto M Davalli; Y Ogawa; Camillo Ricordi; D W Scharp; Susan Bonner-Weir; Gordon C Weir
A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice.
Transplantation 1995;59(6):817-20.
1995: Y Ogawa; Y Noma; Alberto M Davalli; Y J Wu; B Thorens; Susan Bonner-Weir; Gordon C Weir
Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted beta-cells.
Diabetes 1995;44(1):75-9.
1995: Alberto M Davalli; Y Ogawa; L Scaglia; Y J Wu; J Hollister; Susan Bonner-Weir; Gordon C Weir
Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice.
Diabetes 1995;44(1):104-11.
1994: Gordon C Weir; D M Nathan; D E Singer
Standards of care for diabetes.
Diabetes care 1994;17(12):1514-22.
1994: J H Juang; Susan Bonner-Weir; Y J Wu; Gordon C Weir
Beneficial influence of glycemic control upon the growth and function of transplanted islets.
Diabetes 1994;43(11):1334-9.
1994: Alberto M Davalli; Y Ogawa; L Scaglia; Y J Wu; J Hollister; Susan Bonner-Weir; Gordon C Weir
Porcine islet grafts in diabetic nude mice: dynamic insulin secretion and regulated B-cell mass lower glucose levels to the normal porcine range.
Transplantation proceedings 1994;26(3):1098-9.
1994: E Montaña; Susan Bonner-Weir; Gordon C Weir
Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass.
The Journal of clinical investigation 1994;93(4):1577-82.
1994: E Montaña; Susan Bonner-Weir; Gordon C Weir
Transplanted beta-cell replication and mass increase after 95% pancreatectomy.
Transplantation proceedings 1994;26(2):657.
1993: E Montaña; Susan Bonner-Weir; Gordon C Weir
Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice.
The Journal of clinical investigation 1993;91(3):780-7.
1993: G K Hendrick; A Gjinovci; L A Baxter; S Mojsov; C B Wollheim; J F Habener; Gordon C Weir
Glucagon-like peptide-I-(7-37) suppresses hyperglycemia in rats.
Metabolism: clinical and experimental 1993;42(1):1-6.
1992: E Montaña; Susan Bonner-Weir; Gordon C Weir
Beta-cell mass falls progressively when hyperglycemia persists after islet transplantation.
Transplantation proceedings 1992;24(6):2996.
1992: C Chen; B Thorens; Susan Bonner-Weir; Gordon C Weir; J L Leahy
Recovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter.
Diabetes 1992;41(10):1320-7.
1992: J L Leahy; Susan Bonner-Weir; Gordon C Weir
Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion.
Diabetes care 1992;15(3):442-55.
1991: J L Leahy; Gordon C Weir
Beta-cell dysfunction in hyperglycaemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level.
Diabetologia 1991;34(9):640-7.
1991: J L Leahy; P A Halban; Gordon C Weir
Relative hypersecretion of proinsulin in rat model of NIDDM.
Diabetes 1991;40(8):985-9.
1991: F E Smith; Kenneth M Rosen; L Villa-Komaroff; Gordon C Weir; Susan Bonner-Weir
Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6152-6.
1990: D Gefel; G K Hendrick; S Mojsov; J Habener; Gordon C Weir
Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation.
Endocrinology 1990;126(4):2164-8.
1990: Gordon C Weir; S Bonner-Weir
Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes.
The Journal of clinical investigation 1990;85(4):983-7.
1989: Gordon C Weir; S Mojsov; G K Hendrick; J F Habener
Glucagonlike peptide I (7-37) actions on endocrine pancreas.
Diabetes 1989;38(3):338-42.
1989: H C Lee; Susan Bonner-Weir; Gordon C Weir; J L Leahy
Compensatory adaption to partial pancreatectomy in the rat.
Endocrinology 1989;124(3):1571-5.
1988: J L Leahy; Susan Bonner-Weir; Gordon C Weir
Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy.
The Journal of clinical investigation 1988;81(5):1407-14.
1988: J L Leahy; Gordon C Weir
Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia.
Diabetes 1988;37(2):217-22.