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William Weiss

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TOP 3
Miller Huang; William A Weiss
G34, Another Connection between MYCN and a Pediatric Tumor.
Ksenya Shchors; Lamorna Brown Swigart; Tarik Tihan; William A Weiss; Douglas Hanahan; Nan Li; Natalya Lyubynska; Anders I Persson; Fanya Rostker; Mitchel S Berger; Gerard I Evan
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Alexandre Puissant; Jun Qi; William A Weiss; Rhamy Zeid; Gabriela Alexe; Christopher F Bassil; Cyril H Benes; James E Bradner; Yvan H Chanthery; Stacey M Frumm; Matthew J Garnett; Patricia Greninger; William Clay Gustafson; Andrew L Kung; Ultan McDermott; Erin A Nekritz; Kimberly Stegmaier
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.

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All Publications

2013: Miller Huang; William A Weiss
G34, Another Connection between MYCN and a Pediatric Tumor.
Cancer discovery 2013;3(5):484-6.
2013: Ksenya Shchors; Lamorna Brown Swigart; Tarik Tihan; William A Weiss; Douglas Hanahan; Nan Li; Natalya Lyubynska; Anders I Persson; Fanya Rostker; Mitchel S Berger; Gerard I Evan
Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):E1480-9.
2013: Alexandre Puissant; Jun Qi; William A Weiss; Rhamy Zeid; Gabriela Alexe; Christopher F Bassil; Cyril H Benes; James E Bradner; Yvan H Chanthery; Stacey M Frumm; Matthew J Garnett; Patricia Greninger; William Clay Gustafson; Andrew L Kung; Ultan McDermott; Erin A Nekritz; Kimberly Stegmaier
Targeting MYCN in neuroblastoma by BET bromodomain inhibition.
Cancer discovery 2013;3(3):308-23.
2012: Youngho Seo; Henry VanBrocklin; William A Weiss; Stephanie T Murphy; Erin A Nekritz; Shorouk F Dannoon; W Clay Gustafson; Daphne A Haas-Kogan; Miguel Hernandez-Pampaloni; Chang-Lae Lee; Katherine K Matthay
Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2012;14(6):735-42.
2012: Sabine Mueller; Arzu Onar-Thomas; Joanna Phillips; Michael D Prados; Eloy Romero; William A Weiss; John K Wiencke; Shichun Zheng; Mitchel S Berger; Cynthia Cowdrey; Nalin Gupta; Sean M McBride; Daphne A Haas-Kogan
PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome.
Neuro-oncology 2012;14(9):1146-52.
2012: Christine K Cheng; Elizabeth Charron; Andrei Goga; Nathanael S Gray; W Clay Gustafson; Benjamin T Houseman; C David James; Scott A Oakes; Brian Pollok; Kevan M Shokat; William A Weiss; Eli Zunder; Qi-Wen Fan
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12722-7.
2012: Emmanuelle Huillard; Rebecca A Ihrie; C David James; Martin McMahon; Theodore paul nicolaides; Arie Perry; Claudia Petritsch; Joanna J Phillips; Yasuyuki Aoki; Amélie Griveau; Rintaro Hashizume; Todd Waldman; William A Weiss; David H Rowitch
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8710-5.
2012: Fredrik J Swartling; Michael D Taylor; Justin Chen; Louis Chesler; Matthew R Grimmer; Christopher S Hackett; Jasmine Lau; Paul A Northcott; Arie Perry; Anders I Persson; Joanna J Phillips; Vasil Savov; William A Weiss
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.
Cancer cell 2012;21(5):601-13.
2012: Krister J Barkovich; Jimmy A Blair; Qi-Wen Fan; Adam L Garske; Sujatmi Hariono; Theodore paul nicolaides; Kevan M Shokat; Jie Zhang; William A Weiss
Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers.
Cancer discovery 2012;2(5):450-7.
2012: Jasmine Lau; Shirley L Markant; Christin Schmidt; Michael D Taylor; Robert J Wechsler-Reya; William A Weiss
Matching mice to malignancy: molecular subgroups and models of medulloblastoma.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2012;28(4):521-32.
2012: Qi-Wen Fan; William A Weiss
Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.
Methods in molecular biology (Clifton, N.J.) 2012;821():349-59.
2011: Louis Chesler; William A Weiss
Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma.
Seminars in cancer biology 2011;21(4):245-55.
2011: Sista Sugiarto; Scott R Vandenberg; Markus Waldhuber; William A Weiss; Joanna Phillips; Jason Siu; William Stallcup; Noemi Andor; Jennifer Ayers-Ringler; Mitchel S Berger; Gabriele Bergers; Patrizia Hanecker; Chrystelle Lamagna; Daniel A Lim; Elena Gonzalez Munoz; Anders I Persson; Claudia Petritsch
Asymmetry-defective oligodendrocyte progenitors are glioma precursors.
Cancer cell 2011;20(3):328-40.
2011: Sabine Mueller; Xiaodong Yang; Theo L Sottero; Ashley Gragg; Gautam Prasad; Mei-Yin Polley; William A Weiss; Katherine K Matthay; Andrew M Davidoff; Steven G DuBois; Daphne A Haas-Kogan
Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.
Cancer letters 2011;306(2):223-9.
2011: Qi-Wen Fan; William A Weiss
Autophagy and Akt promote survival in glioma.
Autophagy 2011;7(5):536-8.
2011: Swati S More; Melissa Itsara; Xiaodong Yang; Ethan G Geier; Michelle K Tadano; Youngho Seo; Henry VanBrocklin; William A Weiss; Sabine Mueller; Daphne A Haas-Kogan; Steven G Dubois; Katherine K Matthay; Kathleen M Giacomini
Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2339-49.
2011: Gautam Prasad; Theo Sottero; Xiaodong Yang; Sabine Mueller; C David James; William A Weiss; Mei-Yin Polley; Tomoko Ozawa; Mitchel S Berger; Dana T Aftab; Michael D Prados; Daphne A Haas-Kogan
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide.
Neuro-oncology 2011;13(4):384-92.
2010: Anders I Persson; Claudia Petritsch; Fredrik J Swartling; Melissa Itsara; Fraser J Sim; Romane Auvergne; David D Goldenberg; Scott R Vandenberg; Kim N Nguyen; Stanislava Yakovenko; Jennifer Ayers-Ringler; Akiko Nishiyama; William B Stallcup; Mitchel S Berger; Gabriele Bergers; Tracy R McKnight; Steven Goldman; William A Weiss
Non-stem cell origin for oligodendroglioma.
Cancer cell 2010;18(6):669-82.
2010: Chang-Lae Lee; Hilla Wahnishe; George A Sayre; Hyo-Min Cho; Hee-Joung Kim; Miguel Hernandez-Pampaloni; Randall A Hawkins; Shorouk F Dannoon; Henry VanBrocklin; Melissa Itsara; William A Weiss; Xiaodong Yang; Daphne A Haas-Kogan; Katherine K Matthay; Youngho Seo
Radiation dose estimation using preclinical imaging with 124I-metaiodobenzylguanidine (MIBG) PET.
Medical physics 2010;37(9):4861-7.
2010: Fredrik J Swartling; Matthew R Grimmer; Christopher S Hackett; Paul A Northcott; Qi-Wen Fan; David D Goldenberg; Jasmine Lau; Selma Masic; Kim Nguyen; Slava Yakovenko; Xiao-Ning Zhe; Heather C Flynn Gilmer; Rodney Collins; Mai Nagaoka; Joanna J Phillips; Robert B Jenkins; Tarik Tihan; Scott R Vandenberg; C David James; Kohichi Tanaka; Michael D Taylor; William A Weiss; Louis Chesler
Pleiotropic role for MYCN in medulloblastoma.
Genes & development 2010;24(10):1059-72.
2010: W. Gustafson; William A Weiss
Myc proteins as therapeutic targets.
Oncogene 2010;29(9):1249-59.
2010: Qi-Wen Fan; Christine Cheng; Christopher S Hackett; Morri Feldman; Benjamin T Houseman; Theodore paul nicolaides; Daphne A Haas-Kogan; C David James; Scott A Oakes; Jayanta Debnath; Kevan M Shokat; William A Weiss
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Science signaling 2010;3(147):ra81.
2010: Qi-Wen Fan; William A Weiss
Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.
Current topics in microbiology and immunology 2010;347():279-96.
2009: Christopher S Hackett; William A Weiss
A translational end-run for a rare, genetically enigmatic tumor.
Cancer biology & therapy 2009;8(24):2396-7.
2009: F J Swartling; M Ferletta; M Kastemar; William A Weiss; B Westermark
Cyclic GMP-dependent protein kinase II inhibits cell proliferation, Sox9 expression and Akt phosphorylation in human glioma cell lines.
Oncogene 2009;28(35):3121-31.
2009: Anders I Persson; William A Weiss
The side story of stem-like glioma cells.
Cell stem cell 2009;4(3):191-2.
2009: Qi-Wen Fan; Christine Cheng; Zachary A Knight; Daphne A Haas-Kogan; David Stokoe; C David James; Frank McCormick; Kevan M Shokat; William A Weiss
EGFR signals to mTOR through PKC and independently of Akt in glioma.
Science signaling 2009;2(55):ra4.
2008: Louis Chesler; David D Goldenberg; Rodney Collins; Matt Grimmer; Grace E Kim; Tarik Tihan; Kim Nguyen; Slava Yakovenko; Katherine K Matthay; William A Weiss
Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction.
Neoplasia (New York, N.Y.) 2008;10(11):1268-74.
2008: Wei Yu; Annette M Shewan; Paul Brakeman; Dennis J Eastburn; Anirban Datta; David M Bryant; Qi-Wen Fan; William A Weiss; Mirjam M P Zegers; Keith E Mostov
Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity.
EMBO reports 2008;9(9):923-9.
2008: Matthew R Grimmer; William A Weiss
BMPs oppose Math1 in cerebellar development and in medulloblastoma.
Genes & development 2008;22(6):693-9.
2008: Joachim Silber; Daniel A Lim; Claudia Petritsch; Anders I Persson; Alika K Maunakea; Mamie Yu; Scott R Vandenberg; David Ginzinger; C David James; Joseph F Costello; Gabriele Bergers; William A Weiss; Arturo Alvarez-Buylla; J Graeme Hodgson
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.
BMC medicine 2008;6():14.
2007: Gary E Meyer; Louis Chesler; Dandan Liu; Karissa L Gable; Betty A Maddux; David D Goldenberg; Jack F Youngren; Ira D Goldfine; William A Weiss; Katherine K Matthay; Stephen M Rosenthal
Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
Journal of cellular biochemistry 2007;102(6):1529-41.
2007: Louis Chesler; David D Goldenberg; Isha T Seales; Ronit Satchi-Fainaro; Matt Grimmer; Rodney Collins; Chris Struett; Kim N Nguyen; Grace Kim; Tarik Tihan; Yun Bao; Rolf Brekken; Gabriele Bergers; Judah Folkman; William A Weiss
Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma.
Cancer research 2007;67(19):9435-42.
2007: Qi-Wen Fan; Christine K Cheng; Theodore paul nicolaides; Christopher S Hackett; Zachary A Knight; Kevan M Shokat; William A Weiss
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
Cancer research 2007;67(17):7960-5.
2007: Andy J Cheng; Ngan Ching Cheng; Jette Ford; Janice Smith; Jayne E Murray; Claudia Flemming; Maria Lastowska; Michael S Jackson; Christopher S Hackett; William A Weiss; Glenn M Marshall; Ursula R Kees; Murray D Norris; Michelle Haber
Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.
European journal of cancer (Oxford, England : 1990) 2007;43(9):1467-75.
2007: Jimmy A Blair; Daniel Rauh; Charles Kung; Cai-Hong Yun; Qi-Wen Fan; Haridas Rode; Chao Zhang; Michael J Eck; William A Weiss; Kevan M Shokat
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
Nature chemical biology 2007;3(4):229-38.
2006: Matthew R Grimmer; William A Weiss
Childhood tumors of the nervous system as disorders of normal development.
Current opinion in pediatrics 2006;18(6):634-8.
2006: Qi-Wen Fan; William A Weiss
Isoform specific inhibitors of PI3 kinase in glioma.
Cell cycle (Georgetown, Tex.) 2006;5(20):2301-5.
2006: Louis Chesler; Christopher Schlieve; David D Goldenberg; Anna Marie Kenney; Grace Kim; Alex McMillan; Katherine K Matthay; David H Rowitch; William A Weiss
Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.
Cancer research 2006;66(16):8139-46.
2006: Zachary A Knight; Beatriz Gonzalez; Morri E Feldman; Eli R Zunder; David D Goldenberg; Olusegun Williams; Robbie Loewith; David Stokoe; Andras Balla; Balazs Toth; Tamas Balla; William A Weiss; Roger L Williams; Kevan M Shokat
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Cell 2006;125(4):733-47.
2006: Qi-Wen Fan; Zachary A Knight; David D Goldenberg; Wei Yu; Keith E Mostov; David Stokoe; Kevan M Shokat; William A Weiss
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Cancer cell 2006;9(5):341-9.
2006: Qi-Wen Fan; William A Weiss
Chemical genetic approaches to the development of cancer therapeutics.
Current opinion in genetics & development 2006;16(1):85-91.
2005: Tsui-Ting Ching; Alika K Maunakea; Peter Jun; Chibo Hong; Giuseppe Zardo; Daniel Pinkel; Donna G Albertson; Jane Fridlyand; Jian-Hua Mao; Ksenya Shchors; William A Weiss; Joseph F Costello
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3.
Nature genetics 2005;37(6):645-51.
2005: Chibo Hong; Alika K Maunakea; Peter Jun; Andrew W Bollen; J Graeme Hodgson; David D Goldenberg; William A Weiss; Joseph F Costello
Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.
Cancer research 2005;65(9):3617-23.
2005: Qi-Wen Fan; William A Weiss
RNA interference against a glioma-derived allele of EGFR induces blockade at G2M.
Oncogene 2005;24(5):829-37.
2004: Loen M Hansford; Wayne D Thomas; Joanna M Keating; Catherine A Burkhart; Anne E Peaston; Murray D Norris; Michelle Haber; Patricia J Armati; William A Weiss; Glenn M Marshall
Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12664-9.
2004: William A Weiss; Anu Banerjee
Can mouse models for brain tumors inform treatment in pediatric patients?
Seminars in cancer biology 2004;14(1):71-7.
2003: Qi-Wen Fan; Kimberly Musa Specht; Chao Zhang; David D Goldenberg; Kevan M Shokat; William A Weiss
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
Cancer research 2003;63(24):8930-8.
2003: Catherine A Burkhart; Andy J Cheng; Janice Madafiglio; Maria Kavallaris; Mario Mili; Glenn M Marshall; William A Weiss; Levon M Khachigian; Murray D Norris; Michelle Haber
Effects of MYCN antisense oligonucleotide administration on tumorigenesis in a murine model of neuroblastoma.
Journal of the National Cancer Institute 2003;95(18):1394-403.
2003: Christopher S Hackett; J Graeme Hodgson; Mark E Law; Jane Fridlyand; Kazutoyo Osoegawa; Pieter J de Jong; Norma J Nowak; Daniel Pinkel; Donna G Albertson; Ajay Jain; Robert Jenkins; Joe Gray; William A Weiss
Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.
Cancer research 2003;63(17):5266-73.
2003: William A Weiss; Michael J Burns; Christopher S Hackett; Kenneth Aldape; John R Hill; Hiroko Kuriyama; Nagato Kuriyama; Nadezhda Milshteyn; Tim Roberts; Michael F Wendland; Ronald A DePinho; Mark Israel
Genetic determinants of malignancy in a mouse model for oligodendroglioma.
Cancer research 2003;63(7):1589-95.
2002: William A Weiss; Mark Israel; Charles S Cobbs; Eric C Holland; C David James; David N Louis; Cheryl Marks; Andrea I McClatchey; Tim Roberts; Terry Van Dyke; Cynthia Wetmore; Ing-Ming Chiu; Marco Giovannini; Abhijit Guha; Robert J Higgins; Silvia Marino; Ivan Radovanovic; Karlyne M Reilly; Kenneth Aldape
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.
Oncogene 2002;21(49):7453-63.
2002: Qi-Wen Fan; Chao Zhang; Kevan M Shokat; William A Weiss
Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling.
Current biology : CB 2002;12(16):1386-94.
2000: Murray D Norris; Catherine A Burkhart; Glenn M Marshall; William A Weiss; Michelle Haber
Expression of N-myc and MRP genes and their relationship to N-myc gene dosage and tumor formation in a murine neuroblastoma model.
Medical and pediatric oncology 2000;35(6):585-9.
2000: William A Weiss
Genetics of brain tumors.
Current opinion in pediatrics 2000;12(6):543-8.
2000: William A Weiss; Tony E Godfrey; Carla Francisco; John M Bishop
Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma.
Cancer research 2000;60(9):2483-7.
1997: William A Weiss; Kenneth Aldape; G Mohapatra; Burt Feuerstein; John M Bishop
Targeted expression of MYCN causes neuroblastoma in transgenic mice.
The EMBO journal 1997;16(11):2985-95.