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Mitchell Weiss

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Chemicals & Drugs

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beta-Thalassemia

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Alexander Zaslavsky; Keri Schadler; Mitchell J Weiss; William C Aird; Kwan-Hyuck Baek; Stella T Chou; Yeo Jung Kim; Allyson Lieberman; Maxim Pimkin; Sandra W Ryeom
The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.
Christopher S Thom; Claire F Dickson; David A Gell; Mitchell J Weiss
Hemoglobin variants: biochemical properties and clinical correlates.
Stella T Chou; Deborah L French; Paul Gadue; Ross C Hardison; Jason Adam Mills; Richard L Nemiroff; Joanna B Opalinska; Nancy A Speck; Joanna M Tober; Daniel Vandorn; Marta Byrska-Bishop; John Kim Choi; Yu Yao; Mitchell J Weiss
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.

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2013: Alexander Zaslavsky; Keri Schadler; Mitchell J Weiss; William C Aird; Kwan-Hyuck Baek; Stella T Chou; Yeo Jung Kim; Allyson Lieberman; Maxim Pimkin; Sandra W Ryeom
The calcineurin-NFAT pathway negatively regulates megakaryopoiesis.
Blood 2013;121(16):3205-15.
2013: Christopher S Thom; Claire F Dickson; David A Gell; Mitchell J Weiss
Hemoglobin variants: biochemical properties and clinical correlates.
Cold Spring Harbor perspectives in medicine 2013;3(3):a011858.
2012: Stella T Chou; Deborah L French; Paul Gadue; Ross C Hardison; Jason Adam Mills; Richard L Nemiroff; Joanna B Opalinska; Nancy A Speck; Joanna M Tober; Daniel Vandorn; Marta Byrska-Bishop; John Kim Choi; Yu Yao; Mitchell J Weiss
Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17573-8.
2012: Eugene Khandros; Christopher S Thom; Janine D'Souza; Mitchell J Weiss
Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia.
Blood 2012;119(22):5265-75.
2011: Weisheng Wu; Yu Zhang; Gerd A Blobel; Kuan-Bei Chen; Yong Cheng; Francesca Chiaromonte; Gregory E Crawford; Christine M Dorman; Daniela Drautz; Jason Ernst; Terrence S Furey; Belinda Giardine; Cheryl A Keller; Manolis Kellis; Swathi Ashok Kumar; Webb Miller; Tejaswini Mishra; Christapher Morrissey; Max Pimkin; Stephan C Schuster; Yoichiro Shibata; Lingyun Song; James TAYLOR; Mitchell J Weiss; Ross C Hardison
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.
Genome research 2011;21(10):1659-71.
2010: Joanna B Opalinska; Alexey Bersenev; Zhe Zhang; Alec A Schmaier; John Choi; Yu Yao; Janine D'Souza; Wei Tong; Mitchell J Weiss
MicroRNA expression in maturing murine megakaryocytes.
Blood 2010;116(23):e128-38.
2010: Eugene Khandros; Mitchell J Weiss
Protein quality control during erythropoiesis and hemoglobin synthesis.
Hematology/oncology clinics of North America 2010;24(6):1071-88.
2010: Kaavya Krishna Kumar; Claire F Dickson; Mitchell J Weiss; Joel Mackay; David A Gell
AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state.
The Biochemical journal 2010;432(2):275-82.
2010: Duonan Yu; Camila O dos Santos; Guowei Zhao; Jing Jiang; Julio D Amigo; Eugene Khandros; Lou Dore; Yu Yao; Janine D'Souza; Zhe Zhang; Saghi Ghaffari; John Choi; Sherree Friend; Wei Tong; Jordan S Orange; Barry H Paw; Mitchell J Weiss
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta.
Genes & development 2010;24(15):1620-33.
2010: Guowei Zhao; Duonan Yu; Mitchell J Weiss
MicroRNAs in erythropoiesis.
Current opinion in hematology 2010;17(3):155-62.
2009: Yong Cheng; Weisheng Wu; Swathi Ashok Kumar; Duonan Yu; Wulan Deng; Tamara Tripic; David C King; Kuan-Bei Chen; Ying Zhang; Daniela Drautz; Belinda Giardine; Stephan C Schuster; Webb Miller; Francesca Chiaromonte; Yu Zhang; Gerd A Blobel; Mitchell J Weiss; Ross C Hardison
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression.
Genome research 2009;19(12):2172-84.
2009: David A Gell; Liang Feng; Suiping Zhou; Philip Jeffrey; Katerina Bendak; Andrew J Gow; Mitchell J Weiss; Yigong Shi; Joel Mackay
A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin.
The Journal of biological chemistry 2009;284(43):29462-9.
2009: Paul Gadue; Mitchell J Weiss
Stem cells unscramble yolk sac hematopoiesis.
Blood 2009;114(8):1455-6.
2009: Stella T Chou; Eugene Khandros; L Charles Bailey; Kim E Nichols; Christopher R Vakoc; Yu Yao; Zan Huang; John D Crispino; Ross C Hardison; Gerd A Blobel; Mitchell J Weiss
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.
Blood 2009;114(5):983-94.
2009: Mitchell J Weiss; Camila O dos Santos
Chaperoning erythropoiesis.
Blood 2009;113(10):2136-44.
2008: Yong Cheng; David C King; Lou Dore; Xinmin Zhang; Yuepin Zhou; Ying Zhang; Christine Dorman; Demesew Abebe; Swathi A Kumar; Francesca Chiaromonte; Webb Miller; Roland D Green; Mitchell J Weiss; Ross C Hardison
Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif.
Genome research 2008;18(12):1896-905.
2008: Stella T Chou; Joanna B Opalinska; Yu Yao; Myriam A Fernandes; Anna Kalota; John S J Brooks; John K Choi; Alan M Gewirtz; Gwenn-ael Danet-Desnoyers; Richard L Nemiroff; Mitchell J Weiss
Trisomy 21 enhances human fetal erythro-megakaryocytic development.
Blood 2008;112(12):4503-6.
2008: Camila O dos Santos; Lou Dore; Eric Valentine; Suresh G Shelat; Ross C Hardison; Manik Ghosh; Wei Wang; Richard S Eisenstein; Fernando F Costa; Mitchell J Weiss
An iron responsive element-like stem-loop regulates alpha-hemoglobin-stabilizing protein mRNA.
The Journal of biological chemistry 2008;283(40):26956-64.
2008: Lou Dore; Julio D Amigo; Camila O Dos Santos; Zhe Zhang; Xiaowu Gai; John W Tobias; Duonan Yu; Alyssa M Klein; Christine Dorman; Weisheng Wu; Ross C Hardison; Barry H Paw; Mitchell J Weiss
A GATA-1-regulated microRNA locus essential for erythropoiesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3333-8.
2008: Camila O dos Santos; Suiping Zhou; Rodrigo Secolin; Xiaomei Wang; Anderson F Cunha; Douglas R Higgs; Janet Kwiatkowski; Swee Lay Thein; Patrick G Gallagher; Fernando F Costa; Mitchell J Weiss
Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.
American journal of hematology 2008;83(2):103-8.
2007: Zan Huang; Terri D Richmond; Andrew G Muntean; Dwayne Barber; Mitchell J Weiss; John D Crispino
STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice.
The Journal of clinical investigation 2007;117(12):3890-9.
2007: Stella T Chou; Mitchell J Weiss
Diseased red blood cells topple iron balance.
Nature medicine 2007;13(9):1020-1.
2007: Xiang Yu; Yi Kong; Lou Dore; Osheiza Abdulmalik; Anne M Katein; Suiping Zhou; John K Choi; David A Gell; Joel Mackay; Andrew J Gow; Mitchell J Weiss
An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.
The Journal of clinical investigation 2007;117(7):1856-65.
2007: Kazuhiko Adachi; Yi Zhao; Vinaysagar Lakka; Mitchell J Weiss; Saul Surrey
Assembly of recently translated full-length and C-terminal truncated human gamma-globin chains with a pool of alpha-globin chains to form Hb F in a cell-free system.
Archives of biochemistry and biophysics 2007;463(1):60-7.
2006: Hao Wang; Ying Zhang; Yong Cheng; Yuepin Zhou; David C King; James TAYLOR; Francesca Chiaromonte; Jyotsna Kasturi; Hanna Petrykowska; Brian Gibb; Christine Dorman; Webb Miller; Lou Dore; john welch; Mitchell J Weiss; Ross C Hardison
Experimental validation of predicted mammalian erythroid cis-regulatory modules.
Genome research 2006;16(12):1480-92.
2006: Suiping Zhou; John S Olson; Marian Fabian; Mitchell J Weiss; Andrew J Gow
Biochemical fates of alpha hemoglobin bound to alpha hemoglobin-stabilizing protein AHSP.
The Journal of biological chemistry 2006;281(43):32611-8.
2006: David A Gell; Belinda J Westman; Daniel Gorman; Chukong Liew; john welch; Mitchell J Weiss; Joel Mackay
A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP.
Journal of molecular biology 2006;362(2):287-97.
2006: Abby L Olsen; David L Stachura; Mitchell J Weiss
Designer blood: creating hematopoietic lineages from embryonic stem cells.
Blood 2006;107(4):1265-75.
2006: David L Stachura; Stella T Chou; Mitchell J Weiss
Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.
Blood 2006;107(1):87-97.
2005: Liyan Pang; Mitchell J Weiss; Mortimer Poncz
Megakaryocyte biology and related disorders.
The Journal of clinical investigation 2005;115(12):3332-8.
2005: Veerendra Munugalavadla; Lou Dore; Bai Lin Tan; Li Hong; Melanie Vishnu; Mitchell J Weiss; Reuben Kapur
Repression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturation.
Molecular and cellular biology 2005;25(15):6747-59.
2005: Liang Feng; Suiping Zhou; Lichuan Gu; David A Gell; Joel Mackay; Mitchell J Weiss; Andrew J Gow; Yigong Shi
Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem.
Nature 2005;435(7042):697-701.
2005: Christopher R Vakoc; Danielle L Letting; Nele Gheldof; Tomoyuki Sawado; MA Bender; Mark Groudine; Mitchell J Weiss; Job Dekker; Gerd A Blobel
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.
Molecular cell 2005;17(3):453-62.
2005: Mitchell J Weiss; Suiping Zhou; Liang Feng; David A Gell; Joel Mackay; Yigong Shi; Andrew J Gow
Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.
Annals of the New York Academy of Sciences 2005;1054():103-17.
2004: Liang Feng; David A Gell; Suiping Zhou; Lichuan Gu; Yi Kong; Jianqing Li; Min Hu; Nieng Yan; Christopher Lee; Anne M Rich; Robert S Armstrong; Peter A Lay; Andrew J Gow; Mitchell J Weiss; Joel Mackay; Yigong Shi
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin.
Cell 2004;119(5):629-40.
2004: john welch; Jason A Watts; Christopher R Vakoc; Yu Yao; Hao Wang; Ross C Hardison; Gerd A Blobel; Lewis A Chodosh; Mitchell J Weiss
Global regulation of erythroid gene expression by transcription factor GATA-1.
Blood 2004;104(10):3136-47.
2004: Yi Kong; Suiping Zhou; Anthony J Kihm; Anne M Katein; Xiang Yu; David A Gell; Joel Mackay; Kazuhiko Adachi; Linda Foster-Brown; Calvert Louden; Andrew J Gow; Mitchell J Weiss
Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia.
The Journal of clinical investigation 2004;114(10):1457-66.
2004: Qingde Wang; Mana Miyakoda; Weidong Yang; Jaspal Singh Khillan; David L Stachura; Mitchell J Weiss; Kazuko Nishikura
Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.
The Journal of biological chemistry 2004;279(6):4952-61.
2003: Jeffrey A Grass; Meghan E Boyer; Saumen Pal; Jing Wu; Mitchell J Weiss; Emery H Bresnick
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8811-6.
2003: Marcin Rylski; john welch; Ying-Yu Chen; Danielle L Letting; J Alan Diehl; Lewis A Chodosh; Gerd A Blobel; Mitchell J Weiss
GATA-1-mediated proliferation arrest during erythroid maturation.
Molecular and cellular biology 2003;23(14):5031-42.
2003: Danielle L Letting; Carrie Rakowski; Mitchell J Weiss; Gerd A Blobel
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.
Molecular and cellular biology 2003;23(4):1334-40.
2003: Ross C Hardison; Francesca Chiaromonte; Diana Kolbe; H Wang; Hanna Petrykowska; Laura Elnitski; Shan Yang; Belinda Giardine; Yi Zhang; Cathy Riemer; Scott Schwartz; David Haussler; Krishna M Roskin; RJ Weber; Mark Diekhans; W James Kent; Mitchell J Weiss; john welch; Webb Miller
Global predictions and tests of erythroid regulatory regions.
Cold Spring Harbor symposia on quantitative biology 2003;68():335-44.
2003: Mitchell J Weiss
New insights into erythropoietin and epoetin alfa: mechanisms of action, target tissues, and clinical applications.
The oncologist 2003;8 Suppl 3():18-29.
2002: John M Maris; Mitchell J Weiss; Yael Mosse; George Hii; Chun Guo; Peter White; Michael D Hogarty; Tamar Mirensky; Garrett M Brodeur; Timothy R Rebbeck; Margrit Urbanek; Susanne Shusterman
Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13.
Cancer research 2002;62(22):6651-8.
2002: David A Gell; Yi Kong; Sally A Eaton; Mitchell J Weiss; Joel Mackay
Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein.
The Journal of biological chemistry 2002;277(43):40602-9.
2002: Kirby D Johnson; Jeffrey A Grass; Meghan E Boyer; Carol M Kiekhaefer; Gerd A Blobel; Mitchell J Weiss; Emery H Bresnick
Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11760-5.
2002: Anthony J Kihm; Yi Kong; Wei Hong; J Eric Russell; Susan Rouda; Kazuhiko Adachi; M Celeste Simon; Gerd A Blobel; Mitchell J Weiss
An abundant erythroid protein that stabilizes free alpha-haemoglobin.
Nature 2002;417(6890):758-63.
2000: Mitchell J Weiss; Chun Guo; Susanne Shusterman; George Hii; T L Mirensky; Peter White; Michael D Hogarty; Timothy R Rebbeck; D Teare; M Urbanek; Garrett M Brodeur; John M Maris
Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13.
Medical and pediatric oncology 2000;35(6):526-30.
2000: Michael D Hogarty; X Liu; Chun Guo; Patricia M Thompson; Mitchell J Weiss; Peter White; Erik P Sulman; Garrett M Brodeur; John M Maris
Identification of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas.
Medical and pediatric oncology 2000;35(6):512-5.
2000: orian shirihai; T Gregory; C Yu; Stuart H Orkin; Mitchell J Weiss
ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation.
The EMBO journal 2000;19(11):2492-502.
2000: John M Maris; Mitchell J Weiss; Chun Guo; Robert B Gerbing; Daniel O Stram; Peter White; Michael D Hogarty; Erik P Sulman; Patricia M Thompson; John N Lukens; Katherine K Matthay; Robert C Seeger; Garrett M Brodeur
Loss of heterozygosity at 1p36 independently predicts for disease progression but not decreased overall survival probability in neuroblastoma patients: a Children's Cancer Group study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(9):1888-99.
2000: Kim E Nichols; John D Crispino; Mortimer Poncz; J G White; Stuart H Orkin; John M Maris; Mitchell J Weiss
Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1.
Nature genetics 2000;24(3):266-70.
1999: Chun Guo; Peter White; Mitchell J Weiss; Michael D Hogarty; Patricia M Thompson; DO Stram; Robert B Gerbing; KK Matthay; Robert C Seeger; Garrett M Brodeur; John M Maris
Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas.
Oncogene 1999;18(35):4948-57.
1999: T Gregory; C Yu; A Ma; Stuart H Orkin; G A Blobel; Mitchell J Weiss
GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression.
Blood 1999;94(1):87-96.
1999: H L Hung; J Lau; Alex Kim; Mitchell J Weiss; Gerd A Blobel
CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites.
Molecular and cellular biology 1999;19(5):3496-505.