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Karl Weisgraber

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequence

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Mice

Phenomena

Protein Binding

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Procedures

Polyacrylamide Gel Electrophoresis

Disorders

Hyperlipoproteinemia Type III

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Co-Publications
Name
47
Mahley, Robert
24
Innerarity, Thomas
23
Newhouse, Yvonne
19
Rall, SC
14
Strittmatter, Warren
12
Saunders, Ann
11
Phillips, Michael
11
Roses, Allen
11
Lund-Katz, Sissel
9
Huang, Yadong
9
Arnold, Kay
8
Bersot, Thomas
8
Peters-Libeu, Clare
8
Rupp, Bernhard
7
Pitas, Robert

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Publications

TOP 3
Zhong Ning; Weisgraber Karl H
Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches.
Zhong Ning; Ramaswamy Gayathri; Weisgraber Karl H
Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function.
Tesseur Ina; Zhang Hui; Brecht Walter; Corn Jacob; Gong Jian-Sheng; Yanagisawa Katsuhiko; Michikawa Makoto; Weisgraber Karl; Huang Yadong; Wyss-Coray Tony
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.

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All Publications

2009: Zhong Ning; Weisgraber Karl H
Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches.
Current Alzheimer research 2009;6(5):415-8.
2009: Zhong Ning; Ramaswamy Gayathri; Weisgraber Karl H
Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function.
The Journal of biological chemistry 2009;284(40):27273-80.
2009: Tesseur Ina; Zhang Hui; Brecht Walter; Corn Jacob; Gong Jian-Sheng; Yanagisawa Katsuhiko; Michikawa Makoto; Weisgraber Karl; Huang Yadong; Wyss-Coray Tony
Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3.
Journal of neurochemistry 2009;110(4):1254-62.
2009: Mahley Robert W; Weisgraber Karl H; Huang Yadong
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.
Journal of lipid research 2009;50 Suppl():S183-8.
2009: Zhong Ning; Weisgraber Karl H
Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure.
The Journal of biological chemistry 2009;284(10):6027-31.
2009: Hatters Danny M; Voss John C; Budamagunta Madhu S; Newhouse Yvonne N; Weisgraber Karl H
Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy.
Journal of molecular biology 2009;386(1):261-71.
2008: Tamgüney Gültekin; Giles Kurt; Glidden David V; Lessard Pierre; Wille Holger; Tremblay Patrick; Groth Darlene F; Yehiely Fruma; Korth Carsten; Moore Richard C; Tatzelt Jörg; Rubinstein Eric; Boucheix Claude; Yang Xiaoping; Stanley Pamela; Lisanti Michael P; Dwek Raymond A; Rudd Pauline M; Moskovitz Jackob; Epstein Charles J; Cruz Tracey Dawson; Kuziel William A; Maeda Nobuyo; Sap Jan; Ashe Karen Hsiao; Carlson George A; Tesseur Ina; Wyss-Coray Tony; Mucke Lennart; Weisgraber Karl H; Mahley Robert W; Cohen Fred E; Prusiner Stanley B
Genes contributing to prion pathogenesis.
The Journal of general virology 2008;89(Pt 7):1777-88.
2008: Zhong Ning; Scearce-Levie Kimberly; Ramaswamy Gayathri; Weisgraber Karl H
Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(3):179-92.
2007: Mahley Robert W; Huang Yadong; Weisgraber Karl H
Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.
Current Alzheimer research 2007;4(5):537-40.
2007: Zhang Yonghong; Vasudevan Sheeja; Sojitrawala Radiya; Zhao Wentao; Cui Chunxian; Xu Chao; Fan Daping; Newhouse Yvonne; Balestra Reeny; Jerome W Gray; Weisgraber Karl; Li Qianqian; Wang Jianjun
A monomeric, biologically active, full-length human apolipoprotein E.
Biochemistry 2007;46(37):10722-32.
2007: Peters-Libeu Clare A; Newhouse Yvonne; Hall Steven C; Witkowska H Ewa; Weisgraber Karl H
Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution.
Journal of lipid research 2007;48(5):1035-44.
2007: Roses A D; Saunders A M; Huang Y; Strum J; Weisgraber K H; Mahley R W
Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).
The pharmacogenomics journal 2007;7(1):10-28.
2006: Hatters Danny M; Zhong Ning; Rutenber Earl; Weisgraber Karl H
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils.
Journal of molecular biology 2006;361(5):932-44.
2006: Hatters Danny M; Peters-Libeu Clare A; Weisgraber Karl H
Apolipoprotein E structure: insights into function.
Trends in biochemical sciences 2006;31(8):445-54.
2006: Safar Jiri G; Wille Holger; Geschwind Michael D; Deering Camille; Latawiec Diane; Serban Ana; King David J; Legname Giuseppe; Weisgraber Karl H; Mahley Robert W; Miller Bruce L; Dearmond Stephen J; Prusiner Stanley B
Human prions and plasma lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(30):11312-7.
2006: Braun Nicole A; Mohler Peter J; Weisgraber Karl H; Hasty Alyssa H; Linton MacRae F; Yancey Patricia G; Su Yan Ru; Fazio Sergio; Swift Larry L
Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells.
Journal of lipid research 2006;47(6):1176-86.
2006: Mahley Robert W; Huang Yadong; Weisgraber Karl H
Putting cholesterol in its place: apoE and reverse cholesterol transport.
The Journal of clinical investigation 2006;116(5):1226-9.
2006: Mahley Robert W; Weisgraber Karl H; Huang Yadong
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5644-51.
2006: Peters-Libeu Clare A; Newhouse Yvonne; Hatters Danny M; Weisgraber Karl H
Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine.
The Journal of biological chemistry 2006;281(2):1073-9.
2005: Peters-Libeu Clare; Newhouse Yvonne; Krishnan Preethi; Cheung Kenneth; Brooks Elizabeth; Weisgraber Karl; Finkbeiner Steven
Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 12):1065-8.
2005: Ye Shiming; Huang Yadong; Müllendorff Karin; Dong Liming; Giedt Gretchen; Meng Elaine C; Cohen Fred E; Kuntz Irwin D; Weisgraber Karl H; Mahley Robert W
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18700-5.
2005: Newhouse Yvonne; Peters-Libeu Clare; Weisgraber Karl H
Crystallization and preliminary X-ray diffraction analysis of apolipoprotein E-containing lipoprotein particles.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 11):981-4.
2005: Ramaswamy Gayathri; Xu Qin; Huang Yadong; Weisgraber Karl H
Effect of domain interaction on apolipoprotein E levels in mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10658-63.
2005: Hatters Danny M; Budamagunta Madhu S; Voss John C; Weisgraber Karl H
Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms.
The Journal of biological chemistry 2005;280(40):34288-95.
2005: Ruiz Jose; Kouiavskaia Diana; Migliorini Molly; Robinson Susan; Saenko Evgueni L; Gorlatova Natalia; Li Donghua; Lawrence Daniel; Hyman Bradley T; Weisgraber Karl H; Strickland Dudley K
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.
Journal of lipid research 2005;46(8):1721-31.
2005: Hatters Danny M; Peters-Libeu Clare A; Weisgraber Karl H
Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4.
The Journal of biological chemistry 2005;280(28):26477-82.
2005: Hasty Alyssa H; Plummer Michelle R; Weisgraber Karl H; Linton Macrae F; Fazio Sergio; Swift Larry L
The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I.
Journal of lipid research 2005;46(7):1433-9.
2005: Zhang Songwen; Picard Michael H; Vasile Eliza; Zhu Yu; Raffai Robert L; Weisgraber Karl H; Krieger Monty
Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice.
Circulation 2005;111(25):3457-64.
2005: Sauer Ines; Dunay Ildiko R; Weisgraber Karl; Bienert Michael; Dathe Margitta
An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells.
Biochemistry 2005;44(6):2021-9.
2005: Raffai Robert L; Loeb Samuel M; Weisgraber Karl H
Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(2):436-41.
2005: Zhao Yue; Thorngate Fayanne E; Weisgraber Karl H; Williams David L; Parks John S
Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins.
Biochemistry 2005;44(3):1013-25.
2005: Kasravi F Behzad; Lee Diana H; Weisgraber Karl; Harris Hobart W
Lipoprotein-bound endotoxin exerts an immunomodulatory effect on hepatocytes through the lipid A domain of LPS.
Journal of endotoxin research 2005;11(1):19-24.
2004: Farkas Monica H; Weisgraber Karl H; Shepherd Virginia L; Linton MacRae F; Fazio Sergio; Swift Larry L
The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways.
Journal of lipid research 2004;45(8):1546-54.
2004: Xu Qin; Brecht Walter J; Weisgraber Karl H; Mahley Robert W; Huang Yadong
Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer.
The Journal of biological chemistry 2004;279(24):25511-6.
2004: Huang Yadong; Weisgraber Karl H; Mucke Lennart; Mahley Robert W
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease.
Journal of molecular neuroscience : MN 2004;23(3):189-204.
2003: Kasravi F Behzad; Brecht Walter J; Weisgraber Karl H; Harris Hobart W
Induction of cytokine tolerance requires internalization of Chylomicron-Bound LPS into hepatocytes.
The Journal of surgical research 2003;115(2):303-9.
2003: Saito Hiroyuki; Dhanasekaran Padmaja; Baldwin Faye; Weisgraber Karl H; Phillips Michael C; Lund-Katz Sissel
Effects of polymorphism on the lipid interaction of human apolipoprotein E.
The Journal of biological chemistry 2003;278(42):40723-9.
2003: Harris Faith M; Brecht Walter J; Xu Qin; Tesseur Ina; Kekonius Lisa; Wyss-Coray Tony; Fish Jo Dee; Masliah Eliezer; Hopkins Paul C; Scearce-Levie Kimberly; Weisgraber Karl H; Mucke Lennart; Mahley Robert W; Huang Yadong
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10966-71.
2003: Raffaï Robert L; McPherson Ruth; Weisgraber Karl H; Innerarity Thomas L; Rassart Eric; Bersot Thomas P; Milne Ross W
Antibody phenotyping test for the human apolipoprotein E2 isoform.
Clinical chemistry 2003;49(9):1524-6.
2003: Raffai Robert L; Weisgraber Karl H
Cholesterol: from heart attacks to Alzheimer's disease.
Journal of lipid research 2003;44(8):1423-30.
2003: Saito Hiroyuki; Dhanasekaran Padmaja; Nguyen David; Baldwin Faye; Weisgraber Karl H; Wehrli Suzanne; Phillips Michael C; Lund-Katz Sissel
Characterization of the heparin binding sites in human apolipoprotein E.
The Journal of biological chemistry 2003;278(17):14782-7.
2003: Raffaï Robert L; Hasty Alyssa H; Wang Yuwei; Mettler Shelley E; Sanan David A; Linton MacRae F; Fazio Sergio; Weisgraber Karl H
Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance.
The Journal of biological chemistry 2003;278(13):11670-5.
2003: Kasravi F Behzad; Welch William J; Peters-Lideu Clare A; Weisgraber Karl H; Harris Hobart W
Induction of cytokine tolerance in rodent hepatocytes by chylomicron-bound LPS is low-density lipoprotein receptor dependent.
Shock (Augusta, Ga.) 2003;19(2):157-62.
2002: Morrow Julie A; Hatters Danny M; Lu Bin; Hochtl Peter; Oberg Keith A; Rupp Bernhard; Weisgraber Karl H
Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.
The Journal of biological chemistry 2002;277(52):50380-5.
2002: Segall Mark L; Dhanasekaran Padmaja; Baldwin Faye; Anantharamaiah G M; Weisgraber Karl H; Phillips Michael C; Lund-Katz Sissel
Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization.
Journal of lipid research 2002;43(10):1688-700.
2002: Zeleny Michelle; Swertfeger Debi K; Weisgraber Karl H; Hui David Y
Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation.
Biochemistry 2002;41(39):11820-3.
2002: Acharya Prathima; Segall Mark L; Zaiou Mohamed; Morrow Julie; Weisgraber Karl H; Phillips Michael C; Lund-Katz Sissel; Snow Julian
Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism.
Biochimica et biophysica acta 2002;1584(1):9-19.
2002: Ji Zhong-Sheng; Miranda R Dennis; Newhouse Yvonne M; Weisgraber Karl H; Huang Yadong; Mahley Robert W
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
The Journal of biological chemistry 2002;277(24):21821-8.
2002: Raffai Robert L; Weisgraber Karl H
Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism.
The Journal of biological chemistry 2002;277(13):11064-8.
2002: Jaworska-Wilczynska M; Wilczynski G M; Engel W K; Strickland D K; Weisgraber K H; Askanas V
Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle.
Neurology 2002;58(3):438-45.
2001: Saito H; Dhanasekaran P; Baldwin F; Weisgraber K H; Lund-Katz S; Phillips M C
Lipid binding-induced conformational change in human apolipoprotein E. Evidence for two lipid-bound states on spherical particles.
The Journal of biological chemistry 2001;276(44):40949-54.
2001: Libeu C P; Lund-Katz S; Phillips M C; Wehrli S; Hernáiz M J; Capila I; Linhardt R J; Raffaï R L; Newhouse Y M; Zhou F; Weisgraber K H
New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E.
The Journal of biological chemistry 2001;276(42):39138-44.
2001: Raffai R L; Dong L M; Farese R V; Weisgraber K H
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11587-91.
2001: Lund-Katz S; Wehrli S; Zaiou M; Newhouse Y; Weisgraber K H; Phillips M C
Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE.
Journal of lipid research 2001;42(6):894-901.
2001: Dong J; Peters-Libeu C A; Weisgraber K H; Segelke B W; Rupp B; Capila I; Hernáiz M J; LeBrun L A; Linhardt R J
Interaction of the N-terminal domain of apolipoprotein E4 with heparin.
Biochemistry 2001;40(9):2826-34.
2000: Dong J; Balestra M E; Newhouse Y M; Weisgraber K H
Human apolipoprotein E7:lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins.
Journal of lipid research 2000;41(11):1783-9.
2000: Lund-Katz S; Zaiou M; Wehrli S; Dhanasekaran P; Baldwin F; Weisgraber K H; Phillips M C
Effects of lipid interaction on the lysine microenvironments in apolipoprotein E.
The Journal of biological chemistry 2000;275(44):34459-64.
2000: Morrow J A; Segall M L; Lund-Katz S; Phillips M C; Knapp M; Rupp B; Weisgraber K H
Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain.
Biochemistry 2000;39(38):11657-66.
2000: Zaiou M; Arnold K S; Newhouse Y M; Innerarity T L; Weisgraber K H; Segall M L; Phillips M C; Lund-Katz S
Apolipoprotein E;-low density lipoprotein receptor interaction. Influences of basic residue and amphipathic alpha-helix organization in the ligand.
Journal of lipid research 2000;41(7):1087-95.
2000: Lu B; Morrow J A; Weisgraber K H
Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipid.
The Journal of biological chemistry 2000;275(27):20775-81.
2000: Klezovitch O; Formato M; Cherchi G M; Weisgraber K H; Scanu A M
Structural determinants in the C-terminal domain of apolipoprotein E mediating binding to the protein core of human aortic biglycan.
The Journal of biological chemistry 2000;275(25):18913-8.
2000: Segelke B W; Forstner M; Knapp M; Trakhanov S D; Parkin S; Newhouse Y M; Bellamy H D; Weisgraber K H; Rupp B
Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding.
Protein science : a publication of the Protein Society 2000;9(5):886-97.
2000: Raffaï R; Weisgraber K H; MacKenzie R; Rupp B; Rassart E; Hirama T; Innerarity T L; Milne R
Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling.
The Journal of biological chemistry 2000;275(10):7109-16.
2000: Morrow J A; Arnold K S; Dong J; Balestra M E; Innerarity T L; Weisgraber K H
Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor.
The Journal of biological chemistry 2000;275(4):2576-80.
1999: Forstner M; Peters-Libeu C; Contreras-Forrest E; Newhouse Y; Knapp M; Rupp B; Weisgraber K H
Carboxyl-terminal domain of human apolipoprotein E: expression, purification, and crystallization.
Protein expression and purification 1999;17(2):267-72.
1999: Rozek A; Sparrow J T; Weisgraber K H; Cushley R J
Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy.
Biochemistry 1999;38(44):14475-84.
1999: Morrow J A; Arnold K S; Weisgraber K H
Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli.
Protein expression and purification 1999;16(2):224-30.
1999: Raffaï R; Vukmirica J; Weisgraber K H; Rassart E; Innerarity T L; Milne R
Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E.
Protein expression and purification 1999;16(1):84-90.
1999: Orth M; Weng W; Funke H; Steinmetz A; Assmann G; Nauck M; Dierkes J; Ambrosch A; Weisgraber K H; Mahley R W; Wieland H; Luley C
Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1306-15.
1999: Trakhanov S; Parkin S; Raffaï R; Milne R; Newhouse Y M; Weisgraber K H; Rupp B
Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 A.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):122-8.
1999: Gillotte K L; Zaiou M; Lund-Katz S; Anantharamaiah G M; Holvoet P; Dhoest A; Palgunachari M N; Segrest J P; Weisgraber K H; Rothblat G H; Phillips M C
Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid.
The Journal of biological chemistry 1999;274(4):2021-8.
1998: Dong L M; Innerarity T L; Arnold K S; Newhouse Y M; Weisgraber K H
The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity.
Journal of lipid research 1998;39(6):1173-80.
1998: Pitas R E; Ji Z S; Weisgraber K H; Mahley R W
Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E.
Biochemical Society transactions 1998;26(2):257-62.
1998: Dichek H L; Brecht W; Fan J; Ji Z S; McCormick S P; Akeefe H; Conzo L; Sanan D A; Weisgraber K H; Young S G; Taylor J M; Mahley R W
Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake.
The Journal of biological chemistry 1998;273(4):1896-903.
1998: Rozek A; Sparrow J T; Weisgraber K H; Cushley R J
Sequence-specific 1H NMR resonance assignments and secondary structure of human apolipoprotein C-I in the presence of sodium dodecyl sulfate.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(2-3):267-75.
1997: Grunfeld C; Doerrler W; Pang M; Jensen P; Weisgraber K H; Feingold K R
Abnormalities of apolipoprotein E in the acquired immunodeficiency syndrome.
The Journal of clinical endocrinology and metabolism 1997;82(11):3734-40.
1997: Simmons T; Newhouse Y M; Arnold K S; Innerarity T L; Weisgraber K H
Human low density lipoprotein receptor fragment. Successful refolding of a functionally active ligand-binding domain produced in Escherichia coli.
The Journal of biological chemistry 1997;272(41):25531-6.
1997: Meiner V; Tam C; Gunn M D; Dong L M; Weisgraber K H; Novak S; Myers H M; Erickson S K; Farese R V
Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice.
Journal of lipid research 1997;38(9):1928-33.
1997: Gutman C R; Strittmatter W J; Weisgraber K H; Matthew W D
Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(16):6114-21.
1997: Hussain M M; Goldberg I J; Weisgraber K H; Mahley R W; Innerarity T L
Uptake of chylomicrons by the liver, but not by the bone marrow, is modulated by lipoprotein lipase activity.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1407-13.
1996: Mirabella M; Alvarez R B; Engel W K; Weisgraber K H; Askanas V
Apolipoprotein E and apolipoprotein E messenger RNA in muscle of inclusion body myositis and myopathies.
Annals of neurology 1996;40(6):864-72.
1996: Weisgraber K H; Mahley R W
Human apolipoprotein E: the Alzheimer's disease connection.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(13):1485-94.
1996: Askanas V; Engel W K; Mirabella M; Weisgraber K H; Saunders A M; Roses A D; McFerrin J
Apolipoprotein E alleles in sporadic inclusion-body myositis and hereditary inclusion-body myopathy.
Annals of neurology 1996;40(2):264-5.
1996: Dong L M; Parkin S; Trakhanov S D; Rupp B; Simmons T; Arnold K S; Newhouse Y M; Innerarity T L; Weisgraber K H
Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia.
Nature structural biology 1996;3(8):718-22.
1996: Dong L M; Weisgraber K H
Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins.
The Journal of biological chemistry 1996;271(32):19053-7.
1996: Fleming L M; Weisgraber K H; Strittmatter W J; Troncoso J C; Johnson G V
Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins.
Experimental neurology 1996;138(2):252-60.
1996: Montine T J; Huang D Y; Valentine W M; Amarnath V; Saunders A; Weisgraber K H; Graham D G; Strittmatter W J
Crosslinking of apolipoprotein E by products of lipid peroxidation.
Journal of neuropathology and experimental neurology 1996;55(2):202-10.
1996: Roses A D; Einstein G; Gilbert J; Goedert M; Han S H; Huang D; Hulette C; Masliah E; Pericak-Vance M A; Saunders A M; Schmechel D E; Strittmatter W J; Weisgraber K H; Xi P T
Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism.
Annals of the New York Academy of Sciences 1996;777():146-57.
1996: Strittmatter W J; Burke J R; DeSerrano V S; Huang D Y; Matthew W; Saunders A M; Scott B L; Vance J M; Weisgraber K H; Roses A D
Protein: protein interactions in Alzheimer's disease and the CAG triplet repeat diseases.
Cold Spring Harbor symposia on quantitative biology 1996;61():597-605.
1995: Huang D Y; Weisgraber K H; Strittmatter W J; Matthew W D
Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology.
Experimental neurology 1995;136(2):251-7.
1995: Raffai R; Maurice R; Weisgraber K; Innerarity T; Wang X; MacKenzie R; Hirama T; Watson D; Rassart E; Milne R
Molecular characterization of two monoclonal antibodies specific for the LDL receptor-binding site of human apolipoprotein E.
Journal of lipid research 1995;36(9):1905-18.
1995: De Pauw M; Vanloo B; Weisgraber K; Rosseneu M
Comparison of lipid-binding and lecithin:cholesterol acyltransferase activation of the amino- and carboxyl-terminal domains of human apolipoprotein E3.
Biochemistry 1995;34(34):10953-66.
1995: Saxena U; Auerbach B J; Ferguson E; Wölle J; Marcel Y L; Weisgraber K H; Hegele R A; Bisgaier C L
Apolipoprotein B and E basic amino acid clusters influence low-density lipoprotein association with lipoprotein lipase anchored to the subendothelial matrix.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(8):1240-7.
1995: Huang D Y; Weisgraber K H; Goedert M; Saunders A M; Roses A D; Strittmatter W J
ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
Neuroscience letters 1995;192(3):209-12.
1995: Evans K C; Berger E P; Cho C G; Weisgraber K H; Lansbury P T
Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(3):763-7.
1995: Minnich A; Weisgraber K H; Newhouse Y; Dong L M; Fortin L J; Tremblay M; Davignon J
Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins.
Journal of lipid research 1995;36(1):57-66.
1994: Strittmatter W J; Saunders A M; Goedert M; Weisgraber K H; Dong L M; Jakes R; Huang D Y; Pericak-Vance M; Schmechel D; Roses A D
Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11183-6.
1994: Huang D Y; Goedert M; Jakes R; Weisgraber K H; Garner C C; Saunders A M; Pericak-Vance M A; Schmechel D E; Roses A D; Strittmatter W J
Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.
Neuroscience letters 1994;182(1):55-8.
1994: Han S H; Einstein G; Weisgraber K H; Strittmatter W J; Saunders A M; Pericak-Vance M; Roses A D; Schmechel D E
Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study.
Journal of neuropathology and experimental neurology 1994;53(5):535-44.
1994: Dong L M; Wilson C; Wardell M R; Simmons T; Mahley R W; Weisgraber K H; Agard D A
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms.
The Journal of biological chemistry 1994;269(35):22358-65.
1994: Schwarzman A L; Gregori L; Vitek M P; Lyubski S; Strittmatter W J; Enghilde J J; Bhasin R; Silverman J; Weisgraber K H; Coyle P K
Transthyretin sequesters amyloid beta protein and prevents amyloid formation.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(18):8368-72.
1994: Sanan D A; Weisgraber K H; Russell S J; Mahley R W; Huang D; Saunders A; Schmechel D; Wisniewski T; Frangione B; Roses A D
Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.
The Journal of clinical investigation 1994;94(2):860-9.
1994: Wilson C; Mau T; Weisgraber K H; Wardell M R; Mahley R W; Agard D A
Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein.
Structure (London, England : 1993) 1994;2(8):713-8.
1994: Cudney R; Patel S; Weisgraber K; Newhouse Y; McPherson A
Screening and optimization strategies for macromolecular crystal growth.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):414-23.
1994: Nathan B P; Bellosta S; Sanan D A; Weisgraber K H; Mahley R W; Pitas R E
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro.
Science (New York, N.Y.) 1994;264(5160):850-2.
1994: Weisgraber K H; Roses A D; Strittmatter W J
The role of apolipoprotein E in the nervous system.
Current opinion in lipidology 1994;5(2):110-6.
1994: Fazio S; Horie Y; Simonet W S; Weisgraber K H; Taylor J M; Rall S C
Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant.
Journal of lipid research 1994;35(3):408-16.
1994: Strittmatter W J; Weisgraber K H; Goedert M; Saunders A M; Huang D; Corder E H; Dong L M; Jakes R; Alberts M J; Gilbert J R
Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype.
Experimental neurology 1994;125(2):163-71; discussion 172-4.
1994: Weisgraber K H; Newhouse Y M; McPherson A
Crystallization and preliminary X-ray analysis of human plasma apolipoprotein C-I.
Journal of molecular biology 1994;236(1):382-4.
1994: Askanas V; Mirabella M; Engel W K; Alvarez R B; Weisgraber K H
Apolipoprotein E immunoreactive deposits in inclusion-body muscle diseases.
Lancet 1994;343(8893):364-5.
1994: de Silva H V; Lauer S J; Wang J; Simonet W S; Weisgraber K H; Mahley R W; Taylor J M
Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.
The Journal of biological chemistry 1994;269(3):2324-35.
1994: Swaney J B; Weisgraber K H
Effect of apolipoprotein C-I peptides on the apolipoprotein E content and receptor-binding properties of beta-migrating very low density lipoproteins.
Journal of lipid research 1994;35(1):134-42.
1994: Weisgraber K H
Apolipoprotein E: structure-function relationships.
Advances in protein chemistry 1994;45():249-302.
1993: Lund-Katz S; Weisgraber K H; Mahley R W; Phillips M C
Conformation of apolipoprotein E in lipoproteins.
The Journal of biological chemistry 1993;268(31):23008-15.
1993: Strittmatter W J; Weisgraber K H; Huang D Y; Dong L M; Salvesen G S; Pericak-Vance M; Schmechel D; Saunders A M; Goldgaber D; Roses A D
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8098-102.
1993: Bersot T P; Russell S J; Thatcher S R; Pomernacki N K; Mahley R W; Weisgraber K H; Innerarity T L; Fox C S
A unique haplotype of the apolipoprotein B-100 allele associated with familial defective apolipoprotein B-100 in a Chinese man discovered during a study of the prevalence of this disorder.
Journal of lipid research 1993;34(7):1149-54.
1993: Westerlund J A; Weisgraber K H
Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization.
The Journal of biological chemistry 1993;268(21):15745-50.
1993: de Silva H V; Lauer S J; Mahley R W; Weisgraber K H; Taylor J M
Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice.
Biochemical Society transactions 1993;21(2):483-7.
1993: Fazio S; Horie Y; Weisgraber K H; Havekes L M; Rall S C
Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma.
Journal of lipid research 1993;34(3):447-53.
1993: Schmidt E B; Illingworth D R; Bacon S; Russell S J; Thatcher S R; Mahley R W; Weisgraber K H
Hypolipidemic effects of nicotinic acid in patients with familial defective apolipoprotein B-100.
Metabolism: clinical and experimental 1993;42(2):137-9.
1993: Schmidt E B; Illingworth D R; Bacon S; Mahley R W; Weisgraber K H
Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100.
Atherosclerosis 1993;98(2):213-7.
1992: Handelmann G E; Boyles J K; Weisgraber K H; Mahley R W; Pitas R E
Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.
Journal of lipid research 1992;33(11):1677-88.
1992: Thuren T; Weisgraber K H; Sisson P; Waite M
Role of apolipoprotein E in hepatic lipase catalyzed hydrolysis of phospholipid in high-density lipoproteins.
Biochemistry 1992;31(8):2332-8.
1992: Illingworth D R; Vakar F; Mahley R W; Weisgraber K H
Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100.
Lancet 1992;339(8793):598-600.
1992: Horie Y; Fazio S; Westerlund J R; Weisgraber K H; Rall S C
The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia.
The Journal of biological chemistry 1992;267(3):1962-8.
1991: Wilson C; Wardell M R; Weisgraber K H; Mahley R W; Agard D A
Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.
Science (New York, N.Y.) 1991;252(5014):1817-22.
1991: Weisgraber K H; Shinto L H
Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity.
The Journal of biological chemistry 1991;266(18):12029-34.
1991: Wardell M R; Rall S C; Schaefer E J; Kane J P; Weisgraber K H
Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity.
Journal of lipid research 1991;32(3):521-8.
1991: Mahley R W; Weisgraber K H; Innerarity T L; Rall S C
Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism.
JAMA : the journal of the American Medical Association 1991;265(1):78-83.
1990: Weisgraber K H; Mahley R W; Kowal R C; Herz J; Goldstein J L; Brown M S
Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990;265(36):22453-9.
1990: Weisgraber K H
Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.
Journal of lipid research 1990;31(8):1503-11.
1990: Innerarity T L; Mahley R W; Weisgraber K H; Bersot T P; Krauss R M; Vega G L; Grundy S M; Friedl W; Davignon J; McCarthy B J
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Journal of lipid research 1990;31(8):1337-49.
1990: Simonet W S; Bucay N; Lauer S J; Wirak D O; Stevens M E; Weisgraber K H; Pitas R E; Taylor J M
In the absence of a downstream element, the apolipoprotein E gene is expressed at high levels in kidneys of transgenic mice.
The Journal of biological chemistry 1990;265(19):10809-12.
1990: Crook D; Weisgraber K H; Boyles J K; Mahley R W
Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets.
Arteriosclerosis (Dallas, Tex.) 1990;10(4):633-47.
1990: Crook D; Weisgraber K H; Rall S C; Mahley R W
Isolation and characterization of several plasma apolipoproteins of common marmoset monkey.
Arteriosclerosis (Dallas, Tex.) 1990;10(4):625-32.
1990: Kowal R C; Herz J; Weisgraber K H; Mahley R W; Brown M S; Goldstein J L
Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.
The Journal of biological chemistry 1990;265(18):10771-9.
1990: Wardell M R; Rall S C; Brennan S O; Nye E R; George P M; Janus E D; Weisgraber K H
Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity.
Journal of lipid research 1990;31(3):535-43.
1990: Weisgraber K H; Innerarity T L; Rall S C; Mahley R W
Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E.
Annals of the New York Academy of Sciences 1990;598():37-48.
1990: Simonet W S; Bucay N; Lauer S J; Pitas R E; Weisgraber K H; Taylor J M
Downstream regulatory elements stimulate expression of the human apolipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice.
Transactions of the Association of American Physicians 1990;103():119-28.
1989: Gong E L; Nichols A V; Weisgraber K H; Forte T M; Shore V G; Blanche P J
Discoidal complexes containing apolipoprotein E and their transformation by lecithin-cholesterol acyltransferase.
Biochimica et biophysica acta 1989;1006(3):317-28.
1989: Wardell M R; Weisgraber K H; Havekes L M; Rall S C
Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127.
The Journal of biological chemistry 1989;264(35):21205-10.
1989: Mahley R W; Weisgraber K H; Hussain M M; Greenman B; Fisher M; Vogel T; Gorecki M
Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.
The Journal of clinical investigation 1989;83(6):2125-30.
1989: Rall S C; Newhouse Y M; Clarke H R; Weisgraber K H; McCarthy B J; Mahley R W; Bersot T P
Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant.
The Journal of clinical investigation 1989;83(4):1095-101.
1989: Boyles J K; Zoellner C D; Anderson L J; Kosik L M; Pitas R E; Weisgraber K H; Hui D Y; Mahley R W; Gebicke-Haerter P J; Ignatius M J
A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve.
The Journal of clinical investigation 1989;83(3):1015-31.
1989: Weisgraber K H; Newhouse Y M; Taylor J M; Tuan B; Nestruck A C; Davignon J; Mahley R W
Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes.
Arteriosclerosis (Dallas, Tex.) 1989;9(1):50-7.
1988: Weisgraber K H; Newhouse Y M; Mahley R W
Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes.
Biochemical and biophysical research communications 1988;157(3):1212-7.
1988: Weisgraber K H; Innerarity T L; Newhouse Y M; Young S G; Arnold K S; Krauss R M; Vega G L; Grundy S M; Mahley R W
Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9758-62.
1988: Majack R A; Castle C K; Goodman L V; Weisgraber K H; Mahley R W; Shooter E M; Gebicke-Haerter P J
Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state.
The Journal of cell biology 1988;107(3):1207-13.
1988: Aggerbeck L P; Wetterau J R; Weisgraber K H; Mahley R W; Agard D A
Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins.
Journal of molecular biology 1988;202(1):179-81.
1988: Aggerbeck L P; Wetterau J R; Weisgraber K H; Wu C S; Lindgren F T
Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.
The Journal of biological chemistry 1988;263(13):6249-58.
1988: Wetterau J R; Aggerbeck L P; Rall S C; Weisgraber K H
Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.
The Journal of biological chemistry 1988;263(13):6240-8.
1988: Lalazar A; Weisgraber K H; Rall S C; Giladi H; Innerarity T L; Levanon A Z; Boyles J K; Amit B; Gorecki M; Mahley R W
Site-specific mutagenesis of human apolipoprotein E. Receptor binding activity of variants with single amino acid substitutions.
The Journal of biological chemistry 1988;263(8):3542-5.
1987: Innerarity T L; Young S G; Poksay K S; Mahley R W; Smith R S; Milne R W; Marcel Y L; Weisgraber K H
Structural relationship of human apolipoprotein B48 to apolipoprotein B100.
The Journal of clinical investigation 1987;80(6):1794-8.
1987: Innerarity T L; Weisgraber K H; Arnold K S; Mahley R W; Krauss R M; Vega G L; Grundy S M
Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(19):6919-23.
1987: Pitas R E; Boyles J K; Lee S H; Hui D; Weisgraber K H
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.
The Journal of biological chemistry 1987;262(29):14352-60.
1987: Weisgraber K H; Rall S C
Human apolipoprotein B-100 heparin-binding sites.
The Journal of biological chemistry 1987;262(23):11097-103.
1987: Gebicke-Haerter P J; Darby J K; Shooter E M; Riccardi V M; Weisgraber K H; Boyles J K; Mahley R W
Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis.
Experimental neurology 1987;95(2):323-35.
1987: Innerarity T L; Weisgraber K H; Rall S C; Mahley R W
Functional domains of apolipoprotein E and apolipoprotein B.
Acta medica Scandinavica. Supplementum 1987;715():51-9.
1986: Reardon C A; Lau Y F; Paik Y K; Weisgraber K H; Mahley R W; Taylor J M
Expression of the human apolipoprotein E gene in cultured mammalian cells.
The Journal of biological chemistry 1986;261(21):9858-64.
1986: Rall S C; Weisgraber K H; Mahley R W; Ehnholm C; Schamaun O; Olaisen B; Blomhoff J P; Teisberg P
Identification of homozygosity for a human apolipoprotein A-I variant.
Journal of lipid research 1986;27(4):436-41.
1986: Bersot T P; Innerarity T L; Pitas R E; Rall S C; Weisgraber K H; Mahley R W
Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages.
The Journal of clinical investigation 1986;77(2):622-30.
1986: Ignatius M J; Gebicke-Härter P J; Skene J H; Schilling J W; Weisgraber K H; Mahley R W; Shooter E M
Expression of apolipoprotein E during nerve degeneration and regeneration.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):1125-9.
1986: Weisgraber K H; Rall S C; Mahley R W; Milne R W; Marcel Y L; Sparrow J T
Human apolipoprotein E. Determination of the heparin binding sites of apolipoprotein E3.
The Journal of biological chemistry 1986;261(5):2068-76.
1986: Innerarity T L; Arnold K S; Weisgraber K H; Mahley R W
Apolipoprotein E is the determinant that mediates the receptor uptake of beta-very low density lipoproteins by mouse macrophages.
Arteriosclerosis (Dallas, Tex.) 1986;6(1):114-22.
1986: Weisgraber K H; Mahley R W
Characterization of apolipoprotein E-containing lipoproteins.
Methods in enzymology 1986;129():145-66.
1986: Rall S C; Weisgraber K H; Mahley R W
Isolation and characterization of apolipoprotein E.
Methods in enzymology 1986;128():273-87.
1986: Mahley R W; Innerarity T L; Weisgraber K H; Rall S C; Hui D Y; Lalazar A; Boyles J K; Taylor J M; Levy-Wilson B
Cellular and molecular biology of lipoprotein metabolism: characterization of lipoprotein receptor-ligand interactions.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 2():821-8.
1985: Weisgraber K H; Newhouse Y M; Seymour J L; Rall S C; Mahley R W
Preparative immobiline isoelectric focusing of plasma apolipoproteins on vertical slab gels.
Analytical biochemistry 1985;151(2):455-61.
1985: Vogel T; Weisgraber K H; Zeevi M I; Ben-Artzi H; Levanon A Z; Rall S C; Innerarity T L; Hui D Y; Taylor J M; Kanner D
Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(24):8696-700.
1985: Weisgraber K H; Innerarity T L; Rall S C; Mahley R W
Receptor interactions controlling lipoprotein metabolism.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1985;63(8):898-905.
1985: Mahley R W; Innerarity T L; Rall S C; Weisgraber K H
Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia.
Annals of the New York Academy of Sciences 1985;454():209-21.
1985: Weisgraber K H; Innerarity T L; Rall S C; Mahley R W
Apolipoprotein E: receptor binding properties.
Advances in experimental medicine and biology 1985;183():159-71.
1984: Mahley R W; Innerarity T L; Rall S C; Weisgraber K H
Plasma lipoproteins: apolipoprotein structure and function.
Journal of lipid research 1984;25(12):1277-94.
1984: Utermann G; Haas J; Steinmetz A; Paetzold R; Rall S C; Weisgraber K H; Mahley R W
Apolipoprotein A-IGiessen (Pro143----Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase.
European journal of biochemistry / FEBS 1984;144(2):325-31.
1984: Ehnholm C; Mahley R W; Chappell D A; Weisgraber K H; Ludwig E; Witztum J L
Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(17):5566-70.
1984: Funke H; Boyles J; Weisgraber K H; Ludwig E H; Hui D Y; Mahley R W
Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells.
Arteriosclerosis (Dallas, Tex.) 1984;4(5):452-61.
1984: Rall S C; Weisgraber K H; Mahley R W; Ogawa Y; Fielding C J; Utermann G; Haas J; Steinmetz A; Menzel H J; Assmann G
Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted.
The Journal of biological chemistry 1984;259(16):10063-70.
1984: Innerarity T L; Weisgraber K H; Arnold K S; Rall S C; Mahley R W
Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation.
The Journal of biological chemistry 1984;259(11):7261-7.
1984: Utermann G; Weisgraber K H; Weber W; Mahley R W
Genetic polymorphism of apolipoprotein E: a variant form of apolipoprotein E2 distinguished by sodium dodecyl sulfate--polyacrylamide gel electrophoresis.
Journal of lipid research 1984;25(4):378-82.
1984: Weisgraber K H; Rall S C; Innerarity T L; Mahley R W; Kuusi T; Ehnholm C
A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1.
The Journal of clinical investigation 1984;73(4):1024-33.
1984: Menzel H J; Assmann G; Rall S C; Weisgraber K H; Mahley R W
Human apolipoprotein A-I polymorphism. Identification of amino acid substitutions in three electrophoretic variants of the Münster-3 type.
The Journal of biological chemistry 1984;259(5):3070-6.
1984: Innerarity T L; Bersot T P; Arnold K S; Weisgraber K H; Davis P A; Forte T M; Mahley R W
Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma.
Metabolism: clinical and experimental 1984;33(2):186-95.
1984: Steinmetz A; Utermann G; Haas J; Menzel H J; Rall S C; Weisgraber K H; Mahley R W
Mutations of apolipoprotein AI can affect cofactor function for cholesteryl ester formation by lecithin: cholesterol acyltransferase.
Agents and actions. Supplements 1984;16():217-24.
1983: Rall S C; Weisgraber K H; Innerarity T L; Bersot T P; Mahley R W; Blum C B
Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype.
The Journal of clinical investigation 1983;72(4):1288-97.
1983: Weisgraber K H; Innerarity T L; Harder K J; Mahley R W; Milne R W; Marcel Y L; Sparrow J T
The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding.
The Journal of biological chemistry 1983;258(20):12348-54.
1983: Innerarity T L; Friedlander E J; Rall S C; Weisgraber K H; Mahley R W
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
The Journal of biological chemistry 1983;258(20):12341-7.
1983: Rall S C; Weisgraber K H; Innerarity T L; Mahley R W
Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia.
The Journal of clinical investigation 1983;71(4):1023-31.
1983: Weisgraber K H; Rall S C; Bersot T P; Mahley R W; Franceschini G; Sirtori C R
Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I.
The Journal of biological chemistry 1983;258(4):2508-13.
1982: Zannis V I; Breslow J L; Utermann G; Mahley R W; Weisgraber K H; Havel R J; Goldstein J L; Brown M S; Schonfeld G; Hazzard W R; Blum C
Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes.
Journal of lipid research 1982;23(6):911-4.
1982: Rall S C; Weisgraber K H; Innerarity T L; Mahley R W
Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(15):4696-700.
1982: Rall S C; Weisgraber K H; Mahley R W
Human apolipoprotein E. The complete amino acid sequence.
The Journal of biological chemistry 1982;257(8):4171-8.
1982: Weisgraber K H; Innerarity T L; Mahley R W
Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site.
The Journal of biological chemistry 1982;257(5):2518-21.
1981: Mahley R W; Hui D Y; Innerarity T L; Weisgraber K H
Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors.
The Journal of clinical investigation 1981;68(5):1197-206.
1981: Weisgraber K H; Rall S C; Mahley R W
Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.
The Journal of biological chemistry 1981;256(17):9077-83.
1980: Franceschini G; Sirtori C R; Capurso A; Weisgraber K H; Mahley R W
A-IMilano apoprotein. Decreased high density lipoprotein cholesterol levels with significant lipoprotein modifications and without clinical atherosclerosis in an Italian family.
The Journal of clinical investigation 1980;66(5):892-900.
1980: Weisgraber K H; Bersot T P; Mahley R W; Franceschini G; Sirtori C R
A-Imilano apoprotein. Isolation and characterization of a cysteine-containing variant of the A-I apoprotein from human high density lipoproteins.
The Journal of clinical investigation 1980;66(5):901-7.
1980: Weisgraber K H; Troxler R F; Rall S C; Mahley R W
Comparison of the human, canine and swine E apoproteins.
Biochemical and biophysical research communications 1980;95(1):374-80.
1980: Weisgraber K H; Mahley R W
Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography.
Journal of lipid research 1980;21(3):316-25.
1980: Mahley R W; Weisgraber K H; Melchior G W; Innerarity T L; Holcombe K S
Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(1):225-9.
1980: Mahley R W; Innerarity T L; Weisgraber K H
Alterations in metabolic activity of plasma lipoproteins following selective chemical modification of the apoproteins.
Annals of the New York Academy of Sciences 1980;348():265-80.
1979: Mahley R W; Weisgraber K H; Innerarity T L
Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors.
Biochimica et biophysica acta 1979;575(1):81-91.
1979: Mahley R W; Innerarity T L; Weisgraber K B; Oh S Y
Altered metabolism (in vivo and in vitro) of plasma lipoproteins after selective chemical modification of lysine residues of the apoproteins.
The Journal of clinical investigation 1979;64(3):743-50.
1979: Mahley R W; Weisgraber K H; Innerarity T L; Windmueller H G
Accelerated clearance of low-density and high-density lipoproteins and retarded clearance of E apoprotein-containing lipoproteins from the plasma of rats after modification of lysine residues.
Proceedings of the National Academy of Sciences of the United States of America 1979;76(4):1746-50.
1978: Weisgraber K H; Innerarity T L; Mahley R W
Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.
The Journal of biological chemistry 1978;253(24):9053-62.
1978: Weisgraber K H; Bersot T P; Mahley R W
Isolation and characterization of an apoprotein from the d less than 1.006 lipoproteins of human and canine lymph homologous with the rat A-IV apoprotein.
Biochemical and biophysical research communications 1978;85(1):287-92.
1978: Innerarity T L; Mahley R W; Weisgraber K H; Bersot T P
Apoprotein (E--A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E--A-II) complex.
The Journal of biological chemistry 1978;253(17):6289-95.
1978: Weisgraber K H; Mahley R W
Apoprotein (E--A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction.
The Journal of biological chemistry 1978;253(17):6281-8.
1977: Weisgraber K H; Mahley R W; Assmann G
The rat arginine-rich apoprotein and its redistribution following injection of iodinated lipoproteins into normal and hypercholesterolemic rats.
Atherosclerosis 1977;28(2):121-40.
1977: Mahley R W; Innerarity T L; Pitas R E; Weisgraber K H; Brown J H; Gross E
Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.
The Journal of biological chemistry 1977;252(20):7279-87.
1977: Fry D L; Mahley R W; Weisgraber K H; Oh S Y
Simultaneous accumulation of Evans blue dye and albumin in the canine aortic wall.
The American journal of physiology 1977;233(1):H66-79.
1977: Mahley R W; Innerarity T L; Weisgraber K H; Fry D L
Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro.
The American journal of pathology 1977;87(1):205-26.
1976: Mahley R W; Weisgraber K H; Innerarity T
Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey.
Biochemistry 1976;15(14):2979-85.
1976: Mahley R W; Weisgraber K H; Innerarity T; Brewer H B
Characterization of the plasma lipoproteins and apoproteins of the Erythrocebus patas monkey.
Biochemistry 1976;15(9):1928-33.
1975: Mahley R W; Weisgraber K H; Innerarity T; Brewer H B; Assmann G
Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding.
Biochemistry 1975;14(13):2817-23.
1974: Mahley R W; Weisgraber K H; Innerarity T
Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia.
Circulation research 1974;35(5):722-33.
1974: Mahley R W; Weisgraber K H
Canine lipoproteins and atherosclerosis. I. Isolation and characterization of plasma lipoproteins from control dogs.
Circulation research 1974;35(5):713-21.
1974: Mahley R W; Weisgraber K H
An electrophoretic method for the quantitative isolation of human and swine plasma lipoproteins.
Biochemistry 1974;13(9):1964-9.
1972: Weisgraber K H; Weiss U
Pigments of Elsinoe species. VI. A simple synthesis of a related perylenequinone.
Journal of the Chemical Society. Perkin transactions 1 1972;1():83-8.
1971: Andrewes A G; Kjosen H; Liaaen-Jensen S; Weisgraber K H; Lousberg R J; Weiss U
Animal carotenoids. 7. Carotenes of two colour variants of the aphid Macrosiphum liriodendri--identification of natural gamma, gamma-carotene.
Acta chemica Scandinavica 1971;25(10):3878-80.

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